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Entry version 128 (12 Aug 2020)
Sequence version 1 (21 Dec 2004)
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Protein

Interferon-induced protein with tetratricopeptide repeats 1B

Gene

IFIT1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5T764

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon-induced protein with tetratricopeptide repeats 1B
Alternative name(s):
Interferon-induced protein with tetratricopeptide repeats 1-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFIT1B
Synonyms:IFIT1L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000204010.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23442, IFIT1B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T764

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000204010

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA165548753

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5T764, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IFIT1B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762241

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002857281 – 474Interferon-induced protein with tetratricopeptide repeats 1BAdd BLAST474

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T764

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5T764

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5T764

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T764

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T764

PeptideAtlas

More...
PeptideAtlasi
Q5T764

PRoteomics IDEntifications database

More...
PRIDEi
Q5T764

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64644

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T764

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T764

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000204010, Expressed in bone marrow and 25 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000204010, Group enriched (bone marrow, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
136196, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T764, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360874

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5T764, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5T764

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati52 – 85TPR 1Add BLAST34
Repeati95 – 128TPR 2Add BLAST34
Repeati139 – 174TPR 3Add BLAST36
Repeati182 – 216TPR 4Add BLAST35
Repeati251 – 284TPR 5Add BLAST34
Repeati340 – 373TPR 6Add BLAST34
Repeati378 – 412TPR 7Add BLAST35
Repeati437 – 470TPR 8Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili61 – 85Sequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IFIT family.Curated

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1124, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182946

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_043482_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T764

KEGG Orthology (KO)

More...
KOi
K14217

Identification of Orthologs from Complete Genome Data

More...
OMAi
ANPSRYR

Database of Orthologous Groups

More...
OrthoDBi
460948at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T764

TreeFam database of animal gene trees

More...
TreeFami
TF342671

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13176, TPR_7, 1 hit
PF13181, TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028, TPR, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005, TPR, 4 hits
PS50293, TPR_REGION, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5T764-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEESDGKLI EDSLIQLRCH FTWKLLIEAP EIPDLENRIW EEIQFLDTKY
60 70 80 90 100
NVGIHNLLAY VKHLKGQNEE ALVSLKKAED LIQKEHANQA DIRSLVTWGN
110 120 130 140 150
FAWVYYHMGR LAEAQTYLDK VENTCKKFAN PSRYRMECPE VDCEEGWALA
160 170 180 190 200
KCGGKNYERA KTCFEKALEG NPENPEFNTG YAITVYRLDK FNTASGRNKA
210 220 230 240 250
FSLHVLKRAV RLNPDDVYIR VLLALKLQDE GQEAEGEKYI EEALTSISSQ
260 270 280 290 300
AYVFQYAAKF YRRKGSVDKA LELLKMALET TPTSAFLHHQ MGLCYRAQMI
310 320 330 340 350
QIKEATNWQP RGQDRETVDR LVQLAICKFE KTIMLKRTFE MAYVDLAETY
360 370 380 390 400
AEIGHHRKAE EHFQKGLRMK IFEDQLKQEI HYHYGRFQEH HGKSQDKAIT
410 420 430 440 450
HYLKGLKIEK MSHSREKLLN ALEKLAKRCI HQNVRVVESV SLLGLIHKLK
460 470
GEVSDALLCY ERALRLAADL NPIF
Length:474
Mass (Da):54,993
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i163BB9DCFFCEF8DE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052617188L → P. Corresponds to variant dbSNP:rs7072728Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL353751 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50139.1
BC137368 mRNA Translation: AAI37369.1
BC137369 mRNA Translation: AAI37370.1
BC150189 mRNA Translation: AAI50190.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31242.1

NCBI Reference Sequences

More...
RefSeqi
NP_001010987.1, NM_001010987.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000371809; ENSP00000360874; ENSG00000204010

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
439996

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:439996

UCSC genome browser

More...
UCSCi
uc001kgh.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353751 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW50139.1
BC137368 mRNA Translation: AAI37369.1
BC137369 mRNA Translation: AAI37370.1
BC150189 mRNA Translation: AAI50190.1
CCDSiCCDS31242.1
RefSeqiNP_001010987.1, NM_001010987.2

3D structure databases

SMRiQ5T764
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi136196, 6 interactors
IntActiQ5T764, 7 interactors
STRINGi9606.ENSP00000360874

PTM databases

iPTMnetiQ5T764
PhosphoSitePlusiQ5T764

Polymorphism and mutation databases

BioMutaiIFIT1B
DMDMi74762241

Proteomic databases

EPDiQ5T764
jPOSTiQ5T764
MassIVEiQ5T764
MaxQBiQ5T764
PaxDbiQ5T764
PeptideAtlasiQ5T764
PRIDEiQ5T764
ProteomicsDBi64644

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48339, 50 antibodies

Genome annotation databases

EnsembliENST00000371809; ENSP00000360874; ENSG00000204010
GeneIDi439996
KEGGihsa:439996
UCSCiuc001kgh.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
439996
EuPathDBiHostDB:ENSG00000204010.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IFIT1B
HGNCiHGNC:23442, IFIT1B
HPAiENSG00000204010, Group enriched (bone marrow, placenta)
neXtProtiNX_Q5T764
OpenTargetsiENSG00000204010
PharmGKBiPA165548753

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1124, Eukaryota
GeneTreeiENSGT00950000182946
HOGENOMiCLU_043482_1_0_1
InParanoidiQ5T764
KOiK14217
OMAiANPSRYR
OrthoDBi460948at2759
PhylomeDBiQ5T764
TreeFamiTF342671

Enzyme and pathway databases

PathwayCommonsiQ5T764

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
439996, 1 hit in 867 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IFIT1B, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
439996
PharosiQ5T764, Tdark

Protein Ontology

More...
PROi
PR:Q5T764
RNActiQ5T764, protein

Gene expression databases

BgeeiENSG00000204010, Expressed in bone marrow and 25 other tissues

Family and domain databases

Gene3Di1.25.40.10, 3 hits
InterProiView protein in InterPro
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PfamiView protein in Pfam
PF13176, TPR_7, 1 hit
PF13181, TPR_8, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 6 hits
SUPFAMiSSF48452, SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 4 hits
PS50293, TPR_REGION, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFT1B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T764
Secondary accession number(s): A7E245
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: December 21, 2004
Last modified: August 12, 2020
This is version 128 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families
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