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Protein

Adipolin

Gene

C1QTNF12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Names & Taxonomyi

Protein namesi
Recommended name:
Adipolin
Alternative name(s):
Adipose-derived insulin-sensitizing factor
C1q and TNF related protein 121 Publication
Complement C1q tumor necrosis factor-related protein 12
Cleaved into the following 2 chains:
Alternative name(s):
Adipolin fCTRP12
Adipolin full-length form
Alternative name(s):
Adipolin cleaved form
Adipolin gCTRP12
Gene namesi
Name:C1QTNF12Imported
Synonyms:C1QDC2, CTRP12, FAM132AImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000184163.3
HGNCiHGNC:32308 C1QTNF12
MIMi616593 gene
neXtProtiNX_Q5T7M4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi388581
OpenTargetsiENSG00000184163
PharmGKBiPA162386101

Polymorphism and mutation databases

BioMutaiFAM132A
DMDMi145558864

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000028435421 – 302Adipolin fC1QTNF12By similarityAdd BLAST282
ChainiPRO_000043024898 – 302Adipolin gC1QTNF12By similarityAdd BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Processed into Adipolin fC1QTNF12 and Adipolin gC1QTNF12 by FURIN. Insulin enhances endogenous C1QTNF12 cleavage.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei97 – 98Cleavage; by FURINBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ5T7M4
PRIDEiQ5T7M4
ProteomicsDBi64664

Expressioni

Tissue specificityi

Predominantly expressed by adipose tissues.1 Publication

Inductioni

By insulin in subcutaneous adipose tissue.1 Publication

Gene expression databases

BgeeiENSG00000184163 Expressed in 111 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_FAM132A
GenevisibleiQ5T7M4 HS

Organism-specific databases

HPAiHPA024107

Interactioni

Subunit structurei

Homomultimer; disulfide-linked. May interact with ERFE (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9606.ENSP00000329137

Structurei

3D structure databases

ProteinModelPortaliQ5T7M4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini147 – 302C1qPROSITE-ProRule annotationAdd BLAST156

Sequence similaritiesi

Belongs to the adipolin/erythroferrone family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IF62 Eukaryota
ENOG4110RD3 LUCA
GeneTreeiENSGT00390000007846
HOGENOMiHOG000112436
HOVERGENiHBG107865
InParanoidiQ5T7M4
KOiK21410
OMAiRCRGRDK
OrthoDBiEOG091G0HNK
PhylomeDBiQ5T7M4
TreeFamiTF331282

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008983 Tumour_necrosis_fac-like_dom
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5T7M4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRWAWAAVV VLLGPQLVLL GGVGARREAQ RTQQPGQRAD PPNATASASS
60 70 80 90 100
REGLPEAPKP SQASGPEFSD AHMTWLNFVR RPDDGALRKR CGSRDKKPRD
110 120 130 140 150
LFGPPGPPGA EVTAETLLHE FQELLKEATE RRFSGLLDPL LPQGAGLRLV
160 170 180 190 200
GEAFHCRLQG PRRVDKRTLV ELHGFQAPAA QGAFLRGSGL SLASGRFTAP
210 220 230 240 250
VSGIFQFSAS LHVDHSELQG KARLRARDVV CVLICIESLC QRHTCLEAVS
260 270 280 290 300
GLESNSRVFT LQVQGLLQLQ AGQYASVFVD NGSGAVLTIQ AGSSFSGLLL

GT
Length:302
Mass (Da):32,416
Last modified:February 20, 2007 - v2
Checksum:i7A3AA620CD94B31A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05406514G → R. Corresponds to variant dbSNP:rs7539412Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162741 Genomic DNA No translation available.
BC089443 mRNA Translation: AAH89443.1
CCDSiCCDS30554.1
RefSeqiNP_001014980.1, NM_001014980.2
UniGeneiHs.197613

Genome annotation databases

EnsembliENST00000330388; ENSP00000329137; ENSG00000184163
GeneIDi388581
KEGGihsa:388581
UCSCiuc001adl.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162741 Genomic DNA No translation available.
BC089443 mRNA Translation: AAH89443.1
CCDSiCCDS30554.1
RefSeqiNP_001014980.1, NM_001014980.2
UniGeneiHs.197613

3D structure databases

ProteinModelPortaliQ5T7M4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000329137

Polymorphism and mutation databases

BioMutaiFAM132A
DMDMi145558864

Proteomic databases

PaxDbiQ5T7M4
PRIDEiQ5T7M4
ProteomicsDBi64664

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330388; ENSP00000329137; ENSG00000184163
GeneIDi388581
KEGGihsa:388581
UCSCiuc001adl.3 human

Organism-specific databases

CTDi388581
DisGeNETi388581
EuPathDBiHostDB:ENSG00000184163.3
GeneCardsiC1QTNF12
HGNCiHGNC:32308 C1QTNF12
HPAiHPA024107
MIMi616593 gene
neXtProtiNX_Q5T7M4
OpenTargetsiENSG00000184163
PharmGKBiPA162386101
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF62 Eukaryota
ENOG4110RD3 LUCA
GeneTreeiENSGT00390000007846
HOGENOMiHOG000112436
HOVERGENiHBG107865
InParanoidiQ5T7M4
KOiK21410
OMAiRCRGRDK
OrthoDBiEOG091G0HNK
PhylomeDBiQ5T7M4
TreeFamiTF331282

Miscellaneous databases

GenomeRNAii388581
PROiPR:Q5T7M4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184163 Expressed in 111 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_FAM132A
GenevisibleiQ5T7M4 HS

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR001073 C1q_dom
IPR008983 Tumour_necrosis_fac-like_dom
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50871 C1Q, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADIPL_HUMAN
AccessioniPrimary (citable) accession number: Q5T7M4
Secondary accession number(s): Q5EBL5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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