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Protein

Late cornified envelope protein 1B

Gene

LCE1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Precursors of the cornified envelope of the stratum corneum.

Miscellaneous

Belongs to the LCE cluster present on 1q21.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processKeratinization

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Late cornified envelope protein 1B
Alternative name(s):
Late envelope protein 2
Small proline-rich-like epidermal differentiation complex protein 2A
Gene namesi
Name:LCE1B
Synonyms:LEP2, SPRL2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000196734.8
HGNCiHGNC:16611 LCE1B
MIMi612604 gene
neXtProtiNX_Q5T7P3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196734
PharmGKBiPA38171

Polymorphism and mutation databases

BioMutaiLCE1B
DMDMi74745414

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002353251 – 118Late cornified envelope protein 1BAdd BLAST118

Proteomic databases

PaxDbiQ5T7P3
PeptideAtlasiQ5T7P3
PRIDEiQ5T7P3
ProteomicsDBi64674

Expressioni

Tissue specificityi

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication

Inductioni

By UVB.1 Publication

Gene expression databases

BgeeiENSG00000196734
CleanExiHS_LCE1B
GenevisibleiQ5T7P3 HS

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi131639, 23 interactors
IntActiQ5T7P3, 66 interactors
STRINGi9606.ENSP00000353203

Structurei

3D structure databases

ProteinModelPortaliQ5T7P3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 39Pro-richAdd BLAST28
Compositional biasi49 – 116Gly-richAdd BLAST68

Sequence similaritiesi

Belongs to the LCE family.Curated

Phylogenomic databases

GeneTreeiENSGT00810000126943
OMAiCEGSSCC

Family and domain databases

InterProiView protein in InterPro
IPR028205 LCE
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 1 hit
PfamiView protein in Pfam
PF14672 LCE, 2 hits

Sequencei

Sequence statusi: Complete.

Q5T7P3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCQQNQQQC QPPPKCIPKC PPKCLTPRCP PKCPPKCPPV SSCCSVSSGG
60 70 80 90 100
CCGSSSGGSC GSSSGGCCSS GGGGCCLSHH RRRRSHCHRP QSSGCCSQPS
110
GGSSCCGGGS GQHSGGCC
Length:118
Mass (Da):11,626
Last modified:December 21, 2004 - v1
Checksum:i638887B9EBD82BF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162596 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53363.1
BC104232 mRNA Translation: AAI04233.1
BC104233 mRNA Translation: AAI04234.1
CCDSiCCDS1027.1
RefSeqiNP_848126.1, NM_178349.1
UniGeneiHs.375103

Genome annotation databases

EnsembliENST00000360090; ENSP00000353203; ENSG00000196734
GeneIDi353132
KEGGihsa:353132
UCSCiuc001faq.3 human

Similar proteinsi

Entry informationi

Entry nameiLCE1B_HUMAN
AccessioniPrimary (citable) accession number: Q5T7P3
Secondary accession number(s): A4IF40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: July 18, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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