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UniProtKB - Q5T6F2 (UBAP2_HUMAN)

Entry version 140 (07 Oct 2020)
Sequence version 1 (21 Dec 2004)
Previous versions | rss
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Protein

Ubiquitin-associated protein 2

Gene

UBAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5T6F2

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q5T6F2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-associated protein 2
Short name:
UBAP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UBAP2Imported
Synonyms:KIAA1491Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000137073.20

Human Gene Nomenclature Database

More...HGNCi		HGNC:14185, UBAP2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5T6F2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		55833

Open Targets

More...OpenTargetsi		ENSG00000137073

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38379

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5T6F2, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		UBAP2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74745207

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002709811 – 1119Ubiquitin-associated protein 2Add BLAST1119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei166Omega-N-methylarginineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei630PhosphoserineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5T6F2

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5T6F2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5T6F2

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5T6F2

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5T6F2

PeptideAtlas

More...PeptideAtlasi		Q5T6F2

PRoteomics IDEntifications database

More...PRIDEi		Q5T6F2

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		63305
64579 [Q5T6F2-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q5T6F2, 4 sites, 1 O-linked glycan (4 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5T6F2

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q5T6F2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5T6F2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137073, Expressed in sperm and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5T6F2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5T6F2, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000137073, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q5T6F2
With#Exp.IntAct
ASB13 - isoform 2 [Q8WXK3-2]3EBI-2514383,EBI-12015080
ATPAF2 [Q8N5M1]3EBI-2514383,EBI-1166928
BANP - isoform 2 [Q8N9N5-2]3EBI-2514383,EBI-11524452
C10orf55 [Q5SWW7]3EBI-2514383,EBI-12809220
CREM - isoform 22 [Q03060-25]3EBI-2514383,EBI-12884642
DAZAP2 [Q15038]3EBI-2514383,EBI-724310
EFHC1 [Q5JVL4]3EBI-2514383,EBI-743105
FAM168B - isoform 2 [A1KXE4-2]3EBI-2514383,EBI-12193763
FNDC3B - isoform 3 [Q53EP0-3]3EBI-2514383,EBI-10242151
FOXH1 [O75593]3EBI-2514383,EBI-1759806
HGS [O14964]3EBI-2514383,EBI-740220
IGFN1 - isoform 5 [Q86VF2-5]3EBI-2514383,EBI-11955401
ISX [Q2M1V0]3EBI-2514383,EBI-6426064
JMJD7 [P0C870]3EBI-2514383,EBI-9090173
KANK2 [Q63ZY3]3EBI-2514383,EBI-2556193
KRTAP15-1 [Q3LI76]3EBI-2514383,EBI-11992140
LCK - isoform 3 [P06239-3]3EBI-2514383,EBI-13287659
NOXA1 - isoform 2 [Q86UR1-2]3EBI-2514383,EBI-12025760
NPAS2 [Q99743]3EBI-2514383,EBI-3932727
NUTF2 [P61970]3EBI-2514383,EBI-591778
OTX1 [P32242]3EBI-2514383,EBI-740446
PLEKHB2 [Q96CS7]3EBI-2514383,EBI-373552
PPP2CA [P67775]3EBI-2514383,EBI-712311
PRSS53 [Q2L4Q9]3EBI-2514383,EBI-18393698
PSMB8 - isoform 2 [P28062-2]3EBI-2514383,EBI-372312
RBPMS - isoform C [Q93062-3]3EBI-2514383,EBI-740343
RHOXF2 [Q9BQY4]3EBI-2514383,EBI-372094
SHC3 [Q92529]3EBI-2514383,EBI-79084
SPAG8 - isoform 2 [Q99932-2]3EBI-2514383,EBI-11959123
TENT5B [Q96A09]3EBI-2514383,EBI-752030
TEP1 [Q99973]3EBI-2514383,EBI-947859
TEX37 [Q96LM6]3EBI-2514383,EBI-743976
TFG [Q92734]3EBI-2514383,EBI-357061
TLE5 - isoform 2 [Q08117-2]3EBI-2514383,EBI-11741437
TP53BP1 [Q12888]3EBI-2514383,EBI-396540
TRAPPC6A - isoform 2 [O75865-2]3EBI-2514383,EBI-8451480
VENTX [O95231]3EBI-2514383,EBI-10191303
VPS37C [A5D8V6]3EBI-2514383,EBI-2559305
WRAP53 [Q9BUR4]3EBI-2514383,EBI-2563542
Q96EJ43EBI-2514383,EBI-750454

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120938, 89 interactors

Protein interaction database and analysis system

More...IntActi		Q5T6F2, 50 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000368540

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5T6F2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5T6F2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 92UBASequence analysisAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili105 – 130Sequence analysisAdd BLAST26

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPRH, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003453

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_009850_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5T6F2

Identification of Orthologs from Complete Genome Data

More...OMAi		EYSKGYN

Database of Orthologous Groups

More...OrthoDBi		234795at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5T6F2

TreeFam database of animal gene trees

More...TreeFami		TF328468

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015940, UBA
IPR009060, UBA-like_sf
IPR022166, UBAP2/Lig

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12478, DUF3697, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00165, UBA, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46934, SSF46934, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T6F2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMTSVSSDHC RGAREKPQIS AAQSTQPQKQ VVQATAEQMR LAQVIFDKND 
        60         70         80         90        100
SDFEAKVKQL MEVTGKNQDE CIVALHDCNG DVNKAINILL EGNSDTTSWE 
       110        120        130        140        150
TVGCKKKNFA KENSENKENR EKKSEKESSR GRGNNNRKGR GGNRGREFRG 
       160        170        180        190        200
EENGIDCNQV DKPSDRGKRA RGRGFGRGRG RGAGRFSTQG MGTFNPADYS 
       210        220        230        240        250
DSTSTDVCGT KLVVWEAAQN GADEGTELAS NTHNIAQDLS NKSSYGLKGA 
       260        270        280        290        300
WKNSVEEWTT EDWTEDLSET KVFTASSAPA ENHILPGQSI DLVALLQKPV 
       310        320        330        340        350
PHSQASEANS FETSQQQGFG QALVFTNSQH NNQMAPGTGS STAVNSCSPQ 
       360        370        380        390        400
SLSSVLGSGF GELAPPKMAN ITSSQILDQL KAPSLGQFTT TPSTQQNSTS 
       410        420        430        440        450
HPTTTTSWDL KPPTSQSSVL SHLDFKSQPE PSPVLSQLSQ RQQHQSQAVT 
       460        470        480        490        500
VPPPGLESFP SQAKLRESTP GDSPSTVNKL LQLPSTTIEN ISVSVHQPQP 
       510        520        530        540        550
KHIKLAKRRI PPASKIPASA VEMPGSADVT GLNVQFGALE FGSEPSLSEF 
       560        570        580        590        600
GSAPSSENSN QIPISLYSKS LSEPLNTSLS MTSAVQNSTY TTSVITSCSL 
       610        620        630        640        650
TSSSLNSASP VAMSSSYDQS SVHNRIPYQS PVSSSESAPG TIMNGHGGGR 
       660        670        680        690        700
SQQTLDTPKT TGPPSALPSV SSLPSTTSCT ALLPSTSQHT GDLTSSPLSQ 
       710        720        730        740        750
LSSSLSSHQS SLSAHAALSS STSHTHASVE SASSHQSSAT FSTAATSVSS 
       760        770        780        790        800
SASSGASLSS SMNTANSLCL GGTPASASSS SSRAAPLVTS GKAPPNLPQG 
       810        820        830        840        850
VPPLLHNQYL VGPGGLLPAY PIYGYDELQM LQSRLPVDYY GIPFAAPTAL 
       860        870        880        890        900
ASRDGSLANN PYPGDVTKFG RGDSASPAPA TTPAQPQQSQ SQTHHTAQQP 
       910        920        930        940        950
FVNPALPPGY SYTGLPYYTG MPSAFQYGPT MFVPPASAKQ HGVNLSTPTP 
       960        970        980        990       1000
PFQQASGYGQ HGYSTGYDDL TQGTAAGDYS KGGYAGSSQA PNKSAGSGPG 
      1010       1020       1030       1040       1050
KGVSVSSSTT GLPDMTGSVY NKTQTFDKQG FHAGTPPPFS LPSVLGSTGP 
      1060       1070       1080       1090       1100
LASGAAPGYA PPPFLHILPA HQQPHSQLLH HHLPQDAQSG SGQRSQPSSL 
      1110 
QPKSQASKPA YGNSPYWTN
Length:1,119
Mass (Da):117,116
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75E7DC542258F82E
GO
Isoform 2 (identifier: Q5T6F2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-761: Missing.

Show »
Length:358
Mass (Da):36,918
Checksum:i35D33F34C925339C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A305A2A305_HUMAN
Ubiquitin-associated protein 2
UBAP2
412Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5JV08Q5JV08_HUMAN
Ubiquitin-associated protein 2
UBAP2
278Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDN2H0YDN2_HUMAN
Ubiquitin-associated protein 2
UBAP2
117Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SFI5A0A0D9SFI5_HUMAN
Ubiquitin-associated protein 2
UBAP2
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI11763 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11266 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05267714R → Q. Corresponds to variant dbSNP:rs1785506Ensembl.1
Natural variantiVAR_052678429P → L. Corresponds to variant dbSNP:rs10971809Ensembl.1
Natural variantiVAR_029834606N → S1 PublicationCorresponds to variant dbSNP:rs307658Ensembl.1
Natural variantiVAR_029835756A → V2 PublicationsCorresponds to variant dbSNP:rs307692Ensembl.1
Natural variantiVAR_052679762M → I. Corresponds to variant dbSNP:rs16935295EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0560731 – 761Missing in isoform 2. 1 PublicationAdd BLAST761

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK074884 mRNA Translation: BAC11266.1 Different initiation.
AK125935 mRNA Translation: BAG54267.1
AL139113 Genomic DNA No translation available.
AL354989 Genomic DNA No translation available.
BC007890 mRNA Translation: AAH07890.1
BC111762 mRNA Translation: AAI11763.1 Different initiation.
AB040924 mRNA Translation: BAA96015.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6547.1 [Q5T6F2-1]
CCDS75828.1 [Q5T6F2-2]

NCBI Reference Sequences

More...RefSeqi		NP_001269458.1, NM_001282529.1
NP_001269459.1, NM_001282530.1 [Q5T6F2-2]
NP_060919.3, NM_018449.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000360802; ENSP00000354039; ENSG00000137073 [Q5T6F2-1]
ENST00000379238; ENSP00000368540; ENSG00000137073 [Q5T6F2-1]
ENST00000379239; ENSP00000368541; ENSG00000137073 [Q5T6F2-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55833

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55833

UCSC genome browser

More...UCSCi		uc003zto.2, human [Q5T6F2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074884 mRNA Translation: BAC11266.1 Different initiation.
AK125935 mRNA Translation: BAG54267.1
AL139113 Genomic DNA No translation available.
AL354989 Genomic DNA No translation available.
BC007890 mRNA Translation: AAH07890.1
BC111762 mRNA Translation: AAI11763.1 Different initiation.
AB040924 mRNA Translation: BAA96015.1
CCDSiCCDS6547.1 [Q5T6F2-1]
CCDS75828.1 [Q5T6F2-2]
RefSeqiNP_001269458.1, NM_001282529.1
NP_001269459.1, NM_001282530.1 [Q5T6F2-2]
NP_060919.3, NM_018449.3

3D structure databases

SMRiQ5T6F2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi120938, 89 interactors
IntActiQ5T6F2, 50 interactors
STRINGi9606.ENSP00000368540

PTM databases

GlyGeniQ5T6F2, 4 sites, 1 O-linked glycan (4 sites)
iPTMnetiQ5T6F2
MetOSiteiQ5T6F2
PhosphoSitePlusiQ5T6F2

Polymorphism and mutation databases

BioMutaiUBAP2
DMDMi74745207

Proteomic databases

EPDiQ5T6F2
jPOSTiQ5T6F2
MassIVEiQ5T6F2
MaxQBiQ5T6F2
PaxDbiQ5T6F2
PeptideAtlasiQ5T6F2
PRIDEiQ5T6F2
ProteomicsDBi63305
64579 [Q5T6F2-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		11067, 68 antibodies

Genome annotation databases

EnsembliENST00000360802; ENSP00000354039; ENSG00000137073 [Q5T6F2-1]
ENST00000379238; ENSP00000368540; ENSG00000137073 [Q5T6F2-1]
ENST00000379239; ENSP00000368541; ENSG00000137073 [Q5T6F2-2]
GeneIDi55833
KEGGihsa:55833
UCSCiuc003zto.2, human [Q5T6F2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55833
DisGeNETi55833
EuPathDBiHostDB:ENSG00000137073.20

GeneCards: human genes, protein and diseases

More...GeneCardsi		UBAP2
HGNCiHGNC:14185, UBAP2
HPAiENSG00000137073, Low tissue specificity
neXtProtiNX_Q5T6F2
OpenTargetsiENSG00000137073
PharmGKBiPA38379

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QPRH, Eukaryota
GeneTreeiENSGT00390000003453
HOGENOMiCLU_009850_0_0_1
InParanoidiQ5T6F2
OMAiEYSKGYN
OrthoDBi234795at2759
PhylomeDBiQ5T6F2
TreeFamiTF328468

Enzyme and pathway databases

PathwayCommonsiQ5T6F2
SIGNORiQ5T6F2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55833, 4 hits in 871 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		UBAP2, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		UBAP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55833
PharosiQ5T6F2, Tbio

Protein Ontology

More...PROi		PR:Q5T6F2
RNActiQ5T6F2, protein

Gene expression databases

BgeeiENSG00000137073, Expressed in sperm and 244 other tissues
ExpressionAtlasiQ5T6F2, baseline and differential
GenevisibleiQ5T6F2, HS

Family and domain databases

InterProiView protein in InterPro
IPR015940, UBA
IPR009060, UBA-like_sf
IPR022166, UBAP2/Lig
PfamiView protein in Pfam
PF12478, DUF3697, 1 hit
SMARTiView protein in SMART
SM00165, UBA, 1 hit
SUPFAMiSSF46934, SSF46934, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUBAP2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T6F2
Secondary accession number(s): Q2M2R4
, Q5JV03, Q6PK34, Q8NC94, Q9P237
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 21, 2004
Last modified: October 7, 2020
This is version 140 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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