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Entry version 134 (22 Apr 2020)
Sequence version 1 (21 Dec 2004)
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Protein

Acyl-CoA-binding domain-containing protein 5

Gene

ACBD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei98Acyl-CoA1
Binding sitei117Acyl-CoABy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy, Transport
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390918 Peroxisomal lipid metabolism
R-HSA-9603798 Class I peroxisomal membrane protein import

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.R.1.1.1 the membrane contact site (mcs) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACBD5
Synonyms:KIAA1996
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23338 ACBD5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616618 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T8D3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei506 – 526HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
91452

Open Targets

More...
OpenTargetsi
ENSG00000107897

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134892991

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5T8D3 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACBD5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74745508

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002873771 – 534Acyl-CoA-binding domain-containing protein 5Add BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei193PhosphoserineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei196PhosphoserineCombined sources1
Modified residuei200PhosphoserineCombined sources1
Modified residuei215PhosphoserineCombined sources1
Modified residuei279PhosphoserineCombined sources1
Modified residuei313PhosphoserineCombined sources1
Modified residuei400PhosphothreonineCombined sources1
Modified residuei428PhosphoserineCombined sources1
Modified residuei469N6-acetyllysineBy similarity1
Isoform 4 (identifier: Q5T8D3-4)
Modified residuei63PhosphothreonineCombined sources1
Isoform 2 (identifier: Q5T8D3-2)
Modified residuei137PhosphothreonineCombined sources1
Isoform 3 (identifier: Q5T8D3-3)
Modified residuei172PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T8D3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5T8D3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5T8D3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T8D3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T8D3

PeptideAtlas

More...
PeptideAtlasi
Q5T8D3

PRoteomics IDEntifications database

More...
PRIDEi
Q5T8D3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64724 [Q5T8D3-1]
64725 [Q5T8D3-2]
64726 [Q5T8D3-3]
64727 [Q5T8D3-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T8D3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T8D3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000107897 Expressed in brain and 208 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5T8D3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T8D3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000107897 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124836, 28 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T8D3, 26 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000379568

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5T8D3 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1534
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5T8D3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q5T8D3

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 130ACBPROSITE-ProRule annotationAdd BLAST90

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni52 – 61Acyl-CoA binding10
Regioni72 – 76Acyl-CoA binding5

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili190 – 219Sequence analysisAdd BLAST30
Coiled coili447 – 476Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 16Poly-Cys4
Compositional biasi201 – 204Poly-Glu4
Compositional biasi528 – 531Poly-Arg4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATG37 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0817 Eukaryota
COG4281 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156350

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034436_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T8D3

Identification of Orthologs from Complete Genome Data

More...
OMAi
WPFEISP

Database of Orthologous Groups

More...
OrthoDBi
1546859at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T8D3

TreeFam database of animal gene trees

More...
TreeFami
TF319446

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00435 ACBP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.80.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016347 ACBD5
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00887 ACBP, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002412 MA_DBI, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00689 ACOABINDINGP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47027 SSF47027, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T8D3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFQFHAGSWE SWCCCCLIPA DRPWDRGQHW QLEMADTRSV HETRFEAAVK
60 70 80 90 100
VIQSLPKNGS FQPTNEMMLK FYSFYKQATE GPCKLSRPGF WDPIGRYKWD
110 120 130 140 150
AWSSLGDMTK EEAMIAYVEE MKKIIETMPM TEKVEELLRV IGPFYEIVED
160 170 180 190 200
KKSGRSSDIT SVRLEKISKC LEDLGNVLTS TPNAKTVNGK AESSDSGAES
210 220 230 240 250
EEEEAQEEVK GAEQSDNDKK MMKKSADHKN LEVIVTNGYD KDGFVQDIQN
260 270 280 290 300
DIHASSSLNG RSTEEVKPID ENLGQTGKSA VCIHQDINDD HVEDVTGIQH
310 320 330 340 350
LTSDSDSEVY CDSMEQFGQE ESLDSFTSNN GPFQYYLGGH SSQPMENSGF
360 370 380 390 400
REDIQVPPGN GNIGNMQVVA VEGKGEVKHG GEDGRNNSGA PHREKRGGET
410 420 430 440 450
DEFSNVRRGR GHRMQHLSEG TKGRQVGSGG DGERWGSDRG SRGSLNEQIA
460 470 480 490 500
LVLMRLQEDM QNVLQRLQKL ETLTALQAKS STSTLQTAPQ PTSQRPSWWP
510 520 530
FEMSPGVLTF AIIWPFIAQW LVYLYYQRRR RKLN
Length:534
Mass (Da):60,092
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8BE9A09967717653
GO
Isoform 2 (identifier: Q5T8D3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-33: Missing.
     162-172: Missing.

Show »
Length:490
Mass (Da):54,786
Checksum:i35B7F4B27ECE706B
GO
Isoform 3 (identifier: Q5T8D3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-3: MFQ → MLFLS
     162-172: Missing.

Show »
Length:525
Mass (Da):58,978
Checksum:i95E2AD87B672D414
GO
Isoform 4 (identifier: Q5T8D3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-107: Missing.
     162-172: Missing.

Show »
Length:416
Mass (Da):46,268
Checksum:i2FD7CD93EAA41CC9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z2R7B7Z2R7_HUMAN
Acyl-CoA-binding domain-containing ...
ACBD5
523Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T8E0Q5T8E0_HUMAN
Acyl-CoA-binding domain-containing ...
ACBD5
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
X6RDD7X6RDD7_HUMAN
Acyl-CoA-binding domain-containing ...
ACBD5
251Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0B8A0A087X0B8_HUMAN
Acyl-CoA-binding domain-containing ...
ACBD5
67Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH30555 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti332P → Q in AAP30852 (Ref. 1) Curated1
Sequence conflicti419E → D in AAP30852 (Ref. 1) Curated1
Sequence conflicti478A → T in AAP30852 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_032301472T → M. Corresponds to variant dbSNP:rs7918793Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0254481 – 107Missing in isoform 4. 1 PublicationAdd BLAST107
Alternative sequenceiVSP_0254471 – 33Missing in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_0254461 – 3MFQ → MLFLS in isoform 3. 1 Publication3
Alternative sequenceiVSP_025449162 – 172Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF505653 mRNA Translation: AAP30852.1
AK057469 mRNA Translation: BAG51918.1
AL160291 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86062.1
CH471072 Genomic DNA Translation: EAW86061.1
CH471072 Genomic DNA Translation: EAW86063.1
BC030555 mRNA Translation: AAH30555.1 Different initiation.
AL133064 mRNA Translation: CAB61388.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS44368.1 [Q5T8D3-3]
CCDS7154.1 [Q5T8D3-2]
CCDS76290.1 [Q5T8D3-4]
CCDS86078.1 [Q5T8D3-1]

Protein sequence database of the Protein Information Resource

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PIRi
T42665

NCBI Reference Sequences

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RefSeqi
NP_001035938.1, NM_001042473.3 [Q5T8D3-2]
NP_001288180.1, NM_001301251.1 [Q5T8D3-4]
NP_001288181.1, NM_001301252.1 [Q5T8D3-4]
NP_001288182.1, NM_001301253.1 [Q5T8D3-4]
NP_663736.2, NM_145698.4 [Q5T8D3-3]
XP_016872396.1, XM_017016907.1
XP_016872397.1, XM_017016908.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000375888; ENSP00000365049; ENSG00000107897 [Q5T8D3-1]
ENST00000375901; ENSP00000365066; ENSG00000107897 [Q5T8D3-4]
ENST00000375905; ENSP00000365070; ENSG00000107897 [Q5T8D3-2]
ENST00000396271; ENSP00000379568; ENSG00000107897 [Q5T8D3-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
91452

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:91452

UCSC genome browser

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UCSCi
uc001ito.4 human [Q5T8D3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF505653 mRNA Translation: AAP30852.1
AK057469 mRNA Translation: BAG51918.1
AL160291 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86062.1
CH471072 Genomic DNA Translation: EAW86061.1
CH471072 Genomic DNA Translation: EAW86063.1
BC030555 mRNA Translation: AAH30555.1 Different initiation.
AL133064 mRNA Translation: CAB61388.1
CCDSiCCDS44368.1 [Q5T8D3-3]
CCDS7154.1 [Q5T8D3-2]
CCDS76290.1 [Q5T8D3-4]
CCDS86078.1 [Q5T8D3-1]
PIRiT42665
RefSeqiNP_001035938.1, NM_001042473.3 [Q5T8D3-2]
NP_001288180.1, NM_001301251.1 [Q5T8D3-4]
NP_001288181.1, NM_001301252.1 [Q5T8D3-4]
NP_001288182.1, NM_001301253.1 [Q5T8D3-4]
NP_663736.2, NM_145698.4 [Q5T8D3-3]
XP_016872396.1, XM_017016907.1
XP_016872397.1, XM_017016908.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FLVX-ray1.70A/B41-136[»]
SMRiQ5T8D3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi124836, 28 interactors
IntActiQ5T8D3, 26 interactors
STRINGi9606.ENSP00000379568

Protein family/group databases

TCDBi1.R.1.1.1 the membrane contact site (mcs) family

PTM databases

iPTMnetiQ5T8D3
PhosphoSitePlusiQ5T8D3

Polymorphism and mutation databases

BioMutaiACBD5
DMDMi74745508

Proteomic databases

EPDiQ5T8D3
jPOSTiQ5T8D3
MassIVEiQ5T8D3
MaxQBiQ5T8D3
PaxDbiQ5T8D3
PeptideAtlasiQ5T8D3
PRIDEiQ5T8D3
ProteomicsDBi64724 [Q5T8D3-1]
64725 [Q5T8D3-2]
64726 [Q5T8D3-3]
64727 [Q5T8D3-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
2333 113 antibodies

The DNASU plasmid repository

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DNASUi
91452

Genome annotation databases

EnsembliENST00000375888; ENSP00000365049; ENSG00000107897 [Q5T8D3-1]
ENST00000375901; ENSP00000365066; ENSG00000107897 [Q5T8D3-4]
ENST00000375905; ENSP00000365070; ENSG00000107897 [Q5T8D3-2]
ENST00000396271; ENSP00000379568; ENSG00000107897 [Q5T8D3-3]
GeneIDi91452
KEGGihsa:91452
UCSCiuc001ito.4 human [Q5T8D3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
91452
DisGeNETi91452

GeneCards: human genes, protein and diseases

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GeneCardsi
ACBD5
HGNCiHGNC:23338 ACBD5
HPAiENSG00000107897 Low tissue specificity
MIMi616618 gene
neXtProtiNX_Q5T8D3
OpenTargetsiENSG00000107897
PharmGKBiPA134892991

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
GeneTreeiENSGT00940000156350
HOGENOMiCLU_034436_0_0_1
InParanoidiQ5T8D3
OMAiWPFEISP
OrthoDBi1546859at2759
PhylomeDBiQ5T8D3
TreeFamiTF319446

Enzyme and pathway databases

ReactomeiR-HSA-390918 Peroxisomal lipid metabolism
R-HSA-9603798 Class I peroxisomal membrane protein import

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ACBD5 human
EvolutionaryTraceiQ5T8D3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
91452
PharosiQ5T8D3 Tbio

Protein Ontology

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PROi
PR:Q5T8D3
RNActiQ5T8D3 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000107897 Expressed in brain and 208 other tissues
ExpressionAtlasiQ5T8D3 baseline and differential
GenevisibleiQ5T8D3 HS

Family and domain databases

CDDicd00435 ACBP, 1 hit
Gene3Di1.20.80.10, 1 hit
InterProiView protein in InterPro
IPR016347 ACBD5
IPR022408 Acyl-CoA-binding_prot_CS
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PIRSFiPIRSF002412 MA_DBI, 1 hit
PRINTSiPR00689 ACOABINDINGP
SUPFAMiSSF47027 SSF47027, 1 hit
PROSITEiView protein in PROSITE
PS00880 ACB_1, 1 hit
PS51228 ACB_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACBD5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T8D3
Secondary accession number(s): B3KQ56
, D3DRW0, Q5T8D4, Q5T8E1, Q5T8E2, Q86UV1, Q8N6E3, Q9UFB5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 21, 2004
Last modified: April 22, 2020
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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