UniProtKB - Q5T6V5 (QSPP_HUMAN)
Protein
Queuosine salvage protein
Gene
C9orf64
Organism
Homo sapiens (Human)
Status
Functioni
Involved in salvaging queuosine.1 Publication
GO - Biological processi
- tRNA-guanine transglycosylation Source: GO_Central
- tRNA modification Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q5T6V5 |
Names & Taxonomyi
Protein namesi | Recommended name: Queuosine salvage protein1 Publication |
Gene namesi | Name:C9orf64 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28144, C9orf64 |
MIMi | 611342, gene |
neXtProti | NX_Q5T6V5 |
VEuPathDBi | HostDB:ENSG00000165118.14 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 84267 |
OpenTargetsi | ENSG00000165118 |
PharmGKBi | PA134865965 |
Miscellaneous databases
Pharosi | Q5T6V5, Tdark |
Genetic variation databases
BioMutai | C9orf64 |
DMDMi | 73620030 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000089700 | 1 – 341 | Queuosine salvage proteinAdd BLAST | 341 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineCombined sources | 1 |
Keywords - PTMi
AcetylationProteomic databases
EPDi | Q5T6V5 |
jPOSTi | Q5T6V5 |
MassIVEi | Q5T6V5 |
MaxQBi | Q5T6V5 |
PaxDbi | Q5T6V5 |
PeptideAtlasi | Q5T6V5 |
PRIDEi | Q5T6V5 |
ProteomicsDBi | 64614 |
PTM databases
iPTMneti | Q5T6V5 |
PhosphoSitePlusi | Q5T6V5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000165118, Expressed in amniotic fluid and 231 other tissues |
ExpressionAtlasi | Q5T6V5, baseline and differential |
Genevisiblei | Q5T6V5, HS |
Organism-specific databases
HPAi | ENSG00000165118, Low tissue specificity |
Interactioni
Binary interactionsi
Q5T6V5
With | #Exp. | IntAct |
---|---|---|
MEOX2 [Q6FHY5] | 3 | EBI-14710764,EBI-16439278 |
Protein-protein interaction databases
BioGRIDi | 123994, 20 interactors |
IntActi | Q5T6V5, 6 interactors |
STRINGi | 9606.ENSP00000365522 |
Miscellaneous databases
RNActi | Q5T6V5, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the queuosine salvage protein family.Curated
Phylogenomic databases
eggNOGi | KOG2524, Eukaryota |
GeneTreei | ENSGT00390000002374 |
HOGENOMi | CLU_036001_2_1_1 |
InParanoidi | Q5T6V5 |
OMAi | KITMFAD |
OrthoDBi | 1356655at2759 |
PhylomeDBi | Q5T6V5 |
TreeFami | TF105811 |
Family and domain databases
InterProi | View protein in InterPro IPR019438, Q_salvage |
PANTHERi | PTHR21314, PTHR21314, 1 hit |
Pfami | View protein in Pfam PF10343, Q_salvage, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q5T6V5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDGLLNPRES SKFIAENSRD VFIDSGGVRR VAELLLAKAA GPELRVEGWK
60 70 80 90 100
ALHELNPRAA DEAAVNWVFV TDTLNFSFWS EQDEHKCVVR YRGKTYSGYW
110 120 130 140 150
SLCAAVNRAL DEGIPITSAS YYATVTLDQV RNILRSDTDV SMPLVEERHR
160 170 180 190 200
ILNETGKILL EKFGGSFLNC VRESENSAQK LMHLVVESFP SYRDVTLFEG
210 220 230 240 250
KRVSFYKRAQ ILVADTWSVL EGKGDGCFKD ISSITMFADY RLPQVLAHLG
260 270 280 290 300
ALKYSDDLLK KLLKGEMLSY GDRQEVEIRG CSLWCVELIR DCLLELIEQK
310 320 330 340
GEKPNGEINS ILLDYYLWDY AHDHREDMKG IPFHRIRCIY Y
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T6V7 | Q5T6V7_HUMAN | Queuosine salvage protein | C9orf64 hCG_2042994 | 200 | Annotation score: | ||
Q5T6V6 | Q5T6V6_HUMAN | Queuosine salvage protein | C9orf64 | 60 | Annotation score: |
Sequence cautioni
