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Protein

Acyl-CoA-binding domain-containing protein 5

Gene

ACBD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei98Acyl-CoA1
Binding sitei117Acyl-CoABy similarity1

GO - Molecular functioni

GO - Biological processi

  • autophagy of peroxisome Source: UniProtKB
  • fatty acid catabolic process Source: Reactome

Keywordsi

Biological processAutophagy, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-390918 Peroxisomal lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 5
Gene namesi
Name:ACBD5
Synonyms:KIAA1996
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107897.18
HGNCiHGNC:23338 ACBD5
MIMi616618 gene
neXtProtiNX_Q5T8D3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi91452
OpenTargetsiENSG00000107897
PharmGKBiPA134892991

Polymorphism and mutation databases

DMDMi74745508

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002873771 – 534Acyl-CoA-binding domain-containing protein 5Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei193PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei279PhosphoserineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei400PhosphothreonineCombined sources1
Modified residuei428PhosphoserineCombined sources1
Modified residuei469N6-acetyllysineBy similarity1
Isoform 4 (identifier: Q5T8D3-4)
Modified residuei63PhosphothreonineCombined sources1
Isoform 2 (identifier: Q5T8D3-2)
Modified residuei137PhosphothreonineCombined sources1
Isoform 3 (identifier: Q5T8D3-3)
Modified residuei172PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ5T8D3
MaxQBiQ5T8D3
PaxDbiQ5T8D3
PeptideAtlasiQ5T8D3
PRIDEiQ5T8D3
ProteomicsDBi64724
64725 [Q5T8D3-2]
64726 [Q5T8D3-3]
64727 [Q5T8D3-4]

PTM databases

iPTMnetiQ5T8D3
PhosphoSitePlusiQ5T8D3

Expressioni

Gene expression databases

BgeeiENSG00000107897
CleanExiHS_ACBD5
ExpressionAtlasiQ5T8D3 baseline and differential
GenevisibleiQ5T8D3 HS

Organism-specific databases

HPAiHPA011861
HPA012145

Interactioni

Protein-protein interaction databases

BioGridi124836, 22 interactors
IntActiQ5T8D3, 22 interactors
STRINGi9606.ENSP00000379568

Structurei

Secondary structure

1534
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi41 – 58Combined sources18
Helixi65 – 79Combined sources15
Helixi93 – 104Combined sources12
Turni105 – 107Combined sources3
Helixi110 – 127Combined sources18

3D structure databases

ProteinModelPortaliQ5T8D3
SMRiQ5T8D3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ5T8D3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 130ACBPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 61Acyl-CoA binding10
Regioni72 – 76Acyl-CoA binding5

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 219Sequence analysisAdd BLAST30
Coiled coili447 – 476Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 16Poly-Cys4
Compositional biasi201 – 204Poly-Glu4
Compositional biasi528 – 531Poly-Arg4

Sequence similaritiesi

Belongs to the ATG37 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
GeneTreeiENSGT00840000129776
HOVERGENiHBG106445
InParanoidiQ5T8D3
OMAiGRGHRMQ
OrthoDBiEOG091G0NXJ
PhylomeDBiQ5T8D3
TreeFamiTF319446

Family and domain databases

Gene3Di1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR016347 ACBD5
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PIRSFiPIRSF002412 MA_DBI, 1 hit
PRINTSiPR00689 ACOABINDINGP
SUPFAMiSSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T8D3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFQFHAGSWE SWCCCCLIPA DRPWDRGQHW QLEMADTRSV HETRFEAAVK
60 70 80 90 100
VIQSLPKNGS FQPTNEMMLK FYSFYKQATE GPCKLSRPGF WDPIGRYKWD
110 120 130 140 150
AWSSLGDMTK EEAMIAYVEE MKKIIETMPM TEKVEELLRV IGPFYEIVED
160 170 180 190 200
KKSGRSSDIT SVRLEKISKC LEDLGNVLTS TPNAKTVNGK AESSDSGAES
210 220 230 240 250
EEEEAQEEVK GAEQSDNDKK MMKKSADHKN LEVIVTNGYD KDGFVQDIQN
260 270 280 290 300
DIHASSSLNG RSTEEVKPID ENLGQTGKSA VCIHQDINDD HVEDVTGIQH
310 320 330 340 350
LTSDSDSEVY CDSMEQFGQE ESLDSFTSNN GPFQYYLGGH SSQPMENSGF
360 370 380 390 400
REDIQVPPGN GNIGNMQVVA VEGKGEVKHG GEDGRNNSGA PHREKRGGET
410 420 430 440 450
DEFSNVRRGR GHRMQHLSEG TKGRQVGSGG DGERWGSDRG SRGSLNEQIA
460 470 480 490 500
LVLMRLQEDM QNVLQRLQKL ETLTALQAKS STSTLQTAPQ PTSQRPSWWP
510 520 530
FEMSPGVLTF AIIWPFIAQW LVYLYYQRRR RKLN
Length:534
Mass (Da):60,092
Last modified:December 21, 2004 - v1
Checksum:i8BE9A09967717653
GO
Isoform 2 (identifier: Q5T8D3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     162-172: Missing.

Show »
Length:490
Mass (Da):54,786
Checksum:i35B7F4B27ECE706B
GO
Isoform 3 (identifier: Q5T8D3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MFQ → MLFLS
     162-172: Missing.

Show »
Length:525
Mass (Da):58,978
Checksum:i95E2AD87B672D414
GO
Isoform 4 (identifier: Q5T8D3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.
     162-172: Missing.

Show »
Length:416
Mass (Da):46,268
Checksum:i2FD7CD93EAA41CC9
GO

Sequence cautioni

The sequence AAH30555 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti332P → Q in AAP30852 (Ref. 1) Curated1
Sequence conflicti419E → D in AAP30852 (Ref. 1) Curated1
Sequence conflicti478A → T in AAP30852 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032301472T → M. Corresponds to variant dbSNP:rs7918793Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0254481 – 107Missing in isoform 4. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_0254471 – 33Missing in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0254461 – 3MFQ → MLFLS in isoform 3. 1 Publication3
Alternative sequenceiVSP_025449162 – 172Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF505653 mRNA Translation: AAP30852.1
AK057469 mRNA Translation: BAG51918.1
AL160291 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86062.1
CH471072 Genomic DNA Translation: EAW86061.1
CH471072 Genomic DNA Translation: EAW86063.1
BC030555 mRNA Translation: AAH30555.1 Different initiation.
AL133064 mRNA Translation: CAB61388.1
CCDSiCCDS44368.1 [Q5T8D3-3]
CCDS7154.1 [Q5T8D3-2]
CCDS76290.1 [Q5T8D3-4]
PIRiT42665
RefSeqiNP_001035938.1, NM_001042473.3 [Q5T8D3-2]
NP_001288180.1, NM_001301251.1 [Q5T8D3-4]
NP_001288181.1, NM_001301252.1 [Q5T8D3-4]
NP_001288182.1, NM_001301253.1 [Q5T8D3-4]
NP_663736.2, NM_145698.4 [Q5T8D3-3]
XP_016872396.1, XM_017016907.1
XP_016872397.1, XM_017016908.1
UniGeneiHs.530597

Genome annotation databases

EnsembliENST00000375888; ENSP00000365049; ENSG00000107897 [Q5T8D3-1]
ENST00000375901; ENSP00000365066; ENSG00000107897 [Q5T8D3-4]
ENST00000375905; ENSP00000365070; ENSG00000107897 [Q5T8D3-2]
ENST00000396271; ENSP00000379568; ENSG00000107897 [Q5T8D3-3]
GeneIDi91452
KEGGihsa:91452
UCSCiuc001ito.4 human [Q5T8D3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiACBD5_HUMAN
AccessioniPrimary (citable) accession number: Q5T8D3
Secondary accession number(s): B3KQ56
, D3DRW0, Q5T8D4, Q5T8E1, Q5T8E2, Q86UV1, Q8N6E3, Q9UFB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 21, 2004
Last modified: July 18, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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