UniProtKB - Q5T7P8 (SYT6_HUMAN)

BLAST

>sp|Q5T7P8|SYT6_HUMAN Synaptotagmin-6 OS=Homo sapiens OX=9606 GN=SYT6 PE=1 SV=3
MSGVWGAGGPRCQEALAVLASLCRARPPPLGLDVETCRSFELQPPERSPSAAGAGTSVSL
LAVVVIVCGVALVAVFLFLFWKLCWMPWRNKEASSPSSANPPLEALQSPSFRGNMADKLK
DPSTLGFLEAAVKISHTSPDIPAEVQMSVKEHIMRHTRLQRQTTEPASSTRHTSFKRHLP
RQMHVSSVDYGNELPPAAEQPTSIGRIKPELYKQKSVDGEDAKSEATKSCGKINFSLRYD
YETETLIVRILKAFDLPAKDFCGSSDPYVKIYLLPDRKCKLQTRVHRKTLNPTFDENFHF
PVPYEELADRKLHLSVFDFDRFSRHDMIGEVILDNLFEASDLSRETSIWKDIQYATSESV
DLGEIMFSLCYLPTAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLLCDGRRLKKKKTTIK
KNTLNPVYNEAIIFDIPPENMDQVSLLISVMDYDRVGHNEIIGVCRVGITAEGLGRDHWN
EMLAYPRKPIAHWHSLVEVKKSFKEGNPRL

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History
Entry version 142 (10 Oct 2018)
Sequence version 3 (14 Oct 2008)
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Protein

Synaptotagmin-6

Gene

SYT6

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May be involved in Ca²⁺-dependent exocytosis of secretory vesicles through Ca²⁺ and phospholipid binding to the C2 domain or may serve as Ca²⁺ sensors in the process of vesicular trafficking and exocytosis. May mediate Ca²⁺-regulation of exocytosis in acrosomal reaction in sperm (By similarity).By similarity

Cofactorⁱ

Ca²⁺By similarityNote: Binds 3 Ca²⁺ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	260	Calcium 1By similarity	1
Metal bindingⁱ	260	Calcium 2By similarity	1
Metal bindingⁱ	266	Calcium 1By similarity	1
Metal bindingⁱ	318	Calcium 1By similarity	1
Metal bindingⁱ	318	Calcium 2By similarity	1
Metal bindingⁱ	319	Calcium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	320	Calcium 1By similarity	1
Metal bindingⁱ	320	Calcium 2By similarity	1
Metal bindingⁱ	320	Calcium 3By similarity	1
Metal bindingⁱ	323	Calcium 3By similarity	1
Metal bindingⁱ	326	Calcium 2By similarity	1
Metal bindingⁱ	326	Calcium 3By similarity	1

GO - Molecular functionⁱ

calcium-dependent protein binding Source: Ensembl
calcium ion binding Source: GO_Central
clathrin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 7791877
phosphatidylserine binding Source: Ensembl
protein homodimerization activity Source: BHF-UCL
syntaxin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 7791877

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

acrosomal vesicle exocytosis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 11437455
calcium ion-regulated exocytosis of neurotransmitter Source: GO_Central
presynaptic dense core vesicle exocytosis Source: Ensembl
regulation of calcium ion-dependent exocytosis Source: GO_Central
vesicle fusion Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Calcium, Metal-binding

Ligand

Calcium, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Synaptotagmin-6 Alternative name(s): Synaptotagmin VI Short name: SytVI
Gene namesⁱ	Name:SYT6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134207.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18638 SYT6
MIMⁱ	607718 gene
neXtProtⁱ	NX_Q5T7P8

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 59	VesicularSequence analysisAdd BLAST	59
Transmembraneⁱ	60 – 80	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	81 – 510	CytoplasmicSequence analysisAdd BLAST	430

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	148281
Open Targets More...OpenTargetsⁱ	ENSG00000134207
PharmGKBⁱ	PA38614

Polymorphism and mutation databases

BioMutaⁱ	SYT6
DMDMⁱ	209572719

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000183954	1 – 510	Synaptotagmin-6Add BLAST		510

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	216	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

EPDⁱ	Q5T7P8
PaxDbⁱ	Q5T7P8
PeptideAtlas More...PeptideAtlasⁱ	Q5T7P8
PRIDEⁱ	Q5T7P8
ProteomicsDBⁱ	64676 64677 [Q5T7P8-2]

PTM databases

iPTMnetⁱ	Q5T7P8
PhosphoSitePlusⁱ	Q5T7P8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000134207 Expressed in 74 organ(s), highest expression level in neocortex
CleanExⁱ	HS_SYT6
ExpressionAtlasⁱ	Q5T7P8 baseline and differential
Genevisibleⁱ	Q5T7P8 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA058362

HPAⁱ

HPA058362

Interactionⁱ

Subunit structureⁱ

Isoform 1: Homodimer; disulfide-linked via the cysteine motif. Isoform 1: Can also form heterodimers with SYT3, SYT7, SYT9 and SYT10. Isoform 1: Interacts with STX1A, STX1B and STX2; the interaction is Ca²⁺-dependent. Isoform 2: Is not able to form homodimer and heterodimers.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
DVL3	Q92997	5	EBI-10246152,EBI-739789
FXR2	P51116	5	EBI-10246152,EBI-740459
GOLGA2	Q08379	5	EBI-10246152,EBI-618309
KCTD9	Q7L273	5	EBI-10246152,EBI-4397613
KRT40	Q6A162	3	EBI-10246152,EBI-10171697
MTUS2	Q5JR59	3	EBI-10246152,EBI-742948
TNIP1	Q15025	3	EBI-10246152,EBI-357849
TRIM32	Q13049	5	EBI-10246152,EBI-742790
TSGA10	Q9BZW7	3	EBI-10246152,EBI-744794
ZBTB43	O43298	5	EBI-10246152,EBI-740718
ZBTB8A	Q96BR9	3	EBI-10246152,EBI-742740

GO - Molecular functionⁱ

calcium-dependent protein binding Source: Ensembl
clathrin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 7791877
protein homodimerization activity Source: BHF-UCL
syntaxin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 7791877

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	127139, 21 interactors
IntActⁱ	Q5T7P8, 26 interactors
Molecular INTeraction database More...MINTⁱ	Q5T7P8
STRINGⁱ	9606.ENSP00000358559

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5T7P8
SMRⁱ	Q5T7P8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	231 – 332	C2 1PROSITE-ProRule annotationAdd BLAST		102
Domainⁱ	363 – 466	C2 2PROSITE-ProRule annotationAdd BLAST		104

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	12 – 38	Cysteine motifBy similarityAdd BLAST		27
Regionⁱ	482 – 510	Necessary for cell membrane association (isoform 2)By similarityAdd BLAST		29

Domainⁱ

The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.By similarity

Sequence similaritiesⁱ

Belongs to the synaptotagmin family.Curated

Keywords - Domainⁱ

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IT3F Eukaryota ENOG410YBMV LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118973
HOGENOMⁱ	HOG000232128
HOVERGENⁱ	HBG005010
InParanoidⁱ	Q5T7P8
KEGG Orthology (KO) More...KOⁱ	K19906
OMAⁱ	TRHISFK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XMQ
PhylomeDBⁱ	Q5T7P8
TreeFamⁱ	TF315600

Family and domain databases

Gene3Dⁱ	2.60.40.150, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR001565 Synaptotagmin IPR028701 SYT6
PANTHERⁱ	PTHR10024:SF45 PTHR10024:SF45, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00168 C2, 2 hits
PRINTSⁱ	PR00360 C2DOMAIN PR00399 SYNAPTOTAGMN
SMARTⁱ	View protein in SMART SM00239 C2, 2 hits
PROSITEⁱ	View protein in PROSITE PS50004 C2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q5T7P8-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGVWGAGGP RCQEALAVLA SLCRARPPPL GLDVETCRSF ELQPPERSPS 
        60         70         80         90        100
AAGAGTSVSL LAVVVIVCGV ALVAVFLFLF WKLCWMPWRN KEASSPSSAN 
       110        120        130        140        150
PPLEALQSPS FRGNMADKLK DPSTLGFLEA AVKISHTSPD IPAEVQMSVK 
       160        170        180        190        200
EHIMRHTRLQ RQTTEPASST RHTSFKRHLP RQMHVSSVDY GNELPPAAEQ 
       210        220        230        240        250
PTSIGRIKPE LYKQKSVDGE DAKSEATKSC GKINFSLRYD YETETLIVRI 
       260        270        280        290        300
LKAFDLPAKD FCGSSDPYVK IYLLPDRKCK LQTRVHRKTL NPTFDENFHF 
       310        320        330        340        350
PVPYEELADR KLHLSVFDFD RFSRHDMIGE VILDNLFEAS DLSRETSIWK 
       360        370        380        390        400
DIQYATSESV DLGEIMFSLC YLPTAGRLTL TVIKCRNLKA MDITGYSDPY 
       410        420        430        440        450
VKVSLLCDGR RLKKKKTTIK KNTLNPVYNE AIIFDIPPEN MDQVSLLISV 
       460        470        480        490        500
MDYDRVGHNE IIGVCRVGIT AEGLGRDHWN EMLAYPRKPI AHWHSLVEVK 
       510
KSFKEGNPRL

Note: No experimental confirmation available.

Length:510

Mass (Da):57,325

Last modified:October 14, 2008 - v3

Checksum:ⁱDE5478F5B95693D3

Isoform 2 (identifier: Q5T7P8-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-85: Missing.

« Hide

        10         20         30         40         50
MPWRNKEASS PSSANPPLEA LQSPSFRGNM ADKLKDPSTL GFLEAAVKIS 
        60         70         80         90        100
HTSPDIPAEV QMSVKEHIMR HTRLQRQTTE PASSTRHTSF KRHLPRQMHV 
       110        120        130        140        150
SSVDYGNELP PAAEQPTSIG RIKPELYKQK SVDGEDAKSE ATKSCGKINF 
       160        170        180        190        200
SLRYDYETET LIVRILKAFD LPAKDFCGSS DPYVKIYLLP DRKCKLQTRV 
       210        220        230        240        250
HRKTLNPTFD ENFHFPVPYE ELADRKLHLS VFDFDRFSRH DMIGEVILDN 
       260        270        280        290        300
LFEASDLSRE TSIWKDIQYA TSESVDLGEI MFSLCYLPTA GRLTLTVIKC 
       310        320        330        340        350
RNLKAMDITG YSDPYVKVSL LCDGRRLKKK KTTIKKNTLN PVYNEAIIFD 
       360        370        380        390        400
IPPENMDQVS LLISVMDYDR VGHNEIIGVC RVGITAEGLG RDHWNEMLAY 
       410        420 
PRKPIAHWHS LVEVKKSFKE GNPRL

Show »

Length:425

Mass (Da):48,442

Checksum:ⁱF41702F895DAC695

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A286YEX2	A0A286YEX2_HUMAN	Synaptotagmin VI, isoform CRA_b Synaptotagmin VI, isoform CRA_b (Synaptotagmin-6)	SYT6 hCG_38646	528	Annotation score:
V9GY33	V9GY33_HUMAN	Synaptotagmin-6 Synaptotagmin-6	SYT6	125	Annotation score:
V9GYC4	V9GYC4_HUMAN	Synaptotagmin-6 Synaptotagmin-6	SYT6	214	Annotation score:
V9GYY7	V9GYY7_HUMAN	Synaptotagmin-6 Synaptotagmin-6	SYT6	88	Annotation score:
V9GYB1	V9GYB1_HUMAN	Synaptotagmin-6 Synaptotagmin-6	SYT6	71	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_036619	1 – 85	Missing in isoform 2. 1 PublicationAdd BLAST		85

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056448 mRNA Translation: BAG51713.1 AL162594 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56596.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS871.1 [Q5T7P8-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001257734.1, NM_001270805.1 [Q5T7P8-2] NP_995320.1, NM_205848.3 [Q5T7P8-2]
UniGeneⁱ	Hs.370963 Hs.736999

Genome annotation databases

Ensemblⁱ	ENST00000369547; ENSP00000358560; ENSG00000134207 [Q5T7P8-2] ENST00000607941; ENSP00000476507; ENSG00000134207 [Q5T7P8-2] ENST00000609117; ENSP00000477344; ENSG00000134207 [Q5T7P8-2] ENST00000610222; ENSP00000476396; ENSG00000134207 [Q5T7P8-1]
GeneIDⁱ	148281
KEGGⁱ	hsa:148281
UCSC genome browser More...UCSCⁱ	uc001eev.4 human [Q5T7P8-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5T7P8	Synaptotagmin VI		HUMAN		425	UniRef100_Q5T7P8
Uncharacterized protein		PANPA		425
Isoform 2 of Synaptotagmin-6		HUMAN		425

Protein	Similar proteins		Species	Score	Length	Source
Q5T7P8	Synaptotagmin-6		MOUSE		511	UniRef90_Q9R0N8
Synaptotagmin-6		RAT		511
Synaptotagmin-6-like protein		CRIGR		536
Uncharacterized protein		AOTNA		528
Synaptotagmin VI, isoform CRA_b		HUMAN		528
+134