The sequence BAC03538 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 324 | H → Y in BAC03538 (PubMed:14702039).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL354733 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62673.1 BC137461 mRNA Translation: AAI37462.1 BC137462 mRNA Translation: AAI37463.1 BC004407 mRNA No translation available. AK090882 mRNA Translation: BAC03538.1 Different initiation. |
CCDSi | CCDS6666.2 |
RefSeqi | NP_001304926.1, NM_001317997.1 NP_115683.3, NM_032307.4 |
Genome annotation databases
Ensembli | ENST00000376344; ENSP00000365522; ENSG00000165118 |
GeneIDi | 84267 |
KEGGi | hsa:84267 |
UCSCi | uc004anb.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL354733 Genomic DNA No translation available. CH471089 Genomic DNA Translation: EAW62673.1 BC137461 mRNA Translation: AAI37462.1 BC137462 mRNA Translation: AAI37463.1 BC004407 mRNA No translation available. AK090882 mRNA Translation: BAC03538.1 Different initiation. |
CCDSi | CCDS6666.2 |
RefSeqi | NP_001304926.1, NM_001317997.1 NP_115683.3, NM_032307.4 |
3D structure databases
SMRi | Q5T6V5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123994, 20 interactors |
IntActi | Q5T6V5, 6 interactors |
STRINGi | 9606.ENSP00000365522 |
PTM databases
iPTMneti | Q5T6V5 |
PhosphoSitePlusi | Q5T6V5 |
Genetic variation databases
BioMutai | C9orf64 |
DMDMi | 73620030 |
Proteomic databases
EPDi | Q5T6V5 |
jPOSTi | Q5T6V5 |
MassIVEi | Q5T6V5 |
MaxQBi | Q5T6V5 |
PaxDbi | Q5T6V5 |
PeptideAtlasi | Q5T6V5 |
PRIDEi | Q5T6V5 |
ProteomicsDBi | 64614 |
Protocols and materials databases
Antibodypediai | 57741, 100 antibodies |
DNASUi | 84267 |
Genome annotation databases
Ensembli | ENST00000376344; ENSP00000365522; ENSG00000165118 |
GeneIDi | 84267 |
KEGGi | hsa:84267 |
UCSCi | uc004anb.4, human |
Organism-specific databases
CTDi | 84267 |
DisGeNETi | 84267 |
GeneCardsi | C9orf64 |
HGNCi | HGNC:28144, C9orf64 |
HPAi | ENSG00000165118, Low tissue specificity |
MIMi | 611342, gene |
neXtProti | NX_Q5T6V5 |
OpenTargetsi | ENSG00000165118 |
PharmGKBi | PA134865965 |
VEuPathDBi | HostDB:ENSG00000165118.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2524, Eukaryota |
GeneTreei | ENSGT00390000002374 |
HOGENOMi | CLU_036001_2_1_1 |
InParanoidi | Q5T6V5 |
OMAi | KITMFAD |
OrthoDBi | 1356655at2759 |
PhylomeDBi | Q5T6V5 |
TreeFami | TF105811 |
Enzyme and pathway databases
PathwayCommonsi | Q5T6V5 |
Miscellaneous databases
BioGRID-ORCSi | 84267, 5 hits in 873 CRISPR screens |
ChiTaRSi | C9orf64, human |
GeneWikii | C9orf64 |
GenomeRNAii | 84267 |
Pharosi | Q5T6V5, Tdark |
PROi | PR:Q5T6V5 |
RNActi | Q5T6V5, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000165118, Expressed in amniotic fluid and 231 other tissues |
ExpressionAtlasi | Q5T6V5, baseline and differential |
Genevisiblei | Q5T6V5, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019438, Q_salvage |
PANTHERi | PTHR21314, PTHR21314, 1 hit |
Pfami | View protein in Pfam PF10343, Q_salvage, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | QSPP_HUMAN | |
Accessioni | Q5T6V5Primary (citable) accession number: Q5T6V5 Secondary accession number(s): B2RPI6, Q8N2B1, Q9BT18 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 16, 2005 |
Last sequence update: | December 21, 2004 | |
Last modified: | February 10, 2021 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM