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UniProtKB - Q5T753 (LCE1E_HUMAN)

Entry version 105 (29 Sep 2021)
Sequence version 1 (21 Dec 2004)
Previous versions | rss
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Protein

Late cornified envelope protein 1E

Gene

LCE1E

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Precursors of the cornified envelope of the stratum corneum.

Miscellaneous

Belongs to the LCE cluster present on 1q21.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processKeratinization

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5T753

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6809371, Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Late cornified envelope protein 1E
Alternative name(s):
Late envelope protein 5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LCE1E
Synonyms:LEP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29466, LCE1E

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612607, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5T753

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000186226

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		353135

Open Targets

More...OpenTargetsi		ENSG00000186226

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134866413

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5T753, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		LCE1E

Domain mapping of disease mutations (DMDM)

More...DMDMi		74745323

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002353281 – 118Late cornified envelope protein 1EAdd BLAST118

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5T753

PeptideAtlas

More...PeptideAtlasi		Q5T753

PRoteomics IDEntifications database

More...PRIDEi		Q5T753

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		64640

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5T753

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5T753

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By UVB.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000186226, Expressed in zone of skin and 71 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5T753, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5T753, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000186226, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q5T753
With#Exp.IntAct
ALPP [P05187]3EBI-11955335,EBI-1211484
CATSPER1 [Q8NEC5]3EBI-11955335,EBI-744545
CYSRT1 [A8MQ03]3EBI-11955335,EBI-3867333
EFEMP2 [O95967]3EBI-11955335,EBI-743414
FAM9A [Q8IZU1]3EBI-11955335,EBI-8468186
FUCA2 [Q9BTY2]3EBI-11955335,EBI-9050116
GRN [P28799]3EBI-11955335,EBI-747754
KRTAP1-1 [Q07627]3EBI-11955335,EBI-11959885
KRTAP1-5 [Q9BYS1]3EBI-11955335,EBI-11741292
KRTAP10-10 [P60014]3EBI-11955335,EBI-11955579
KRTAP10-11 [P60412]3EBI-11955335,EBI-10217483
KRTAP10-5 [P60370]3EBI-11955335,EBI-10172150
KRTAP10-6 [P60371]3EBI-11955335,EBI-12012928
KRTAP10-8 [P60410]3EBI-11955335,EBI-10171774
KRTAP10-9 [P60411]3EBI-11955335,EBI-10172052
KRTAP12-1 [P59990]3EBI-11955335,EBI-10210845
KRTAP12-3 [P60328]3EBI-11955335,EBI-11953334
KRTAP12-4 [P60329]3EBI-11955335,EBI-10176396
KRTAP17-1 [Q9BYP8]3EBI-11955335,EBI-11988175
KRTAP2-4 [Q9BYR9]3EBI-11955335,EBI-14065470
KRTAP4-11 [Q9BYQ6]3EBI-11955335,EBI-10302392
KRTAP4-12 [Q9BQ66]6EBI-11955335,EBI-739863
KRTAP4-2 [Q9BYR5]3EBI-11955335,EBI-10172511
KRTAP4-4 [Q9BYR3]3EBI-11955335,EBI-11958132
KRTAP4-5 [Q9BYR2]3EBI-11955335,EBI-11993254
KRTAP5-11 [Q6L8G4]4EBI-11955335,EBI-11993296
KRTAP5-2 [Q701N4]5EBI-11955335,EBI-11958178
KRTAP5-4 [Q6L8H1]3EBI-11955335,EBI-11963072
KRTAP5-6 [Q6L8G9]3EBI-11955335,EBI-10250562
KRTAP5-7 [Q6L8G8]3EBI-11955335,EBI-11987425
KRTAP5-9 [P26371]6EBI-11955335,EBI-3958099
KRTAP9-2 [Q9BYQ4]5EBI-11955335,EBI-1044640
KRTAP9-3 [Q9BYQ3]3EBI-11955335,EBI-1043191
KRTAP9-8 [Q9BYQ0]3EBI-11955335,EBI-11958364
LCE1A [Q5T7P2]3EBI-11955335,EBI-11962058
LCE1B [Q5T7P3]3EBI-11955335,EBI-10245913
LCE1D [Q5T752]3EBI-11955335,EBI-11741311
itself3EBI-11955335,EBI-11955335
LCE1F [Q5T754]6EBI-11955335,EBI-11958008
LCE2B [O14633]3EBI-11955335,EBI-11478468
LCE2C [Q5TA81]3EBI-11955335,EBI-11973993
LCE3B [Q5TA77]3EBI-11955335,EBI-11974495
LCE4A [Q5TA78]6EBI-11955335,EBI-10246358
LCE5A [Q5TCM9]3EBI-11955335,EBI-11955689
MACO1 [Q8N5G2]3EBI-11955335,EBI-2683507
MEOX2 [Q6FHY5]3EBI-11955335,EBI-16439278
NOTCH2NLC [P0DPK4]3EBI-11955335,EBI-22310682
NTAQ1 [Q96HA8]3EBI-11955335,EBI-741158
PIAS2 - isoform PIAS2-alpha [O75928-2]3EBI-11955335,EBI-348567
RGS17 [Q9UGC6]3EBI-11955335,EBI-3918154
RNF4 [P78317]3EBI-11955335,EBI-2340927
SMCP [P49901]3EBI-11955335,EBI-750494
TGM1 [P22735]3EBI-11955335,EBI-2562368
TRIM42 [Q8IWZ5]3EBI-11955335,EBI-5235829
ZCCHC7 [Q8N3Z6]3EBI-11955335,EBI-7265024

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131642, 60 interactors

Protein interaction database and analysis system

More...IntActi		Q5T753, 54 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357759

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5T753, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23
Regioni84 – 118DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi92 – 110Polar residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LCE family.Curated

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183301

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_152038_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		GCCERSG

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028205, LCE

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14672, LCE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5T753-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCQQSQQQC QPPPKCTPKC PPKCPTPKCP PKCPPKCPPV SSCCSVSSGG 
        60         70         80         90        100
CCGSSSGGSC GSSSGGCCSS GGGGCCLSHH RHHRSHRHRP QSSDCCSQPS 
       110 
GGSSCCGGGS GQHSGGCC
Length:118
Mass (Da):11,616
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA897B2577ADD89A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWQ4A0A087WWQ4_HUMAN
Late cornified envelope protein 1E
LCE1E
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06006659S → G. Corresponds to variant dbSNP:rs11205106Ensembl.1
Natural variantiVAR_062117111G → S. Corresponds to variant dbSNP:rs56313719Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL353779 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53366.1
CH471121 Genomic DNA Translation: EAW53367.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1024.1

NCBI Reference Sequences

More...RefSeqi		NP_848130.1, NM_178353.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368770; ENSP00000357759; ENSG00000186226
ENST00000368771; ENSP00000357760; ENSG00000186226

Database of genes from NCBI RefSeq genomes

More...GeneIDi		353135

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:353135

UCSC genome browser

More...UCSCi		uc001fan.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353779 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53366.1
CH471121 Genomic DNA Translation: EAW53367.1
CCDSiCCDS1024.1
RefSeqiNP_848130.1, NM_178353.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi131642, 60 interactors
IntActiQ5T753, 54 interactors
STRINGi9606.ENSP00000357759

PTM databases

iPTMnetiQ5T753
PhosphoSitePlusiQ5T753

Genetic variation databases

BioMutaiLCE1E
DMDMi74745323

Proteomic databases

PaxDbiQ5T753
PeptideAtlasiQ5T753
PRIDEiQ5T753
ProteomicsDBi64640

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		353135

Genome annotation databases

EnsembliENST00000368770; ENSP00000357759; ENSG00000186226
ENST00000368771; ENSP00000357760; ENSG00000186226
GeneIDi353135
KEGGihsa:353135
UCSCiuc001fan.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		353135
DisGeNETi353135

GeneCards: human genes, protein and diseases

More...GeneCardsi		LCE1E
HGNCiHGNC:29466, LCE1E
HPAiENSG00000186226, Tissue enriched (skin)
MIMi612607, gene
neXtProtiNX_Q5T753
OpenTargetsiENSG00000186226
PharmGKBiPA134866413
VEuPathDBiHostDB:ENSG00000186226

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00950000183301
HOGENOMiCLU_152038_0_0_1
OMAiGCCERSG

Enzyme and pathway databases

PathwayCommonsiQ5T753
ReactomeiR-HSA-6809371, Formation of the cornified envelope

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		353135, 324 hits in 927 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		353135
PharosiQ5T753, Tdark

Protein Ontology

More...PROi		PR:Q5T753
RNActiQ5T753, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000186226, Expressed in zone of skin and 71 other tissues
ExpressionAtlasiQ5T753, baseline and differential
GenevisibleiQ5T753, HS

Family and domain databases

InterProiView protein in InterPro
IPR028205, LCE
PfamiView protein in Pfam
PF14672, LCE, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLCE1E_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T753
Secondary accession number(s): D3DV30
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: September 29, 2021
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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