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UniProtKB - Q5T750 (XP32_HUMAN)

Entry version 102 (11 Dec 2019)
Sequence version 1 (21 Dec 2004)
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Protein

Skin-specific protein 32

Gene

XP32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • epidermis development Source: UniProtKB
Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Skin-specific protein 32
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XP32
Synonyms:C1orf68
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000198854.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:29468 C1orf68

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5T750

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		100129271

Open Targets

More...OpenTargetsi		ENSG00000198854

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672518

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5T750 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C1orf68

Domain mapping of disease mutations (DMDM)

More...DMDMi		74745320

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003078081 – 250Skin-specific protein 32Add BLAST250

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5T750

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5T750

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5T750

PeptideAtlas

More...PeptideAtlasi		Q5T750

PRoteomics IDEntifications database

More...PRIDEi		Q5T750

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		64637

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5T750

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5T750

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed at high levels in normal and psoriatic skin, but not in normal keratinocytes, A-431 cells, or any of the other cell lines or tissues tested.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198854 Expressed in 67 organ(s), highest expression level in skin of leg

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5T750 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		139295, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q5T750, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357764

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5T750 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 250Cys-richAdd BLAST218

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4726 Eukaryota
ENOG410XY8D LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111580

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000154874

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5T750

Identification of Orthologs from Complete Genome Data

More...OMAi		APCSTSY

Database of Orthologous Groups

More...OrthoDBi		1169402at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5T750

TreeFam database of animal gene trees

More...TreeFami		TF351578

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026078 Skin_specific_32
IPR026075 SPRR/LCE

The PANTHER Classification System

More...PANTHERi		PTHR23263 PTHR23263, 1 hit
PTHR23263:SF4 PTHR23263:SF4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5T750-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCDQQKQPQF PPSCVKGSGL GAGQGSNGAS VKCPVPCQTQ TVCVTGPAPC 
        60         70         80         90        100
PTQTYVKYQV PCQTQTYVKC PAPCQRTYVK YPTPCQTYVK CPAPCQTTYV 
       110        120        130        140        150
KCPTPCQTYV KCPAPCQMTY IKSPAPCQTQ TCYVQGASPC QSYYVQAPAS 
       160        170        180        190        200
GSTSQYCVTD PCSAPCSTSY CCLAPRTFGV SPLRRWIQRP QNCNTGSSGC 
       210        220        230        240        250
CENSGSSGCC GSGGCGCSCG CGSSGCCCLG IIPMRSRGPA CCDHEDDCCC
Length:250
Mass (Da):26,238
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i098B586CCE67D6E3
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB83961 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti235R → K in AAB83961 (PubMed:9344646).Curated1
Sequence conflicti238G → S in AAB83961 (PubMed:9344646).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05973926S → T. Corresponds to variant dbSNP:rs1332500Ensembl.1
Natural variantiVAR_059740159T → P. Corresponds to variant dbSNP:rs873775Ensembl.1
Natural variantiVAR_061726173L → V. Corresponds to variant dbSNP:rs59194678Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL353779 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53369.1
AF005081 mRNA Translation: AAB83961.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44226.1

NCBI Reference Sequences

More...RefSeqi		NP_001019850.1, NM_001024679.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000368775; ENSP00000357764; ENSG00000198854

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100129271

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:100129271

UCSC genome browser

More...UCSCi		uc010pdu.3 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353779 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53369.1
AF005081 mRNA Translation: AAB83961.1 Frameshift.
CCDSiCCDS44226.1
RefSeqiNP_001019850.1, NM_001024679.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi139295, 8 interactors
IntActiQ5T750, 6 interactors
STRINGi9606.ENSP00000357764

PTM databases

iPTMnetiQ5T750
PhosphoSitePlusiQ5T750

Polymorphism and mutation databases

BioMutaiC1orf68
DMDMi74745320

Proteomic databases

jPOSTiQ5T750
MassIVEiQ5T750
PaxDbiQ5T750
PeptideAtlasiQ5T750
PRIDEiQ5T750
ProteomicsDBi64637

Genome annotation databases

EnsembliENST00000368775; ENSP00000357764; ENSG00000198854
GeneIDi100129271
KEGGihsa:100129271
UCSCiuc010pdu.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		100129271
DisGeNETi100129271
EuPathDBiHostDB:ENSG00000198854.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		C1orf68
HGNCiHGNC:29468 C1orf68
neXtProtiNX_Q5T750
OpenTargetsiENSG00000198854
PharmGKBiPA142672518

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4726 Eukaryota
ENOG410XY8D LUCA
GeneTreeiENSGT00730000111580
HOGENOMiHOG000154874
InParanoidiQ5T750
OMAiAPCSTSY
OrthoDBi1169402at2759
PhylomeDBiQ5T750
TreeFamiTF351578

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		100129271
PharosiQ5T750 Tdark

Protein Ontology

More...PROi		PR:Q5T750
RNActiQ5T750 protein

Gene expression databases

BgeeiENSG00000198854 Expressed in 67 organ(s), highest expression level in skin of leg
GenevisibleiQ5T750 HS

Family and domain databases

InterProiView protein in InterPro
IPR026078 Skin_specific_32
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 1 hit
PTHR23263:SF4 PTHR23263:SF4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXP32_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T750
Secondary accession number(s): O14634
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 21, 2004
Last modified: December 11, 2019
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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