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Protein

Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

Gene

TSTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei355Cysteine persulfide intermediatePROSITE-ProRule annotation1

Names & Taxonomyi

Protein namesi
Recommended name:
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2
Alternative name(s):
Rhodanese domain-containing protein 2
Gene namesi
Name:TSTD2
Synonyms:C9orf97
ORF Names:PP4189
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136925.14
HGNCiHGNC:30087 TSTD2
neXtProtiNX_Q5T7W7

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136925
PharmGKBiPA165586365

Polymorphism and mutation databases

BioMutaiTSTD2
DMDMi74745447

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002306731 – 516Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2Add BLAST516

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei269PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T7W7
MaxQBiQ5T7W7
PaxDbiQ5T7W7
PeptideAtlasiQ5T7W7
PRIDEiQ5T7W7
ProteomicsDBi64695
64696 [Q5T7W7-2]

PTM databases

iPTMnetiQ5T7W7
PhosphoSitePlusiQ5T7W7

Expressioni

Gene expression databases

BgeeiENSG00000136925 Expressed in 221 organ(s), highest expression level in secondary oocyte
CleanExiHS_C9orf97
ExpressionAtlasiQ5T7W7 baseline and differential
GenevisibleiQ5T7W7 HS

Organism-specific databases

HPAiHPA022537
HPA024241
HPA064304

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi127681, 4 interactors
IntActiQ5T7W7, 36 interactors
MINTiQ5T7W7

Structurei

3D structure databases

ProteinModelPortaliQ5T7W7
SMRiQ5T7W7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini301 – 396RhodanesePROSITE-ProRule annotationAdd BLAST96

Phylogenomic databases

eggNOGiENOG410II1G Eukaryota
COG1054 LUCA
GeneTreeiENSGT00390000016307
HOVERGENiHBG080327
InParanoidiQ5T7W7
OMAiSECSYCG
OrthoDBiEOG091G0FPA
PhylomeDBiQ5T7W7
TreeFamiTF324329

Family and domain databases

CDDicd01518 RHOD_YceA, 1 hit
Gene3Di3.40.250.10, 1 hit
InterProiView protein in InterPro
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR022111 Rhodanese_C
PfamiView protein in Pfam
PF00581 Rhodanese, 1 hit
PF12368 Rhodanese_C, 1 hit
SMARTiView protein in SMART
SM00450 RHOD, 1 hit
SUPFAMiSSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T7W7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPSSTSPDQG DDLENCILRF SDLDLKDMSL INPSSSLKAE LDGSTKKKYS
60 70 80 90 100
FAKKKAFALF VKTKEVPTKR SFECKEKLWK CCRQLFTDQT SIHRHVATQH
110 120 130 140 150
ADEIYHQTAS ILKQLAVTLS TSKSLSSADE KNPLKECLPH SHDVSAWLPD
160 170 180 190 200
ISCFNPDELI SGQGSEEGEV LLYYCYHDLE DPQWICAWQT ALCQHLHLTG
210 220 230 240 250
KIRIAAEGIN GTVGGSKLAT RLYVEVMLSF PLFKDDLCKD DFKTSKGGAH
260 270 280 290 300
CFPELRVGVF EEIVPMGISP KKISYKKPGI HLSPGEFHKE VEKFLSQANQ
310 320 330 340 350
EQSDTILLDC RNFYESKIGR FQGCLAPDIR KFSYFPSYVD KNLELFREKR
360 370 380 390 400
VLMYCTGGIR CERGSAYLKA KGVCKEVFQL KGGIHKYLEE FPDGFYKGKL
410 420 430 440 450
FVFDERYALS YNSDVVSECS YCGARWDQYK LCSTPQCRQL VLTCPACQGQ
460 470 480 490 500
GFTACCVTCQ DKGSRKVSGP MQDSFKEECE CTARRPRIPR ELLQHVRQPV
510
SPEPGPDADE DGPVLM
Length:516
Mass (Da):58,263
Last modified:December 21, 2004 - v1
Checksum:i8C39781FD73CDA9F
GO
Isoform 2 (identifier: Q5T7W7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-260: Missing.
     261-278: EEIVPMGISPKKISYKKP → MDLCLADSSVSAPAPHRQ
     418-427: ECSYCGARWD → GRSAQAQSPN
     428-516: Missing.

Note: No experimental confirmation available.
Show »
Length:167
Mass (Da):19,001
Checksum:iCBEA9BA49CF22814
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T7X0Q5T7X0_HUMAN
Thiosulfate sulfurtransferase/rhoda...
TSTD2
59Annotation score:
A0A1Y8ELM0A0A1Y8ELM0_HUMAN
Thiosulfate sulfurtransferase/rhoda...
TSTD2
7Annotation score:

Sequence cautioni

The sequence AAH35604 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB71188 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB71271 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30L → F in BAC87530 (PubMed:14702039).Curated1
Sequence conflicti304D → N in BAB71188 (PubMed:14702039).Curated1
Sequence conflicti433S → C in BAC87530 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05084283R → Q3 PublicationsCorresponds to variant dbSNP:rs2773347Ensembl.1
Natural variantiVAR_050843109A → D. Corresponds to variant dbSNP:rs10817858Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0178251 – 260Missing in isoform 2. 1 PublicationAdd BLAST260
Alternative sequenceiVSP_017826261 – 278EEIVP…SYKKP → MDLCLADSSVSAPAPHRQ in isoform 2. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_017827418 – 427ECSYCGARWD → GRSAQAQSPN in isoform 2. 1 Publication10
Alternative sequenceiVSP_017828428 – 516Missing in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF258575 mRNA Translation: AAG23778.1
AK056453 mRNA Translation: BAB71188.1 Different initiation.
AK056752 mRNA Translation: BAB71271.1 Different initiation.
AK128615 mRNA Translation: BAC87530.1
AK291199 mRNA Translation: BAF83888.1
AL162385 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58848.1
BC035604 mRNA Translation: AAH35604.1 Different initiation.
CCDSiCCDS6727.2 [Q5T7W7-1]
RefSeqiNP_640339.4, NM_139246.4 [Q5T7W7-1]
UniGeneiHs.723236

Genome annotation databases

EnsembliENST00000341170; ENSP00000342499; ENSG00000136925 [Q5T7W7-1]
GeneIDi158427
KEGGihsa:158427
UCSCiuc004axn.4 human [Q5T7W7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF258575 mRNA Translation: AAG23778.1
AK056453 mRNA Translation: BAB71188.1 Different initiation.
AK056752 mRNA Translation: BAB71271.1 Different initiation.
AK128615 mRNA Translation: BAC87530.1
AK291199 mRNA Translation: BAF83888.1
AL162385 Genomic DNA No translation available.
CH471105 Genomic DNA Translation: EAW58848.1
BC035604 mRNA Translation: AAH35604.1 Different initiation.
CCDSiCCDS6727.2 [Q5T7W7-1]
RefSeqiNP_640339.4, NM_139246.4 [Q5T7W7-1]
UniGeneiHs.723236

3D structure databases

ProteinModelPortaliQ5T7W7
SMRiQ5T7W7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127681, 4 interactors
IntActiQ5T7W7, 36 interactors
MINTiQ5T7W7

PTM databases

iPTMnetiQ5T7W7
PhosphoSitePlusiQ5T7W7

Polymorphism and mutation databases

BioMutaiTSTD2
DMDMi74745447

Proteomic databases

EPDiQ5T7W7
MaxQBiQ5T7W7
PaxDbiQ5T7W7
PeptideAtlasiQ5T7W7
PRIDEiQ5T7W7
ProteomicsDBi64695
64696 [Q5T7W7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341170; ENSP00000342499; ENSG00000136925 [Q5T7W7-1]
GeneIDi158427
KEGGihsa:158427
UCSCiuc004axn.4 human [Q5T7W7-1]

Organism-specific databases

CTDi158427
EuPathDBiHostDB:ENSG00000136925.14
GeneCardsiTSTD2
H-InvDBiHIX0008213
HGNCiHGNC:30087 TSTD2
HPAiHPA022537
HPA024241
HPA064304
neXtProtiNX_Q5T7W7
OpenTargetsiENSG00000136925
PharmGKBiPA165586365
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II1G Eukaryota
COG1054 LUCA
GeneTreeiENSGT00390000016307
HOVERGENiHBG080327
InParanoidiQ5T7W7
OMAiSECSYCG
OrthoDBiEOG091G0FPA
PhylomeDBiQ5T7W7
TreeFamiTF324329

Miscellaneous databases

ChiTaRSiTSTD2 human
GenomeRNAii158427
PROiPR:Q5T7W7

Gene expression databases

BgeeiENSG00000136925 Expressed in 221 organ(s), highest expression level in secondary oocyte
CleanExiHS_C9orf97
ExpressionAtlasiQ5T7W7 baseline and differential
GenevisibleiQ5T7W7 HS

Family and domain databases

CDDicd01518 RHOD_YceA, 1 hit
Gene3Di3.40.250.10, 1 hit
InterProiView protein in InterPro
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR022111 Rhodanese_C
PfamiView protein in Pfam
PF00581 Rhodanese, 1 hit
PF12368 Rhodanese_C, 1 hit
SMARTiView protein in SMART
SM00450 RHOD, 1 hit
SUPFAMiSSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTSTD2_HUMAN
AccessioniPrimary (citable) accession number: Q5T7W7
Secondary accession number(s): A6NMJ4
, A8K584, Q6ZQZ6, Q8IYM3, Q8WY73, Q96ML6, Q96MU1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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