Protein	Similar proteins		Species	Score	Length	Source
Q5T7P8	Synaptotagmin-6		MOUSE		511	UniRef50_Q9R0N8
Synaptotagmin-6		RAT		511
Synaptotagmin-C		DIPOM		537
Synaptotagmin-6-like protein		CRIGR		536
Synaptotagmin 6		CALJA		528
+713

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056448 mRNA Translation: BAG51713.1 AL162594 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56596.1
CCDSⁱ	CCDS871.1 [Q5T7P8-2]
RefSeqⁱ	NP_001257734.1, NM_001270805.1 [Q5T7P8-2] NP_995320.1, NM_205848.3 [Q5T7P8-2]
UniGeneⁱ	Hs.370963 Hs.736999

3D structure databases

ProteinModelPortalⁱ	Q5T7P8
SMRⁱ	Q5T7P8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127139, 21 interactors
IntActⁱ	Q5T7P8, 26 interactors
MINTⁱ	Q5T7P8
STRINGⁱ	9606.ENSP00000358559

PTM databases

iPTMnetⁱ	Q5T7P8
PhosphoSitePlusⁱ	Q5T7P8

Polymorphism and mutation databases

BioMutaⁱ	SYT6
DMDMⁱ	209572719

Proteomic databases

EPDⁱ	Q5T7P8
PaxDbⁱ	Q5T7P8
PeptideAtlasⁱ	Q5T7P8
PRIDEⁱ	Q5T7P8
ProteomicsDBⁱ	64676 64677 [Q5T7P8-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	148281
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369547; ENSP00000358560; ENSG00000134207 [Q5T7P8-2] ENST00000607941; ENSP00000476507; ENSG00000134207 [Q5T7P8-2] ENST00000609117; ENSP00000477344; ENSG00000134207 [Q5T7P8-2] ENST00000610222; ENSP00000476396; ENSG00000134207 [Q5T7P8-1]
GeneIDⁱ	148281
KEGGⁱ	hsa:148281
UCSCⁱ	uc001eev.4 human [Q5T7P8-1]

Organism-specific databases

CTDⁱ	148281
DisGeNETⁱ	148281
EuPathDBⁱ	HostDB:ENSG00000134207.14
GeneCardsⁱ	SYT6
HGNCⁱ	HGNC:18638 SYT6
HPAⁱ	HPA058362
MIMⁱ	607718 gene
neXtProtⁱ	NX_Q5T7P8
OpenTargetsⁱ	ENSG00000134207
PharmGKBⁱ	PA38614
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IT3F Eukaryota ENOG410YBMV LUCA
GeneTreeⁱ	ENSGT00760000118973
HOGENOMⁱ	HOG000232128
HOVERGENⁱ	HBG005010
InParanoidⁱ	Q5T7P8
KOⁱ	K19906
OMAⁱ	TRHISFK
OrthoDBⁱ	EOG091G0XMQ
PhylomeDBⁱ	Q5T7P8
TreeFamⁱ	TF315600

Miscellaneous databases

ChiTaRSⁱ	SYT6 human
GenomeRNAiⁱ	148281
Protein Ontology More...PROⁱ	PR:Q5T7P8
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134207 Expressed in 74 organ(s), highest expression level in neocortex
CleanExⁱ	HS_SYT6
ExpressionAtlasⁱ	Q5T7P8 baseline and differential
Genevisibleⁱ	Q5T7P8 HS

Family and domain databases

Gene3Dⁱ	2.60.40.150, 2 hits
InterProⁱ	View protein in InterPro IPR000008 C2_dom IPR035892 C2_domain_sf IPR001565 Synaptotagmin IPR028701 SYT6
PANTHERⁱ	PTHR10024:SF45 PTHR10024:SF45, 1 hit
Pfamⁱ	View protein in Pfam PF00168 C2, 2 hits
PRINTSⁱ	PR00360 C2DOMAIN PR00399 SYNAPTOTAGMN
SMARTⁱ	View protein in SMART SM00239 C2, 2 hits
PROSITEⁱ	View protein in PROSITE PS50004 C2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYT6_HUMAN
Accessionⁱ	Q5T7P8Primary (citable) accession number: Q5T7P8 Secondary accession number(s): B1AMB8, B3KPK1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
	Last sequence update:	October 14, 2008
	Last modified:	October 10, 2018
	This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5T7P8 (SYT6_HUMAN)

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Synaptotagmin-6

SYT6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

Plasma membrane

Cytosol

Cytosol

Endoplasmic reticulum

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