UniProtKB - Q5T700 (LRAD1_HUMAN)
Protein
Low-density lipoprotein receptor class A domain-containing protein 1
Gene
LDLRAD1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Low-density lipoprotein receptor class A domain-containing protein 1 |
Gene namesi | Name:LDLRAD1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000203985.10 |
HGNCi | HGNC:32069, LDLRAD1 |
neXtProti | NX_Q5T700 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 43 – 63 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 388633 |
OpenTargetsi | ENSG00000203985 |
PharmGKBi | PA142671554 |
Miscellaneous databases
Pharosi | Q5T700, Tdark |
Polymorphism and mutation databases
BioMutai | LDLRAD1 |
DMDMi | 74745299 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299376 | 1 – 205 | Low-density lipoprotein receptor class A domain-containing protein 1Add BLAST | 205 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 72 ↔ 89 | PROSITE-ProRule annotation | ||
Disulfide bondi | 83 ↔ 102 | PROSITE-ProRule annotation | ||
Disulfide bondi | 96 ↔ 113 | PROSITE-ProRule annotation | ||
Disulfide bondi | 141 ↔ 160 | PROSITE-ProRule annotation | ||
Disulfide bondi | 163 ↔ 180 | PROSITE-ProRule annotation | ||
Disulfide bondi | 170 ↔ 193 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, LipoproteinProteomic databases
MassIVEi | Q5T700 |
PaxDbi | Q5T700 |
PeptideAtlasi | Q5T700 |
PRIDEi | Q5T700 |
ProteomicsDBi | 64626 [Q5T700-1] 64627 [Q5T700-2] 64628 [Q5T700-3] 7255 |
Expressioni
Gene expression databases
Bgeei | ENSG00000203985, Expressed in right uterine tube and 51 other tissues |
Organism-specific databases
HPAi | ENSG00000203985, Group enriched (fallopian tube, lung, ovary) |
Interactioni
Binary interactionsi
Hide detailsQ5T700
Protein-protein interaction databases
BioGRIDi | 132783, 34 interactors |
IntActi | Q5T700, 34 interactors |
STRINGi | 9606.ENSP00000360411 |
Miscellaneous databases
RNActi | Q5T700, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 71 – 114 | LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST | 44 | |
Domaini | 115 – 161 | LDL-receptor class A 2; atypicalPROSITE-ProRule annotationAdd BLAST | 47 | |
Domaini | 162 – 203 | LDL-receptor class A 3; atypicalPROSITE-ProRule annotationAdd BLAST | 42 |
Sequence similaritiesi
Belongs to the LDLR family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S044, Eukaryota |
GeneTreei | ENSGT00390000008557 |
HOGENOMi | CLU_115457_0_0_1 |
InParanoidi | Q5T700 |
OMAi | VTACPPC |
OrthoDBi | 1360842at2759 |
PhylomeDBi | Q5T700 |
TreeFami | TF343451 |
Family and domain databases
Gene3Di | 4.10.400.10, 2 hits |
InterProi | View protein in InterPro IPR036055, LDL_receptor-like_sf IPR002172, LDrepeatLR_classA_rpt IPR040093, LRAD1 |
PANTHERi | PTHR22722:SF5, PTHR22722:SF5, 1 hit |
Pfami | View protein in Pfam PF00057, Ldl_recept_a, 1 hit |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00192, LDLa, 3 hits |
SUPFAMi | SSF57424, SSF57424, 2 hits |
PROSITEi | View protein in PROSITE PS01209, LDLRA_1, 1 hit PS50068, LDLRA_2, 1 hit |
s (4)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q5T700-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNKVFPQGEN GYTAAESKAH PGGEAGGGHL CCSRRGACLS ASLLLLLATV
60 70 80 90 100
AALIALVTIL GLPSCTPGAQ ACITLTNRTG FLCHDQRSCI PASGVCDGVR
110 120 130 140 150
TCTHGEDEDE SLCRDVPQSL PHFLVAHCGD PASWIYSDQK CDGTNNCGDC
160 170 180 190 200
SDELSPVTVC PPCGPGWWRC PSTFFKYCDC IPRHLCRDHV QHCSDWSDEY
ACPGP
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027617 | 1 – 66 | MNKVF…LPSCT → MQGTRAELSAHSPSRAAGNR RHEQGLP in isoform 2. 1 PublicationAdd BLAST | 66 | |
Alternative sequenceiVSP_027618 | 25 – 114 | AGGGH…ESLCR → G in isoform 3. 1 PublicationAdd BLAST | 90 | |
Alternative sequenceiVSP_054532 | 25 – 67 | Missing in isoform 4. 1 PublicationAdd BLAST | 43 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL353898 Genomic DNA No translation available. BC103740 mRNA No translation available. BC127708 mRNA Translation: AAI27709.1 BC127709 mRNA Translation: AAI27710.1 BC140760 mRNA Translation: AAI40761.1 BC144466 mRNA Translation: AAI44467.1 |
CCDSi | CCDS30725.1 [Q5T700-1] CCDS60145.1 [Q5T700-3] CCDS60146.1 [Q5T700-4] CCDS60147.1 [Q5T700-2] |
RefSeqi | NP_001010978.2, NM_001010978.3 [Q5T700-1] NP_001263321.1, NM_001276392.1 [Q5T700-2] NP_001263322.1, NM_001276393.1 [Q5T700-4] NP_001263323.1, NM_001276394.1 [Q5T700-3] |
Genome annotation databases
Ensembli | ENST00000371360; ENSP00000360411; ENSG00000203985 [Q5T700-1] ENST00000371362; ENSP00000360413; ENSG00000203985 [Q5T700-3] ENST00000420619; ENSP00000411017; ENSG00000203985 [Q5T700-2] ENST00000545928; ENSP00000445871; ENSG00000203985 [Q5T700-4] |
GeneIDi | 388633 |
KEGGi | hsa:388633 |
UCSCi | uc001cwm.3, human [Q5T700-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL353898 Genomic DNA No translation available. BC103740 mRNA No translation available. BC127708 mRNA Translation: AAI27709.1 BC127709 mRNA Translation: AAI27710.1 BC140760 mRNA Translation: AAI40761.1 BC144466 mRNA Translation: AAI44467.1 |
CCDSi | CCDS30725.1 [Q5T700-1] CCDS60145.1 [Q5T700-3] CCDS60146.1 [Q5T700-4] CCDS60147.1 [Q5T700-2] |
RefSeqi | NP_001010978.2, NM_001010978.3 [Q5T700-1] NP_001263321.1, NM_001276392.1 [Q5T700-2] NP_001263322.1, NM_001276393.1 [Q5T700-4] NP_001263323.1, NM_001276394.1 [Q5T700-3] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 132783, 34 interactors |
IntActi | Q5T700, 34 interactors |
STRINGi | 9606.ENSP00000360411 |
Polymorphism and mutation databases
BioMutai | LDLRAD1 |
DMDMi | 74745299 |
Proteomic databases
MassIVEi | Q5T700 |
PaxDbi | Q5T700 |
PeptideAtlasi | Q5T700 |
PRIDEi | Q5T700 |
ProteomicsDBi | 64626 [Q5T700-1] 64627 [Q5T700-2] 64628 [Q5T700-3] 7255 |
Protocols and materials databases
Antibodypediai | 46892, 95 antibodies |
Genome annotation databases
Ensembli | ENST00000371360; ENSP00000360411; ENSG00000203985 [Q5T700-1] ENST00000371362; ENSP00000360413; ENSG00000203985 [Q5T700-3] ENST00000420619; ENSP00000411017; ENSG00000203985 [Q5T700-2] ENST00000545928; ENSP00000445871; ENSG00000203985 [Q5T700-4] |
GeneIDi | 388633 |
KEGGi | hsa:388633 |
UCSCi | uc001cwm.3, human [Q5T700-1] |
Organism-specific databases
CTDi | 388633 |
DisGeNETi | 388633 |
EuPathDBi | HostDB:ENSG00000203985.10 |
GeneCardsi | LDLRAD1 |
HGNCi | HGNC:32069, LDLRAD1 |
HPAi | ENSG00000203985, Group enriched (fallopian tube, lung, ovary) |
neXtProti | NX_Q5T700 |
OpenTargetsi | ENSG00000203985 |
PharmGKBi | PA142671554 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S044, Eukaryota |
GeneTreei | ENSGT00390000008557 |
HOGENOMi | CLU_115457_0_0_1 |
InParanoidi | Q5T700 |
OMAi | VTACPPC |
OrthoDBi | 1360842at2759 |
PhylomeDBi | Q5T700 |
TreeFami | TF343451 |
Enzyme and pathway databases
PathwayCommonsi | Q5T700 |
Miscellaneous databases
BioGRID-ORCSi | 388633, 3 hits in 839 CRISPR screens |
GenomeRNAii | 388633 |
Pharosi | Q5T700, Tdark |
PROi | PR:Q5T700 |
RNActi | Q5T700, protein |
Gene expression databases
Bgeei | ENSG00000203985, Expressed in right uterine tube and 51 other tissues |
Family and domain databases
Gene3Di | 4.10.400.10, 2 hits |
InterProi | View protein in InterPro IPR036055, LDL_receptor-like_sf IPR002172, LDrepeatLR_classA_rpt IPR040093, LRAD1 |
PANTHERi | PTHR22722:SF5, PTHR22722:SF5, 1 hit |
Pfami | View protein in Pfam PF00057, Ldl_recept_a, 1 hit |
PRINTSi | PR00261, LDLRECEPTOR |
SMARTi | View protein in SMART SM00192, LDLa, 3 hits |
SUPFAMi | SSF57424, SSF57424, 2 hits |
PROSITEi | View protein in PROSITE PS01209, LDLRA_1, 1 hit PS50068, LDLRA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LRAD1_HUMAN | |
Accessioni | Q5T700Primary (citable) accession number: Q5T700 Secondary accession number(s): A0PJY0, B7ZME3, Q5T6Z9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 125 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM