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UniProtKB - Q5T6X5 (GPC6A_HUMAN)

Entry version 141 (29 Sep 2021)
Sequence version 1 (21 Dec 2004)
Previous versions | rss
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Protein

G-protein coupled receptor family C group 6 member A

Gene

GPRC6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+. Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5T6X5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-416476, G alpha (q) signalling events
R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors)

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.14.7.3, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G-protein coupled receptor family C group 6 member A
Short name:
hGPRC6A
Alternative name(s):
G-protein coupled receptor GPCR33
Short name:
hGPCR33
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPRC6A
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18510, GPRC6A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613572, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5T6X5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000173612

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 594ExtracellularSequence analysisAdd BLAST576
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei595 – 615Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini616 – 631CytoplasmicSequence analysisAdd BLAST16
Transmembranei632 – 652Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini653 – 669ExtracellularSequence analysisAdd BLAST17
Transmembranei670 – 690Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini691 – 704CytoplasmicSequence analysisAdd BLAST14
Transmembranei705 – 725Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini726 – 748ExtracellularSequence analysisAdd BLAST23
Transmembranei749 – 769Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini770 – 782CytoplasmicSequence analysisAdd BLAST13
Transmembranei783 – 803Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini804 – 810ExtracellularSequence analysis7
Transmembranei811 – 831Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini832 – 926CytoplasmicSequence analysisAdd BLAST95

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi149S → A: Loss of function. 1 Publication1
Mutagenesisi172T → A: Loss of function. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		222545

Open Targets

More...OpenTargetsi		ENSG00000173612

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38342

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5T6X5, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523873

DrugCentral

More...DrugCentrali		Q5T6X5

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		55

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GPRC6A

Domain mapping of disease mutations (DMDM)

More...DMDMi		74745292

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004319619 – 926G-protein coupled receptor family C group 6 member AAdd BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi121N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi131Interchain1 Publication
Glycosylationi259N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi332N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi378N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi452N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi555N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi567N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi733N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5T6X5

PeptideAtlas

More...PeptideAtlasi		Q5T6X5

PRoteomics IDEntifications database

More...PRIDEi		Q5T6X5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		64622 [Q5T6X5-1]
64623 [Q5T6X5-2]
64624 [Q5T6X5-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q5T6X5, 9 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5T6X5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5T6X5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000173612, Expressed in adrenal tissue and 13 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5T6X5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000173612, Group enriched (adrenal gland, kidney, prostate, salivary gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000309493

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5T6X5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 3 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1056, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158416

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005389_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5T6X5

Identification of Orthologs from Complete Genome Data

More...OMAi		VFIITDQ

Database of Orthologous Groups

More...OrthoDBi		119538at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5T6X5

TreeFam database of animal gene trees

More...TreeFami		TF331269

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.10.50.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR000337, GPCR_3
IPR011500, GPCR_3_9-Cys_dom
IPR038550, GPCR_3_9-Cys_sf
IPR017978, GPCR_3_C
IPR000068, GPCR_3_Ca_sens_rcpt-rel
IPR017979, GPCR_3_CS
IPR028082, Peripla_BP_I

The PANTHER Classification System

More...PANTHERi		PTHR24061, PTHR24061, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF07562, NCD3G, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00592, CASENSINGR
PR00248, GPCRMGR

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53822, SSF53822, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00980, G_PROTEIN_RECEP_F3_2, 1 hit
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5T6X5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFLIILITC FVIILATSQP CQTPDDFVAA TSPGHIIIGG LFAIHEKMLS 
        60         70         80         90        100
SEDSPRRPQI QECVGFEISV FLQTLAMIHS IEMINNSTLL PGVKLGYEIY 
       110        120        130        140        150
DTCTEVTVAM AATLRFLSKF NCSRETVEFK CDYSSYMPRV KAVIGSGYSE 
       160        170        180        190        200
ITMAVSRMLN LQLMPQVGYE STAEILSDKI RFPSFLRTVP SDFHQIKAMA 
       210        220        230        240        250
HLIQKSGWNW IGIITTDDDY GRLALNTFII QAEANNVCIA FKEVLPAFLS 
       260        270        280        290        300
DNTIEVRINR TLKKIILEAQ VNVIVVFLRQ FHVFDLFNKA IEMNINKMWI 
       310        320        330        340        350
ASDNWSTATK ITTIPNVKKI GKVVGFAFRR GNISSFHSFL QNLHLLPSDS 
       360        370        380        390        400
HKLLHEYAMH LSACAYVKDT DLSQCIFNHS QRTLAYKANK AIERNFVMRN 
       410        420        430        440        450
DFLWDYAEPG LIHSIQLAVF ALGYAIRDLC QARDCQNPNA FQPWELLGVL 
       460        470        480        490        500
KNVTFTDGWN SFHFDAHGDL NTGYDVVLWK EINGHMTVTK MAEYDLQNDV 
       510        520        530        540        550
FIIPDQETKN EFRNLKQIQS KCSKECSPGQ MKKTTRSQHI CCYECQNCPE 
       560        570        580        590        600
NHYTNQTDMP HCLLCNNKTH WAPVRSTMCF EKEVEYLNWN DSLAILLLIL 
       610        620        630        640        650
SLLGIIFVLV VGIIFTRNLN TPVVKSSGGL RVCYVILLCH FLNFASTSFF 
       660        670        680        690        700
IGEPQDFTCK TRQTMFGVSF TLCISCILTK SLKILLAFSF DPKLQKFLKC 
       710        720        730        740        750
LYRPILIIFT CTGIQVVICT LWLIFAAPTV EVNVSLPRVI ILECEEGSIL 
       760        770        780        790        800
AFGTMLGYIA ILAFICFIFA FKGKYENYNE AKFITFGMLI YFIAWITFIP 
       810        820        830        840        850
IYATTFGKYV PAVEIIVILI SNYGILYCTF IPKCYVIICK QEINTKSAFL 
       860        870        880        890        900
KMIYSYSSHS VSSIALSPAS LDSMSGNVTM TNPSSSGKSA TWQKSKDLQA 
       910        920 
QAFAHICREN ATSVSKTLPR KRMSSI
Note: Major isoform.
Length:926
Mass (Da):104,753
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2019C884FF092EEF
GO
Isoform 2 (identifier: Q5T6X5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-445: Missing.

Show »
Length:751
Mass (Da):84,565
Checksum:i0A5019AAB24393D8
GO
Isoform 3 (identifier: Q5T6X5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-516: Missing.

Show »
Length:855
Mass (Da):96,526
Checksum:i0C93431762234E38
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC05904 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02396691P → S2 PublicationsCorresponds to variant dbSNP:rs2274911Ensembl.1
Natural variantiVAR_049283144I → R. Corresponds to variant dbSNP:rs28360548Ensembl.1
Natural variantiVAR_061203599I → T. Corresponds to variant dbSNP:rs35937022Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016454271 – 445Missing in isoform 2. 1 PublicationAdd BLAST175
Alternative sequenceiVSP_016455446 – 516Missing in isoform 3. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY435125 mRNA Translation: AAS13465.1
AY435126 mRNA Translation: AAS13466.1
AY435127 mRNA Translation: AAS13467.1
AF502962 mRNA Translation: AAM22230.1
AL354716 Genomic DNA No translation available.
AB065680 Genomic DNA Translation: BAC05904.1 Sequence problems.
AB083615 Genomic DNA Translation: BAB89328.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5112.1 [Q5T6X5-1]
CCDS69184.1 [Q5T6X5-3]
CCDS69185.1 [Q5T6X5-2]

NCBI Reference Sequences

More...RefSeqi		NP_001273283.1, NM_001286354.1 [Q5T6X5-2]
NP_001273284.1, NM_001286355.1 [Q5T6X5-3]
NP_683766.2, NM_148963.3 [Q5T6X5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000310357; ENSP00000309493; ENSG00000173612 [Q5T6X5-1]
ENST00000368549; ENSP00000357537; ENSG00000173612 [Q5T6X5-3]
ENST00000530250; ENSP00000433465; ENSG00000173612 [Q5T6X5-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		222545

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:222545

UCSC genome browser

More...UCSCi		uc003pxj.3, human [Q5T6X5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY435125 mRNA Translation: AAS13465.1
AY435126 mRNA Translation: AAS13466.1
AY435127 mRNA Translation: AAS13467.1
AF502962 mRNA Translation: AAM22230.1
AL354716 Genomic DNA No translation available.
AB065680 Genomic DNA Translation: BAC05904.1 Sequence problems.
AB083615 Genomic DNA Translation: BAB89328.1
CCDSiCCDS5112.1 [Q5T6X5-1]
CCDS69184.1 [Q5T6X5-3]
CCDS69185.1 [Q5T6X5-2]
RefSeqiNP_001273283.1, NM_001286354.1 [Q5T6X5-2]
NP_001273284.1, NM_001286355.1 [Q5T6X5-3]
NP_683766.2, NM_148963.3 [Q5T6X5-1]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000309493

Chemistry databases

ChEMBLiCHEMBL4523873
DrugCentraliQ5T6X5
GuidetoPHARMACOLOGYi55

Protein family/group databases

TCDBi9.A.14.7.3, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyGeniQ5T6X5, 9 sites
iPTMnetiQ5T6X5
PhosphoSitePlusiQ5T6X5

Genetic variation databases

BioMutaiGPRC6A
DMDMi74745292

Proteomic databases

PaxDbiQ5T6X5
PeptideAtlasiQ5T6X5
PRIDEiQ5T6X5
ProteomicsDBi64622 [Q5T6X5-1]
64623 [Q5T6X5-2]
64624 [Q5T6X5-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19443, 285 antibodies

The DNASU plasmid repository

More...DNASUi		222545

Genome annotation databases

EnsembliENST00000310357; ENSP00000309493; ENSG00000173612 [Q5T6X5-1]
ENST00000368549; ENSP00000357537; ENSG00000173612 [Q5T6X5-3]
ENST00000530250; ENSP00000433465; ENSG00000173612 [Q5T6X5-2]
GeneIDi222545
KEGGihsa:222545
UCSCiuc003pxj.3, human [Q5T6X5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		222545
DisGeNETi222545

GeneCards: human genes, protein and diseases

More...GeneCardsi		GPRC6A
HGNCiHGNC:18510, GPRC6A
HPAiENSG00000173612, Group enriched (adrenal gland, kidney, prostate, salivary gland)
MIMi613572, gene
neXtProtiNX_Q5T6X5
OpenTargetsiENSG00000173612
PharmGKBiPA38342
VEuPathDBiHostDB:ENSG00000173612

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1056, Eukaryota
GeneTreeiENSGT00940000158416
HOGENOMiCLU_005389_1_0_1
InParanoidiQ5T6X5
OMAiVFIITDQ
OrthoDBi119538at2759
PhylomeDBiQ5T6X5
TreeFamiTF331269

Enzyme and pathway databases

PathwayCommonsiQ5T6X5
ReactomeiR-HSA-416476, G alpha (q) signalling events
R-HSA-420499, Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		222545, 5 hits in 1008 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GPRC6A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		222545
PharosiQ5T6X5, Tchem

Protein Ontology

More...PROi		PR:Q5T6X5
RNActiQ5T6X5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000173612, Expressed in adrenal tissue and 13 other tissues
GenevisibleiQ5T6X5, HS

Family and domain databases

Gene3Di2.10.50.30, 1 hit
InterProiView protein in InterPro
IPR001828, ANF_lig-bd_rcpt
IPR000337, GPCR_3
IPR011500, GPCR_3_9-Cys_dom
IPR038550, GPCR_3_9-Cys_sf
IPR017978, GPCR_3_C
IPR000068, GPCR_3_Ca_sens_rcpt-rel
IPR017979, GPCR_3_CS
IPR028082, Peripla_BP_I
PANTHERiPTHR24061, PTHR24061, 1 hit
PfamiView protein in Pfam
PF00003, 7tm_3, 1 hit
PF01094, ANF_receptor, 1 hit
PF07562, NCD3G, 1 hit
PRINTSiPR00592, CASENSINGR
PR00248, GPCRMGR
SUPFAMiSSF53822, SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00980, G_PROTEIN_RECEP_F3_2, 1 hit
PS50259, G_PROTEIN_RECEP_F3_4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPC6A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T6X5
Secondary accession number(s): Q6JK43
, Q6JK44, Q8NGU8, Q8NHZ9, Q8TDT6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 21, 2004
Last modified: September 29, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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