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Entry version 120 (18 Sep 2019)
Sequence version 1 (21 Dec 2004)
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Protein

KN motif and ankyrin repeat domain-containing protein 4

Gene

KANK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the control of cytoskeleton formation by regulating actin polymerization.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
KN motif and ankyrin repeat domain-containing protein 4
Alternative name(s):
Ankyrin repeat domain-containing protein 38
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KANK4
Synonyms:ANKRD38
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27263 KANK4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614612 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T7N3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
163782

Open Targets

More...
OpenTargetsi
ENSG00000132854

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162392639

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5T7N3

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KANK4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74745407

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002443641 – 995KN motif and ankyrin repeat domain-containing protein 4Add BLAST995

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T7N3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5T7N3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5T7N3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T7N3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T7N3

PeptideAtlas

More...
PeptideAtlasi
Q5T7N3

PRoteomics IDEntifications database

More...
PRIDEi
Q5T7N3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64669 [Q5T7N3-1]
64670 [Q5T7N3-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T7N3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T7N3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongly expressed in colon, liver, lung, skeletal muscle and kidney.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000132854 Expressed in 151 organ(s), highest expression level in trigeminal ganglion

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5T7N3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T7N3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014030

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127879, 14 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T7N3, 19 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360195

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5T7N3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati823 – 853ANK 1Add BLAST31
Repeati862 – 890ANK 2Add BLAST29
Repeati895 – 924ANK 3Add BLAST30
Repeati928 – 958ANK 4Add BLAST31
Repeati962 – 992ANK 5Add BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili343 – 404Sequence analysisAdd BLAST62

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi184 – 315Pro-richAdd BLAST132

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0514 Eukaryota
COG0666 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158468

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231305

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T7N3

KEGG Orthology (KO)

More...
KOi
K22808

Identification of Orthologs from Complete Genome Data

More...
OMAi
KDPPKSH

Database of Orthologous Groups

More...
OrthoDBi
98668at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T7N3

TreeFam database of animal gene trees

More...
TreeFami
TF324499

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR021939 KN_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 1 hit
PF12075 KN_motif, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T7N3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKTDAKDQS SQGDEEKDPP KSHPYSVETP YGFHLDLDFL KYVDDIEKGN
60 70 80 90 100
TIKRIPIHRR AKQAKFSTLP RNFSLPDSGA RPPAAPPLQN WSPVVPREAS
110 120 130 140 150
LGTQEQNQSP PLGNAPQAST SRSEVSYHRK ALLAEATRQL EAAEPEDAEL
160 170 180 190 200
TFGSGRPQLL RASSMPATLL HSRASEEPGL SLGPPAPPAL PPLQGEGSVC
210 220 230 240 250
DGTFEPAEGL AGFHSSSPRA STRIPELVQE GAEPPEGVVK VPNHLPLPGP
260 270 280 290 300
PFSFQNVLVV LEDKEDEHNA REAEVLFTPG SPTPSPPPLP SPIPENELLL
310 320 330 340 350
EEIELNISEI PPPPPVEVDM RSIGIRVTEE SLGLARVDPG SISSLKQQVS
360 370 380 390 400
ALEGELSGRT EELAQVRTAL QQQEEEIKAR EQRIRELEFT VAQLEGQFHQ
410 420 430 440 450
ENAKDTQGQT DVMVNTDPVH GLLTRESCDK GIEVNLLGSM ESESWGHRGE
460 470 480 490 500
ENGLLWGPDG HKQGNQSPAE RVLLPQLSLP QGPEQVLTSS VHSFLSTELR
510 520 530 540 550
IEEAGTEQEG GPQGGTRGAG GFLWGSDRKT PPAGREETSS NLPGKEHPGR
560 570 580 590 600
PPSSPTDATI GQYVKKIQEL LQEQWNCLEH GYPELASAIK QPASKLSSIQ
610 620 630 640 650
SQLLSSLNLL LSAYSAQAHP PKEPPASSSS PPVEISPSTS LKSIMKKKDY
660 670 680 690 700
GFRAGGNGTK KNLQFVGVNG GYETTSSEET SGEDSTPEDL SDSEAEKKCD
710 720 730 740 750
GPDHKHVKDA HLTCEAGQGI PEGTCHAAQE SGPGEEVPHS KAERYKPSEE
760 770 780 790 800
FLNACRALSQ HLPETGTTTD QLLRQSLNTI SQEWFRVSSR KSSSPAVVAS
810 820 830 840 850
YLHEVQPHSP HFLKLLVNLA DHNGNTALHY SVSHSNFSIV KLLLETGVCN
860 870 880 890 900
VDHQNKAGYT AVMITPLASA ETNEDMAVVW KLLREGNVNI QATQGGQTAL
910 920 930 940 950
MLGVSHDRED MVQALLSCQA DVNLQDHDGS SALMVACHHG NVDLVRLLLA
960 970 980 990
HPACDSSLTD KAGRTALSIA LKSPTHMEIA GLLRAHAEQG RSLGL
Length:995
Mass (Da):107,342
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25379EB22B44C760
GO
Isoform 2 (identifier: Q5T7N3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-628: Missing.
     629-633: SSPPV → MEKTD

Note: No experimental confirmation available.
Show »
Length:367
Mass (Da):39,563
Checksum:i5E34B07F149259FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1ALP6B1ALP6_HUMAN
KN motif and ankyrin repeat domain-...
KANK4
351Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B1ALP5B1ALP5_HUMAN
KN motif and ankyrin repeat domain-...
KANK4
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti297E → G in CAD89966 (PubMed:17974005).Curated1
Sequence conflicti786R → H in BAC03774 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_048306701G → S. Corresponds to variant dbSNP:rs17123306Ensembl.1
Natural variantiVAR_048307768T → A. Corresponds to variant dbSNP:rs11207949Ensembl.1
Natural variantiVAR_080961801Y → H Found in a patient with nephrotic syndrome; unknown pathological significance; no effect on protein localization. 1 PublicationCorresponds to variant dbSNP:rs145623004EnsemblClinVar.1
Natural variantiVAR_026902822H → R3 PublicationsCorresponds to variant dbSNP:rs2258470Ensembl.1
Natural variantiVAR_026903840V → A3 PublicationsCorresponds to variant dbSNP:rs2666472Ensembl.1
Natural variantiVAR_026904935V → L3 PublicationsCorresponds to variant dbSNP:rs2941679Ensembl.1
Natural variantiVAR_048308987A → V. Corresponds to variant dbSNP:rs34591898Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0195521 – 628Missing in isoform 2. 1 PublicationAdd BLAST628
Alternative sequenceiVSP_019553629 – 633SSPPV → MEKTD in isoform 2. 1 Publication5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK091941 mRNA Translation: BAC03774.1
AL139343 Genomic DNA No translation available.
AL162739 Genomic DNA No translation available.
BC041418 mRNA Translation: AAH41418.1
BC060866 mRNA Translation: AAH60866.1
AL832644 mRNA Translation: CAD89966.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS620.1 [Q5T7N3-1]
CCDS81334.1 [Q5T7N3-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001307198.1, NM_001320269.1 [Q5T7N3-2]
NP_859063.3, NM_181712.4 [Q5T7N3-1]
XP_011539145.1, XM_011540843.2 [Q5T7N3-1]
XP_016855973.1, XM_017000484.1 [Q5T7N3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000354381; ENSP00000346352; ENSG00000132854 [Q5T7N3-2]
ENST00000371153; ENSP00000360195; ENSG00000132854 [Q5T7N3-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
163782

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:163782

UCSC genome browser

More...
UCSCi
uc001dah.5 human [Q5T7N3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091941 mRNA Translation: BAC03774.1
AL139343 Genomic DNA No translation available.
AL162739 Genomic DNA No translation available.
BC041418 mRNA Translation: AAH41418.1
BC060866 mRNA Translation: AAH60866.1
AL832644 mRNA Translation: CAD89966.1
CCDSiCCDS620.1 [Q5T7N3-1]
CCDS81334.1 [Q5T7N3-2]
RefSeqiNP_001307198.1, NM_001320269.1 [Q5T7N3-2]
NP_859063.3, NM_181712.4 [Q5T7N3-1]
XP_011539145.1, XM_011540843.2 [Q5T7N3-1]
XP_016855973.1, XM_017000484.1 [Q5T7N3-2]

3D structure databases

SMRiQ5T7N3
ModBaseiSearch...

Protein-protein interaction databases

BioGridi127879, 14 interactors
IntActiQ5T7N3, 19 interactors
STRINGi9606.ENSP00000360195

PTM databases

iPTMnetiQ5T7N3
PhosphoSitePlusiQ5T7N3

Polymorphism and mutation databases

BioMutaiKANK4
DMDMi74745407

Proteomic databases

EPDiQ5T7N3
jPOSTiQ5T7N3
MassIVEiQ5T7N3
MaxQBiQ5T7N3
PaxDbiQ5T7N3
PeptideAtlasiQ5T7N3
PRIDEiQ5T7N3
ProteomicsDBi64669 [Q5T7N3-1]
64670 [Q5T7N3-2]

Genome annotation databases

EnsembliENST00000354381; ENSP00000346352; ENSG00000132854 [Q5T7N3-2]
ENST00000371153; ENSP00000360195; ENSG00000132854 [Q5T7N3-1]
GeneIDi163782
KEGGihsa:163782
UCSCiuc001dah.5 human [Q5T7N3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
163782
DisGeNETi163782

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KANK4
HGNCiHGNC:27263 KANK4
HPAiHPA014030
MIMi614612 gene
neXtProtiNX_Q5T7N3
OpenTargetsiENSG00000132854
PharmGKBiPA162392639

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0514 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00940000158468
HOGENOMiHOG000231305
InParanoidiQ5T7N3
KOiK22808
OMAiKDPPKSH
OrthoDBi98668at2759
PhylomeDBiQ5T7N3
TreeFamiTF324499

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KANK4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
163782
PharosiQ5T7N3

Protein Ontology

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PROi
PR:Q5T7N3

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000132854 Expressed in 151 organ(s), highest expression level in trigeminal ganglion
ExpressionAtlasiQ5T7N3 baseline and differential
GenevisibleiQ5T7N3 HS

Family and domain databases

Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR021939 KN_motif
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF12075 KN_motif, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKANK4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T7N3
Secondary accession number(s): B1ALP7
, Q6P9A0, Q86T71, Q86VE6, Q8NAX3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 21, 2004
Last modified: September 18, 2019
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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