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Entry version 106 (08 May 2019)
Sequence version 2 (22 Jul 2008)
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Protein

Protein FAM102B

Gene

FAM102B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein FAM102B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAM102B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:27637 FAM102B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T8I3

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
284611

Open Targets

More...
OpenTargetsi
ENSG00000162636

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142671785

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAM102B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
205831290

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002361801 – 360Protein FAM102BAdd BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei228PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei288PhosphoserineCombined sources1
Modified residuei320PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1
Modified residuei350PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5T8I3

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5T8I3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T8I3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T8I3

PeptideAtlas

More...
PeptideAtlasi
Q5T8I3

PRoteomics IDEntifications database

More...
PRIDEi
Q5T8I3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
64733
64734 [Q5T8I3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T8I3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T8I3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162636 Expressed in 199 organ(s), highest expression level in dorsolateral prefrontal cortex

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T8I3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA028451

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
129914, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T8I3, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359052

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5T8I3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 142C2 NT-typePROSITE-ProRule annotationAdd BLAST142

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 10Poly-Lys8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FAM102 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IWVB Eukaryota
ENOG4110G47 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156132

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230902

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T8I3

Identification of Orthologs from Complete Genome Data

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OMAi
PCKMSAS

Database of Orthologous Groups

More...
OrthoDBi
725501at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T8I3

TreeFam database of animal gene trees

More...
TreeFami
TF320966

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039931 FAM102-like
IPR019448 NT-C2

The PANTHER Classification System

More...
PANTHERi
PTHR21456 PTHR21456, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10358 NT-C2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51840 C2_NT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5T8I3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMKKKKFKFK VDFELEELSS VPFVNGVLFC KMRLLDGGSF TAESSREVVQ
60 70 80 90 100
ANCVRWRKKF SFMCKMSASA ATGILDPCIY RVSVRKELKG GKAYAKLGFA
110 120 130 140 150
DLNLAEFAGS GNTTRRCLLE GYDTKNTRQD NSILKVLISM QLMSGDPCFK
160 170 180 190 200
TPPSTSMSIP IAGESESLQE DRKGGETLKV HLGIADLSAK SASVPDELGA
210 220 230 240 250
CGHSRTSSYA SQQSKVSGYS TCHSRSSSFS ELCHRRNTSV GSTSTGVESI
260 270 280 290 300
LEPCDEIEQK IAEPNLDTAD KEDTASEKLS RCPVKQDSVE SQLKRVDDTR
310 320 330 340 350
VDADDIVEKI LQSQDFSLDS SAEEEGLRLF VGPGGSTTFG SHHLPNRVGS
360
GAYEQVVIKR
Length:360
Mass (Da):39,308
Last modified:July 22, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6B10349E4B755FE4
GO
Isoform 2 (identifier: Q5T8I3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     347-360: RVGSGAYEQVVIKR → SALEAPSLL

Note: No experimental confirmation available.
Show »
Length:355
Mass (Da):38,647
Checksum:i4EE6DAEDB7F01040
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI27899 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI40864 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI40866 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI50531 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_034833347 – 360RVGSG…VVIKR → SALEAPSLL in isoform 2. CuratedAdd BLAST14

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL160171 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56323.1
BC127898 mRNA Translation: AAI27899.2 Different initiation.
BC140863 mRNA Translation: AAI40864.1 Different initiation.
BC140865 mRNA Translation: AAI40866.1 Different initiation.
BC150530 mRNA Translation: AAI50531.1 Different initiation.
CR749397 mRNA Translation: CAH18243.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30786.2 [Q5T8I3-1]

NCBI Reference Sequences

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RefSeqi
NP_001010883.2, NM_001010883.2 [Q5T8I3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370035; ENSP00000359052; ENSG00000162636 [Q5T8I3-1]
ENST00000405454; ENSP00000386084; ENSG00000162636 [Q5T8I3-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
284611

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:284611

UCSC genome browser

More...
UCSCi
uc010ouy.3 human [Q5T8I3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL160171 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56323.1
BC127898 mRNA Translation: AAI27899.2 Different initiation.
BC140863 mRNA Translation: AAI40864.1 Different initiation.
BC140865 mRNA Translation: AAI40866.1 Different initiation.
BC150530 mRNA Translation: AAI50531.1 Different initiation.
CR749397 mRNA Translation: CAH18243.1
CCDSiCCDS30786.2 [Q5T8I3-1]
RefSeqiNP_001010883.2, NM_001010883.2 [Q5T8I3-1]

3D structure databases

SMRiQ5T8I3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129914, 11 interactors
IntActiQ5T8I3, 5 interactors
STRINGi9606.ENSP00000359052

PTM databases

iPTMnetiQ5T8I3
PhosphoSitePlusiQ5T8I3

Polymorphism and mutation databases

BioMutaiFAM102B
DMDMi205831290

Proteomic databases

EPDiQ5T8I3
jPOSTiQ5T8I3
MaxQBiQ5T8I3
PaxDbiQ5T8I3
PeptideAtlasiQ5T8I3
PRIDEiQ5T8I3
ProteomicsDBi64733
64734 [Q5T8I3-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370035; ENSP00000359052; ENSG00000162636 [Q5T8I3-1]
ENST00000405454; ENSP00000386084; ENSG00000162636 [Q5T8I3-2]
GeneIDi284611
KEGGihsa:284611
UCSCiuc010ouy.3 human [Q5T8I3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
284611
DisGeNETi284611

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FAM102B

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0000835
HGNCiHGNC:27637 FAM102B
HPAiHPA028451
neXtProtiNX_Q5T8I3
OpenTargetsiENSG00000162636
PharmGKBiPA142671785

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IWVB Eukaryota
ENOG4110G47 LUCA
GeneTreeiENSGT00940000156132
HOGENOMiHOG000230902
InParanoidiQ5T8I3
OMAiPCKMSAS
OrthoDBi725501at2759
PhylomeDBiQ5T8I3
TreeFamiTF320966

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FAM102B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
284611

Protein Ontology

More...
PROi
PR:Q5T8I3

Gene expression databases

BgeeiENSG00000162636 Expressed in 199 organ(s), highest expression level in dorsolateral prefrontal cortex
GenevisibleiQ5T8I3 HS

Family and domain databases

InterProiView protein in InterPro
IPR039931 FAM102-like
IPR019448 NT-C2
PANTHERiPTHR21456 PTHR21456, 1 hit
PfamiView protein in Pfam
PF10358 NT-C2, 1 hit
PROSITEiView protein in PROSITE
PS51840 C2_NT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiF102B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T8I3
Secondary accession number(s): A1L1A1
, B0QZ46, B0QZ47, Q68DH7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 22, 2008
Last modified: May 8, 2019
This is version 106 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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