Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 124 (12 Aug 2020)
Sequence version 1 (21 Dec 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Keratinocyte proline-rich protein

Gene

KPRP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5T749

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratinocyte proline-rich protein
Short name:
hKPRP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KPRP
Synonyms:C1orf45
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000203786.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:31823, KPRP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
613260, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T749

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
448834

Open Targets

More...
OpenTargetsi
ENSG00000203786

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162393640

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5T749, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KPRP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74745319

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002710081 – 579Keratinocyte proline-rich proteinAdd BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei394PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T749

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5T749

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5T749

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T749

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T749

PeptideAtlas

More...
PeptideAtlasi
Q5T749

PRoteomics IDEntifications database

More...
PRIDEi
Q5T749

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64636

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T749

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T749

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the upper layer of epidermis and psoriasis (at protein level). Expressed in the upper layer of epidermis and psoriasis.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the periderm of fetal skin from 16th week gestational age and in the granular and horny layers of the epidermis at 24th week gestational age and thereafter (at protein level).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By calcium and in psoriatic lesions.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000203786, Expressed in skin of leg and 53 other tissues

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000203786, Tissue enriched (skin)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q5T749
With#Exp.IntAct
AKAP8L [Q9ULX6]3EBI-10981970,EBI-357530
ANKS1A [Q49AR9]3EBI-10981970,EBI-11954519
ATG9A - isoform 3 [Q7Z3C6-3]5EBI-10981970,EBI-12006308
BTC [P35070]3EBI-10981970,EBI-6590057
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-10981970,EBI-11976299
CATSPER1 [Q8NEC5]5EBI-10981970,EBI-744545
CCDC57 - isoform 2 [Q2TAC2-2]3EBI-10981970,EBI-10961624
CES1 - isoform 3 [P23141-3]3EBI-10981970,EBI-12360993
CKS1B [P61024]3EBI-10981970,EBI-456371
CLCNKA - isoform 3 [P51800-3]3EBI-10981970,EBI-11980535
CNFN [Q9BYD5]3EBI-10981970,EBI-12819063
CNNM3 [Q8NE01]3EBI-10981970,EBI-741032
COL8A1 [P27658]3EBI-10981970,EBI-747133
CREB5 - isoform 3 [Q02930-3]5EBI-10981970,EBI-10192698
CYSRT1 [A8MQ03]7EBI-10981970,EBI-3867333
DMRT3 [Q9NQL9]5EBI-10981970,EBI-9679045
DYRK1A [Q13627]3EBI-10981970,EBI-1053596
EIF3E [P60228]3EBI-10981970,EBI-347740
ESR2 - isoform 3 [Q92731-3]3EBI-10981970,EBI-12259414
FAM221B [A6H8Z2]3EBI-10981970,EBI-12006844
FAM72B - isoform 2 [Q86X60-2]3EBI-10981970,EBI-12886238
FBXO17 [Q96EF6]3EBI-10981970,EBI-2510157
FCHO1 [A0A0C3SFZ9]3EBI-10981970,EBI-11977403
FHL2 [Q14192]3EBI-10981970,EBI-701903
FHL3 [Q13643]4EBI-10981970,EBI-741101
FRS3 [O43559]5EBI-10981970,EBI-725515
GLRX3 [O76003]3EBI-10981970,EBI-374781
GNE - isoform 2 [Q9Y223-2]3EBI-10981970,EBI-11975289
GRAP2 [O75791]3EBI-10981970,EBI-740418
GUCD1 - isoform 2 [Q96NT3-2]3EBI-10981970,EBI-11978177
HCK - isoform 2 [P08631-2]3EBI-10981970,EBI-9834454
HEXIM2 [Q96MH2]3EBI-10981970,EBI-5460660
HNRNPF [P52597]3EBI-10981970,EBI-352986
HOXA1 [P49639]8EBI-10981970,EBI-740785
HOXC8 [P31273]3EBI-10981970,EBI-1752118
HSD3B7 [Q9H2F3]3EBI-10981970,EBI-3918847
ITGB4 - isoform Beta-4A [P16144-2]3EBI-10981970,EBI-11051601
ITIH6 [Q6UXX5]3EBI-10981970,EBI-11028396
KRTAP1-5 [Q9BYS1]3EBI-10981970,EBI-11741292
KRTAP10-8 [P60410]3EBI-10981970,EBI-10171774
KRTAP12-3 [P60328]6EBI-10981970,EBI-11953334
KRTAP13-2 [Q52LG2]3EBI-10981970,EBI-11953846
KRTAP13-3 [Q3SY46]3EBI-10981970,EBI-10241252
KRTAP15-1 [Q3LI76]3EBI-10981970,EBI-11992140
KRTAP19-1 [Q8IUB9]3EBI-10981970,EBI-12811111
KRTAP19-2 [Q3LHN2]3EBI-10981970,EBI-12196745
KRTAP19-5 [Q3LI72]3EBI-10981970,EBI-1048945
KRTAP19-6 [Q3LI70]3EBI-10981970,EBI-12805508
KRTAP19-7 [Q3SYF9]3EBI-10981970,EBI-10241353
KRTAP3-2 [Q9BYR7]3EBI-10981970,EBI-751260
KRTAP4-2 [Q9BYR5]3EBI-10981970,EBI-10172511
KRTAP4-5 [Q9BYR2]5EBI-10981970,EBI-11993254
KRTAP5-3 [Q6L8H2]3EBI-10981970,EBI-11974251
KRTAP5-7 [Q6L8G8]3EBI-10981970,EBI-11987425
KRTAP5-9 [P26371]3EBI-10981970,EBI-3958099
KRTAP6-1 [Q3LI64]3EBI-10981970,EBI-12111050
KRTAP6-2 [Q3LI66]3EBI-10981970,EBI-11962084
LCE3C [Q5T5A8]5EBI-10981970,EBI-10245291
LCE3D [Q9BYE3]3EBI-10981970,EBI-6658837
LCE3E [Q5T5B0]3EBI-10981970,EBI-10245456
LIMS1 - isoform 3 [P48059-3]3EBI-10981970,EBI-12864460
LMO2 - isoform 3 [P25791-3]3EBI-10981970,EBI-11959475
LNX1 [Q8TBB1]3EBI-10981970,EBI-739832
MAPKBP1 [O60336]5EBI-10981970,EBI-947402
MEOX2 [Q6FHY5]3EBI-10981970,EBI-16439278
MIIP [Q5JXC2]3EBI-10981970,EBI-2801965
MLH1 [P40692]3EBI-10981970,EBI-744248
NCK2 [O43639]3EBI-10981970,EBI-713635
NID2 [Q8IV28]3EBI-10981970,EBI-10261509
NOTCH2NLC [P0DPK4]3EBI-10981970,EBI-22310682
NPBWR2 [P48146]3EBI-10981970,EBI-10210114
NR4A3 [Q92570]3EBI-10981970,EBI-13644623
NTN4 [Q9HB63]3EBI-10981970,EBI-743459
NUFIP2 [Q7Z417]5EBI-10981970,EBI-1210753
OTX1 [P32242]6EBI-10981970,EBI-740446
PDGFRB [P09619]3EBI-10981970,EBI-641237
PHLDA1 [A2BDE7]3EBI-10981970,EBI-14084211
PLA2G10 [O15496]3EBI-10981970,EBI-726466
PLSCR4 [Q9NRQ2]3EBI-10981970,EBI-769257
POU4F2 [Q12837]5EBI-10981970,EBI-17236143
PPIL1 [Q9Y3C6]3EBI-10981970,EBI-2557649
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-10981970,EBI-12000762
RBP3 [P10745]3EBI-10981970,EBI-12806054
RGL2 [O15211]3EBI-10981970,EBI-712355
RNF38 [Q9H0F5]3EBI-10981970,EBI-2341200
SEMA3B - isoform 2 [Q13214-2]3EBI-10981970,EBI-11017428
SH3KBP1 [Q96B97]5EBI-10981970,EBI-346595
SLC15A2 [Q16348]3EBI-10981970,EBI-12806032
SPRED2 [Q7Z698]3EBI-10981970,EBI-7082156
SPRY1 [O43609]3EBI-10981970,EBI-3866665
SPRY3 [O43610]3EBI-10981970,EBI-12290641
STK16 [O75716]3EBI-10981970,EBI-749295
TEKT4 [Q8WW24]3EBI-10981970,EBI-750487
TFAP2D [Q7Z6R9]3EBI-10981970,EBI-11952651
TNS2 [Q63HR2]5EBI-10981970,EBI-949753
TRIM42 [Q8IWZ5]3EBI-10981970,EBI-5235829
TRIP6 [Q15654]3EBI-10981970,EBI-742327
UBASH3A - isoform 2 [P57075-2]5EBI-10981970,EBI-7353612
UBASH3B [Q8TF42]5EBI-10981970,EBI-1380492
VGLL3 - isoform 2 [A8MV65-2]3EBI-10981970,EBI-11957216
VWC2 [Q2TAL6]3EBI-10981970,EBI-11957238
ZNF587 [Q96SQ5]3EBI-10981970,EBI-6427977
A0A384ME253EBI-10981970,EBI-10211777

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
138665, 45 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T749, 130 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000475216

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5T749, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5T749

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 209Gln-richAdd BLAST206
Compositional biasi257 – 510Pro-richAdd BLAST254

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S65C, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111554

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_024690_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T749

Identification of Orthologs from Complete Genome Data

More...
OMAi
YTETCYV

Database of Orthologous Groups

More...
OrthoDBi
1260706at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T749

TreeFam database of animal gene trees

More...
TreeFami
TF351578

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5T749-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCDQQQIQCR LPLQQCCVKG PSFCSSQSPF AQSQVVVQAP CEMQIVDCPA
60 70 80 90 100
SCPVQVCQVS DQAPCQSQTT QVKCQSKTKQ VKGQAQCQSK TTQVKGQAAS
110 120 130 140 150
QSQTSSVQSQ APCQSEVSYV QCEASQPVQT CFVECAPVCY TETCYVECPV
160 170 180 190 200
QNYVPCPAPQ PVQMYRGRPA VCQPQGRFST QCQYQGSYSS CGPQFQSRAT
210 220 230 240 250
CNNYTPQFQL RPSYSSCFPQ YRSRTSFSPC VPQCQTQGSY GSFTEQHRSR
260 270 280 290 300
STSRCLPPPR RLQLFPRSCS PPRRFEPCSS SYLPLRPSEG FPNYCTPPRR
310 320 330 340 350
SEPIYNSRCP RRPISSCSQR RGPKCRIEIS SPCCPRQVPP QRCPVEIPPI
360 370 380 390 400
RRRSQSCGPQ PSWGASCPEL RPHVEPRPLP SFCPPRRLDQ CPESPLQRCP
410 420 430 440 450
PPAPRPRLRP EPCISLEPRP RPLPRQLSEP CLYPEPLPAL RPTPRPVPLP
460 470 480 490 500
RPGQCEIPEP RPCLQPCEHP EPCPRPEPIP LPAPCPSPEP CRETWRSPSP
510 520 530 540 550
CWGPNPVPYP GDLGCHESSP HRLDTEAPYC GPSSYNQGQE SGAGCGPGDV
560 570
FPERRGQDGH GDQGNAFAGV KGEAKSAYF
Length:579
Mass (Da):64,136
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB29AE2276D15A04
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02984014Q → H. Corresponds to variant dbSNP:rs17612167Ensembl.1
Natural variantiVAR_02984137V → A. Corresponds to variant dbSNP:rs944683Ensembl.1
Natural variantiVAR_029842113C → R. Corresponds to variant dbSNP:rs16834457Ensembl.1
Natural variantiVAR_029843168R → H. Corresponds to variant dbSNP:rs16834461Ensembl.1
Natural variantiVAR_029844413C → S. Corresponds to variant dbSNP:rs4329520Ensembl.1
Natural variantiVAR_029845532P → T. Corresponds to variant dbSNP:rs6703294Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY960854 mRNA Translation: AAX59055.1
AL353779 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30862.1

NCBI Reference Sequences

More...
RefSeqi
NP_001020402.1, NM_001025231.1
XP_011507873.1, XM_011509571.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000606109; ENSP00000475216; ENSG00000203786

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
448834

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:448834

UCSC genome browser

More...
UCSCi
uc057lai.1, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY960854 mRNA Translation: AAX59055.1
AL353779 Genomic DNA No translation available.
CCDSiCCDS30862.1
RefSeqiNP_001020402.1, NM_001025231.1
XP_011507873.1, XM_011509571.1

3D structure databases

SMRiQ5T749
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi138665, 45 interactors
IntActiQ5T749, 130 interactors
STRINGi9606.ENSP00000475216

PTM databases

iPTMnetiQ5T749
PhosphoSitePlusiQ5T749

Polymorphism and mutation databases

BioMutaiKPRP
DMDMi74745319

Proteomic databases

EPDiQ5T749
jPOSTiQ5T749
MassIVEiQ5T749
MaxQBiQ5T749
PaxDbiQ5T749
PeptideAtlasiQ5T749
PRIDEiQ5T749
ProteomicsDBi64636

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
50318, 32 antibodies

The DNASU plasmid repository

More...
DNASUi
448834

Genome annotation databases

EnsembliENST00000606109; ENSP00000475216; ENSG00000203786
GeneIDi448834
KEGGihsa:448834
UCSCiuc057lai.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
448834
DisGeNETi448834
EuPathDBiHostDB:ENSG00000203786.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KPRP
HGNCiHGNC:31823, KPRP
HPAiENSG00000203786, Tissue enriched (skin)
MIMi613260, gene
neXtProtiNX_Q5T749
OpenTargetsiENSG00000203786
PharmGKBiPA162393640

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502S65C, Eukaryota
GeneTreeiENSGT00730000111554
HOGENOMiCLU_024690_0_0_1
InParanoidiQ5T749
OMAiYTETCYV
OrthoDBi1260706at2759
PhylomeDBiQ5T749
TreeFamiTF351578

Enzyme and pathway databases

PathwayCommonsiQ5T749

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
448834, 6 hits in 865 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
448834
PharosiQ5T749, Tdark

Protein Ontology

More...
PROi
PR:Q5T749
RNActiQ5T749, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000203786, Expressed in skin of leg and 53 other tissues

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKPRP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T749
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 21, 2004
Last modified: August 12, 2020
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again