UniProtKB - Q5T7P3 (LCE1B_HUMAN)
Protein
Late cornified envelope protein 1B
Gene
LCE1B
Organism
Homo sapiens (Human)
Status
Functioni
Precursors of the cornified envelope of the stratum corneum.
Miscellaneous
Belongs to the LCE cluster present on 1q21.
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- keratinization Source: UniProtKB-KW
Keywordsi
Biological process | Keratinization |
Enzyme and pathway databases
PathwayCommonsi | Q5T7P3 |
Reactomei | R-HSA-6809371, Formation of the cornified envelope |
Names & Taxonomyi
Protein namesi | Recommended name: Late cornified envelope protein 1BAlternative name(s): Late envelope protein 2 Small proline-rich-like epidermal differentiation complex protein 2A |
Gene namesi | Name:LCE1B Synonyms:LEP2, SPRL2A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000196734.8 |
HGNCi | HGNC:16611, LCE1B |
MIMi | 612604, gene |
neXtProti | NX_Q5T7P3 |
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000196734 |
PharmGKBi | PA38171 |
Miscellaneous databases
Pharosi | Q5T7P3, Tdark |
Polymorphism and mutation databases
BioMutai | LCE1B |
DMDMi | 74745414 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000235325 | 1 – 118 | Late cornified envelope protein 1BAdd BLAST | 118 |
Proteomic databases
MassIVEi | Q5T7P3 |
PaxDbi | Q5T7P3 |
PeptideAtlasi | Q5T7P3 |
PRIDEi | Q5T7P3 |
ProteomicsDBi | 64674 |
Expressioni
Tissue specificityi
Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication
Inductioni
By UVB.1 Publication
Gene expression databases
Bgeei | ENSG00000196734, Expressed in zone of skin and 71 other tissues |
Genevisiblei | Q5T7P3, HS |
Organism-specific databases
HPAi | ENSG00000196734, Tissue enriched (skin) |
Interactioni
Binary interactionsi
Q5T7P3
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 131639, 74 interactors |
IntActi | Q5T7P3, 69 interactors |
STRINGi | 9606.ENSP00000353203 |
Miscellaneous databases
RNActi | Q5T7P3, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 12 – 39 | Pro-richAdd BLAST | 28 | |
Compositional biasi | 49 – 116 | Gly-richAdd BLAST | 68 |
Sequence similaritiesi
Belongs to the LCE family.Curated
Phylogenomic databases
GeneTreei | ENSGT00950000183278 |
HOGENOMi | CLU_152038_0_0_1 |
OMAi | TCIPKCP |
Family and domain databases
InterProi | View protein in InterPro IPR028205, LCE IPR026075, SPRR/LCE |
PANTHERi | PTHR23263, PTHR23263, 1 hit |
Pfami | View protein in Pfam PF14672, LCE, 2 hits |
i Sequence
Sequence statusi: Complete.
Q5T7P3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSCQQNQQQC QPPPKCIPKC PPKCLTPRCP PKCPPKCPPV SSCCSVSSGG
60 70 80 90 100
CCGSSSGGSC GSSSGGCCSS GGGGCCLSHH RRRRSHCHRP QSSGCCSQPS
110
GGSSCCGGGS GQHSGGCC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL162596 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53363.1 BC104232 mRNA Translation: AAI04233.1 BC104233 mRNA Translation: AAI04234.1 |
CCDSi | CCDS1027.1 |
RefSeqi | NP_848126.1, NM_178349.1 |
Genome annotation databases
Ensembli | ENST00000360090; ENSP00000353203; ENSG00000196734 |
GeneIDi | 353132 |
KEGGi | hsa:353132 |
UCSCi | uc001faq.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL162596 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53363.1 BC104232 mRNA Translation: AAI04233.1 BC104233 mRNA Translation: AAI04234.1 |
CCDSi | CCDS1027.1 |
RefSeqi | NP_848126.1, NM_178349.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 131639, 74 interactors |
IntActi | Q5T7P3, 69 interactors |
STRINGi | 9606.ENSP00000353203 |
Polymorphism and mutation databases
BioMutai | LCE1B |
DMDMi | 74745414 |
Proteomic databases
MassIVEi | Q5T7P3 |
PaxDbi | Q5T7P3 |
PeptideAtlasi | Q5T7P3 |
PRIDEi | Q5T7P3 |
ProteomicsDBi | 64674 |
Protocols and materials databases
Antibodypediai | 47013, 52 antibodies |
Genome annotation databases
Ensembli | ENST00000360090; ENSP00000353203; ENSG00000196734 |
GeneIDi | 353132 |
KEGGi | hsa:353132 |
UCSCi | uc001faq.3, human |
Organism-specific databases
CTDi | 353132 |
EuPathDBi | HostDB:ENSG00000196734.8 |
GeneCardsi | LCE1B |
HGNCi | HGNC:16611, LCE1B |
HPAi | ENSG00000196734, Tissue enriched (skin) |
MIMi | 612604, gene |
neXtProti | NX_Q5T7P3 |
OpenTargetsi | ENSG00000196734 |
PharmGKBi | PA38171 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000183278 |
HOGENOMi | CLU_152038_0_0_1 |
OMAi | TCIPKCP |
Enzyme and pathway databases
PathwayCommonsi | Q5T7P3 |
Reactomei | R-HSA-6809371, Formation of the cornified envelope |
Miscellaneous databases
BioGRID-ORCSi | 353132, 24 hits in 811 CRISPR screens |
GenomeRNAii | 353132 |
Pharosi | Q5T7P3, Tdark |
PROi | PR:Q5T7P3 |
RNActi | Q5T7P3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000196734, Expressed in zone of skin and 71 other tissues |
Genevisiblei | Q5T7P3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028205, LCE IPR026075, SPRR/LCE |
PANTHERi | PTHR23263, PTHR23263, 1 hit |
Pfami | View protein in Pfam PF14672, LCE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LCE1B_HUMAN | |
Accessioni | Q5T7P3Primary (citable) accession number: Q5T7P3 Secondary accession number(s): A4IF40 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 104 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM