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UniProtKB - Q5T7P8 (SYT6_HUMAN)

Entry version 164 (25 May 2022)
Sequence version 3 (14 Oct 2008)
Previous versions | rss
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Protein

Synaptotagmin-6

Gene

SYT6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. May mediate Ca2+-regulation of exocytosis in acrosomal reaction in sperm (By similarity).

By similarity

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotationNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi260Calcium 1PROSITE-ProRule annotation1
Metal bindingi260Calcium 2PROSITE-ProRule annotation1
Metal bindingi266Calcium 1PROSITE-ProRule annotation1
Metal bindingi318Calcium 1PROSITE-ProRule annotation1
Metal bindingi318Calcium 2PROSITE-ProRule annotation1
Metal bindingi319Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi320Calcium 1PROSITE-ProRule annotation1
Metal bindingi320Calcium 2PROSITE-ProRule annotation1
Metal bindingi320Calcium 3PROSITE-ProRule annotation1
Metal bindingi323Calcium 3PROSITE-ProRule annotation1
Metal bindingi326Calcium 2PROSITE-ProRule annotation1
Metal bindingi326Calcium 3PROSITE-ProRule annotation1
Metal bindingi392Calcium 4PROSITE-ProRule annotation1
Metal bindingi398Calcium 4PROSITE-ProRule annotation1
Metal bindingi452Calcium 4PROSITE-ProRule annotation1
Metal bindingi454Calcium 4PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5T7P8

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q5T7P8

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptotagmin-6
Alternative name(s):
Synaptotagmin VI
Short name:
SytVI
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SYT6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18638, SYT6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607718, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5T7P8

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000134207

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 59VesicularSequence analysisAdd BLAST59
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Topological domaini81 – 510CytoplasmicSequence analysisAdd BLAST430

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		148281

Open Targets

More...OpenTargetsi		ENSG00000134207

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38614

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5T7P8, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SYT6

Domain mapping of disease mutations (DMDM)

More...DMDMi		209572719

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001839541 – 510Synaptotagmin-6Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei216PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5T7P8

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5T7P8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5T7P8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5T7P8

PeptideAtlas

More...PeptideAtlasi		Q5T7P8

PRoteomics IDEntifications database

More...PRIDEi		Q5T7P8

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		64676 [Q5T7P8-1]
64677 [Q5T7P8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5T7P8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5T7P8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134207, Expressed in cortical plate and 98 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5T7P8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5T7P8, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134207, Group enriched (brain, pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 1: Homodimer; disulfide-linked via the cysteine motif. Isoform 1: Can also form heterodimers with SYT3, SYT7, SYT9 and SYT10. Isoform 1:

Interacts with STX1A, STX1B and STX2; the interaction is Ca2+-dependent. Isoform 2: Is not able to form homodimer and heterodimers.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127139, 141 interactors

Protein interaction database and analysis system

More...IntActi		Q5T7P8, 34 interactors

Molecular INTeraction database

More...MINTi		Q5T7P8

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000477344

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5T7P8, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q5T7P8

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5T7P8

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini229 – 350C2 1PROSITE-ProRule annotationAdd BLAST122
Domaini361 – 494C2 2PROSITE-ProRule annotationAdd BLAST134

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni12 – 38Cysteine motifBy similarityAdd BLAST27
Regioni157 – 178DisorderedSequence analysisAdd BLAST22
Regioni482 – 510Necessary for cell membrane association (isoform 2)By similarityAdd BLAST29

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1028, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157665

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_023008_8_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5T7P8

Identification of Orthologs from Complete Genome Data

More...OMAi		VMRVGCN

Database of Orthologous Groups

More...OrthoDBi		925064at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5T7P8

TreeFam database of animal gene trees

More...TreeFami		TF315600

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.150, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR001565, Synaptotagmin
IPR028701, SYT6

The PANTHER Classification System

More...PANTHERi		PTHR10024:SF45, PTHR10024:SF45, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00168, C2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00360, C2DOMAIN
PR00399, SYNAPTOTAGMN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00239, C2, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49562, SSF49562, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50004, C2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T7P8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGVWGAGGP RCQEALAVLA SLCRARPPPL GLDVETCRSF ELQPPERSPS 
        60         70         80         90        100
AAGAGTSVSL LAVVVIVCGV ALVAVFLFLF WKLCWMPWRN KEASSPSSAN 
       110        120        130        140        150
PPLEALQSPS FRGNMADKLK DPSTLGFLEA AVKISHTSPD IPAEVQMSVK 
       160        170        180        190        200
EHIMRHTRLQ RQTTEPASST RHTSFKRHLP RQMHVSSVDY GNELPPAAEQ 
       210        220        230        240        250
PTSIGRIKPE LYKQKSVDGE DAKSEATKSC GKINFSLRYD YETETLIVRI 
       260        270        280        290        300
LKAFDLPAKD FCGSSDPYVK IYLLPDRKCK LQTRVHRKTL NPTFDENFHF 
       310        320        330        340        350
PVPYEELADR KLHLSVFDFD RFSRHDMIGE VILDNLFEAS DLSRETSIWK 
       360        370        380        390        400
DIQYATSESV DLGEIMFSLC YLPTAGRLTL TVIKCRNLKA MDITGYSDPY 
       410        420        430        440        450
VKVSLLCDGR RLKKKKTTIK KNTLNPVYNE AIIFDIPPEN MDQVSLLISV 
       460        470        480        490        500
MDYDRVGHNE IIGVCRVGIT AEGLGRDHWN EMLAYPRKPI AHWHSLVEVK 
       510
KSFKEGNPRL
Length:510
Mass (Da):57,325
Last modified:October 14, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE5478F5B95693D3
GO
Isoform 2 (identifier: Q5T7P8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:425
Mass (Da):48,442
Checksum:iF41702F895DAC695
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GYC4V9GYC4_HUMAN
Synaptotagmin-6
SYT6
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286YEX2A0A286YEX2_HUMAN
Synaptotagmin-6
SYT6
418Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYY7V9GYY7_HUMAN
Synaptotagmin-6
SYT6
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7I2PMW4A0A7I2PMW4_HUMAN
Synaptotagmin VI, isoform CRA_b
SYT6 hCG_38646
528Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GY33V9GY33_HUMAN
Synaptotagmin-6
SYT6
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYB1V9GYB1_HUMAN
Synaptotagmin-6
SYT6
71Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0366191 – 85Missing in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK056448 mRNA Translation: BAG51713.1
AL162594 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56596.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS871.1 [Q5T7P8-2]

NCBI Reference Sequences

More...RefSeqi		NP_001257734.1, NM_001270805.1 [Q5T7P8-2]
NP_995320.1, NM_205848.3 [Q5T7P8-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000607941.5; ENSP00000476507.1; ENSG00000134207.17 [Q5T7P8-2]
ENST00000609117.5; ENSP00000477344.1; ENSG00000134207.17 [Q5T7P8-2]
ENST00000610222.3; ENSP00000476396.1; ENSG00000134207.17

Database of genes from NCBI RefSeq genomes

More...GeneIDi		148281

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:148281

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000610222.3; ENSP00000476396.1; NM_001253772.2; NP_001240701.1

UCSC genome browser

More...UCSCi		uc001eev.4, human [Q5T7P8-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056448 mRNA Translation: BAG51713.1
AL162594 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56596.1
CCDSiCCDS871.1 [Q5T7P8-2]
RefSeqiNP_001257734.1, NM_001270805.1 [Q5T7P8-2]
NP_995320.1, NM_205848.3 [Q5T7P8-2]

3D structure databases

AlphaFoldDBiQ5T7P8
SMRiQ5T7P8
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127139, 141 interactors
IntActiQ5T7P8, 34 interactors
MINTiQ5T7P8
STRINGi9606.ENSP00000477344

PTM databases

iPTMnetiQ5T7P8
PhosphoSitePlusiQ5T7P8

Genetic variation databases

BioMutaiSYT6
DMDMi209572719

Proteomic databases

EPDiQ5T7P8
jPOSTiQ5T7P8
MassIVEiQ5T7P8
PaxDbiQ5T7P8
PeptideAtlasiQ5T7P8
PRIDEiQ5T7P8
ProteomicsDBi64676 [Q5T7P8-1]
64677 [Q5T7P8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		53758, 331 antibodies from 27 providers

The DNASU plasmid repository

More...DNASUi		148281

Genome annotation databases

EnsembliENST00000607941.5; ENSP00000476507.1; ENSG00000134207.17 [Q5T7P8-2]
ENST00000609117.5; ENSP00000477344.1; ENSG00000134207.17 [Q5T7P8-2]
ENST00000610222.3; ENSP00000476396.1; ENSG00000134207.17
GeneIDi148281
KEGGihsa:148281
MANE-SelectiENST00000610222.3; ENSP00000476396.1; NM_001253772.2; NP_001240701.1
UCSCiuc001eev.4, human [Q5T7P8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		148281
DisGeNETi148281

GeneCards: human genes, protein and diseases

More...GeneCardsi		SYT6
HGNCiHGNC:18638, SYT6
HPAiENSG00000134207, Group enriched (brain, pancreas)
MIMi607718, gene
neXtProtiNX_Q5T7P8
OpenTargetsiENSG00000134207
PharmGKBiPA38614
VEuPathDBiHostDB:ENSG00000134207

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1028, Eukaryota
GeneTreeiENSGT00940000157665
HOGENOMiCLU_023008_8_3_1
InParanoidiQ5T7P8
OMAiVMRVGCN
OrthoDBi925064at2759
PhylomeDBiQ5T7P8
TreeFamiTF315600

Enzyme and pathway databases

PathwayCommonsiQ5T7P8
SignaLinkiQ5T7P8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		148281, 12 hits in 1066 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SYT6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		148281
PharosiQ5T7P8, Tbio

Protein Ontology

More...PROi		PR:Q5T7P8
RNActiQ5T7P8, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134207, Expressed in cortical plate and 98 other tissues
ExpressionAtlasiQ5T7P8, baseline and differential
GenevisibleiQ5T7P8, HS

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR001565, Synaptotagmin
IPR028701, SYT6
PANTHERiPTHR10024:SF45, PTHR10024:SF45, 1 hit
PfamiView protein in Pfam
PF00168, C2, 2 hits
PRINTSiPR00360, C2DOMAIN
PR00399, SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239, C2, 2 hits
SUPFAMiSSF49562, SSF49562, 2 hits
PROSITEiView protein in PROSITE
PS50004, C2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSYT6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T7P8
Secondary accession number(s): B1AMB8, B3KPK1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 14, 2008
Last modified: May 25, 2022
This is version 164 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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