UniProtKB - Q5T848 (GP158_HUMAN)
Protein
Probable G-protein coupled receptor 158
Gene
GPR158
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
GO - Biological processi
- protein localization to plasma membrane Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q5T848 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 158 |
Gene namesi | Name:GPR158 Synonyms:KIAA1136 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000151025.9 |
HGNCi | HGNC:23689, GPR158 |
MIMi | 614573, gene |
neXtProti | NX_Q5T848 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 417 | ExtracellularSequence analysisAdd BLAST | 394 | |
Transmembranei | 418 – 438 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 439 – 451 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 452 – 472 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 473 – 483 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 484 – 506 | Helical; Name=3Sequence analysisAdd BLAST | 23 | |
Topological domaini | 507 – 528 | CytoplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 529 – 549 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 550 – 579 | ExtracellularSequence analysisAdd BLAST | 30 | |
Transmembranei | 580 – 600 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 601 – 613 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 614 – 634 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 635 – 643 | ExtracellularSequence analysis | 9 | |
Transmembranei | 644 – 664 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 665 – 1215 | CytoplasmicSequence analysisAdd BLAST | 551 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 57512 |
OpenTargetsi | ENSG00000151025 |
PharmGKBi | PA134939018 |
Miscellaneous databases
Pharosi | Q5T848, Tbio |
Polymorphism and mutation databases
BioMutai | GPR158 |
DMDMi | 67461010 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000012969 | 24 – 1215 | Probable G-protein coupled receptor 158Add BLAST | 1192 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 98 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 143 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 215 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 274 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 333 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 694 | PhosphoserineBy similarity | 1 | |
Modified residuei | 705 | PhosphoserineBy similarity | 1 | |
Modified residuei | 708 | PhosphoserineBy similarity | 1 | |
Cross-linki | 774 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 865 | PhosphoserineBy similarity | 1 | |
Modified residuei | 946 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1080 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MassIVEi | Q5T848 |
PaxDbi | Q5T848 |
PeptideAtlasi | Q5T848 |
PRIDEi | Q5T848 |
ProteomicsDBi | 64705 |
PTM databases
GlyGeni | Q5T848, 5 sites |
iPTMneti | Q5T848 |
PhosphoSitePlusi | Q5T848 |
Expressioni
Gene expression databases
Bgeei | ENSG00000151025, Expressed in caudate nucleus and 111 other tissues |
ExpressionAtlasi | Q5T848, baseline and differential |
Genevisiblei | Q5T848, HS |
Organism-specific databases
HPAi | ENSG00000151025, Tissue enhanced (brain, seminal vesicle) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 121576, 4 interactors |
IntActi | Q5T848, 2 interactors |
STRINGi | 9606.ENSP00000365529 |
Miscellaneous databases
RNActi | Q5T848, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 3 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4418, Eukaryota |
GeneTreei | ENSGT00940000155918 |
HOGENOMi | CLU_006832_1_0_1 |
InParanoidi | Q5T848 |
OMAi | RGPDQHI |
OrthoDBi | 63351at2759 |
PhylomeDBi | Q5T848 |
TreeFami | TF319114 |
Family and domain databases
InterProi | View protein in InterPro IPR017978, GPCR_3_C IPR043458, GPR158/179 |
PANTHERi | PTHR32546, PTHR32546, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5T848-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGAMAYPLLL CLLLAQLGLG AVGASRDPQG RPDSPRERTP KGKPHAQQPG
60 70 80 90 100
RASASDSSAP WSRSTDGTIL AQKLAEEVPM DVASYLYTGD SHQLKRANCS
110 120 130 140 150
GRYELAGLPG KWPALASAHP SLHRALDTLT HATNFLNVML QSNKSREQNL
160 170 180 190 200
QDDLDWYQAL VWSLLEGEPS ISRAAITFST DSLSAPAPQV FLQATREESR
210 220 230 240 250
ILLQDLSSSA PHLANATLET EWFHGLRRKW RPHLHRRGPN QGPRGLGHSW
260 270 280 290 300
RRKDGLGGDK SHFKWSPPYL ECENGSYKPG WLVTLSSAIY GLQPNLVPEF
310 320 330 340 350
RGVMKVDINL QKVDIDQCSS DGWFSGTHKC HLNNSECMPI KGLGFVLGAY
360 370 380 390 400
ECICKAGFYH PGVLPVNNFR RRGPDQHISG STKDVSEEAY VCLPCREGCP
410 420 430 440 450
FCADDSPCFV QEDKYLRLAI ISFQALCMLL DFVSMLVVYH FRKAKSIRAS
460 470 480 490 500
GLILLETILF GSLLLYFPVV ILYFEPSTFR CILLRWARLL GFATVYGTVT
510 520 530 540 550
LKLHRVLKVF LSRTAQRIPY MTGGRVMRML AVILLVVFWF LIGWTSSVCQ
560 570 580 590 600
NLEKQISLIG QGKTSDHLIF NMCLIDRWDY MTAVAEFLFL LWGVYLCYAV
610 620 630 640 650
RTVPSAFHEP RYMAVAVHNE LIISAIFHTI RFVLASRLQS DWMLMLYFAH
660 670 680 690 700
THLTVTVTIG LLLIPKFSHS SNNPRDDIAT EAYEDELDMG RSGSYLNSSI
710 720 730 740 750
NSAWSEHSLD PEDIRDELKK LYAQLEIYKR KKMITNNPHL QKKRCSKKGL
760 770 780 790 800
GRSIMRRITE IPETVSRQCS KEDKEGADHG TAKGTALIRK NPPESSGNTG
810 820 830 840 850
KSKEETLKNR VFSLKKSHST YDHVRDQTEE SSSLPTESQE EETTENSTLE
860 870 880 890 900
SLSGKKLTQK LKEDSEAEST ESVPLVCKSA SAHNLSSEKK TGHPRTSMLQ
910 920 930 940 950
KSLSVIASAK EKTLGLAGKT QTAGVEERTK SQKPLPKDKE TNRNHSNSDN
960 970 980 990 1000
TETKDPAPQN SNPAEEPRKP QKSGIMKQQR VNPTTANSDL NPGTTQMKDN
1010 1020 1030 1040 1050
FDIGEVCPWE VYDLTPGPVP SESKVQKHVS IVASEMEKNP TFSLKEKSHH
1060 1070 1080 1090 1100
KPKAAEVCQQ SNQKRIDKAE VCLWESQGQS ILEDEKLLIS KTPVLPERAK
1110 1120 1130 1140 1150
EENGGQPRAA NVCAGQSEEL PPKAVASKTE NENLNQIGHQ EKKTSSSEEN
1160 1170 1180 1190 1200
VRGSYNSSNN FQQPLTSRAE VCPWEFETPA QPNAGRSVAL PASSALSANK
1210
IAGPRKEEIW DSFKV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3IUC3 | A0A3B3IUC3_HUMAN | Probable G-protein-coupled receptor... | GPR158 | 1,136 | Annotation score: |
Sequence cautioni
The sequence AAS18315 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 620 – 630 | ELIISAIFHTI → SWIVNSMNSHF (PubMed:10574461).CuratedAdd BLAST | 11 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049285 | 425 | A → G1 PublicationCorresponds to variant dbSNP:rs2480345Ensembl. | 1 | |
Natural variantiVAR_049286 | 1209 | I → V. Corresponds to variant dbSNP:rs10828833Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY528411 mRNA Translation: AAS18315.1 Different initiation. AL161654 Genomic DNA No translation available. AL355587 Genomic DNA No translation available. AL139821 Genomic DNA No translation available. AB032962 mRNA Translation: BAA86450.2 |
CCDSi | CCDS31166.1 |
RefSeqi | NP_065803.2, NM_020752.2 |
Genome annotation databases
Ensembli | ENST00000376351; ENSP00000365529; ENSG00000151025 |
GeneIDi | 57512 |
KEGGi | hsa:57512 |
UCSCi | uc001isj.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY528411 mRNA Translation: AAS18315.1 Different initiation. AL161654 Genomic DNA No translation available. AL355587 Genomic DNA No translation available. AL139821 Genomic DNA No translation available. AB032962 mRNA Translation: BAA86450.2 |
CCDSi | CCDS31166.1 |
RefSeqi | NP_065803.2, NM_020752.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121576, 4 interactors |
IntActi | Q5T848, 2 interactors |
STRINGi | 9606.ENSP00000365529 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q5T848, 5 sites |
iPTMneti | Q5T848 |
PhosphoSitePlusi | Q5T848 |
Polymorphism and mutation databases
BioMutai | GPR158 |
DMDMi | 67461010 |
Proteomic databases
MassIVEi | Q5T848 |
PaxDbi | Q5T848 |
PeptideAtlasi | Q5T848 |
PRIDEi | Q5T848 |
ProteomicsDBi | 64705 |
Protocols and materials databases
ABCDi | Q5T848, 2 sequenced antibodies |
Antibodypediai | 2922, 91 antibodies |
Genome annotation databases
Ensembli | ENST00000376351; ENSP00000365529; ENSG00000151025 |
GeneIDi | 57512 |
KEGGi | hsa:57512 |
UCSCi | uc001isj.4, human |
Organism-specific databases
CTDi | 57512 |
DisGeNETi | 57512 |
EuPathDBi | HostDB:ENSG00000151025.9 |
GeneCardsi | GPR158 |
HGNCi | HGNC:23689, GPR158 |
HPAi | ENSG00000151025, Tissue enhanced (brain, seminal vesicle) |
MIMi | 614573, gene |
neXtProti | NX_Q5T848 |
OpenTargetsi | ENSG00000151025 |
PharmGKBi | PA134939018 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4418, Eukaryota |
GeneTreei | ENSGT00940000155918 |
HOGENOMi | CLU_006832_1_0_1 |
InParanoidi | Q5T848 |
OMAi | RGPDQHI |
OrthoDBi | 63351at2759 |
PhylomeDBi | Q5T848 |
TreeFami | TF319114 |
Enzyme and pathway databases
PathwayCommonsi | Q5T848 |
Miscellaneous databases
BioGRID-ORCSi | 57512, 2 hits in 840 CRISPR screens |
ChiTaRSi | GPR158, human |
GeneWikii | GPR158 |
GenomeRNAii | 57512 |
Pharosi | Q5T848, Tbio |
PROi | PR:Q5T848 |
RNActi | Q5T848, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000151025, Expressed in caudate nucleus and 111 other tissues |
ExpressionAtlasi | Q5T848, baseline and differential |
Genevisiblei | Q5T848, HS |
Family and domain databases
InterProi | View protein in InterPro IPR017978, GPCR_3_C IPR043458, GPR158/179 |
PANTHERi | PTHR32546, PTHR32546, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit |
PROSITEi | View protein in PROSITE PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP158_HUMAN | |
Accessioni | Q5T848Primary (citable) accession number: Q5T848 Secondary accession number(s): Q6QR81, Q9ULT3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries