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Protein
Submitted name:

Solute carrier family 22 member 2

Gene

SLC22A2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Solute carrier family 22 member 2Imported
Gene namesi
Name:SLC22A2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112499.12
HGNCiHGNC:10966 SLC22A2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Transmembranei157 – 175HelicalSequence analysisAdd BLAST19
Transmembranei181 – 204HelicalSequence analysisAdd BLAST24
Transmembranei216 – 237HelicalSequence analysisAdd BLAST22
Transmembranei243 – 262HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000112499

PTM / Processingi

Proteomic databases

PeptideAtlasiQ5T7Q5
PRIDEiQ5T7Q5

Expressioni

Gene expression databases

BgeeiENSG00000112499 Expressed in 61 organ(s), highest expression level in nephron tubule
ExpressionAtlasiQ5T7Q5 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5T7Q5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 334MFSInterPro annotationAdd BLAST333

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234568
HOVERGENiHBG061545

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5T7Q5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFFLLALLSA TFAPIYVGIV FLGFTPDHRC RSPGVAELSL RCGWSPAEEL
60 70 80 90 100
NYTVPGPGPA GEASPRQCRR YEVDWNQSTF DCVDPLASLD TNRSRLPLGP
110 120 130 140 150
CRDGWVYETP GSSIVTEFNL VCANSWMLDL FQSSVNVGFF IGSMSIGYIA
160 170 180 190 200
DRFGRKLCLL TTVLINAAAG VLMAISPTYT WMLIFRLIQG LVSKAGWLIG
210 220 230 240 250
YILITEFVGR RYRRTVGIFY QVAYTVGLLV LAGVAYALPH WRWLQFTVSL
260 270 280 290 300
PNFFFLLYYW CIPESPRWLI SQNKNAEAMR IIKHIAKKNG KSLPASLQRL
310 320 330
RLEEETGKKL NPSFLDLVRT PQIRKHTMIL MYNW
Length:334
Mass (Da):37,874
Last modified:December 21, 2004 - v1
Checksum:iFE46F4944FDC649A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O15244S22A2_HUMAN
Solute carrier family 22 member 2
SLC22A2 OCT2
555Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162582 Genomic DNA No translation available.
AL645733 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000366952; ENSP00000355919; ENSG00000112499
UCSCiuc063sqv.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162582 Genomic DNA No translation available.
AL645733 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliQ5T7Q5
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ5T7Q5
PRIDEiQ5T7Q5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366952; ENSP00000355919; ENSG00000112499
UCSCiuc063sqv.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000112499.12
HGNCiHGNC:10966 SLC22A2
OpenTargetsiENSG00000112499
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0255 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000118852
HOGENOMiHOG000234568
HOVERGENiHBG061545

Miscellaneous databases

ChiTaRSiSLC22A2 human

Gene expression databases

BgeeiENSG00000112499 Expressed in 61 organ(s), highest expression level in nephron tubule
ExpressionAtlasiQ5T7Q5 baseline and differential

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
SUPFAMiSSF103473 SSF103473, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5T7Q5_HUMAN
AccessioniPrimary (citable) accession number: Q5T7Q5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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