ACBD5

Functionⁱ

Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.

1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	98	Acyl-CoA		1
Binding siteⁱ	117	Acyl-CoABy similarity		1

GO - Molecular functionⁱ

fatty-acyl-CoA binding Source: InterPro
lipid binding Source: UniProtKB-KW

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagy of peroxisome
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- Ref.8
  "Peroxisomal Atg37 binds Atg30 or palmitoyl-CoA to regulate phagophore formation during pexophagy."
  Nazarko T.Y., Ozeki K., Till A., Ramakrishnan G., Lotfi P., Yan M., Subramani S.
  J. Cell Biol. 204:541-557(2014) [PubMed] [Europe PMC] [Abstract]
  Cited for: SUBCELLULAR LOCATION, FUNCTION.

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Autophagy, Transport
Ligand	Lipid-binding

Enzyme and pathway databases

PathwayCommonsⁱ	Q5T8D3
Reactomeⁱ	R-HSA-390918, Peroxisomal lipid metabolism R-HSA-8980692, RHOA GTPase cycle R-HSA-9013106, RHOC GTPase cycle R-HSA-9603798, Class I peroxisomal membrane protein import

Protein family/group databases

TCDBⁱ	1.R.1.1.1, the membrane contact site (mcs) family

TCDBⁱ

1.R.1.1.1, the membrane contact site (mcs) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Acyl-CoA-binding domain-containing protein 5
Gene namesⁱ	Name:ACBD5 Synonyms:KIAA1996
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23338, ACBD5
MIMⁱ	616618, gene
neXtProtⁱ	NX_Q5T8D3
VEuPathDBⁱ	HostDB:ENSG00000107897

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	506 – 526	HelicalSequence analysisAdd BLAST		21

Keywords - Cellular componentⁱ

Membrane, Peroxisome

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Retinal dystrophy with leukodystrophy (RDLKD)2 Publications

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disorder characterized by progressive leukodystrophy associated with developmental delay, spastic paraparesis, ataxia, and retinal dystrophy. Patients may show facial dysmorphism. Laboratory investigations reveal an abnormal profile of very-long chain fatty acid in plasma.

Related information in OMIM

Keywords - Diseaseⁱ

Leukodystrophy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	91452
MalaCards human disease database More...MalaCardsⁱ	ACBD5
MIMⁱ	618863, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000107897
PharmGKBⁱ	PA134892991

Miscellaneous databases

Pharosⁱ	Q5T8D3, Tbio

Pharosⁱ

Q5T8D3, Tbio

Genetic variation databases

BioMutaⁱ	ACBD5
DMDMⁱ	74745508

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000287377	1 – 534	Acyl-CoA-binding domain-containing protein 5Add BLAST		534

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	193	PhosphoserineCombined sources	1
Modified residueⁱ	194	PhosphoserineCombined sources	1
Modified residueⁱ	196	PhosphoserineCombined sources	1
Modified residueⁱ	200	PhosphoserineCombined sources	1
Modified residueⁱ	215	PhosphoserineCombined sources	1
Modified residueⁱ	279	PhosphoserineCombined sources	1
Modified residueⁱ	313	PhosphoserineCombined sources	1
Modified residueⁱ	400	PhosphothreonineCombined sources	1
Modified residueⁱ	428	PhosphoserineCombined sources	1
Modified residueⁱ	469	N6-acetyllysineBy similarity	1
Isoform 4 (identifier: Q5T8D3-4)
Modified residueⁱ	63	PhosphothreonineCombined sources	1
Isoform 2 (identifier: Q5T8D3-2)
Modified residueⁱ	137	PhosphothreonineCombined sources	1
Isoform 3 (identifier: Q5T8D3-3)
Modified residueⁱ	172	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q5T8D3
jPOSTⁱ	Q5T8D3
MassIVEⁱ	Q5T8D3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5T8D3
PaxDbⁱ	Q5T8D3
PeptideAtlas More...PeptideAtlasⁱ	Q5T8D3
PRIDEⁱ	Q5T8D3
ProteomicsDBⁱ	64724 [Q5T8D3-1] 64725 [Q5T8D3-2] 64726 [Q5T8D3-3] 64727 [Q5T8D3-4]

