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UniProtKB - Q5T749 (KPRP_HUMAN)
Protein
Keratinocyte proline-rich protein
Gene
KPRP
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Keratinocyte proline-rich proteinShort name: hKPRP |
Gene namesi | Name:KPRP Synonyms:C1orf45 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:31823, KPRP |
MIMi | 613260, gene |
neXtProti | NX_Q5T749 |
VEuPathDBi | HostDB:ENSG00000203786 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 448834 |
OpenTargetsi | ENSG00000203786 |
PharmGKBi | PA162393640 |
Miscellaneous databases
Pharosi | Q5T749, Tdark |
Genetic variation databases
BioMutai | KPRP |
DMDMi | 74745319 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000271008 | 1 – 579 | Keratinocyte proline-rich proteinAdd BLAST | 579 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 394 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q5T749 |
jPOSTi | Q5T749 |
MassIVEi | Q5T749 |
MaxQBi | Q5T749 |
PaxDbi | Q5T749 |
PeptideAtlasi | Q5T749 |
PRIDEi | Q5T749 |
ProteomicsDBi | 64636 |
PTM databases
iPTMneti | Q5T749 |
PhosphoSitePlusi | Q5T749 |
Expressioni
Tissue specificityi
Expressed in the upper layer of epidermis and psoriasis (at protein level). Expressed in the upper layer of epidermis and psoriasis.1 Publication
Developmental stagei
Expressed in the periderm of fetal skin from 16th week gestational age and in the granular and horny layers of the epidermis at 24th week gestational age and thereafter (at protein level).1 Publication
Inductioni
By calcium and in psoriatic lesions.1 Publication
Gene expression databases
Bgeei | ENSG00000203786, Expressed in skin of leg and 53 other tissues |
Organism-specific databases
HPAi | ENSG00000203786, Tissue enriched (skin) |
Interactioni
Binary interactionsi
Q5T749
Protein-protein interaction databases
BioGRIDi | 138665, 238 interactors |
IntActi | Q5T749, 133 interactors |
MINTi | Q5T749 |
STRINGi | 9606.ENSP00000475216 |
Miscellaneous databases
RNActi | Q5T749, protein |
Structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 526 – 579 | DisorderedSequence analysisAdd BLAST | 54 |
Phylogenomic databases
eggNOGi | ENOG502S65C, Eukaryota |
GeneTreei | ENSGT00730000111554 |
HOGENOMi | CLU_024690_0_0_1 |
InParanoidi | Q5T749 |
OMAi | KPQGCTS |
OrthoDBi | 1260706at2759 |
PhylomeDBi | Q5T749 |
TreeFami | TF351578 |
i Sequence
Sequence statusi: Complete.
Q5T749-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCDQQQIQCR LPLQQCCVKG PSFCSSQSPF AQSQVVVQAP CEMQIVDCPA
60 70 80 90 100
SCPVQVCQVS DQAPCQSQTT QVKCQSKTKQ VKGQAQCQSK TTQVKGQAAS
110 120 130 140 150
QSQTSSVQSQ APCQSEVSYV QCEASQPVQT CFVECAPVCY TETCYVECPV
160 170 180 190 200
QNYVPCPAPQ PVQMYRGRPA VCQPQGRFST QCQYQGSYSS CGPQFQSRAT
210 220 230 240 250
CNNYTPQFQL RPSYSSCFPQ YRSRTSFSPC VPQCQTQGSY GSFTEQHRSR
260 270 280 290 300
STSRCLPPPR RLQLFPRSCS PPRRFEPCSS SYLPLRPSEG FPNYCTPPRR
310 320 330 340 350
SEPIYNSRCP RRPISSCSQR RGPKCRIEIS SPCCPRQVPP QRCPVEIPPI
360 370 380 390 400
RRRSQSCGPQ PSWGASCPEL RPHVEPRPLP SFCPPRRLDQ CPESPLQRCP
410 420 430 440 450
PPAPRPRLRP EPCISLEPRP RPLPRQLSEP CLYPEPLPAL RPTPRPVPLP
460 470 480 490 500
RPGQCEIPEP RPCLQPCEHP EPCPRPEPIP LPAPCPSPEP CRETWRSPSP
510 520 530 540 550
CWGPNPVPYP GDLGCHESSP HRLDTEAPYC GPSSYNQGQE SGAGCGPGDV
560 570
FPERRGQDGH GDQGNAFAGV KGEAKSAYF
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029840 | 14 | Q → H. Corresponds to variant dbSNP:rs17612167Ensembl. | 1 | |
Natural variantiVAR_029841 | 37 | V → A. Corresponds to variant dbSNP:rs944683Ensembl. | 1 | |
Natural variantiVAR_029842 | 113 | C → R. Corresponds to variant dbSNP:rs16834457Ensembl. | 1 | |
Natural variantiVAR_029843 | 168 | R → H. Corresponds to variant dbSNP:rs16834461Ensembl. | 1 | |
Natural variantiVAR_029844 | 413 | C → S. Corresponds to variant dbSNP:rs4329520Ensembl. | 1 | |
Natural variantiVAR_029845 | 532 | P → T. Corresponds to variant dbSNP:rs6703294Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY960854 mRNA Translation: AAX59055.1 AL353779 Genomic DNA No translation available. |
CCDSi | CCDS30862.1 |
RefSeqi | NP_001020402.1, NM_001025231.1 XP_011507873.1, XM_011509571.1 |
Genome annotation databases
Ensembli | ENST00000606109; ENSP00000475216; ENSG00000203786 |
GeneIDi | 448834 |
KEGGi | hsa:448834 |
UCSCi | uc057lai.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY960854 mRNA Translation: AAX59055.1 AL353779 Genomic DNA No translation available. |
CCDSi | CCDS30862.1 |
RefSeqi | NP_001020402.1, NM_001025231.1 XP_011507873.1, XM_011509571.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 138665, 238 interactors |
IntActi | Q5T749, 133 interactors |
MINTi | Q5T749 |
STRINGi | 9606.ENSP00000475216 |
PTM databases
iPTMneti | Q5T749 |
PhosphoSitePlusi | Q5T749 |
Genetic variation databases
BioMutai | KPRP |
DMDMi | 74745319 |
Proteomic databases
EPDi | Q5T749 |
jPOSTi | Q5T749 |
MassIVEi | Q5T749 |
MaxQBi | Q5T749 |
PaxDbi | Q5T749 |
PeptideAtlasi | Q5T749 |
PRIDEi | Q5T749 |
ProteomicsDBi | 64636 |
Protocols and materials databases
Antibodypediai | 50318, 33 antibodies from 11 providers |
DNASUi | 448834 |
Genome annotation databases
Ensembli | ENST00000606109; ENSP00000475216; ENSG00000203786 |
GeneIDi | 448834 |
KEGGi | hsa:448834 |
UCSCi | uc057lai.1, human |
Organism-specific databases
CTDi | 448834 |
DisGeNETi | 448834 |
GeneCardsi | KPRP |
HGNCi | HGNC:31823, KPRP |
HPAi | ENSG00000203786, Tissue enriched (skin) |
MIMi | 613260, gene |
neXtProti | NX_Q5T749 |
OpenTargetsi | ENSG00000203786 |
PharmGKBi | PA162393640 |
VEuPathDBi | HostDB:ENSG00000203786 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S65C, Eukaryota |
GeneTreei | ENSGT00730000111554 |
HOGENOMi | CLU_024690_0_0_1 |
InParanoidi | Q5T749 |
OMAi | KPQGCTS |
OrthoDBi | 1260706at2759 |
PhylomeDBi | Q5T749 |
TreeFami | TF351578 |
Enzyme and pathway databases
PathwayCommonsi | Q5T749 |
SignaLinki | Q5T749 |
Miscellaneous databases
BioGRID-ORCSi | 448834, 9 hits in 1032 CRISPR screens |
GenomeRNAii | 448834 |
Pharosi | Q5T749, Tdark |
PROi | PR:Q5T749 |
RNActi | Q5T749, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000203786, Expressed in skin of leg and 53 other tissues |
Family and domain databases
MobiDBi | Search... |
Entry informationi
Entry namei | KPRP_HUMAN | |
Accessioni | Q5T749Primary (citable) accession number: Q5T749 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 23, 2022 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot