UniProtKB - Q5T7N2 (LITD1_HUMAN)
Protein
LINE-1 type transposase domain-containing protein 1
Gene
L1TD1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- single-stranded RNA binding Source: GO_Central
GO - Biological processi
- transposition, RNA-mediated Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q5T7N2 |
Names & Taxonomyi
Protein namesi | Recommended name: LINE-1 type transposase domain-containing protein 1Alternative name(s): ES cell-associated protein 11 |
Gene namesi | Name:L1TD1 Synonyms:ECAT11 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000240563.1 |
HGNCi | HGNC:25595, L1TD1 |
neXtProti | NX_Q5T7N2 |
Subcellular locationi
Other locations
- ribonucleoprotein complex Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 54596 |
OpenTargetsi | ENSG00000240563 |
PharmGKBi | PA145008170 |
Miscellaneous databases
Pharosi | Q5T7N2, Tbio |
Polymorphism and mutation databases
BioMutai | L1TD1 |
DMDMi | 74745406 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000307217 | 2 – 865 | LINE-1 type transposase domain-containing protein 1Add BLAST | 864 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 2 | PhosphoserineCombined sources | 1 | |
Modified residuei | 149 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 154 | PhosphoserineCombined sources | 1 | |
Modified residuei | 472 | PhosphoserineCombined sources | 1 | |
Modified residuei | 476 | PhosphoserineCombined sources | 1 | |
Modified residuei | 478 | PhosphoserineCombined sources | 1 | |
Modified residuei | 518 | PhosphoserineCombined sources | 1 | |
Modified residuei | 561 | PhosphoserineCombined sources | 1 | |
Modified residuei | 573 | PhosphoserineCombined sources | 1 | |
Modified residuei | 640 | PhosphoserineCombined sources | 1 | |
Modified residuei | 648 | PhosphoserineCombined sources | 1 | |
Modified residuei | 665 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q5T7N2 |
jPOSTi | Q5T7N2 |
MassIVEi | Q5T7N2 |
PaxDbi | Q5T7N2 |
PeptideAtlasi | Q5T7N2 |
PRIDEi | Q5T7N2 |
ProteomicsDBi | 64668 |
PTM databases
iPTMneti | Q5T7N2 |
PhosphoSitePlusi | Q5T7N2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000240563, Expressed in amniotic fluid and 96 other tissues |
Genevisiblei | Q5T7N2, HS |
Organism-specific databases
HPAi | ENSG00000240563, Tissue enhanced (lymphoid tissue, placenta) |
Interactioni
Binary interactionsi
Q5T7N2
With | #Exp. | IntAct |
---|---|---|
HNRNPA2B1 [P22626] | 2 | EBI-7216220,EBI-299649 |
Protein-protein interaction databases
BioGRIDi | 120072, 22 interactors |
IntActi | Q5T7N2, 326 interactors |
MINTi | Q5T7N2 |
STRINGi | 9606.ENSP00000419901 |
Miscellaneous databases
RNActi | Q5T7N2, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q5T7N2 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q5T7N2 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 642 – 684 | Sequence analysisAdd BLAST | 43 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 369 – 488 | Glu-richAdd BLAST | 120 | |
Compositional biasi | 534 – 537 | Poly-Glu | 4 |
Sequence similaritiesi
Belongs to the transposase 22 family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502SRQ0, Eukaryota |
GeneTreei | ENSGT01000000214409 |
HOGENOMi | CLU_336140_0_0_1 |
InParanoidi | Q5T7N2 |
OMAi | FEPKFLC |
OrthoDBi | 455018at2759 |
PhylomeDBi | Q5T7N2 |
TreeFami | TF351152 |
Family and domain databases
Gene3Di | 3.30.250.20, 2 hits 3.30.70.1820, 1 hit |
InterProi | View protein in InterPro IPR042566, L1_C IPR035300, L1_dsRBD IPR043636, L1_RRM_dom IPR004244, Transposase_22 IPR042497, Transposase_L1_sf |
PANTHERi | PTHR11505, PTHR11505, 2 hits |
Pfami | View protein in Pfam PF17490, Tnp_22_dsRBD, 2 hits PF02994, Transposase_22, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5T7N2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDVSTSVQS KFARLAKKKE NITYMKREQL TETDKDIAPV LDLKCKDVSA
60 70 80 90 100
IMNKFKVLME IQDLMFEEMR ETLKNDLKAV LGGKATIPEV KNSENSSSRT
110 120 130 140 150
EFQQIINLAL QKTGMVGKIE GENSKIGDDN ENLTFKLEVN ELSGKLDNTN
160 170 180 190 200
EYNSNDGKKL PQGESRSYEV MGSMEETLCN IDDRDGNRNV HLEFTERESR
210 220 230 240 250
KDGEDEFVKE MREERKFQKL KNKEEVLKAS REEKVLMDEG AVLTLVADLS
260 270 280 290 300
SATLDISKQW SNVFNILREN DFEPKFLCEV KLAFKCDGEI KTFSDLQSLR
310 320 330 340 350
KFASQKSSVK ELLKDVLPQK EEINQGGRKY GIQEKRDKTL IDSKHRAGEI
360 370 380 390 400
TSDGLSFLFL KEVKVAKPEE MKNLETQEEE FSELEELDEE ASGMEDDEDT
410 420 430 440 450
SGLEEEEEEP SGLEEEEEEE ASGLEEDEAS GLEEEEEQTS EQDSTFQGHT
460 470 480 490 500
LVDAKHEVEI TSDGMETTFI DSVEDSESEE EEEGKSSETG KVKTTSLTEK
510 520 530 540 550
KASRRQKEIP FSYLVGDSGK KKLVKHQVVH KTQEEEETAV PTSQGTGTPC
560 570 580 590 600
LTLCLASPSK SLEMSHDEHK KHSHTNLSIS TGVTKLKKTE EKKHRTLHTE
610 620 630 640 650
ELTSKEADLT EETEENLRSS VINSIREIKE EIGNLKSSHS GVLEIENSVD
660 670 680 690 700
DLSSRMDILE ERIDSLEDQI EEFSKDTMQM TKQIISKERQ RDIEERSRSC
710 720 730 740 750
NIRLIGIPEK ESYENRAEDI IKEIIDENFA ELKKGSSLEI VSACRVPSKI
760 770 780 790 800
DEKRLTPRHI LVKFWNSSDK EKIIRASRER REITYQGTRI RLTADLSLDT
810 820 830 840 850
LDARSKWSNV FKVLLEKGFN PRILYPAKMA FDFRGKTKVF LSIEEFRDYV
860
LHMPTLRELL GNNIP
Sequence cautioni
The sequence BAA91878 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA91878 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 548 | T → I in BAA92011 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035377 | 27 | R → S. Corresponds to variant dbSNP:rs7552335Ensembl. | 1 | |
Natural variantiVAR_035378 | 246 | V → A4 PublicationsCorresponds to variant dbSNP:rs7542665Ensembl. | 1 | |
Natural variantiVAR_035379 | 309 | V → M4 PublicationsCorresponds to variant dbSNP:rs7533274Ensembl. | 1 | |
Natural variantiVAR_035380 | 329 | K → N3 PublicationsCorresponds to variant dbSNP:rs2457828Ensembl. | 1 | |
Natural variantiVAR_035381 | 549 | P → T. Corresponds to variant dbSNP:rs11207933Ensembl. | 1 | |
Natural variantiVAR_035382 | 613 | T → I. Corresponds to variant dbSNP:rs2886644Ensembl. | 1 | |
Natural variantiVAR_051094 | 860 | L → V. Corresponds to variant dbSNP:rs11207934Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB211065 mRNA Translation: BAD95492.1 AK001746 mRNA Translation: BAA91878.1 Sequence problems. AK001973 mRNA Translation: BAA92011.1 AL834314 mRNA Translation: CAD38984.1 AL162739 Genomic DNA No translation available. BC111559 mRNA Translation: AAI11560.1 |
