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Protein
Submitted name:

Steroidogenic factor 1

Gene

NR5A1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Steroidogenic factor 1Imported
Gene namesi
Name:NR5A1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136931.9
HGNCiHGNC:7983 NR5A1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000136931

PTM / Processingi

Proteomic databases

PeptideAtlasiQ5T6F7
PRIDEiQ5T6F7

Expressioni

Gene expression databases

BgeeiENSG00000136931 Expressed in 55 organ(s), highest expression level in right adrenal gland cortex
ExpressionAtlasiQ5T6F7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ5T6F7
SMRiQ5T6F7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 243NR LBDInterPro annotationAdd BLAST224

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.SAAS annotation

Phylogenomic databases

eggNOGiKOG4218 Eukaryota
ENOG410YWC2 LUCA
GeneTreeiENSGT00870000136388
HOGENOMiHOG000063718
HOVERGENiHBG106677

Family and domain databases

InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR016355 NR5_fam
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
PANTHERiPTHR24086 PTHR24086, 1 hit
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PRINTSiPR00398 STRDHORMONER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q5T6F7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VEEEGDVSNR GVELLQLEPD EDQVRARILG CLQEPTKSRP DQPAAFGLLC
60 70 80 90 100
RMADQTFISI VDWARRCMVF KELEVADQMT LLQNCWSELL VFDHIYRQVQ
110 120 130 140 150
HGKEGSILLV TGQEVELTTV ATQAGSLLHS LVLRAQELVL QLLALQLDRQ
160 170 180 190 200
EFVCLKFIIL FSLDLKFLNN HILVKDAQEK ANAALLDYTL CHYPHCGDKF
210 220 230 240
QQLLLCLVEV RALSMQAKEY LYHKHLGNEM PRNNLLIEML QAKQT
Length:245
Mass (Da):28,044
Last modified:December 21, 2004 - v1
Checksum:iFFF59DB89B687AC5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q13285STF1_HUMAN
Steroidogenic factor 1
NR5A1 AD4BP, FTZF1, SF1
461Annotation score:
F1DAM0F1DAM0_HUMAN
Steroidogenic factor 1 nuclear rece...
NR5A1
421Annotation score:
Q5T6F6Q5T6F6_HUMAN
Steroidogenic factor 1
NR5A1
177Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137846 Genomic DNA No translation available.
AL354979 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000373587; ENSP00000362689; ENSG00000136931
UCSCiuc064vqb.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137846 Genomic DNA No translation available.
AL354979 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliQ5T6F7
SMRiQ5T6F7
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ5T6F7
PRIDEiQ5T6F7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373587; ENSP00000362689; ENSG00000136931
UCSCiuc064vqb.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000136931.9
HGNCiHGNC:7983 NR5A1
OpenTargetsiENSG00000136931
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4218 Eukaryota
ENOG410YWC2 LUCA
GeneTreeiENSGT00870000136388
HOGENOMiHOG000063718
HOVERGENiHBG106677

Gene expression databases

BgeeiENSG00000136931 Expressed in 55 organ(s), highest expression level in right adrenal gland cortex
ExpressionAtlasiQ5T6F7 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR016355 NR5_fam
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
PANTHERiPTHR24086 PTHR24086, 1 hit
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PRINTSiPR00398 STRDHORMONER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ5T6F7_HUMAN
AccessioniPrimary (citable) accession number: Q5T6F7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 21, 2004
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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