Late cornified envelope protein 1D

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• identical protein binding Source: IntAct <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "A reference map of the human binary protein interactome."
    Luck K., Kim D.K., Lambourne L., Spirohn K., Begg B.E., Bian W., Brignall R., Cafarelli T., Campos-Laborie F.J., Charloteaux B., Choi D., Cote A.G., Daley M., Deimling S., Desbuleux A., Dricot A., Gebbia M., Hardy M.F.

    , Kishore N., Knapp J.J., Kovacs I.A., Lemmens I., Mee M.W., Mellor J.C., Pollis C., Pons C., Richardson A.D., Schlabach S., Teeking B., Yadav A., Babor M., Balcha D., Basha O., Bowman-Colin C., Chin S.F., Choi S.G., Colabella C., Coppin G., D'Amata C., De Ridder D., De Rouck S., Duran-Frigola M., Ennajdaoui H., Goebels F., Goehring L., Gopal A., Haddad G., Hatchi E., Helmy M., Jacob Y., Kassa Y., Landini S., Li R., van Lieshout N., MacWilliams A., Markey D., Paulson J.N., Rangarajan S., Rasla J., Rayhan A., Rolland T., San-Miguel A., Shen Y., Sheykhkarimli D., Sheynkman G.M., Simonovsky E., Tasan M., Tejeda A., Tropepe V., Twizere J.C., Wang Y., Weatheritt R.J., Weile J., Xia Y., Yang X., Yeger-Lotem E., Zhong Q., Aloy P., Bader G.D., De Las Rivas J., Gaudet S., Hao T., Rak J., Tavernier J., Hill D.E., Vidal M., Roth F.P., Calderwood M.A.
    Nature 580:402-408(2020) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to calcium ion Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Differentially expressed late constituents of the epidermal cornified envelope."
    Marshall D., Hardman M.J., Nield K.M., Byrne C.
    Proc Natl Acad Sci U S A 98:13031-13036(2001) [PubMed] [Europe PMC] [Abstract]
• cognition Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals."
    Swaminathan S., Huentelman M.J., Corneveaux J.J., Myers A.J., Faber K.M., Foroud T., Mayeux R., Shen L., Kim S., Turk M., Hardy J., Reiman E.M., Saykin A.J., Weiner M., Aisen P., Weiner M., Aisen P., Petersen R.

    , Jack C.R. Jr., Jagust W., Trojanowki J.Q., Toga A.W., Beckett L., Green R.C., Saykin A.J., Morris J., Liu E., Green R.C., Montine T., Petersen R., Aisen P., Gamst A., Thomas R.G., Donohue M., Walter S., Gessert D., Sather T., Beckett L., Harvey D., Gamst A., Donohue M., Kornak J., Jack C.R. Jr., Dale A., Bernstein M., Felmlee J., Fox N., Thompson P., Schuff N., Alexander G., DeCarli C., Jagust W., Bandy D., Koeppe R.A., Foster N., Reiman E.M., Chen K., Mathis C., Morris J., Cairns N.J., Taylor-Reinwald L., Trojanowki J.Q., Shaw L., Lee V.M., Korecka M., Toga A.W., Crawford K., Neu S., Saykin A.J., Foroud T.M., Potkin S., Shen L., Kachaturian Z., Frank R., Snyder P.J., Molchan S., Kaye J., Quinn J., Lind B., Dolen S., Schneider L.S., Pawluczyk S., Spann B.M., Brewer J., Vanderswag H., Heidebrink J.L., Lord J.L., Petersen R., Johnson K., Doody R.S., Villanueva-Meyer J., Chowdhury M., Stern Y., Honig L.S., Bell K.L., Morris J.C., Ances B., Carroll M., Leon S., Mintun M.A., Schneider S., Marson D., Griffith R., Clark D., Grossman H., Mitsis E., Romirowsky A., deToledo-Morrell L., Shah R.C., Duara R., Varon D., Roberts P., Albert M., Onyike C., Kielb S., Rusinek H., de Leon M.J., Glodzik L., De Santi S., Doraiswamy P., Petrella J.R., Coleman R., Arnold S.E., Karlawish J.H., Wolk D., Smith C.D., Jicha G., Hardy P., Lopez O.L., Oakley M., Simpson D.M., Porsteinsson A.P., Goldstein B.S., Martin K., Makino K.M., Ismail M., Brand C., Mulnard R.A., Thai G., Mc-Adams-Ortiz C., Womack K., Mathews D., Quiceno M., Diaz-Arrastia R., King R., Weiner M., Martin-Cook K., DeVous M., Levey A.I., Lah J.J., Cellar J.S., Burns J.M., Anderson H.S., Swerdlow R.H., Apostolova L., Lu P.H., Bartzokis G., Silverman D.H., Graff-Radford N.R., Parfitt F., Johnson H., Farlow M.R., Hake A.M., Matthews B.R., Herring S., van Dyck C.H., Carson R.E., MacAvoy M.G., Chertkow H., Bergman H., Hosein C., Black S., Stefanovic B., Caldwell C., Hsiung G.Y., Feldman H., Mudge B., Assaly M., Kertesz A., Rogers J., Trost D., Bernick C., Munic D., Kerwin D., Mesulam M.M., Lipowski K., Wu C.K., Johnson N., Sadowsky C., Martinez W., Villena T., Turner R.S., Johnson K., Reynolds B., Sperling R.A., Johnson K.A., Marshall G., Frey M., Yesavage J., Taylor J.L., Lane B., Rosen A., Tinklenberg J., Sabbagh M., Belden C., Jacobson S., Kowall N., Killiany R., Budson A.E., Norbash A., Johnson P.L., Obisesan T.O., Wolday S., Bwayo S.K., Lerner A., Hudson L., Ogrocki P., Fletcher E., Carmichael O., Olichney J., DeCarli C., Kittur S., Borrie M., Lee T.Y., Bartha R., Johnson S., Asthana S., Carlsson C.M., Potkin S.G., Preda A., Nguyen D., Tariot P., Fleisher A., Reeder S., Bates V., Capote H., Rainka M., Scharre D.W., Kataki M., Zimmerman E.A., Celmins D., Brown A.D., Pearlson G.D., Blank K., Anderson K., Saykin A.J., Santulli R.B., Schwartz E.S., Sink K.M., Williamson J.D., Garg P., Watkins F., Ott B.R., Querfurth H., Tremont G., Salloway S., Malloy P., Correia S., Rosen H.J., Miller B.L., Mintzer J., Spicer K., Rachinsky I., Rogers J., Kertesz A., Drost D., Mayeux R., Foroud T., Lee J.H., Wijsman E.M., Green R., Kowall N., Farrer L., Schmechel D.E., Blacker D., Growdon J., Hyman B.T., Tanzi R.E., Boeve B., Graff-Radford N., Pericak-Vance M., Silverman J.M., Beeri M.S., Sano M., Johnson N., Mesulam M., Weintraub S., Bigio E., Kaye J., Kramer P., Bennett D.A., Harrell L.E., Bartzokis G., Geffen D., Markesbery W., Smith C., Trojanowski J.Q., Van Deerlin V., DeKosky S.T., Sweet R., Chui I., Varpetian A., Diaz-Arrastia R., Rosenberg R., Bird T., Raskind M., Schellenberg G.D., Goate A., Morris J., Morrison-Bogorad M., Miller M.
    PLoS One 7:e50640-e50640(2012) [PubMed] [Europe PMC] [Abstract]
• keratinization Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "A reference map of the human binary protein interactome."
    Luck K., Kim D.K., Lambourne L., Spirohn K., Begg B.E., Bian W., Brignall R., Cafarelli T., Campos-Laborie F.J., Charloteaux B., Choi D., Cote A.G., Daley M., Deimling S., Desbuleux A., Dricot A., Gebbia M., Hardy M.F.

    , Kishore N., Knapp J.J., Kovacs I.A., Lemmens I., Mee M.W., Mellor J.C., Pollis C., Pons C., Richardson A.D., Schlabach S., Teeking B., Yadav A., Babor M., Balcha D., Basha O., Bowman-Colin C., Chin S.F., Choi S.G., Colabella C., Coppin G., D'Amata C., De Ridder D., De Rouck S., Duran-Frigola M., Ennajdaoui H., Goebels F., Goehring L., Gopal A., Haddad G., Hatchi E., Helmy M., Jacob Y., Kassa Y., Landini S., Li R., van Lieshout N., MacWilliams A., Markey D., Paulson J.N., Rangarajan S., Rasla J., Rayhan A., Rolland T., San-Miguel A., Shen Y., Sheykhkarimli D., Sheynkman G.M., Simonovsky E., Tasan M., Tejeda A., Tropepe V., Twizere J.C., Wang Y., Weatheritt R.J., Weile J., Xia Y., Yang X., Yeger-Lotem E., Zhong Q., Aloy P., Bader G.D., De Las Rivas J., Gaudet S., Hao T., Rak J., Tavernier J., Hill D.E., Vidal M., Roth F.P., Calderwood M.A.
    Nature 580:402-408(2020) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSCQQSQQQC QPPPKCTPKC TPKCPAPKCP PKCPPVSSCC SVSSGGCCGS 
        60         70         80         90        100
SSGGGCGSNS GGCCSSGGGG CCLSHHRRHR SHRRRPQSSD CCSQPSGGSS 
       110 
CCGGGSSQHS GGCC                                        

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. SIMILARITY comments
   Index of protein domains and families