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Protein

Synaptotagmin-6

Gene

SYT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. May mediate Ca2+-regulation of exocytosis in acrosomal reaction in sperm (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi260Calcium 1By similarity1
Metal bindingi260Calcium 2By similarity1
Metal bindingi266Calcium 1By similarity1
Metal bindingi318Calcium 1By similarity1
Metal bindingi318Calcium 2By similarity1
Metal bindingi319Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi320Calcium 1By similarity1
Metal bindingi320Calcium 2By similarity1
Metal bindingi320Calcium 3By similarity1
Metal bindingi323Calcium 3By similarity1
Metal bindingi326Calcium 2By similarity1
Metal bindingi326Calcium 3By similarity1

GO - Molecular functioni

  • calcium-dependent protein binding Source: Ensembl
  • calcium ion binding Source: GO_Central
  • clathrin binding Source: BHF-UCL
  • phosphatidylserine binding Source: Ensembl
  • protein homodimerization activity Source: BHF-UCL
  • syntaxin binding Source: BHF-UCL

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-6
Alternative name(s):
Synaptotagmin VI
Short name:
SytVI
Gene namesi
Name:SYT6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000134207.14
HGNCiHGNC:18638 SYT6
MIMi607718 gene
neXtProtiNX_Q5T7P8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 59VesicularSequence analysisAdd BLAST59
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 510CytoplasmicSequence analysisAdd BLAST430

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi148281
OpenTargetsiENSG00000134207
PharmGKBiPA38614

Polymorphism and mutation databases

BioMutaiSYT6
DMDMi209572719

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839541 – 510Synaptotagmin-6Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei216PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ5T7P8
PaxDbiQ5T7P8
PeptideAtlasiQ5T7P8
PRIDEiQ5T7P8
ProteomicsDBi64676
64677 [Q5T7P8-2]

PTM databases

iPTMnetiQ5T7P8
PhosphoSitePlusiQ5T7P8

Expressioni

Gene expression databases

BgeeiENSG00000134207
CleanExiHS_SYT6
ExpressionAtlasiQ5T7P8 baseline and differential
GenevisibleiQ5T7P8 HS

Organism-specific databases

HPAiHPA058362

Interactioni

Subunit structurei

Isoform 1: Homodimer; disulfide-linked via the cysteine motif. Isoform 1: Can also form heterodimers with SYT3, SYT7, SYT9 and SYT10. Isoform 1: Interacts with STX1A, STX1B and STX2; the interaction is Ca2+-dependent. Isoform 2: Is not able to form homodimer and heterodimers.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • calcium-dependent protein binding Source: Ensembl
  • clathrin binding Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • syntaxin binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi127139, 21 interactors
IntActiQ5T7P8, 26 interactors
MINTiQ5T7P8
STRINGi9606.ENSP00000358559

Structurei

3D structure databases

ProteinModelPortaliQ5T7P8
SMRiQ5T7P8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini231 – 332C2 1PROSITE-ProRule annotationAdd BLAST102
Domaini363 – 466C2 2PROSITE-ProRule annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni12 – 38Cysteine motifBy similarityAdd BLAST27
Regioni482 – 510Necessary for cell membrane association (isoform 2)By similarityAdd BLAST29

Domaini

The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3F Eukaryota
ENOG410YBMV LUCA
GeneTreeiENSGT00760000118973
HOGENOMiHOG000232128
HOVERGENiHBG005010
InParanoidiQ5T7P8
KOiK19906
OMAiTRHISFK
OrthoDBiEOG091G0XMQ
PhylomeDBiQ5T7P8
TreeFamiTF315600

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR028701 SYT6
PANTHERiPTHR10024:SF45 PTHR10024:SF45, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T7P8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGVWGAGGP RCQEALAVLA SLCRARPPPL GLDVETCRSF ELQPPERSPS
60 70 80 90 100
AAGAGTSVSL LAVVVIVCGV ALVAVFLFLF WKLCWMPWRN KEASSPSSAN
110 120 130 140 150
PPLEALQSPS FRGNMADKLK DPSTLGFLEA AVKISHTSPD IPAEVQMSVK
160 170 180 190 200
EHIMRHTRLQ RQTTEPASST RHTSFKRHLP RQMHVSSVDY GNELPPAAEQ
210 220 230 240 250
PTSIGRIKPE LYKQKSVDGE DAKSEATKSC GKINFSLRYD YETETLIVRI
260 270 280 290 300
LKAFDLPAKD FCGSSDPYVK IYLLPDRKCK LQTRVHRKTL NPTFDENFHF
310 320 330 340 350
PVPYEELADR KLHLSVFDFD RFSRHDMIGE VILDNLFEAS DLSRETSIWK
360 370 380 390 400
DIQYATSESV DLGEIMFSLC YLPTAGRLTL TVIKCRNLKA MDITGYSDPY
410 420 430 440 450
VKVSLLCDGR RLKKKKTTIK KNTLNPVYNE AIIFDIPPEN MDQVSLLISV
460 470 480 490 500
MDYDRVGHNE IIGVCRVGIT AEGLGRDHWN EMLAYPRKPI AHWHSLVEVK
510
KSFKEGNPRL
Note: No experimental confirmation available.
Length:510
Mass (Da):57,325
Last modified:October 14, 2008 - v3
Checksum:iDE5478F5B95693D3
GO
Isoform 2 (identifier: Q5T7P8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:425
Mass (Da):48,442
Checksum:iF41702F895DAC695
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0366191 – 85Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056448 mRNA Translation: BAG51713.1
AL162594 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56596.1
CCDSiCCDS871.1 [Q5T7P8-2]
RefSeqiNP_001257734.1, NM_001270805.1 [Q5T7P8-2]
NP_995320.1, NM_205848.3 [Q5T7P8-2]
UniGeneiHs.370963
Hs.736999

Genome annotation databases

EnsembliENST00000369547; ENSP00000358560; ENSG00000134207 [Q5T7P8-2]
ENST00000607941; ENSP00000476507; ENSG00000134207 [Q5T7P8-2]
ENST00000609117; ENSP00000477344; ENSG00000134207 [Q5T7P8-2]
ENST00000610222; ENSP00000476396; ENSG00000134207 [Q5T7P8-1]
GeneIDi148281
KEGGihsa:148281
UCSCiuc001eev.4 human [Q5T7P8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSYT6_HUMAN
AccessioniPrimary (citable) accession number: Q5T7P8
Secondary accession number(s): B1AMB8, B3KPK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 14, 2008
Last modified: July 18, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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