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Protein

Protein FAM69A

Gene

FAM69A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM69A
Gene namesi
Name:FAM69A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000154511.11
HGNCiHGNC:32213 FAM69A
MIMi614542 gene
neXtProtiNX_Q5T7M9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27CytoplasmicSequence analysisAdd BLAST27
Transmembranei28 – 48HelicalSequence analysisAdd BLAST21
Topological domaini49 – 428LumenalSequence analysisAdd BLAST380

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi388650
OpenTargetsiENSG00000154511
PharmGKBiPA142671883

Polymorphism and mutation databases

BioMutaiFAM69A
DMDMi74745404

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002824231 – 428Protein FAM69AAdd BLAST428

Post-translational modificationi

Among the many cysteines in the lumenal domain, most are probably involved in disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ5T7M9
MaxQBiQ5T7M9
PaxDbiQ5T7M9
PeptideAtlasiQ5T7M9
PRIDEiQ5T7M9
ProteomicsDBi64665
64666 [Q5T7M9-2]

PTM databases

iPTMnetiQ5T7M9
PhosphoSitePlusiQ5T7M9
SwissPalmiQ5T7M9

Expressioni

Gene expression databases

BgeeiENSG00000154511 Expressed in 214 organ(s), highest expression level in endothelial cell
ExpressionAtlasiQ5T7M9 baseline and differential
GenevisibleiQ5T7M9 HS

Organism-specific databases

HPAiHPA015718
HPA017281

Interactioni

Protein-protein interaction databases

BioGridi132793, 38 interactors
IntActiQ5T7M9, 1 interactor
MINTiQ5T7M9

Structurei

3D structure databases

ProteinModelPortaliQ5T7M9
SMRiQ5T7M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM69 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE6T Eukaryota
ENOG4110ANJ LUCA
GeneTreeiENSGT00390000006452
HOGENOMiHOG000253951
HOVERGENiHBG057071
InParanoidiQ5T7M9
OMAiVIKCQME
OrthoDBiEOG091G09OE
PhylomeDBiQ5T7M9
TreeFamiTF313319

Family and domain databases

InterProiView protein in InterPro
IPR022049 FAM69_kinase_dom
IPR029244 FAM69_N
PfamiView protein in Pfam
PF12260 PIP49_C, 1 hit
PF14875 PIP49_N, 1 hit
SMARTiView protein in SMART
SM01299 PIP49_N, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T7M9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARSLCPGAW LRKPYYLQAR FSYVRMKYLF FSWLVVFVGS WIIYVQYSTY
60 70 80 90 100
TELCRGKDCK KIICDKYKTG VIDGPACNSL CVTETLYFGK CLSTKPNNQM
110 120 130 140 150
YLGIWDNLPG VVKCQMEQAL HLDFGTELEP RKEIVLFDKP TRGTTVQKFK
160 170 180 190 200
EMVYSLFKAK LGDQGNLSEL VNLILTVADG DKDGQVSLGE AKSAWALLQL
210 220 230 240 250
NEFLLMVILQ DKEHTPKLMG FCGDLYVMES VEYTSLYGIS LPWVIELFIP
260 270 280 290 300
SGFRRSMDQL FTPSWPRKAK IAIGLLEFVE DVFHGPYGNF LMCDTSAKNL
310 320 330 340 350
GYNDKYDLKM VDMRKIVPET NLKELIKDRH CESDLDCVYG TDCRTSCDQS
360 370 380 390 400
TMKCTSEVIQ PNLAKACQLL KDYLLRGAPS EIREELEKQL YSCIALKVTA
410 420
NQMEMEHSLI LNNLKTLLWK KISYTNDS
Length:428
Mass (Da):49,024
Last modified:December 21, 2004 - v1
Checksum:i1A348DD44643AA4C
GO
Isoform 2 (identifier: Q5T7M9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-162: KAKLG → KDQHR
     163-428: Missing.

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,978
Checksum:i7CBFB6FD9182C318
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WZK6A0A087WZK6_HUMAN
Protein FAM69A
FAM69A
369Annotation score:
A0A087WZ97A0A087WZ97_HUMAN
Protein FAM69A
FAM69A
403Annotation score:
A0A087X2C2A0A087X2C2_HUMAN
Protein FAM69A
FAM69A
383Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024140158 – 162KAKLG → KDQHR in isoform 2. 1 Publication5
Alternative sequenceiVSP_024141163 – 428Missing in isoform 2. 1 PublicationAdd BLAST266

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093577 Genomic DNA No translation available.
AL162740 Genomic DNA No translation available.
BC070342 mRNA Translation: AAH70342.1
CCDSiCCDS44173.1 [Q5T7M9-1]
CCDS72825.1 [Q5T7M9-2]
RefSeqiNP_001006606.2, NM_001006605.4 [Q5T7M9-1]
NP_001239202.1, NM_001252273.1 [Q5T7M9-2]
UniGeneiHs.180946

Genome annotation databases

EnsembliENST00000370310; ENSP00000359333; ENSG00000154511 [Q5T7M9-1]
ENST00000615519; ENSP00000483279; ENSG00000154511 [Q5T7M9-2]
GeneIDi388650
KEGGihsa:388650
UCSCiuc001dpc.4 human [Q5T7M9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC093577 Genomic DNA No translation available.
AL162740 Genomic DNA No translation available.
BC070342 mRNA Translation: AAH70342.1
CCDSiCCDS44173.1 [Q5T7M9-1]
CCDS72825.1 [Q5T7M9-2]
RefSeqiNP_001006606.2, NM_001006605.4 [Q5T7M9-1]
NP_001239202.1, NM_001252273.1 [Q5T7M9-2]
UniGeneiHs.180946

3D structure databases

ProteinModelPortaliQ5T7M9
SMRiQ5T7M9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi132793, 38 interactors
IntActiQ5T7M9, 1 interactor
MINTiQ5T7M9

PTM databases

iPTMnetiQ5T7M9
PhosphoSitePlusiQ5T7M9
SwissPalmiQ5T7M9

Polymorphism and mutation databases

BioMutaiFAM69A
DMDMi74745404

Proteomic databases

EPDiQ5T7M9
MaxQBiQ5T7M9
PaxDbiQ5T7M9
PeptideAtlasiQ5T7M9
PRIDEiQ5T7M9
ProteomicsDBi64665
64666 [Q5T7M9-2]

Protocols and materials databases

DNASUi388650
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370310; ENSP00000359333; ENSG00000154511 [Q5T7M9-1]
ENST00000615519; ENSP00000483279; ENSG00000154511 [Q5T7M9-2]
GeneIDi388650
KEGGihsa:388650
UCSCiuc001dpc.4 human [Q5T7M9-1]

Organism-specific databases

CTDi388650
DisGeNETi388650
EuPathDBiHostDB:ENSG00000154511.11
GeneCardsiFAM69A
HGNCiHGNC:32213 FAM69A
HPAiHPA015718
HPA017281
MIMi614542 gene
neXtProtiNX_Q5T7M9
OpenTargetsiENSG00000154511
PharmGKBiPA142671883
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE6T Eukaryota
ENOG4110ANJ LUCA
GeneTreeiENSGT00390000006452
HOGENOMiHOG000253951
HOVERGENiHBG057071
InParanoidiQ5T7M9
OMAiVIKCQME
OrthoDBiEOG091G09OE
PhylomeDBiQ5T7M9
TreeFamiTF313319

Miscellaneous databases

ChiTaRSiFAM69A human
GenomeRNAii388650
PROiPR:Q5T7M9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000154511 Expressed in 214 organ(s), highest expression level in endothelial cell
ExpressionAtlasiQ5T7M9 baseline and differential
GenevisibleiQ5T7M9 HS

Family and domain databases

InterProiView protein in InterPro
IPR022049 FAM69_kinase_dom
IPR029244 FAM69_N
PfamiView protein in Pfam
PF12260 PIP49_C, 1 hit
PF14875 PIP49_N, 1 hit
SMARTiView protein in SMART
SM01299 PIP49_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFA69A_HUMAN
AccessioniPrimary (citable) accession number: Q5T7M9
Secondary accession number(s): Q6IRV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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