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Entry version 106 (13 Feb 2019)
Sequence version 1 (21 Dec 2004)
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Protein

Small RNA 2'-O-methyltransferase

Gene

HENMT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarityNote: Binds 1 Mg2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei36S-adenosyl-L-methionineCombined sources1 Publication1
Binding sitei55S-adenosyl-L-methionine; via carbonyl oxygenCombined sources1 Publication1
Binding sitei78S-adenosyl-L-methionineCombined sources1 Publication1
Binding sitei83S-adenosyl-L-methionineCombined sources1 Publication1
Binding sitei115S-adenosyl-L-methionine; via amide nitrogenCombined sources1
Binding sitei131S-adenosyl-L-methionine; via carbonyl oxygenCombined sources1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi132MagnesiumBy similarity1
Metal bindingi135MagnesiumBy similarity1
Metal bindingi136Magnesium; via tele nitrogenBy similarity1
Metal bindingi181Magnesium; via tele nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • piRNA metabolic process Source: UniProtKB
  • production of siRNA involved in RNA interference Source: GO_Central
  • RNA methylation Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase
Biological processRNA-mediated gene silencing
LigandMetal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small RNA 2'-O-methyltransferase (EC:2.1.1.n8By similarity)
Alternative name(s):
HEN1 methyltransferase homolog 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HENMT1
Synonyms:C1orf59
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162639.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26400 HENMT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612178 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T8I9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
113802

Open Targets

More...
OpenTargetsi
ENSG00000162639

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA128394748

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HENMT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74745527

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003041391 – 393Small RNA 2'-O-methyltransferaseAdd BLAST393

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T8I9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5T8I9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T8I9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T8I9

PeptideAtlas

More...
PeptideAtlasi
Q5T8I9

PRoteomics IDEntifications database

More...
PRIDEi
Q5T8I9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
64735

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T8I9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T8I9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162639 Expressed in 170 organ(s), highest expression level in oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5T8I9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T8I9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028464
HPA028497

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125261, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T8I9, 4 interactors

Molecular INTeraction database

More...
MINTi
Q5T8I9

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359049

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1393
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XCXX-ray2.84A14-262[»]
5WY0X-ray2.00A31-258[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5T8I9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5T8I9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1045 Eukaryota
ENOG410XSD6 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000004798

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000049068

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG097349

KEGG Orthology (KO)

More...
KOi
K20798

Database of Orthologous Groups

More...
OrthoDBi
789470at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T8I9

TreeFam database of animal gene trees

More...
TreeFami
TF315178

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026610 Hen1
IPR029063 SAM-dependent_MTases

The PANTHER Classification System

More...
PANTHERi
PTHR21404 PTHR21404, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5T8I9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEENNLQCSS VVDGNFEEVP RETAIQFKPP LYRQRYQFVK NLVDQHEPKK
60 70 80 90 100
VADLGCGDTS LLRLLKVNPC IELLVGVDIN EDKLRWRGDS LAPFLGDFLK
110 120 130 140 150
PRDLNLTITL YHGSVVERDS RLLGFDLITC IELIEHLDSG DLARFPEVVF
160 170 180 190 200
GYLSPSMIVI STPNSEFNPL FPSVTLRDSD HKFEWTRMEF QTWALYVANR
210 220 230 240 250
YDYSVEFTGV GEPPAGAENV GYCTQIGIFR KNGGKATESC LSEQHDQHVY
260 270 280 290 300
KAVFTTSYPS LQQERFFKLV LVNEVSQQVE SLRVSHLPRR KEQAGERGDK
310 320 330 340 350
PKDIGGSKAP VPCFGPVFTE VEKAKIENSP TPFCVGDKFF VPLQRLLAYP
360 370 380 390
KLNRLCANEE MMRSVIADSI PLSSDGSAVV ADLRNYFDEQ FEF
Length:393
Mass (Da):44,525
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i897A46664A44F6C5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MRN1A0A0A0MRN1_HUMAN
Small RNA 2'-O-methyltransferase
HENMT1
424Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RGV9X6RGV9_HUMAN
Small RNA 2'-O-methyltransferase
HENMT1
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti154S → F in BAB70852 (PubMed:14702039).Curated1
Sequence conflicti365V → A in BAB70852 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_035017129T → A. Corresponds to variant dbSNP:rs9988420Ensembl.1
Natural variantiVAR_035018230R → Q. Corresponds to variant dbSNP:rs35974434Ensembl.1
Natural variantiVAR_035019361M → I1 PublicationCorresponds to variant dbSNP:rs17850887Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055087 mRNA Translation: BAB70852.1
AL160171 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56326.1
BC012198 mRNA Translation: AAH12198.1
BC088366 mRNA Translation: AAH88366.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS787.1

NCBI Reference Sequences

More...
RefSeqi
NP_001096062.1, NM_001102592.1
NP_653185.2, NM_144584.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.7962

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370032; ENSP00000359049; ENSG00000162639
ENST00000402983; ENSP00000385655; ENSG00000162639

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
113802

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:113802

UCSC genome browser

More...
UCSCi
uc001dvt.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055087 mRNA Translation: BAB70852.1
AL160171 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56326.1
BC012198 mRNA Translation: AAH12198.1
BC088366 mRNA Translation: AAH88366.1
CCDSiCCDS787.1
RefSeqiNP_001096062.1, NM_001102592.1
NP_653185.2, NM_144584.2
UniGeneiHs.7962

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XCXX-ray2.84A14-262[»]
5WY0X-ray2.00A31-258[»]
ProteinModelPortaliQ5T8I9
SMRiQ5T8I9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125261, 10 interactors
IntActiQ5T8I9, 4 interactors
MINTiQ5T8I9
STRINGi9606.ENSP00000359049

PTM databases

iPTMnetiQ5T8I9
PhosphoSitePlusiQ5T8I9

Polymorphism and mutation databases

BioMutaiHENMT1
DMDMi74745527

Proteomic databases

EPDiQ5T8I9
jPOSTiQ5T8I9
MaxQBiQ5T8I9
PaxDbiQ5T8I9
PeptideAtlasiQ5T8I9
PRIDEiQ5T8I9
ProteomicsDBi64735

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
113802
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370032; ENSP00000359049; ENSG00000162639
ENST00000402983; ENSP00000385655; ENSG00000162639
GeneIDi113802
KEGGihsa:113802
UCSCiuc001dvt.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
113802
DisGeNETi113802
EuPathDBiHostDB:ENSG00000162639.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HENMT1
HGNCiHGNC:26400 HENMT1
HPAiHPA028464
HPA028497
MIMi612178 gene
neXtProtiNX_Q5T8I9
OpenTargetsiENSG00000162639
PharmGKBiPA128394748

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1045 Eukaryota
ENOG410XSD6 LUCA
GeneTreeiENSGT00390000004798
HOGENOMiHOG000049068
HOVERGENiHBG097349
KOiK20798
OrthoDBi789470at2759
PhylomeDBiQ5T8I9
TreeFamiTF315178

Enzyme and pathway databases

ReactomeiR-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HENMT1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
113802

Protein Ontology

More...
PROi
PR:Q5T8I9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162639 Expressed in 170 organ(s), highest expression level in oocyte
ExpressionAtlasiQ5T8I9 baseline and differential
GenevisibleiQ5T8I9 HS

Family and domain databases

InterProiView protein in InterPro
IPR026610 Hen1
IPR029063 SAM-dependent_MTases
PANTHERiPTHR21404 PTHR21404, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHENMT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T8I9
Secondary accession number(s): A8MRR6
, B1AM16, B1AM17, Q96EJ7, Q96NN0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 21, 2004
Last modified: February 13, 2019
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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