PTM databases

GlyGenⁱ	Q5T8D3, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	Q5T8D3
PhosphoSitePlusⁱ	Q5T8D3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000107897, Expressed in brain and 221 other tissues
ExpressionAtlasⁱ	Q5T8D3, baseline and differential
Genevisibleⁱ	Q5T8D3, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000107897, Low tissue specificity

HPAⁱ

ENSG00000107897, Low tissue specificity

Interactionⁱ

Binary interactionsⁱ

Hide details

Isoform 2 [Q5T8D3-2]

With	#Exp.	IntAct
GRM2 [Q14416]	3	EBI-10961679,EBI-10232876
SLC38A7 [Q9NVC3]	3	EBI-10961679,EBI-10314552
STX1B [P61266]	3	EBI-10961679,EBI-9071709
TMEM229B [Q8NBD8]	3	EBI-10961679,EBI-12195227

Protein-protein interaction databases

BioGRIDⁱ	124836, 63 interactors
IntActⁱ	Q5T8D3, 26 interactors
STRINGⁱ	9606.ENSP00000379568

Miscellaneous databases

RNActⁱ	Q5T8D3, protein

RNActⁱ

Q5T8D3, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	41 – 58	Combined sources	18
Helixⁱ	65 – 79	Combined sources	15
Helixⁱ	93 – 104	Combined sources	12
Turnⁱ	105 – 107	Combined sources	3
Helixⁱ	110 – 127	Combined sources	18

Show more details

3D structure databases

SMRⁱ	Q5T8D3
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q5T8D3

EvolutionaryTraceⁱ

Q5T8D3

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	41 – 130	ACBPROSITE-ProRule annotationAdd BLAST		90

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	52 – 61	Acyl-CoA binding	10
Regionⁱ	72 – 76	Acyl-CoA binding	5
Regionⁱ	181 – 225	DisorderedSequence analysisAdd BLAST	45
Regionⁱ	376 – 442	DisorderedSequence analysisAdd BLAST	67

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	190 – 219	Sequence analysisAdd BLAST		30
Coiled coilⁱ	447 – 476	Sequence analysisAdd BLAST		30

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	210 – 225	Basic and acidic residuesSequence analysisAdd BLAST		16
Compositional biasⁱ	376 – 419	Basic and acidic residuesSequence analysisAdd BLAST		44

Sequence similaritiesⁱ

Belongs to the ATG37 family.Curated

Keywords - Domainⁱ

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0817, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000156350
HOGENOMⁱ	CLU_034436_0_0_1
InParanoidⁱ	Q5T8D3
OMAⁱ	DAMIAYV
Database of Orthologous Groups More...OrthoDBⁱ	1546859at2759
PhylomeDBⁱ	Q5T8D3
TreeFamⁱ	TF319446

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00435, ACBP, 1 hit
Gene3Dⁱ	1.20.80.10, 1 hit
InterProⁱ	View protein in InterPro IPR016347, ACBD5 IPR022408, Acyl-CoA-binding_prot_CS IPR000582, Acyl-CoA-binding_protein IPR035984, Acyl-CoA-binding_sf IPR014352, FERM/acyl-CoA-bd_prot_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00887, ACBP, 1 hit
PIRSFⁱ	PIRSF002412, MA_DBI, 1 hit
PRINTSⁱ	PR00689, ACOABINDINGP
SUPFAMⁱ	SSF47027, SSF47027, 1 hit
PROSITEⁱ	View protein in PROSITE PS00880, ACB_1, 1 hit PS51228, ACB_2, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 20 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q5T8D3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFQFHAGSWE SWCCCCLIPA DRPWDRGQHW QLEMADTRSV HETRFEAAVK 
        60         70         80         90        100
VIQSLPKNGS FQPTNEMMLK FYSFYKQATE GPCKLSRPGF WDPIGRYKWD 
       110        120        130        140        150
AWSSLGDMTK EEAMIAYVEE MKKIIETMPM TEKVEELLRV IGPFYEIVED 
       160        170        180        190        200
KKSGRSSDIT SVRLEKISKC LEDLGNVLTS TPNAKTVNGK AESSDSGAES 
       210        220        230        240        250
EEEEAQEEVK GAEQSDNDKK MMKKSADHKN LEVIVTNGYD KDGFVQDIQN 
       260        270        280        290        300
DIHASSSLNG RSTEEVKPID ENLGQTGKSA VCIHQDINDD HVEDVTGIQH 
       310        320        330        340        350
LTSDSDSEVY CDSMEQFGQE ESLDSFTSNN GPFQYYLGGH SSQPMENSGF 
       360        370        380        390        400
REDIQVPPGN GNIGNMQVVA VEGKGEVKHG GEDGRNNSGA PHREKRGGET 
       410        420        430        440        450
DEFSNVRRGR GHRMQHLSEG TKGRQVGSGG DGERWGSDRG SRGSLNEQIA 
       460        470        480        490        500
LVLMRLQEDM QNVLQRLQKL ETLTALQAKS STSTLQTAPQ PTSQRPSWWP 
       510        520        530 
FEMSPGVLTF AIIWPFIAQW LVYLYYQRRR RKLN

Length:534

Mass (Da):60,092

Last modified:December 21, 2004 - v1

Checksum:ⁱ8BE9A09967717653

GO

Isoform 2 (identifier: Q5T8D3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-33: Missing.
162-172: Missing.

« Hide

        10         20         30         40         50
MADTRSVHET RFEAAVKVIQ SLPKNGSFQP TNEMMLKFYS FYKQATEGPC 
        60         70         80         90        100
KLSRPGFWDP IGRYKWDAWS SLGDMTKEEA MIAYVEEMKK IIETMPMTEK 
       110        120        130        140        150
VEELLRVIGP FYEIVEDKKS GRSSDITSDL GNVLTSTPNA KTVNGKAESS 
       160        170        180        190        200
DSGAESEEEE AQEEVKGAEQ SDNDKKMMKK SADHKNLEVI VTNGYDKDGF 
       210        220        230        240        250
VQDIQNDIHA SSSLNGRSTE EVKPIDENLG QTGKSAVCIH QDINDDHVED 
       260        270        280        290        300
VTGIQHLTSD SDSEVYCDSM EQFGQEESLD SFTSNNGPFQ YYLGGHSSQP 
       310        320        330        340        350
MENSGFREDI QVPPGNGNIG NMQVVAVEGK GEVKHGGEDG RNNSGAPHRE 
       360        370        380        390        400
KRGGETDEFS NVRRGRGHRM QHLSEGTKGR QVGSGGDGER WGSDRGSRGS 
       410        420        430        440        450
LNEQIALVLM RLQEDMQNVL QRLQKLETLT ALQAKSSTST LQTAPQPTSQ 
       460        470        480        490
RPSWWPFEMS PGVLTFAIIW PFIAQWLVYL YYQRRRRKLN

Show »

Length:490

Mass (Da):54,786

Checksum:ⁱ35B7F4B27ECE706B

GO

Isoform 3 (identifier: Q5T8D3-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-3: MFQ → MLFLS
162-172: Missing.

« Hide

        10         20         30         40         50
MLFLSFHAGS WESWCCCCLI PADRPWDRGQ HWQLEMADTR SVHETRFEAA 
        60         70         80         90        100
VKVIQSLPKN GSFQPTNEMM LKFYSFYKQA TEGPCKLSRP GFWDPIGRYK 
       110        120        130        140        150
WDAWSSLGDM TKEEAMIAYV EEMKKIIETM PMTEKVEELL RVIGPFYEIV 
       160        170        180        190        200
EDKKSGRSSD ITSDLGNVLT STPNAKTVNG KAESSDSGAE SEEEEAQEEV 
       210        220        230        240        250
KGAEQSDNDK KMMKKSADHK NLEVIVTNGY DKDGFVQDIQ NDIHASSSLN 
       260        270        280        290        300
GRSTEEVKPI DENLGQTGKS AVCIHQDIND DHVEDVTGIQ HLTSDSDSEV 
       310        320        330        340        350
YCDSMEQFGQ EESLDSFTSN NGPFQYYLGG HSSQPMENSG FREDIQVPPG 
       360        370        380        390        400
NGNIGNMQVV AVEGKGEVKH GGEDGRNNSG APHREKRGGE TDEFSNVRRG 
       410        420        430        440        450
RGHRMQHLSE GTKGRQVGSG GDGERWGSDR GSRGSLNEQI ALVLMRLQED 
       460        470        480        490        500
MQNVLQRLQK LETLTALQAK SSTSTLQTAP QPTSQRPSWW PFEMSPGVLT 
       510        520 
FAIIWPFIAQ WLVYLYYQRR RRKLN

Show »

Length:525

Mass (Da):58,978

Checksum:ⁱ95E2AD87B672D414

GO

Isoform 4 (identifier: Q5T8D3-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-107: Missing.
162-172: Missing.

« Hide

        10         20         30         40         50
MTKEEAMIAY VEEMKKIIET MPMTEKVEEL LRVIGPFYEI VEDKKSGRSS 
        60         70         80         90        100
DITSDLGNVL TSTPNAKTVN GKAESSDSGA ESEEEEAQEE VKGAEQSDND 
       110        120        130        140        150
KKMMKKSADH KNLEVIVTNG YDKDGFVQDI QNDIHASSSL NGRSTEEVKP 
       160        170        180        190        200
IDENLGQTGK SAVCIHQDIN DDHVEDVTGI QHLTSDSDSE VYCDSMEQFG 
       210        220        230        240        250
QEESLDSFTS NNGPFQYYLG GHSSQPMENS GFREDIQVPP GNGNIGNMQV 
       260        270        280        290        300
VAVEGKGEVK HGGEDGRNNS GAPHREKRGG ETDEFSNVRR GRGHRMQHLS 
       310        320        330        340        350
EGTKGRQVGS GGDGERWGSD RGSRGSLNEQ IALVLMRLQE DMQNVLQRLQ 
       360        370        380        390        400
KLETLTALQA KSSTSTLQTA PQPTSQRPSW WPFEMSPGVL TFAIIWPFIA 
       410 
QWLVYLYYQR RRRKLN

Show »