CCDSi | CCDS619.1 |
RefSeqi | NP_001158307.1, NM_001164835.1 NP_061952.3, NM_019079.4 |
Genome annotation databases
Ensembli | ENST00000498273; ENSP00000419901; ENSG00000240563 |
GeneIDi | 54596 |
KEGGi | hsa:54596 |
UCSCi | uc001dae.6, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB211065 mRNA Translation: BAD95492.1 AK001746 mRNA Translation: BAA91878.1 Sequence problems. AK001973 mRNA Translation: BAA92011.1 AL834314 mRNA Translation: CAD38984.1 AL162739 Genomic DNA No translation available. BC111559 mRNA Translation: AAI11560.1 |
CCDSi | CCDS619.1 |
RefSeqi | NP_001158307.1, NM_001164835.1 NP_061952.3, NM_019079.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2LR6 | NMR | - | A/B | 235-321 | [»] | |
3SOO | X-ray | 2.73 | A/B/C | 235-321 | [»] | |
SMRi | Q5T7N2 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120072, 22 interactors |
IntActi | Q5T7N2, 326 interactors |
MINTi | Q5T7N2 |
STRINGi | 9606.ENSP00000419901 |
PTM databases
iPTMneti | Q5T7N2 |
PhosphoSitePlusi | Q5T7N2 |
Polymorphism and mutation databases
BioMutai | L1TD1 |
DMDMi | 74745406 |
Proteomic databases
EPDi | Q5T7N2 |
jPOSTi | Q5T7N2 |
MassIVEi | Q5T7N2 |
PaxDbi | Q5T7N2 |
PeptideAtlasi | Q5T7N2 |
PRIDEi | Q5T7N2 |
ProteomicsDBi | 64668 |
Protocols and materials databases
Antibodypediai | 33329, 75 antibodies |
Genome annotation databases
Ensembli | ENST00000498273; ENSP00000419901; ENSG00000240563 |
GeneIDi | 54596 |
KEGGi | hsa:54596 |
UCSCi | uc001dae.6, human |
Organism-specific databases
CTDi | 54596 |
DisGeNETi | 54596 |
EuPathDBi | HostDB:ENSG00000240563.1 |
GeneCardsi | L1TD1 |
HGNCi | HGNC:25595, L1TD1 |
HPAi | ENSG00000240563, Tissue enhanced (lymphoid tissue, placenta) |
neXtProti | NX_Q5T7N2 |
OpenTargetsi | ENSG00000240563 |
PharmGKBi | PA145008170 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SRQ0, Eukaryota |
GeneTreei | ENSGT01000000214409 |
HOGENOMi | CLU_336140_0_0_1 |
InParanoidi | Q5T7N2 |
OMAi | FEPKFLC |
OrthoDBi | 455018at2759 |
PhylomeDBi | Q5T7N2 |
TreeFami | TF351152 |
Enzyme and pathway databases
PathwayCommonsi | Q5T7N2 |
Miscellaneous databases
BioGRID-ORCSi | 54596, 5 hits in 820 CRISPR screens |
EvolutionaryTracei | Q5T7N2 |
GeneWikii | L1TD1 |
GenomeRNAii | 54596 |
Pharosi | Q5T7N2, Tbio |
PROi | PR:Q5T7N2 |
RNActi | Q5T7N2, protein |
Gene expression databases
Bgeei | ENSG00000240563, Expressed in amniotic fluid and 96 other tissues |
Genevisiblei | Q5T7N2, HS |
Family and domain databases
Gene3Di | 3.30.250.20, 2 hits 3.30.70.1820, 1 hit |
InterProi | View protein in InterPro IPR042566, L1_C IPR035300, L1_dsRBD IPR043636, L1_RRM_dom IPR004244, Transposase_22 IPR042497, Transposase_L1_sf |
PANTHERi | PTHR11505, PTHR11505, 2 hits |
Pfami | View protein in Pfam PF17490, Tnp_22_dsRBD, 2 hits PF02994, Transposase_22, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LITD1_HUMAN | |
Accessioni | Q5T7N2Primary (citable) accession number: Q5T7N2 Secondary accession number(s): Q8NDA1, Q9NUV8, Q9NV78 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations