UniProtKB - Q5T6X5 (GPC6A_HUMAN)
Protein
G-protein coupled receptor family C group 6 member A
Gene
GPRC6A
Organism
Homo sapiens (Human)
Status
Functioni
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+. Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.2 Publications
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- signaling receptor activity Source: GO_Central
GO - Biological processi
- calcium-mediated signaling Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- response to amino acid Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q5T6X5 |
Reactomei | R-HSA-416476, G alpha (q) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Protein family/group databases
TCDBi | 9.A.14.7.3, the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor family C group 6 member AShort name: hGPRC6A Alternative name(s): G-protein coupled receptor GPCR33 Short name: hGPCR33 |
Gene namesi | Name:GPRC6A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000173612.9 |
HGNCi | HGNC:18510, GPRC6A |
MIMi | 613572, gene |
neXtProti | NX_Q5T6X5 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein By similarity
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Other locations
- cell surface Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 19 – 594 | ExtracellularSequence analysisAdd BLAST | 576 | |
Transmembranei | 595 – 615 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 616 – 631 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 632 – 652 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 653 – 669 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 670 – 690 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 691 – 704 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 705 – 725 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 726 – 748 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 749 – 769 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 770 – 782 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 783 – 803 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 804 – 810 | ExtracellularSequence analysis | 7 | |
Transmembranei | 811 – 831 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 832 – 926 | CytoplasmicSequence analysisAdd BLAST | 95 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 149 | S → A: Loss of function. 1 Publication | 1 | |
Mutagenesisi | 172 | T → A: Loss of function. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 222545 |
OpenTargetsi | ENSG00000173612 |
PharmGKBi | PA38342 |
Miscellaneous databases
Pharosi | Q5T6X5, Tchem |
Chemistry databases
DrugCentrali | Q5T6X5 |
GuidetoPHARMACOLOGYi | 55 |
Polymorphism and mutation databases
BioMutai | GPRC6A |
DMDMi | 74745292 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000043196 | 19 – 926 | G-protein coupled receptor family C group 6 member AAdd BLAST | 908 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 121 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 131 | Interchain1 Publication | ||
Glycosylationi | 259 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 332 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 378 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 452 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 555 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 567 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 590 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 733 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | Q5T6X5 |
PaxDbi | Q5T6X5 |
PeptideAtlasi | Q5T6X5 |
PRIDEi | Q5T6X5 |
ProteomicsDBi | 64622 [Q5T6X5-1] 64623 [Q5T6X5-2] 64624 [Q5T6X5-3] |
PTM databases
GlyGeni | Q5T6X5, 9 sites |
iPTMneti | Q5T6X5 |
PhosphoSitePlusi | Q5T6X5 |
Expressioni
Tissue specificityi
Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues.1 Publication
Gene expression databases
Bgeei | ENSG00000173612, Expressed in adrenal tissue and 13 other tissues |
Genevisiblei | Q5T6X5, HS |
Organism-specific databases
HPAi | ENSG00000173612, Group enriched (adrenal gland, kidney, prostate, salivary gland) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
1 PublicationProtein-protein interaction databases
STRINGi | 9606.ENSP00000309493 |
Miscellaneous databases
RNActi | Q5T6X5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 3 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT00940000158416 |
HOGENOMi | CLU_005389_1_0_1 |
InParanoidi | Q5T6X5 |
OMAi | VILCKQE |
OrthoDBi | 119538at2759 |
PhylomeDBi | Q5T6X5 |
TreeFami | TF331269 |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR000068, GPCR_3_Ca_sens_rcpt-rel IPR017979, GPCR_3_CS IPR028082, Peripla_BP_I |
PANTHERi | PTHR24061, PTHR24061, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00592, CASENSINGR PR00248, GPCRMGR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
s (3)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q5T6X5-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAFLIILITC FVIILATSQP CQTPDDFVAA TSPGHIIIGG LFAIHEKMLS
60 70 80 90 100
SEDSPRRPQI QECVGFEISV FLQTLAMIHS IEMINNSTLL PGVKLGYEIY
110 120 130 140 150
DTCTEVTVAM AATLRFLSKF NCSRETVEFK CDYSSYMPRV KAVIGSGYSE
160 170 180 190 200
ITMAVSRMLN LQLMPQVGYE STAEILSDKI RFPSFLRTVP SDFHQIKAMA
210 220 230 240 250
HLIQKSGWNW IGIITTDDDY GRLALNTFII QAEANNVCIA FKEVLPAFLS
260 270 280 290 300
DNTIEVRINR TLKKIILEAQ VNVIVVFLRQ FHVFDLFNKA IEMNINKMWI
310 320 330 340 350
ASDNWSTATK ITTIPNVKKI GKVVGFAFRR GNISSFHSFL QNLHLLPSDS
360 370 380 390 400
HKLLHEYAMH LSACAYVKDT DLSQCIFNHS QRTLAYKANK AIERNFVMRN
410 420 430 440 450
DFLWDYAEPG LIHSIQLAVF ALGYAIRDLC QARDCQNPNA FQPWELLGVL
460 470 480 490 500
KNVTFTDGWN SFHFDAHGDL NTGYDVVLWK EINGHMTVTK MAEYDLQNDV
510 520 530 540 550
FIIPDQETKN EFRNLKQIQS KCSKECSPGQ MKKTTRSQHI CCYECQNCPE
560 570 580 590 600
NHYTNQTDMP HCLLCNNKTH WAPVRSTMCF EKEVEYLNWN DSLAILLLIL
610 620 630 640 650
SLLGIIFVLV VGIIFTRNLN TPVVKSSGGL RVCYVILLCH FLNFASTSFF
660 670 680 690 700
IGEPQDFTCK TRQTMFGVSF TLCISCILTK SLKILLAFSF DPKLQKFLKC
710 720 730 740 750
LYRPILIIFT CTGIQVVICT LWLIFAAPTV EVNVSLPRVI ILECEEGSIL
760 770 780 790 800
AFGTMLGYIA ILAFICFIFA FKGKYENYNE AKFITFGMLI YFIAWITFIP
810 820 830 840 850
IYATTFGKYV PAVEIIVILI SNYGILYCTF IPKCYVIICK QEINTKSAFL
860 870 880 890 900
KMIYSYSSHS VSSIALSPAS LDSMSGNVTM TNPSSSGKSA TWQKSKDLQA
910 920
QAFAHICREN ATSVSKTLPR KRMSSI
Note: Major isoform.
Sequence cautioni
The sequence BAC05904 differs from that shown. Reason: Erroneous gene model prediction.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023966 | 91 | P → S2 PublicationsCorresponds to variant dbSNP:rs2274911Ensembl. | 1 | |
Natural variantiVAR_049283 | 144 | I → R. Corresponds to variant dbSNP:rs28360548Ensembl. | 1 | |
Natural variantiVAR_061203 | 599 | I → T. Corresponds to variant dbSNP:rs35937022Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016454 | 271 – 445 | Missing in isoform 2. 1 PublicationAdd BLAST | 175 | |
Alternative sequenceiVSP_016455 | 446 – 516 | Missing in isoform 3. 1 PublicationAdd BLAST | 71 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY435125 mRNA Translation: AAS13465.1 AY435126 mRNA Translation: AAS13466.1 AY435127 mRNA Translation: AAS13467.1 AF502962 mRNA Translation: AAM22230.1 AL354716 Genomic DNA No translation available. AB065680 Genomic DNA Translation: BAC05904.1 Sequence problems. AB083615 Genomic DNA Translation: BAB89328.1 |
CCDSi | CCDS5112.1 [Q5T6X5-1] CCDS69184.1 [Q5T6X5-3] CCDS69185.1 [Q5T6X5-2] |
RefSeqi | NP_001273283.1, NM_001286354.1 [Q5T6X5-2] NP_001273284.1, NM_001286355.1 [Q5T6X5-3] NP_683766.2, NM_148963.3 [Q5T6X5-1] |
Genome annotation databases
Ensembli | ENST00000310357; ENSP00000309493; ENSG00000173612 [Q5T6X5-1] ENST00000368549; ENSP00000357537; ENSG00000173612 [Q5T6X5-3] ENST00000530250; ENSP00000433465; ENSG00000173612 [Q5T6X5-2] |
GeneIDi | 222545 |
KEGGi | hsa:222545 |
UCSCi | uc003pxj.3, human [Q5T6X5-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY435125 mRNA Translation: AAS13465.1 AY435126 mRNA Translation: AAS13466.1 AY435127 mRNA Translation: AAS13467.1 AF502962 mRNA Translation: AAM22230.1 AL354716 Genomic DNA No translation available. AB065680 Genomic DNA Translation: BAC05904.1 Sequence problems. AB083615 Genomic DNA Translation: BAB89328.1 |
CCDSi | CCDS5112.1 [Q5T6X5-1] CCDS69184.1 [Q5T6X5-3] CCDS69185.1 [Q5T6X5-2] |
RefSeqi | NP_001273283.1, NM_001286354.1 [Q5T6X5-2] NP_001273284.1, NM_001286355.1 [Q5T6X5-3] NP_683766.2, NM_148963.3 [Q5T6X5-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000309493 |
Chemistry databases
DrugCentrali | Q5T6X5 |
GuidetoPHARMACOLOGYi | 55 |
Protein family/group databases
TCDBi | 9.A.14.7.3, the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyGeni | Q5T6X5, 9 sites |
iPTMneti | Q5T6X5 |
PhosphoSitePlusi | Q5T6X5 |
Polymorphism and mutation databases
BioMutai | GPRC6A |
DMDMi | 74745292 |
Proteomic databases
MassIVEi | Q5T6X5 |
PaxDbi | Q5T6X5 |
PeptideAtlasi | Q5T6X5 |
PRIDEi | Q5T6X5 |
ProteomicsDBi | 64622 [Q5T6X5-1] 64623 [Q5T6X5-2] 64624 [Q5T6X5-3] |
Protocols and materials databases
Antibodypediai | 19443, 269 antibodies |
DNASUi | 222545 |
Genome annotation databases
Ensembli | ENST00000310357; ENSP00000309493; ENSG00000173612 [Q5T6X5-1] ENST00000368549; ENSP00000357537; ENSG00000173612 [Q5T6X5-3] ENST00000530250; ENSP00000433465; ENSG00000173612 [Q5T6X5-2] |
GeneIDi | 222545 |
KEGGi | hsa:222545 |
UCSCi | uc003pxj.3, human [Q5T6X5-1] |
Organism-specific databases
CTDi | 222545 |
DisGeNETi | 222545 |
EuPathDBi | HostDB:ENSG00000173612.9 |
GeneCardsi | GPRC6A |
HGNCi | HGNC:18510, GPRC6A |
HPAi | ENSG00000173612, Group enriched (adrenal gland, kidney, prostate, salivary gland) |
MIMi | 613572, gene |
neXtProti | NX_Q5T6X5 |
OpenTargetsi | ENSG00000173612 |
PharmGKBi | PA38342 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1056, Eukaryota |
GeneTreei | ENSGT00940000158416 |
HOGENOMi | CLU_005389_1_0_1 |
InParanoidi | Q5T6X5 |
OMAi | VILCKQE |
OrthoDBi | 119538at2759 |
PhylomeDBi | Q5T6X5 |
TreeFami | TF331269 |
Enzyme and pathway databases
PathwayCommonsi | Q5T6X5 |
Reactomei | R-HSA-416476, G alpha (q) signalling events R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors) |
Miscellaneous databases
BioGRID-ORCSi | 222545, 5 hits in 843 CRISPR screens |
GeneWikii | GPRC6A |
GenomeRNAii | 222545 |
Pharosi | Q5T6X5, Tchem |
PROi | PR:Q5T6X5 |
RNActi | Q5T6X5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173612, Expressed in adrenal tissue and 13 other tissues |
Genevisiblei | Q5T6X5, HS |
Family and domain databases
Gene3Di | 2.10.50.30, 1 hit |
InterProi | View protein in InterPro IPR001828, ANF_lig-bd_rcpt IPR000337, GPCR_3 IPR011500, GPCR_3_9-Cys_dom IPR038550, GPCR_3_9-Cys_sf IPR017978, GPCR_3_C IPR000068, GPCR_3_Ca_sens_rcpt-rel IPR017979, GPCR_3_CS IPR028082, Peripla_BP_I |
PANTHERi | PTHR24061, PTHR24061, 1 hit |
Pfami | View protein in Pfam PF00003, 7tm_3, 1 hit PF01094, ANF_receptor, 1 hit PF07562, NCD3G, 1 hit |
PRINTSi | PR00592, CASENSINGR PR00248, GPCRMGR |
SUPFAMi | SSF53822, SSF53822, 1 hit |
PROSITEi | View protein in PROSITE PS00980, G_PROTEIN_RECEP_F3_2, 1 hit PS50259, G_PROTEIN_RECEP_F3_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPC6A_HUMAN | |
Accessioni | Q5T6X5Primary (citable) accession number: Q5T6X5 Secondary accession number(s): Q6JK43 Q8TDT6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | December 21, 2004 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries