Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q5T749 (KPRP_HUMAN)

Protein

Keratinocyte proline-rich protein

Gene

KPRP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratinocyte proline-rich protein
Short name:
hKPRP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KPRP
Synonyms:C1orf45
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000203786.6

Human Gene Nomenclature Database

More...HGNCi		HGNC:31823 KPRP

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613260 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5T749

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		448834

Open Targets

More...OpenTargetsi		ENSG00000203786

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162393640

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KPRP

Domain mapping of disease mutations (DMDM)

More...DMDMi		74745319

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002710081 – 579Keratinocyte proline-rich proteinAdd BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei394PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5T749

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5T749

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5T749

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5T749

PeptideAtlas

More...PeptideAtlasi		Q5T749

PRoteomics IDEntifications database

More...PRIDEi		Q5T749

ProteomicsDB human proteome resource

More...ProteomicsDBi		64636

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5T749

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5T749

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the upper layer of epidermis and psoriasis (at protein level). Expressed in the upper layer of epidermis and psoriasis.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the periderm of fetal skin from 16th week gestational age and in the granular and horny layers of the epidermis at 24th week gestational age and thereafter (at protein level).1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By calcium and in psoriatic lesions.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000203786 Expressed in 48 organ(s), highest expression level in skin of leg

CleanEx database of gene expression profiles

More...CleanExi		HS_KPRP

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA031988
HPA031990

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		138665, 33 interactors

Protein interaction database and analysis system

More...IntActi		Q5T749, 111 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000357762

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q5T749

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5T749

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 209Gln-richAdd BLAST206
Compositional biasi257 – 510Pro-richAdd BLAST254

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J21S Eukaryota
ENOG410XY8H LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00730000111554

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000113243

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG081862

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5T749

Identification of Orthologs from Complete Genome Data

More...OMAi		YTETCYV

Database of Orthologous Groups

More...OrthoDBi		1260706at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5T749

TreeFam database of animal gene trees

More...TreeFami		TF351578

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR033193 KPRP

The PANTHER Classification System

More...PANTHERi		PTHR12241:SF98 PTHR12241:SF98, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5T749-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCDQQQIQCR LPLQQCCVKG PSFCSSQSPF AQSQVVVQAP CEMQIVDCPA 
        60         70         80         90        100
SCPVQVCQVS DQAPCQSQTT QVKCQSKTKQ VKGQAQCQSK TTQVKGQAAS 
       110        120        130        140        150
QSQTSSVQSQ APCQSEVSYV QCEASQPVQT CFVECAPVCY TETCYVECPV 
       160        170        180        190        200
QNYVPCPAPQ PVQMYRGRPA VCQPQGRFST QCQYQGSYSS CGPQFQSRAT 
       210        220        230        240        250
CNNYTPQFQL RPSYSSCFPQ YRSRTSFSPC VPQCQTQGSY GSFTEQHRSR 
       260        270        280        290        300
STSRCLPPPR RLQLFPRSCS PPRRFEPCSS SYLPLRPSEG FPNYCTPPRR 
       310        320        330        340        350
SEPIYNSRCP RRPISSCSQR RGPKCRIEIS SPCCPRQVPP QRCPVEIPPI 
       360        370        380        390        400
RRRSQSCGPQ PSWGASCPEL RPHVEPRPLP SFCPPRRLDQ CPESPLQRCP 
       410        420        430        440        450
PPAPRPRLRP EPCISLEPRP RPLPRQLSEP CLYPEPLPAL RPTPRPVPLP 
       460        470        480        490        500
RPGQCEIPEP RPCLQPCEHP EPCPRPEPIP LPAPCPSPEP CRETWRSPSP 
       510        520        530        540        550
CWGPNPVPYP GDLGCHESSP HRLDTEAPYC GPSSYNQGQE SGAGCGPGDV 
       560        570 
FPERRGQDGH GDQGNAFAGV KGEAKSAYF
Length:579
Mass (Da):64,136
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB29AE2276D15A04
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02984014Q → H. Corresponds to variant dbSNP:rs17612167Ensembl.1
Natural variantiVAR_02984137V → A. Corresponds to variant dbSNP:rs944683Ensembl.1
Natural variantiVAR_029842113C → R. Corresponds to variant dbSNP:rs16834457Ensembl.1
Natural variantiVAR_029843168R → H. Corresponds to variant dbSNP:rs16834461Ensembl.1
Natural variantiVAR_029844413C → S. Corresponds to variant dbSNP:rs4329520Ensembl.1
Natural variantiVAR_029845532P → T. Corresponds to variant dbSNP:rs6703294Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY960854 mRNA Translation: AAX59055.1
AL353779 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS30862.1

NCBI Reference Sequences

More...RefSeqi		NP_001020402.1, NM_001025231.1
XP_011507873.1, XM_011509571.1

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.149386

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000606109; ENSP00000475216; ENSG00000203786

Database of genes from NCBI RefSeq genomes

More...GeneIDi		448834

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:448834

UCSC genome browser

More...UCSCi		uc057lai.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY960854 mRNA Translation: AAX59055.1
AL353779 Genomic DNA No translation available.
CCDSiCCDS30862.1
RefSeqiNP_001020402.1, NM_001025231.1
XP_011507873.1, XM_011509571.1
UniGeneiHs.149386

3D structure databases

ProteinModelPortaliQ5T749
SMRiQ5T749
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138665, 33 interactors
IntActiQ5T749, 111 interactors
STRINGi9606.ENSP00000357762

PTM databases

iPTMnetiQ5T749
PhosphoSitePlusiQ5T749

Polymorphism and mutation databases

BioMutaiKPRP
DMDMi74745319

Proteomic databases

EPDiQ5T749
jPOSTiQ5T749
MaxQBiQ5T749
PaxDbiQ5T749
PeptideAtlasiQ5T749
PRIDEiQ5T749
ProteomicsDBi64636

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		448834
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000606109; ENSP00000475216; ENSG00000203786
GeneIDi448834
KEGGihsa:448834
UCSCiuc057lai.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		448834
DisGeNETi448834
EuPathDBiHostDB:ENSG00000203786.6

GeneCards: human genes, protein and diseases

More...GeneCardsi		KPRP
HGNCiHGNC:31823 KPRP
HPAiHPA031988
HPA031990
MIMi613260 gene
neXtProtiNX_Q5T749
OpenTargetsiENSG00000203786
PharmGKBiPA162393640

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J21S Eukaryota
ENOG410XY8H LUCA
GeneTreeiENSGT00730000111554
HOGENOMiHOG000113243
HOVERGENiHBG081862
InParanoidiQ5T749
OMAiYTETCYV
OrthoDBi1260706at2759
PhylomeDBiQ5T749
TreeFamiTF351578

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		448834

Protein Ontology

More...PROi		PR:Q5T749

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000203786 Expressed in 48 organ(s), highest expression level in skin of leg
CleanExiHS_KPRP

Family and domain databases

InterProiView protein in InterPro
IPR033193 KPRP
PANTHERiPTHR12241:SF98 PTHR12241:SF98, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKPRP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T749
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 21, 2004
Last modified: January 16, 2019
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again