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UniProtKB - Q5T6V5 (QSPP_HUMAN)

Entry version 114 (11 Dec 2019)
Sequence version 1 (21 Dec 2004)
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Protein

Queuosine salvage protein

Gene

C9orf64

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in salvaging queuosine.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Queuosine salvage protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C9orf64
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000165118.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:28144 C9orf64

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611342 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5T6V5

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000165118

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134865965

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5T6V5 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		C9orf64

Domain mapping of disease mutations (DMDM)

More...DMDMi		73620030

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000897001 – 341Queuosine salvage proteinAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5T6V5

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5T6V5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5T6V5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5T6V5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5T6V5

PeptideAtlas

More...PeptideAtlasi		Q5T6V5

PRoteomics IDEntifications database

More...PRIDEi		Q5T6V5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		64614

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5T6V5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5T6V5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000165118 Expressed in 216 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5T6V5 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5T6V5 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA054903
HPA066190

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		123994, 15 interactors

Protein interaction database and analysis system

More...IntActi		Q5T6V5, 6 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000365522

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5T6V5 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the queuosine salvage protein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2524 Eukaryota
ENOG410XRIA LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002374

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000010664

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5T6V5

Identification of Orthologs from Complete Genome Data

More...OMAi		KITMFAD

Database of Orthologous Groups

More...OrthoDBi		1356655at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5T6V5

TreeFam database of animal gene trees

More...TreeFami		TF105811

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019438 Q_salvage

The PANTHER Classification System

More...PANTHERi		PTHR21314 PTHR21314, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10343 Q_salvage, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q5T6V5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGLLNPRES SKFIAENSRD VFIDSGGVRR VAELLLAKAA GPELRVEGWK 
        60         70         80         90        100
ALHELNPRAA DEAAVNWVFV TDTLNFSFWS EQDEHKCVVR YRGKTYSGYW 
       110        120        130        140        150
SLCAAVNRAL DEGIPITSAS YYATVTLDQV RNILRSDTDV SMPLVEERHR 
       160        170        180        190        200
ILNETGKILL EKFGGSFLNC VRESENSAQK LMHLVVESFP SYRDVTLFEG 
       210        220        230        240        250
KRVSFYKRAQ ILVADTWSVL EGKGDGCFKD ISSITMFADY RLPQVLAHLG 
       260        270        280        290        300
ALKYSDDLLK KLLKGEMLSY GDRQEVEIRG CSLWCVELIR DCLLELIEQK 
       310        320        330        340 
GEKPNGEINS ILLDYYLWDY AHDHREDMKG IPFHRIRCIY Y
Length:341
Mass (Da):39,029
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50AF5A7D7197D7B2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T6V7Q5T6V7_HUMAN
Queuosine salvage protein
C9orf64 hCG_2042994
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T6V6Q5T6V6_HUMAN
Queuosine salvage protein
C9orf64
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC03538 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti324H → Y in BAC03538 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL354733 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62673.1
BC137461 mRNA Translation: AAI37462.1
BC137462 mRNA Translation: AAI37463.1
BC004407 mRNA No translation available.
AK090882 mRNA Translation: BAC03538.1 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6666.2

NCBI Reference Sequences

More...RefSeqi		NP_001304926.1, NM_001317997.1
NP_115683.3, NM_032307.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000376344; ENSP00000365522; ENSG00000165118

Database of genes from NCBI RefSeq genomes

More...GeneIDi		84267

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:84267

UCSC genome browser

More...UCSCi		uc004anb.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL354733 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62673.1
BC137461 mRNA Translation: AAI37462.1
BC137462 mRNA Translation: AAI37463.1
BC004407 mRNA No translation available.
AK090882 mRNA Translation: BAC03538.1 Different initiation.
CCDSiCCDS6666.2
RefSeqiNP_001304926.1, NM_001317997.1
NP_115683.3, NM_032307.4

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi123994, 15 interactors
IntActiQ5T6V5, 6 interactors
STRINGi9606.ENSP00000365522

PTM databases

iPTMnetiQ5T6V5
PhosphoSitePlusiQ5T6V5

Polymorphism and mutation databases

BioMutaiC9orf64
DMDMi73620030

Proteomic databases

EPDiQ5T6V5
jPOSTiQ5T6V5
MassIVEiQ5T6V5
MaxQBiQ5T6V5
PaxDbiQ5T6V5
PeptideAtlasiQ5T6V5
PRIDEiQ5T6V5
ProteomicsDBi64614

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		84267

Genome annotation databases

EnsembliENST00000376344; ENSP00000365522; ENSG00000165118
GeneIDi84267
KEGGihsa:84267
UCSCiuc004anb.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84267
EuPathDBiHostDB:ENSG00000165118.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		C9orf64
HGNCiHGNC:28144 C9orf64
HPAiHPA054903
HPA066190
MIMi611342 gene
neXtProtiNX_Q5T6V5
OpenTargetsiENSG00000165118
PharmGKBiPA134865965

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2524 Eukaryota
ENOG410XRIA LUCA
GeneTreeiENSGT00390000002374
HOGENOMiHOG000010664
InParanoidiQ5T6V5
OMAiKITMFAD
OrthoDBi1356655at2759
PhylomeDBiQ5T6V5
TreeFamiTF105811

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		C9orf64 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		C9orf64

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		84267
PharosiQ5T6V5 Tdark

Protein Ontology

More...PROi		PR:Q5T6V5
RNActiQ5T6V5 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000165118 Expressed in 216 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ5T6V5 baseline and differential
GenevisibleiQ5T6V5 HS

Family and domain databases

InterProiView protein in InterPro
IPR019438 Q_salvage
PANTHERiPTHR21314 PTHR21314, 1 hit
PfamiView protein in Pfam
PF10343 Q_salvage, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQSPP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T6V5
Secondary accession number(s): B2RPI6, Q8N2B1, Q9BT18
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: December 21, 2004
Last modified: December 11, 2019
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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