Length:416

Mass (Da):46,268

Checksum:ⁱ2FD7CD93EAA41CC9

GO

Computationally mapped potential isoform sequencesⁱ

There are 20 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	B7Z2R7	B7Z2R7_HUMAN	Acyl-CoA-binding domain-containing ... Acyl-CoA-binding domain-containing protein 5	ACBD5	523	Annotation score:
	A0A7I2V347	A0A7I2V347_HUMAN	Acyl-CoA-binding domain-containing ... Acyl-CoA-binding domain-containing protein 5	ACBD5 hCG_25243	501	Annotation score:
	A0A7I2YQE9	A0A7I2YQE9_HUMAN	Acyl-CoA-binding domain-containing ... Acyl-CoA-binding domain-containing protein 5	ACBD5	534	Annotation score:
	A0A7I2V2M2	A0A7I2V2M2_HUMAN	Acyl-CoA-binding domain-containing ... Acyl-CoA-binding domain-containing protein 5	ACBD5	472	Annotation score:
	A0A7I2V2Y9	A0A7I2V2Y9_HUMAN	Acyl-CoA-binding domain-containing ... Acyl-CoA-binding domain-containing protein 5	ACBD5	501	Annotation score:
	A0A7I2V560	A0A7I2V560_HUMAN	Acyl-CoA-binding domain-containing ... Acyl-CoA-binding domain-containing protein 5	ACBD5	521	Annotation score:
	A0A7I2YQD7	A0A7I2YQD7_HUMAN	Acyl-CoA-binding domain-containing ... Acyl-CoA-binding domain-containing protein 5	ACBD5	521	Annotation score:
	A0A7I2YQJ9	A0A7I2YQJ9_HUMAN	Acyl-CoA-binding domain-containing ... Acyl-CoA-binding domain-containing protein 5	ACBD5	518	Annotation score:
	A0A7I2V5E1	A0A7I2V5E1_HUMAN	Acyl-CoA-binding domain-containing ... Acyl-CoA-binding domain-containing protein 5	ACBD5	515	Annotation score:
	A0A7I2V690	A0A7I2V690_HUMAN	Acyl-CoA-binding domain-containing ... Acyl-CoA-binding domain-containing protein 5	ACBD5	422	Annotation score:
There are more potential isoformsShow all

Sequence cautionⁱ

The sequence AAH30555 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	332	P → Q in AAP30852 (Ref. 1) Curated	1
Sequence conflictⁱ	419	E → D in AAP30852 (Ref. 1) Curated	1
Sequence conflictⁱ	478	A → T in AAP30852 (Ref. 1) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_032301	472	T → M. Corresponds to variant dbSNP:rs7918793Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_025448	1 – 107	Missing in isoform 4. 1 PublicationAdd BLAST	107
Alternative sequenceⁱVSP_025447	1 – 33	Missing in isoform 2. 1 PublicationAdd BLAST	33
Alternative sequenceⁱVSP_025446	1 – 3	MFQ → MLFLS in isoform 3. 1 Publication	3
Alternative sequenceⁱVSP_025449	162 – 172	Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST	11

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF505653 mRNA Translation: AAP30852.1 AK057469 mRNA Translation: BAG51918.1 AL160291 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86062.1 CH471072 Genomic DNA Translation: EAW86061.1 CH471072 Genomic DNA Translation: EAW86063.1 BC030555 mRNA Translation: AAH30555.1 Different initiation. AL133064 mRNA Translation: CAB61388.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44368.1 [Q5T8D3-3] CCDS7154.1 [Q5T8D3-2] CCDS76290.1 [Q5T8D3-4] CCDS86078.1 [Q5T8D3-1]
PIRⁱ	T42665
NCBI Reference Sequences More...RefSeqⁱ	NP_001035938.1, NM_001042473.3 [Q5T8D3-2] NP_001288180.1, NM_001301251.1 [Q5T8D3-4] NP_001288181.1, NM_001301252.1 [Q5T8D3-4] NP_001288182.1, NM_001301253.1 [Q5T8D3-4] NP_663736.2, NM_145698.4 [Q5T8D3-3] XP_016872396.1, XM_017016907.1 XP_016872397.1, XM_017016908.1

Genome annotation databases

Ensemblⁱ	ENST00000375888; ENSP00000365049; ENSG00000107897 [Q5T8D3-1] ENST00000375901; ENSP00000365066; ENSG00000107897 [Q5T8D3-4] ENST00000375905; ENSP00000365070; ENSG00000107897 [Q5T8D3-2] ENST00000396271; ENSP00000379568; ENSG00000107897 [Q5T8D3-3] ENST00000679293; ENSP00000503631; ENSG00000107897 [Q5T8D3-2]
GeneIDⁱ	91452
KEGGⁱ	hsa:91452
UCSC genome browser More...UCSCⁱ	uc001ito.4, human [Q5T8D3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5T8D3	Acyl-CoA-binding domain-containing protein 5		PANTR		534	UniRef100_Q5T8D3
Acyl-CoA-binding domain-containing protein 5		PANPA		534
Acyl-CoA-binding domain-containing protein 5		PANTR		534
Q5T8D3-2	Acyl-CoA-binding domain-containing protein 5		PANTR		548	UniRef100_K7AA69
Acyl-CoA-binding domain-containing protein 5		PANPA		525
Isoform 3 of Acyl-CoA-binding domain-containing protein 5		HUMAN		525
Acyl-CoA-binding domain-containing protein 5		PANTR		525
Acyl-CoA-binding domain-containing protein 5		PANTR		525
+3

Protein	Similar proteins		Species	Score	Length	Source
Q5T8D3	Acyl-CoA-binding domain-containing protein 5		PANTR		534	UniRef90_Q5T8D3
Acyl-CoA-binding domain-containing protein 5		PANPA		534
Isoform 3 of Acyl-CoA-binding domain-containing protein 5		HUMAN		525
Acyl-CoA-binding domain-containing protein 5		PAPAN		542
Acyl-CoA-binding domain-containing protein 5		SAIBB		536
+143

Protein	Similar proteins		Species	Score	Length	Source
Q5T8D3	Acyl-CoA-binding domain-containing protein 5		BOVIN		533	UniRef50_Q5T8D3
Acyl-CoA-binding domain-containing protein 5		PONAB		525
Acyl-CoA-binding domain-containing protein 5		PANTR		534
Acyl-CoA-binding domain-containing protein 5		PANPA		534
Isoform 3 of Acyl-CoA-binding domain-containing protein 5		HUMAN		525
+572

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF505653 mRNA Translation: AAP30852.1 AK057469 mRNA Translation: BAG51918.1 AL160291 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86062.1 CH471072 Genomic DNA Translation: EAW86061.1 CH471072 Genomic DNA Translation: EAW86063.1 BC030555 mRNA Translation: AAH30555.1 Different initiation. AL133064 mRNA Translation: CAB61388.1
CCDSⁱ	CCDS44368.1 [Q5T8D3-3] CCDS7154.1 [Q5T8D3-2] CCDS76290.1 [Q5T8D3-4] CCDS86078.1 [Q5T8D3-1]
PIRⁱ	T42665
RefSeqⁱ	NP_001035938.1, NM_001042473.3 [Q5T8D3-2] NP_001288180.1, NM_001301251.1 [Q5T8D3-4] NP_001288181.1, NM_001301252.1 [Q5T8D3-4] NP_001288182.1, NM_001301253.1 [Q5T8D3-4] NP_663736.2, NM_145698.4 [Q5T8D3-3] XP_016872396.1, XM_017016907.1 XP_016872397.1, XM_017016908.1

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3FLV	X-ray	1.70	A/B	41-136	[»]
SMRⁱ	Q5T8D3
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	124836, 63 interactors
IntActⁱ	Q5T8D3, 26 interactors
STRINGⁱ	9606.ENSP00000379568

Protein family/group databases

TCDBⁱ	1.R.1.1.1, the membrane contact site (mcs) family

TCDBⁱ

1.R.1.1.1, the membrane contact site (mcs) family

PTM databases

GlyGenⁱ	Q5T8D3, 1 site, 1 O-linked glycan (1 site)
iPTMnetⁱ	Q5T8D3
PhosphoSitePlusⁱ	Q5T8D3

Genetic variation databases

BioMutaⁱ	ACBD5
DMDMⁱ	74745508

Proteomic databases

EPDⁱ	Q5T8D3
jPOSTⁱ	Q5T8D3
MassIVEⁱ	Q5T8D3
MaxQBⁱ	Q5T8D3
PaxDbⁱ	Q5T8D3
PeptideAtlasⁱ	Q5T8D3
PRIDEⁱ	Q5T8D3
ProteomicsDBⁱ	64724 [Q5T8D3-1] 64725 [Q5T8D3-2] 64726 [Q5T8D3-3] 64727 [Q5T8D3-4]

Protocols and materials databases

Antibodypediaⁱ	2333, 121 antibodies
The DNASU plasmid repository More...DNASUⁱ	91452

Genome annotation databases

Ensemblⁱ	ENST00000375888; ENSP00000365049; ENSG00000107897 [Q5T8D3-1] ENST00000375901; ENSP00000365066; ENSG00000107897 [Q5T8D3-4] ENST00000375905; ENSP00000365070; ENSG00000107897 [Q5T8D3-2] ENST00000396271; ENSP00000379568; ENSG00000107897 [Q5T8D3-3] ENST00000679293; ENSP00000503631; ENSG00000107897 [Q5T8D3-2]
GeneIDⁱ	91452
KEGGⁱ	hsa:91452
UCSCⁱ	uc001ito.4, human [Q5T8D3-1]

Organism-specific databases

CTDⁱ	91452
DisGeNETⁱ	91452
GeneCardsⁱ	ACBD5
HGNCⁱ	HGNC:23338, ACBD5
HPAⁱ	ENSG00000107897, Low tissue specificity
MalaCardsⁱ	ACBD5
MIMⁱ	616618, gene 618863, phenotype
neXtProtⁱ	NX_Q5T8D3
OpenTargetsⁱ	ENSG00000107897
PharmGKBⁱ	PA134892991
VEuPathDBⁱ	HostDB:ENSG00000107897
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0817, Eukaryota
GeneTreeⁱ	ENSGT00940000156350
HOGENOMⁱ	CLU_034436_0_0_1
InParanoidⁱ	Q5T8D3
OMAⁱ	DAMIAYV
OrthoDBⁱ	1546859at2759
PhylomeDBⁱ	Q5T8D3
TreeFamⁱ	TF319446

Enzyme and pathway databases

PathwayCommonsⁱ	Q5T8D3
Reactomeⁱ	R-HSA-390918, Peroxisomal lipid metabolism R-HSA-8980692, RHOA GTPase cycle R-HSA-9013106, RHOC GTPase cycle R-HSA-9603798, Class I peroxisomal membrane protein import

Miscellaneous databases

BioGRID-ORCSⁱ	91452, 6 hits in 1017 CRISPR screens
ChiTaRSⁱ	ACBD5, human
EvolutionaryTraceⁱ	Q5T8D3
GenomeRNAiⁱ	91452
Pharosⁱ	Q5T8D3, Tbio
Protein Ontology More...PROⁱ	PR:Q5T8D3
RNActⁱ	Q5T8D3, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000107897, Expressed in brain and 221 other tissues
ExpressionAtlasⁱ	Q5T8D3, baseline and differential
Genevisibleⁱ	Q5T8D3, HS

Family and domain databases

CDDⁱ	cd00435, ACBP, 1 hit
Gene3Dⁱ	1.20.80.10, 1 hit
InterProⁱ	View protein in InterPro IPR016347, ACBD5 IPR022408, Acyl-CoA-binding_prot_CS IPR000582, Acyl-CoA-binding_protein IPR035984, Acyl-CoA-binding_sf IPR014352, FERM/acyl-CoA-bd_prot_sf
Pfamⁱ	View protein in Pfam PF00887, ACBP, 1 hit
PIRSFⁱ	PIRSF002412, MA_DBI, 1 hit
PRINTSⁱ	PR00689, ACOABINDINGP
SUPFAMⁱ	SSF47027, SSF47027, 1 hit
PROSITEⁱ	View protein in PROSITE PS00880, ACB_1, 1 hit PS51228, ACB_2, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ACBD5_HUMAN
Accessionⁱ	Q5T8D3Primary (citable) accession number: Q5T8D3 Secondary accession number(s): B3KQ56 Q9UFB5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
	Last sequence update:	December 21, 2004
	Last modified:	September 29, 2021
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q5T8D3 (ACBD5_HUMAN)

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Acyl-CoA-binding domain-containing protein 5

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

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GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Peroxisome

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Peroxisome

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Isoform 2 [Q5T8D3-2]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