UniProtKB - Q5T6F7 (Q5T6F7_HUMAN)

BLAST

>tr|Q5T6F7|Q5T6F7_HUMAN Steroidogenic factor 1 (Fragment) OS=Homo sapiens OX=9606 GN=NR5A1 PE=1 SV=1
VEEEGDVSNRGVELLQLEPDEDQVRARILGCLQEPTKSRPDQPAAFGLLCRMADQTFISI
VDWARRCMVFKELEVADQMTLLQNCWSELLVFDHIYRQVQHGKEGSILLVTGQEVELTTV
ATQAGSLLHSLVLRAQELVLQLLALQLDRQEFVCLKFIILFSLDLKFLNNHILVKDAQEK
ANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEML
QAKQT

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History
Entry version 112 (07 Nov 2018)
Sequence version 1 (21 Dec 2004)
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Protein

Submitted name:

Steroidogenic factor 1

Gene

NR5A1

Organism

Homo sapiens (Human)

Status

Unreviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: InterPro
steroid hormone receptor activity Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of transcription, DNA-templated Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	ReceptorSAAS annotation
Biological process	Transcription, Transcription regulationSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Steroidogenic factor 1Imported
Gene namesⁱ	Name:NR5A1Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136931.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:7983 NR5A1

Keywords - Cellular componentⁱ

NucleusSAAS annotation

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000136931

OpenTargetsⁱ

ENSG00000136931

PTM / Processingⁱ

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q5T6F7
PRIDEⁱ	Q5T6F7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000136931 Expressed in 55 organ(s), highest expression level in right adrenal gland cortex
ExpressionAtlasⁱ	Q5T6F7 baseline and differential

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5T6F7
SMRⁱ	Q5T6F7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	20 – 243	NR LBDInterPro annotationAdd BLAST		224

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family.SAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG4218 Eukaryota ENOG410YWC2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136388
HOGENOMⁱ	HOG000063718
HOVERGENⁱ	HBG106677

Family and domain databases

InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR016355 NR5_fam IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt
PANTHERⁱ	PTHR24086 PTHR24086, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q5T6F7-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
VEEEGDVSNR GVELLQLEPD EDQVRARILG CLQEPTKSRP DQPAAFGLLC 
        60         70         80         90        100
RMADQTFISI VDWARRCMVF KELEVADQMT LLQNCWSELL VFDHIYRQVQ 
       110        120        130        140        150
HGKEGSILLV TGQEVELTTV ATQAGSLLHS LVLRAQELVL QLLALQLDRQ 
       160        170        180        190        200
EFVCLKFIIL FSLDLKFLNN HILVKDAQEK ANAALLDYTL CHYPHCGDKF 
       210        220        230        240 
QQLLLCLVEV RALSMQAKEY LYHKHLGNEM PRNNLLIEML QAKQT

Length:245

Mass (Da):28,044

Last modified:December 21, 2004 - v1

Checksum:ⁱFFF59DB89B687AC5

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q13285	STF1_HUMAN	Steroidogenic factor 1 Steroidogenic factor 1, SF-1, STF-1, hSF-1 (Adrenal 4-binding protein) (Fushi tarazu factor homolog 1) (Nuclear receptor subfamily 5 group A member 1) (Steroid hormone receptor Ad4BP)	NR5A1 AD4BP, FTZF1, SF1	461	Annotation score:
F1DAM0	F1DAM0_HUMAN	Steroidogenic factor 1 nuclear rece... Steroidogenic factor 1 nuclear receptor	NR5A1	421	Annotation score:
Q5T6F6	Q5T6F6_HUMAN	Steroidogenic factor 1 Steroidogenic factor 1	NR5A1	177	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL137846 Genomic DNA No translation available. AL354979 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL137846 Genomic DNA No translation available.
AL354979 Genomic DNA No translation available.

Genome annotation databases

Ensemblⁱ	ENST00000373587; ENSP00000362689; ENSG00000136931
UCSC genome browser More...UCSCⁱ	uc064vqb.1 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5T6F7	Uncharacterized protein		MACMU		245	UniRef90_Q5T6F7
NR5A1 isoform 3 (Fragment)		PONAB		245
NR5A1 isoform 4 (Fragment)		PANTR		245

Protein	Similar proteins		Species	Score	Length	Source
Q5T6F7	NR5A1 isoform 3 (Fragment)		PONAB		245	UniRef50_Q5T6F7
NR5A1 isoform 4 (Fragment)		PANTR		245
Uncharacterized protein		MACMU		245
UPI0006D8E32B		LATCH		278
UPI0006B7B0DD		ZONAL		253
+17

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL137846 Genomic DNA No translation available. AL354979 Genomic DNA No translation available.

Select the link destinations:
EMBLⁱ
GenBankⁱ
DDBJⁱ

Links Updated

AL137846 Genomic DNA No translation available.
AL354979 Genomic DNA No translation available.

3D structure databases

ProteinModelPortalⁱ	Q5T6F7
SMRⁱ	Q5T6F7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlasⁱ	Q5T6F7
PRIDEⁱ	Q5T6F7

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000373587; ENSP00000362689; ENSG00000136931
UCSCⁱ	uc064vqb.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000136931.9
HGNCⁱ	HGNC:7983 NR5A1
OpenTargetsⁱ	ENSG00000136931
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4218 Eukaryota ENOG410YWC2 LUCA
GeneTreeⁱ	ENSGT00870000136388
HOGENOMⁱ	HOG000063718
HOVERGENⁱ	HBG106677

Gene expression databases

Bgeeⁱ	ENSG00000136931 Expressed in 55 organ(s), highest expression level in right adrenal gland cortex
ExpressionAtlasⁱ	Q5T6F7 baseline and differential

Family and domain databases

InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR016355 NR5_fam IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt
PANTHERⁱ	PTHR24086 PTHR24086, 1 hit
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q5T6F7_HUMAN
Accessionⁱ	Q5T6F7Primary (citable) accession number: Q5T6F7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 21, 2004
	Last sequence update:	December 21, 2004
	Last modified:	November 7, 2018
	This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q5T6F7 (Q5T6F7_HUMAN)

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Steroidogenic factor 1

NR5A1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