UniProtKB - Q5T750 (XP32_HUMAN)
Protein
Skin-specific protein 32
Gene
XP32
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- epidermis development Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q5T750 |
Names & Taxonomyi
Protein namesi | Recommended name: Skin-specific protein 32 |
Gene namesi | Name:XP32 Synonyms:C1orf68 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000198854.5 |
HGNCi | HGNC:29468, C1orf68 |
neXtProti | NX_Q5T750 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 100129271 |
OpenTargetsi | ENSG00000198854 |
PharmGKBi | PA142672518 |
Miscellaneous databases
Pharosi | Q5T750, Tdark |
Polymorphism and mutation databases
BioMutai | C1orf68 |
DMDMi | 74745320 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000307808 | 1 – 250 | Skin-specific protein 32Add BLAST | 250 |
Proteomic databases
MassIVEi | Q5T750 |
PaxDbi | Q5T750 |
PeptideAtlasi | Q5T750 |
PRIDEi | Q5T750 |
ProteomicsDBi | 64637 |
PTM databases
iPTMneti | Q5T750 |
PhosphoSitePlusi | Q5T750 |
Expressioni
Tissue specificityi
Expressed at high levels in normal and psoriatic skin, but not in normal keratinocytes, A-431 cells, or any of the other cell lines or tissues tested.1 Publication
Gene expression databases
Bgeei | ENSG00000198854, Expressed in skin of leg and 81 other tissues |
Genevisiblei | Q5T750, HS |
Organism-specific databases
HPAi | ENSG00000198854, Tissue enriched (skin) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 139295, 11 interactors |
IntActi | Q5T750, 6 interactors |
STRINGi | 9606.ENSP00000357764 |
Miscellaneous databases
RNActi | Q5T750, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 33 – 250 | Cys-richAdd BLAST | 218 |
Phylogenomic databases
eggNOGi | KOG4726, Eukaryota |
GeneTreei | ENSGT00730000111580 |
HOGENOMi | CLU_085400_0_0_1 |
InParanoidi | Q5T750 |
OMAi | PCSTSYC |
OrthoDBi | 1169402at2759 |
PhylomeDBi | Q5T750 |
TreeFami | TF351578 |
Family and domain databases
InterProi | View protein in InterPro IPR026078, Skin_specific_32 IPR026075, SPRR/LCE |
PANTHERi | PTHR23263, PTHR23263, 1 hit PTHR23263:SF4, PTHR23263:SF4, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5T750-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCDQQKQPQF PPSCVKGSGL GAGQGSNGAS VKCPVPCQTQ TVCVTGPAPC
60 70 80 90 100
PTQTYVKYQV PCQTQTYVKC PAPCQRTYVK YPTPCQTYVK CPAPCQTTYV
110 120 130 140 150
KCPTPCQTYV KCPAPCQMTY IKSPAPCQTQ TCYVQGASPC QSYYVQAPAS
160 170 180 190 200
GSTSQYCVTD PCSAPCSTSY CCLAPRTFGV SPLRRWIQRP QNCNTGSSGC
210 220 230 240 250
CENSGSSGCC GSGGCGCSCG CGSSGCCCLG IIPMRSRGPA CCDHEDDCCC
Sequence cautioni
The sequence AAB83961 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 235 | R → K in AAB83961 (PubMed:9344646).Curated | 1 | |
Sequence conflicti | 238 | G → S in AAB83961 (PubMed:9344646).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059739 | 26 | S → T. Corresponds to variant dbSNP:rs1332500Ensembl. | 1 | |
Natural variantiVAR_059740 | 159 | T → P. Corresponds to variant dbSNP:rs873775Ensembl. | 1 | |
Natural variantiVAR_061726 | 173 | L → V. Corresponds to variant dbSNP:rs59194678Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL353779 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53369.1 AF005081 mRNA Translation: AAB83961.1 Frameshift. |
CCDSi | CCDS44226.1 |
RefSeqi | NP_001019850.1, NM_001024679.2 |
Genome annotation databases
Ensembli | ENST00000368775; ENSP00000357764; ENSG00000198854 |
GeneIDi | 100129271 |
KEGGi | hsa:100129271 |
UCSCi | uc010pdu.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL353779 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW53369.1 AF005081 mRNA Translation: AAB83961.1 Frameshift. |
CCDSi | CCDS44226.1 |
RefSeqi | NP_001019850.1, NM_001024679.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 139295, 11 interactors |
IntActi | Q5T750, 6 interactors |
STRINGi | 9606.ENSP00000357764 |
PTM databases
iPTMneti | Q5T750 |
PhosphoSitePlusi | Q5T750 |
Polymorphism and mutation databases
BioMutai | C1orf68 |
DMDMi | 74745320 |
Proteomic databases
MassIVEi | Q5T750 |
PaxDbi | Q5T750 |
PeptideAtlasi | Q5T750 |
PRIDEi | Q5T750 |
ProteomicsDBi | 64637 |
Protocols and materials databases
Antibodypediai | 50316, 9 antibodies |
Genome annotation databases
Ensembli | ENST00000368775; ENSP00000357764; ENSG00000198854 |
GeneIDi | 100129271 |
KEGGi | hsa:100129271 |
UCSCi | uc010pdu.3, human |
Organism-specific databases
CTDi | 100129271 |
DisGeNETi | 100129271 |
EuPathDBi | HostDB:ENSG00000198854.5 |
GeneCardsi | C1orf68 |
HGNCi | HGNC:29468, C1orf68 |
HPAi | ENSG00000198854, Tissue enriched (skin) |
neXtProti | NX_Q5T750 |
OpenTargetsi | ENSG00000198854 |
PharmGKBi | PA142672518 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4726, Eukaryota |
GeneTreei | ENSGT00730000111580 |
HOGENOMi | CLU_085400_0_0_1 |
InParanoidi | Q5T750 |
OMAi | PCSTSYC |
OrthoDBi | 1169402at2759 |
PhylomeDBi | Q5T750 |
TreeFami | TF351578 |
Enzyme and pathway databases
PathwayCommonsi | Q5T750 |
Miscellaneous databases
BioGRID-ORCSi | 100129271, 3 hits in 830 CRISPR screens |
GenomeRNAii | 100129271 |
Pharosi | Q5T750, Tdark |
PROi | PR:Q5T750 |
RNActi | Q5T750, protein |
Gene expression databases
Bgeei | ENSG00000198854, Expressed in skin of leg and 81 other tissues |
Genevisiblei | Q5T750, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026078, Skin_specific_32 IPR026075, SPRR/LCE |
PANTHERi | PTHR23263, PTHR23263, 1 hit PTHR23263:SF4, PTHR23263:SF4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | XP32_HUMAN | |
Accessioni | Q5T750Primary (citable) accession number: Q5T750 Secondary accession number(s): O14634 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 107 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations