UniProtKB - Q5T6X2 (Q5T6X2_HUMAN)
Protein
Submitted name:
Epididymis secretory sperm binding protein
Gene
KLF5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: Ensembl
- MRF binding Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- angiogenesis Source: Ensembl
- cellular response to leukemia inhibitory factor Source: Ensembl
- cellular response to organic cyclic compound Source: Ensembl
- cellular response to peptide Source: Ensembl
- intestinal epithelial cell development Source: Ensembl
- microvillus assembly Source: Ensembl
- myotube differentiation involved in skeletal muscle regeneration Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of fat cell differentiation Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of transcription by transcription factor localization Source: Ensembl
- regulation of microvillus assembly Source: Ensembl
- satellite cell activation involved in skeletal muscle regeneration Source: Ensembl
- skeletal muscle satellite cell differentiation Source: Ensembl
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Epididymis secretory sperm binding proteinImportedSubmitted name: Kruppel-like factor 5 (Intestinal)ImportedSubmitted name: Kruppel-like factor 5 (Intestinal), isoform CRA_aImported |
Gene namesi | Name:KLF5Imported ORF Names:hCG_32789Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000102554.13 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- intracellular membrane-bounded organelle Source: HPA
- transcription regulator complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSG00000102554, Expressed in palpebral conjunctiva and 223 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 373 – 402 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 403 – 432 | C2H2-typeInterPro annotationAdd BLAST | 30 | |
Domaini | 433 – 457 | C2H2-typeInterPro annotationAdd BLAST | 25 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 83 | DisorderedSequence analysisAdd BLAST | 83 | |
Regioni | 295 – 321 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 63 – 80 | Pro-richSequence analysisAdd BLAST | 18 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
OMAi | FQTRCEM |
OrthoDBi | 382638at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR030401, KLF5 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF82, PTHR23235:SF82, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
i Sequence
Sequence statusi: Complete.
Q5T6X2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE
60 70 80 90 100
LKHAHHRPQA QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL
110 120 130 140 150
PPVPIIPEHK KYRRDSASVV DQFFTDTEGL PYSINMNVFL PDITHLRTGL
160 170 180 190 200
YKSQRPCVTH IKTEPVAIFS HQSETTAPPP APTQALPEFT SIFSSHQTAA
210 220 230 240 250
PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP SSTNQTAAMD
260 270 280 290 300
TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF
310 320 330 340 350
PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN
360 370 380 390 400
SQNIQPVRYN RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE
410 420 430 440 450
KPYKCTWEGC DWRFARSDEL TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL
HMKRHQN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT006641 mRNA Translation: AAP35287.1 GQ891345 mRNA Translation: ADO22207.1 CH471093 Genomic DNA Translation: EAW80524.1 CH471093 Genomic DNA Translation: EAW80525.1 |
RefSeqi | NP_001721.2, NM_001730.4 |
Genome annotation databases
GeneIDi | 688 |
KEGGi | hsa:688 |
UCSCi | uc001vje.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BT006641 mRNA Translation: AAP35287.1 GQ891345 mRNA Translation: ADO22207.1 CH471093 Genomic DNA Translation: EAW80524.1 CH471093 Genomic DNA Translation: EAW80525.1 |
RefSeqi | NP_001721.2, NM_001730.4 |
3D structure databases
SMRi | Q5T6X2 |
ModBasei | Search... |
Chemistry databases
BindingDBi | Q5T6X2 |
Proteomic databases
MaxQBi | Q5T6X2 |
Protocols and materials databases
Antibodypediai | 24429, 324 antibodies |
DNASUi | 688 |
Genome annotation databases
GeneIDi | 688 |
KEGGi | hsa:688 |
UCSCi | uc001vje.4, human |
Organism-specific databases
CTDi | 688 |
EuPathDBi | HostDB:ENSG00000102554.13 |
PharmGKBi | PA30139 |
Phylogenomic databases
OMAi | FQTRCEM |
OrthoDBi | 382638at2759 |
Miscellaneous databases
BioGRID-ORCSi | 688, 127 hits in 869 CRISPR screens |
ChiTaRSi | KLF5, human |
GenomeRNAii | 688 |
Gene expression databases
Bgeei | ENSG00000102554, Expressed in palpebral conjunctiva and 223 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR030401, KLF5 IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR23235:SF82, PTHR23235:SF82, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5T6X2_HUMAN | |
Accessioni | Q5T6X2Primary (citable) accession number: Q5T6X2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |