UniProtKB - Q5T7P8 (SYT6_HUMAN)
Synaptotagmin-6
SYT6
Functioni
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 260 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 260 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 266 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 318 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 318 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 319 | Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation | 1 | |
Metal bindingi | 320 | Calcium 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 320 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 320 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 323 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 326 | Calcium 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 326 | Calcium 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 392 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 398 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 452 | Calcium 4PROSITE-ProRule annotation | 1 | |
Metal bindingi | 454 | Calcium 4PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- calcium-dependent protein binding Source: Ensembl
- calcium ion binding Source: GO_Central
- clathrin binding Source: BHF-UCL
- phosphatidylserine binding Source: GO_Central
- protein homodimerization activity Source: BHF-UCL
- SNARE binding Source: GO_Central
- syntaxin binding Source: BHF-UCL
GO - Biological processi
- acrosomal vesicle exocytosis Source: BHF-UCL
- calcium-ion regulated exocytosis Source: GO_Central
- calcium ion-regulated exocytosis of neurotransmitter Source: GO_Central
- cellular response to calcium ion Source: GO_Central
- regulation of calcium ion-dependent exocytosis Source: GO_Central
- regulation of dopamine secretion Source: GO_Central
- vesicle-mediated transport Source: GO_Central
Keywordsi
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q5T7P8 |
Names & Taxonomyi
Protein namesi | Recommended name: Synaptotagmin-6Alternative name(s): Synaptotagmin VI Short name: SytVI |
Gene namesi | Name:SYT6 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000134207.14 |
HGNCi | HGNC:18638, SYT6 |
MIMi | 607718, gene |
neXtProti | NX_Q5T7P8 |
Subcellular locationi
Other locations
- synaptic vesicle membrane By similarity; Single-pass membrane protein By similarity
Other locations
- Membrane By similarity; Single-pass membrane protein By similarity
Note: Localized predominantly to endoplasmic reticulum (ER) and/or Golgi-like perinuclear compartment (By similarity).By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Cytosol
- cytosol By similarity
Cytosol
- cytosol Source: UniProtKB
Endoplasmic reticulum
- perinuclear endoplasmic reticulum Source: BHF-UCL
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- exocytic vesicle Source: GO_Central
- extrinsic component of membrane Source: UniProtKB
- integral component of membrane Source: UniProtKB
- synaptic vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 59 | VesicularSequence analysisAdd BLAST | 59 | |
Transmembranei | 60 – 80 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 81 – 510 | CytoplasmicSequence analysisAdd BLAST | 430 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, SynapsePathology & Biotechi
Organism-specific databases
DisGeNETi | 148281 |
OpenTargetsi | ENSG00000134207 |
PharmGKBi | PA38614 |
Miscellaneous databases
Pharosi | Q5T7P8, Tbio |
Polymorphism and mutation databases
BioMutai | SYT6 |
DMDMi | 209572719 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000183954 | 1 – 510 | Synaptotagmin-6Add BLAST | 510 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 216 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
EPDi | Q5T7P8 |
jPOSTi | Q5T7P8 |
MassIVEi | Q5T7P8 |
PaxDbi | Q5T7P8 |
PeptideAtlasi | Q5T7P8 |
PRIDEi | Q5T7P8 |
ProteomicsDBi | 64676 [Q5T7P8-1] 64677 [Q5T7P8-2] |
PTM databases
iPTMneti | Q5T7P8 |
PhosphoSitePlusi | Q5T7P8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000134207, Expressed in cortical plate and 98 other tissues |
ExpressionAtlasi | Q5T7P8, baseline and differential |
Genevisiblei | Q5T7P8, HS |
Organism-specific databases
HPAi | ENSG00000134207, Group enriched (brain, kidney, pancreas) |
Interactioni
Subunit structurei
Isoform 1: Homodimer; disulfide-linked via the cysteine motif. Isoform 1: Can also form heterodimers with SYT3, SYT7, SYT9 and SYT10. Isoform 1:
Interacts with STX1A, STX1B and STX2; the interaction is Ca2+-dependent. Isoform 2: Is not able to form homodimer and heterodimers.
By similarityBinary interactionsi
Hide detailsIsoform 2 [Q5T7P8-2]
GO - Molecular functioni
- calcium-dependent protein binding Source: Ensembl
- clathrin binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
- SNARE binding Source: GO_Central
- syntaxin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 127139, 35 interactors |
IntActi | Q5T7P8, 32 interactors |
MINTi | Q5T7P8 |
STRINGi | 9606.ENSP00000477344 |
Miscellaneous databases
RNActi | Q5T7P8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 229 – 350 | C2 1PROSITE-ProRule annotationAdd BLAST | 122 | |
Domaini | 361 – 494 | C2 2PROSITE-ProRule annotationAdd BLAST | 134 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 12 – 38 | Cysteine motifBy similarityAdd BLAST | 27 | |
Regioni | 482 – 510 | Necessary for cell membrane association (isoform 2)By similarityAdd BLAST | 29 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000157665 |
HOGENOMi | CLU_023008_8_3_1 |
InParanoidi | Q5T7P8 |
OMAi | HIMRHAR |
OrthoDBi | 925064at2759 |
PhylomeDBi | Q5T7P8 |
TreeFami | TF315600 |
Family and domain databases
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR001565, Synaptotagmin IPR028701, SYT6 |
PANTHERi | PTHR10024:SF45, PTHR10024:SF45, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGVWGAGGP RCQEALAVLA SLCRARPPPL GLDVETCRSF ELQPPERSPS
60 70 80 90 100
AAGAGTSVSL LAVVVIVCGV ALVAVFLFLF WKLCWMPWRN KEASSPSSAN
110 120 130 140 150
PPLEALQSPS FRGNMADKLK DPSTLGFLEA AVKISHTSPD IPAEVQMSVK
160 170 180 190 200
EHIMRHTRLQ RQTTEPASST RHTSFKRHLP RQMHVSSVDY GNELPPAAEQ
210 220 230 240 250
PTSIGRIKPE LYKQKSVDGE DAKSEATKSC GKINFSLRYD YETETLIVRI
260 270 280 290 300
LKAFDLPAKD FCGSSDPYVK IYLLPDRKCK LQTRVHRKTL NPTFDENFHF
310 320 330 340 350
PVPYEELADR KLHLSVFDFD RFSRHDMIGE VILDNLFEAS DLSRETSIWK
360 370 380 390 400
DIQYATSESV DLGEIMFSLC YLPTAGRLTL TVIKCRNLKA MDITGYSDPY
410 420 430 440 450
VKVSLLCDGR RLKKKKTTIK KNTLNPVYNE AIIFDIPPEN MDQVSLLISV
460 470 480 490 500
MDYDRVGHNE IIGVCRVGIT AEGLGRDHWN EMLAYPRKPI AHWHSLVEVK
510
KSFKEGNPRL
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketV9GYC4 | V9GYC4_HUMAN | Synaptotagmin-6 | SYT6 | 214 | Annotation score: | ||
V9GYY7 | V9GYY7_HUMAN | Synaptotagmin-6 | SYT6 | 88 | Annotation score: | ||
V9GY33 | V9GY33_HUMAN | Synaptotagmin-6 | SYT6 | 125 | Annotation score: | ||
A0A286YEX2 | A0A286YEX2_HUMAN | Synaptotagmin-6 | SYT6 | 418 | Annotation score: | ||
V9GYB1 | V9GYB1_HUMAN | Synaptotagmin-6 | SYT6 | 71 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036619 | 1 – 85 | Missing in isoform 2. 1 PublicationAdd BLAST | 85 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056448 mRNA Translation: BAG51713.1 AL162594 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56596.1 |
CCDSi | CCDS871.1 [Q5T7P8-2] |
RefSeqi | NP_001257734.1, NM_001270805.1 [Q5T7P8-2] NP_995320.1, NM_205848.3 [Q5T7P8-2] |
Genome annotation databases
Ensembli | ENST00000369547; ENSP00000358560; ENSG00000134207 [Q5T7P8-2] ENST00000607941; ENSP00000476507; ENSG00000134207 [Q5T7P8-2] ENST00000609117; ENSP00000477344; ENSG00000134207 [Q5T7P8-2] ENST00000610222; ENSP00000476396; ENSG00000134207 [Q5T7P8-1] |
GeneIDi | 148281 |
KEGGi | hsa:148281 |
UCSCi | uc001eev.4, human [Q5T7P8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK056448 mRNA Translation: BAG51713.1 AL162594 Genomic DNA No translation available. CH471122 Genomic DNA Translation: EAW56596.1 |
CCDSi | CCDS871.1 [Q5T7P8-2] |
RefSeqi | NP_001257734.1, NM_001270805.1 [Q5T7P8-2] NP_995320.1, NM_205848.3 [Q5T7P8-2] |
3D structure databases
SMRi | Q5T7P8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 127139, 35 interactors |
IntActi | Q5T7P8, 32 interactors |
MINTi | Q5T7P8 |
STRINGi | 9606.ENSP00000477344 |
PTM databases
iPTMneti | Q5T7P8 |
PhosphoSitePlusi | Q5T7P8 |
Polymorphism and mutation databases
BioMutai | SYT6 |
DMDMi | 209572719 |
Proteomic databases
EPDi | Q5T7P8 |
jPOSTi | Q5T7P8 |
MassIVEi | Q5T7P8 |
PaxDbi | Q5T7P8 |
PeptideAtlasi | Q5T7P8 |
PRIDEi | Q5T7P8 |
ProteomicsDBi | 64676 [Q5T7P8-1] 64677 [Q5T7P8-2] |
Protocols and materials databases
Antibodypediai | 53758, 319 antibodies |
DNASUi | 148281 |
Genome annotation databases
Ensembli | ENST00000369547; ENSP00000358560; ENSG00000134207 [Q5T7P8-2] ENST00000607941; ENSP00000476507; ENSG00000134207 [Q5T7P8-2] ENST00000609117; ENSP00000477344; ENSG00000134207 [Q5T7P8-2] ENST00000610222; ENSP00000476396; ENSG00000134207 [Q5T7P8-1] |
GeneIDi | 148281 |
KEGGi | hsa:148281 |
UCSCi | uc001eev.4, human [Q5T7P8-1] |
Organism-specific databases
CTDi | 148281 |
DisGeNETi | 148281 |
EuPathDBi | HostDB:ENSG00000134207.14 |
GeneCardsi | SYT6 |
HGNCi | HGNC:18638, SYT6 |
HPAi | ENSG00000134207, Group enriched (brain, kidney, pancreas) |
MIMi | 607718, gene |
neXtProti | NX_Q5T7P8 |
OpenTargetsi | ENSG00000134207 |
PharmGKBi | PA38614 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1028, Eukaryota |
GeneTreei | ENSGT00940000157665 |
HOGENOMi | CLU_023008_8_3_1 |
InParanoidi | Q5T7P8 |
OMAi | HIMRHAR |
OrthoDBi | 925064at2759 |
PhylomeDBi | Q5T7P8 |
TreeFami | TF315600 |
Enzyme and pathway databases
PathwayCommonsi | Q5T7P8 |
Miscellaneous databases
BioGRID-ORCSi | 148281, 3 hits in 840 CRISPR screens |
ChiTaRSi | SYT6, human |
GenomeRNAii | 148281 |
Pharosi | Q5T7P8, Tbio |
PROi | PR:Q5T7P8 |
RNActi | Q5T7P8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134207, Expressed in cortical plate and 98 other tissues |
ExpressionAtlasi | Q5T7P8, baseline and differential |
Genevisiblei | Q5T7P8, HS |
Family and domain databases
Gene3Di | 2.60.40.150, 2 hits |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR001565, Synaptotagmin IPR028701, SYT6 |
PANTHERi | PTHR10024:SF45, PTHR10024:SF45, 1 hit |
Pfami | View protein in Pfam PF00168, C2, 2 hits |
PRINTSi | PR00360, C2DOMAIN PR00399, SYNAPTOTAGMN |
SMARTi | View protein in SMART SM00239, C2, 2 hits |
PROSITEi | View protein in PROSITE PS50004, C2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYT6_HUMAN | |
Accessioni | Q5T7P8Primary (citable) accession number: Q5T7P8 Secondary accession number(s): B1AMB8, B3KPK1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 7, 2005 |
Last sequence update: | October 14, 2008 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM