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Protein

Ubiquitin-associated protein 2

Gene

UBAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-associated protein 2
Short name:
UBAP-2
Gene namesi
Name:UBAP2Imported
Synonyms:KIAA1491Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000137073.20
HGNCiHGNC:14185 UBAP2
neXtProtiNX_Q5T6F2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi55833
OpenTargetsiENSG00000137073
PharmGKBiPA38379

Polymorphism and mutation databases

DMDMi74745207

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002709811 – 1119Ubiquitin-associated protein 2Add BLAST1119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei166Omega-N-methylarginineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei439PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei630PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ5T6F2
MaxQBiQ5T6F2
PaxDbiQ5T6F2
PeptideAtlasiQ5T6F2
PRIDEiQ5T6F2
ProteomicsDBi64579

PTM databases

iPTMnetiQ5T6F2
PhosphoSitePlusiQ5T6F2

Expressioni

Gene expression databases

BgeeiENSG00000137073 Expressed in 235 organ(s), highest expression level in sperm
CleanExiHS_UBAP2
ExpressionAtlasiQ5T6F2 baseline and differential
GenevisibleiQ5T6F2 HS

Organism-specific databases

HPAiHPA021684

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi120938, 37 interactors
IntActiQ5T6F2, 45 interactors
STRINGi9606.ENSP00000354039

Structurei

3D structure databases

ProteinModelPortaliQ5T6F2
SMRiQ5T6F2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 92UBASequence analysisAdd BLAST45

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili105 – 130Sequence analysisAdd BLAST26

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGWX Eukaryota
ENOG4110RI8 LUCA
GeneTreeiENSGT00390000003453
HOGENOMiHOG000231679
HOVERGENiHBG058387
InParanoidiQ5T6F2
OMAiTKLVVWE
OrthoDBiEOG091G0GRY
PhylomeDBiQ5T6F2
TreeFamiTF328468

Family and domain databases

InterProiView protein in InterPro
IPR022166 DUF3697_Uba2
IPR015940 UBA
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF12478 DUF3697, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T6F2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMTSVSSDHC RGAREKPQIS AAQSTQPQKQ VVQATAEQMR LAQVIFDKND
60 70 80 90 100
SDFEAKVKQL MEVTGKNQDE CIVALHDCNG DVNKAINILL EGNSDTTSWE
110 120 130 140 150
TVGCKKKNFA KENSENKENR EKKSEKESSR GRGNNNRKGR GGNRGREFRG
160 170 180 190 200
EENGIDCNQV DKPSDRGKRA RGRGFGRGRG RGAGRFSTQG MGTFNPADYS
210 220 230 240 250
DSTSTDVCGT KLVVWEAAQN GADEGTELAS NTHNIAQDLS NKSSYGLKGA
260 270 280 290 300
WKNSVEEWTT EDWTEDLSET KVFTASSAPA ENHILPGQSI DLVALLQKPV
310 320 330 340 350
PHSQASEANS FETSQQQGFG QALVFTNSQH NNQMAPGTGS STAVNSCSPQ
360 370 380 390 400
SLSSVLGSGF GELAPPKMAN ITSSQILDQL KAPSLGQFTT TPSTQQNSTS
410 420 430 440 450
HPTTTTSWDL KPPTSQSSVL SHLDFKSQPE PSPVLSQLSQ RQQHQSQAVT
460 470 480 490 500
VPPPGLESFP SQAKLRESTP GDSPSTVNKL LQLPSTTIEN ISVSVHQPQP
510 520 530 540 550
KHIKLAKRRI PPASKIPASA VEMPGSADVT GLNVQFGALE FGSEPSLSEF
560 570 580 590 600
GSAPSSENSN QIPISLYSKS LSEPLNTSLS MTSAVQNSTY TTSVITSCSL
610 620 630 640 650
TSSSLNSASP VAMSSSYDQS SVHNRIPYQS PVSSSESAPG TIMNGHGGGR
660 670 680 690 700
SQQTLDTPKT TGPPSALPSV SSLPSTTSCT ALLPSTSQHT GDLTSSPLSQ
710 720 730 740 750
LSSSLSSHQS SLSAHAALSS STSHTHASVE SASSHQSSAT FSTAATSVSS
760 770 780 790 800
SASSGASLSS SMNTANSLCL GGTPASASSS SSRAAPLVTS GKAPPNLPQG
810 820 830 840 850
VPPLLHNQYL VGPGGLLPAY PIYGYDELQM LQSRLPVDYY GIPFAAPTAL
860 870 880 890 900
ASRDGSLANN PYPGDVTKFG RGDSASPAPA TTPAQPQQSQ SQTHHTAQQP
910 920 930 940 950
FVNPALPPGY SYTGLPYYTG MPSAFQYGPT MFVPPASAKQ HGVNLSTPTP
960 970 980 990 1000
PFQQASGYGQ HGYSTGYDDL TQGTAAGDYS KGGYAGSSQA PNKSAGSGPG
1010 1020 1030 1040 1050
KGVSVSSSTT GLPDMTGSVY NKTQTFDKQG FHAGTPPPFS LPSVLGSTGP
1060 1070 1080 1090 1100
LASGAAPGYA PPPFLHILPA HQQPHSQLLH HHLPQDAQSG SGQRSQPSSL
1110
QPKSQASKPA YGNSPYWTN
Length:1,119
Mass (Da):117,116
Last modified:December 21, 2004 - v1
Checksum:i75E7DC542258F82E
GO
Isoform 2 (identifier: Q5T6F2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-761: Missing.

Note: No experimental confirmation available.
Show »
Length:358
Mass (Da):36,918
Checksum:i35D33F34C925339C
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2A305A2A305_HUMAN
Ubiquitin-associated protein 2
UBAP2
412Annotation score:
A0A0D9SFI5A0A0D9SFI5_HUMAN
Ubiquitin-associated protein 2
UBAP2
176Annotation score:
H0YDN2H0YDN2_HUMAN
Ubiquitin-associated protein 2
UBAP2
117Annotation score:
Q5JV08Q5JV08_HUMAN
Ubiquitin-associated protein 2
UBAP2
278Annotation score:

Sequence cautioni

The sequence AAI11763 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11266 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05267714R → Q. Corresponds to variant dbSNP:rs1785506Ensembl.1
Natural variantiVAR_052678429P → L. Corresponds to variant dbSNP:rs10971809Ensembl.1
Natural variantiVAR_029834606N → S1 PublicationCorresponds to variant dbSNP:rs307658Ensembl.1
Natural variantiVAR_029835756A → V2 PublicationsCorresponds to variant dbSNP:rs307692Ensembl.1
Natural variantiVAR_052679762M → I. Corresponds to variant dbSNP:rs16935295Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0560731 – 761Missing in isoform 2. 1 PublicationAdd BLAST761

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074884 mRNA Translation: BAC11266.1 Different initiation.
AK125935 mRNA Translation: BAG54267.1
AL139113 Genomic DNA No translation available.
AL354989 Genomic DNA No translation available.
BC007890 mRNA Translation: AAH07890.1
BC111762 mRNA Translation: AAI11763.1 Different initiation.
AB040924 mRNA Translation: BAA96015.1
CCDSiCCDS6547.1 [Q5T6F2-1]
CCDS75828.1 [Q5T6F2-2]
RefSeqiNP_001269458.1, NM_001282529.1
NP_001269459.1, NM_001282530.1 [Q5T6F2-2]
NP_060919.3, NM_018449.3
UniGeneiHs.493739

Genome annotation databases

EnsembliENST00000360802; ENSP00000354039; ENSG00000137073 [Q5T6F2-1]
ENST00000379238; ENSP00000368540; ENSG00000137073 [Q5T6F2-1]
ENST00000379239; ENSP00000368541; ENSG00000137073 [Q5T6F2-2]
GeneIDi55833
KEGGihsa:55833
UCSCiuc003zto.2 human [Q5T6F2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074884 mRNA Translation: BAC11266.1 Different initiation.
AK125935 mRNA Translation: BAG54267.1
AL139113 Genomic DNA No translation available.
AL354989 Genomic DNA No translation available.
BC007890 mRNA Translation: AAH07890.1
BC111762 mRNA Translation: AAI11763.1 Different initiation.
AB040924 mRNA Translation: BAA96015.1
CCDSiCCDS6547.1 [Q5T6F2-1]
CCDS75828.1 [Q5T6F2-2]
RefSeqiNP_001269458.1, NM_001282529.1
NP_001269459.1, NM_001282530.1 [Q5T6F2-2]
NP_060919.3, NM_018449.3
UniGeneiHs.493739

3D structure databases

ProteinModelPortaliQ5T6F2
SMRiQ5T6F2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120938, 37 interactors
IntActiQ5T6F2, 45 interactors
STRINGi9606.ENSP00000354039

PTM databases

iPTMnetiQ5T6F2
PhosphoSitePlusiQ5T6F2

Polymorphism and mutation databases

DMDMi74745207

Proteomic databases

EPDiQ5T6F2
MaxQBiQ5T6F2
PaxDbiQ5T6F2
PeptideAtlasiQ5T6F2
PRIDEiQ5T6F2
ProteomicsDBi64579

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000360802; ENSP00000354039; ENSG00000137073 [Q5T6F2-1]
ENST00000379238; ENSP00000368540; ENSG00000137073 [Q5T6F2-1]
ENST00000379239; ENSP00000368541; ENSG00000137073 [Q5T6F2-2]
GeneIDi55833
KEGGihsa:55833
UCSCiuc003zto.2 human [Q5T6F2-1]

Organism-specific databases

CTDi55833
DisGeNETi55833
EuPathDBiHostDB:ENSG00000137073.20
GeneCardsiUBAP2
H-InvDBiHIX0007986
HGNCiHGNC:14185 UBAP2
HPAiHPA021684
neXtProtiNX_Q5T6F2
OpenTargetsiENSG00000137073
PharmGKBiPA38379
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGWX Eukaryota
ENOG4110RI8 LUCA
GeneTreeiENSGT00390000003453
HOGENOMiHOG000231679
HOVERGENiHBG058387
InParanoidiQ5T6F2
OMAiTKLVVWE
OrthoDBiEOG091G0GRY
PhylomeDBiQ5T6F2
TreeFamiTF328468

Miscellaneous databases

ChiTaRSiUBAP2 human
GeneWikiiUBAP2
GenomeRNAii55833
PROiPR:Q5T6F2

Gene expression databases

BgeeiENSG00000137073 Expressed in 235 organ(s), highest expression level in sperm
CleanExiHS_UBAP2
ExpressionAtlasiQ5T6F2 baseline and differential
GenevisibleiQ5T6F2 HS

Family and domain databases

InterProiView protein in InterPro
IPR022166 DUF3697_Uba2
IPR015940 UBA
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF12478 DUF3697, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBAP2_HUMAN
AccessioniPrimary (citable) accession number: Q5T6F2
Secondary accession number(s): Q2M2R4
, Q5JV03, Q6PK34, Q8NC94, Q9P237
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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