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UniProtKB - Q5T6F2 (UBAP2_HUMAN)
Protein
Ubiquitin-associated protein 2
Gene
UBAP2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
- RNA binding Source: UniProtKB
GO - Biological processi
- regulation of gene expression Source: FlyBase
Enzyme and pathway databases
PathwayCommonsi | Q5T6F2 |
SignaLinki | Q5T6F2 |
SIGNORi | Q5T6F2 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin-associated protein 2Short name: UBAP-2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14185, UBAP2 |
neXtProti | NX_Q5T6F2 |
VEuPathDBi | HostDB:ENSG00000137073 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 55833 |
OpenTargetsi | ENSG00000137073 |
PharmGKBi | PA38379 |
Miscellaneous databases
Pharosi | Q5T6F2, Tbio |
Genetic variation databases
BioMutai | UBAP2 |
DMDMi | 74745207 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000270981 | 1 – 1119 | Ubiquitin-associated protein 2Add BLAST | 1119 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 166 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 432 | PhosphoserineCombined sources | 1 | |
Modified residuei | 439 | PhosphoserineCombined sources | 1 | |
Modified residuei | 473 | PhosphoserineCombined sources | 1 | |
Modified residuei | 630 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
EPDi | Q5T6F2 |
jPOSTi | Q5T6F2 |
MassIVEi | Q5T6F2 |
MaxQBi | Q5T6F2 |
PaxDbi | Q5T6F2 |
PeptideAtlasi | Q5T6F2 |
PRIDEi | Q5T6F2 |
ProteomicsDBi | 63305 64579 [Q5T6F2-1] |
PTM databases
GlyGeni | Q5T6F2, 36 sites, 2 O-linked glycans (36 sites) |
iPTMneti | Q5T6F2 |
MetOSitei | Q5T6F2 |
PhosphoSitePlusi | Q5T6F2 |
Expressioni
Gene expression databases
Bgeei | ENSG00000137073, Expressed in sperm and 245 other tissues |
ExpressionAtlasi | Q5T6F2, baseline and differential |
Genevisiblei | Q5T6F2, HS |
Organism-specific databases
HPAi | ENSG00000137073, Low tissue specificity |
Interactioni
Binary interactionsi
Q5T6F2
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 120938, 130 interactors |
IntActi | Q5T6F2, 54 interactors |
MINTi | Q5T6F2 |
STRINGi | 9606.ENSP00000368540 |
Miscellaneous databases
RNActi | Q5T6F2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 92 | UBASequence analysisAdd BLAST | 45 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 26 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 110 – 202 | DisorderedSequence analysisAdd BLAST | 93 | |
Regioni | 385 – 476 | DisorderedSequence analysisAdd BLAST | 92 | |
Regioni | 622 – 736 | DisorderedSequence analysisAdd BLAST | 115 | |
Regioni | 853 – 905 | DisorderedSequence analysisAdd BLAST | 53 | |
Regioni | 937 – 966 | DisorderedSequence analysisAdd BLAST | 30 | |
Regioni | 982 – 1020 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 1082 – 1119 | DisorderedSequence analysisAdd BLAST | 38 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 105 – 130 | Sequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 110 – 171 | Basic and acidic residuesSequence analysisAdd BLAST | 62 | |
Compositional biasi | 188 – 202 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 385 – 452 | Polar residuesSequence analysisAdd BLAST | 68 | |
Compositional biasi | 462 – 476 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 878 – 900 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 940 – 966 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 985 – 1020 | Polar residuesSequence analysisAdd BLAST | 36 |
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | ENOG502QPRH, Eukaryota |
GeneTreei | ENSGT00390000003453 |
HOGENOMi | CLU_009850_0_0_1 |
InParanoidi | Q5T6F2 |
OMAi | PSQAKHR |
OrthoDBi | 234795at2759 |
PhylomeDBi | Q5T6F2 |
TreeFami | TF328468 |
Family and domain databases
InterProi | View protein in InterPro IPR015940, UBA IPR009060, UBA-like_sf IPR022166, UBAP2/Lig |
Pfami | View protein in Pfam PF12478, DUF3697, 1 hit |
SMARTi | View protein in SMART SM00165, UBA, 1 hit |
SUPFAMi | SSF46934, SSF46934, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5T6F2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMTSVSSDHC RGAREKPQIS AAQSTQPQKQ VVQATAEQMR LAQVIFDKND
60 70 80 90 100
SDFEAKVKQL MEVTGKNQDE CIVALHDCNG DVNKAINILL EGNSDTTSWE
110 120 130 140 150
TVGCKKKNFA KENSENKENR EKKSEKESSR GRGNNNRKGR GGNRGREFRG
160 170 180 190 200
EENGIDCNQV DKPSDRGKRA RGRGFGRGRG RGAGRFSTQG MGTFNPADYS
210 220 230 240 250
DSTSTDVCGT KLVVWEAAQN GADEGTELAS NTHNIAQDLS NKSSYGLKGA
260 270 280 290 300
WKNSVEEWTT EDWTEDLSET KVFTASSAPA ENHILPGQSI DLVALLQKPV
310 320 330 340 350
PHSQASEANS FETSQQQGFG QALVFTNSQH NNQMAPGTGS STAVNSCSPQ
360 370 380 390 400
SLSSVLGSGF GELAPPKMAN ITSSQILDQL KAPSLGQFTT TPSTQQNSTS
410 420 430 440 450
HPTTTTSWDL KPPTSQSSVL SHLDFKSQPE PSPVLSQLSQ RQQHQSQAVT
460 470 480 490 500
VPPPGLESFP SQAKLRESTP GDSPSTVNKL LQLPSTTIEN ISVSVHQPQP
510 520 530 540 550
KHIKLAKRRI PPASKIPASA VEMPGSADVT GLNVQFGALE FGSEPSLSEF
560 570 580 590 600
GSAPSSENSN QIPISLYSKS LSEPLNTSLS MTSAVQNSTY TTSVITSCSL
610 620 630 640 650
TSSSLNSASP VAMSSSYDQS SVHNRIPYQS PVSSSESAPG TIMNGHGGGR
660 670 680 690 700
SQQTLDTPKT TGPPSALPSV SSLPSTTSCT ALLPSTSQHT GDLTSSPLSQ
710 720 730 740 750
LSSSLSSHQS SLSAHAALSS STSHTHASVE SASSHQSSAT FSTAATSVSS
760 770 780 790 800
SASSGASLSS SMNTANSLCL GGTPASASSS SSRAAPLVTS GKAPPNLPQG
810 820 830 840 850
VPPLLHNQYL VGPGGLLPAY PIYGYDELQM LQSRLPVDYY GIPFAAPTAL
860 870 880 890 900
ASRDGSLANN PYPGDVTKFG RGDSASPAPA TTPAQPQQSQ SQTHHTAQQP
910 920 930 940 950
FVNPALPPGY SYTGLPYYTG MPSAFQYGPT MFVPPASAKQ HGVNLSTPTP
960 970 980 990 1000
PFQQASGYGQ HGYSTGYDDL TQGTAAGDYS KGGYAGSSQA PNKSAGSGPG
1010 1020 1030 1040 1050
KGVSVSSSTT GLPDMTGSVY NKTQTFDKQG FHAGTPPPFS LPSVLGSTGP
1060 1070 1080 1090 1100
LASGAAPGYA PPPFLHILPA HQQPHSQLLH HHLPQDAQSG SGQRSQPSSL
1110
QPKSQASKPA YGNSPYWTN
Computationally mapped potential isoform sequencesi
There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA2A305 | A2A305_HUMAN | Ubiquitin-associated protein 2 | UBAP2 | 70 | Annotation score: | ||
Q5JV08 | Q5JV08_HUMAN | Ubiquitin-associated protein 2 | UBAP2 | 278 | Annotation score: | ||
A0A0D9SFI5 | A0A0D9SFI5_HUMAN | Ubiquitin-associated protein 2 | UBAP2 | 176 | Annotation score: | ||
H0YDN2 | H0YDN2_HUMAN | Ubiquitin-associated protein 2 | UBAP2 | 117 | Annotation score: | ||
A0A804HIK1 | A0A804HIK1_HUMAN | Ubiquitin-associated protein 2 | UBAP2 | 214 | Annotation score: | ||
A0A804HLJ4 | A0A804HLJ4_HUMAN | Ubiquitin-associated protein 2 | UBAP2 | 271 | Annotation score: | ||
A0A804HLD2 | A0A804HLD2_HUMAN | Ubiquitin-associated protein 2 | UBAP2 | 60 | Annotation score: | ||
A0A8C8KGQ8 | A0A8C8KGQ8_HUMAN | Ubiquitin-associated protein 2 | UBAP2 | 1,072 | Annotation score: | ||
A0A8C8MQ70 | A0A8C8MQ70_HUMAN | Ubiquitin-associated protein 2 | UBAP2 | 1,066 | Annotation score: | ||
A0A804HIV8 | A0A804HIV8_HUMAN | Ubiquitin-associated protein 2 | UBAP2 | 84 | Annotation score: | ||
There is more potential isoformShow all |
Sequence cautioni
The sequence AAI11763 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC11266 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052677 | 14 | R → Q. Corresponds to variant dbSNP:rs1785506Ensembl. | 1 | |
Natural variantiVAR_052678 | 429 | P → L. Corresponds to variant dbSNP:rs10971809Ensembl. | 1 | |
Natural variantiVAR_029834 | 606 | N → S1 PublicationCorresponds to variant dbSNP:rs307658Ensembl. | 1 | |
Natural variantiVAR_029835 | 756 | A → V2 PublicationsCorresponds to variant dbSNP:rs307692Ensembl. | 1 | |
Natural variantiVAR_052679 | 762 | M → I. Corresponds to variant dbSNP:rs16935295EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056073 | 1 – 761 | Missing in isoform 2. 1 PublicationAdd BLAST | 761 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074884 mRNA Translation: BAC11266.1 Different initiation. AK125935 mRNA Translation: BAG54267.1 AL139113 Genomic DNA No translation available. AL354989 Genomic DNA No translation available. BC007890 mRNA Translation: AAH07890.1 BC111762 mRNA Translation: AAI11763.1 Different initiation. AB040924 mRNA Translation: BAA96015.1 |
CCDSi | CCDS6547.1 [Q5T6F2-1] CCDS75828.1 [Q5T6F2-2] |
RefSeqi | NP_001269458.1, NM_001282529.1 NP_001269459.1, NM_001282530.1 [Q5T6F2-2] NP_060919.3, NM_018449.3 |
Genome annotation databases
Ensembli | ENST00000379238.7; ENSP00000368540.2; ENSG00000137073.24 ENST00000682239.1; ENSP00000507293.1; ENSG00000137073.24 ENST00000684158.1; ENSP00000508372.1; ENSG00000137073.24 |
GeneIDi | 55833 |
KEGGi | hsa:55833 |
MANE-Selecti | ENST00000379238.7; ENSP00000368540.2; NM_001370062.2; NP_001356991.2 |
UCSCi | uc003zto.2, human [Q5T6F2-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK074884 mRNA Translation: BAC11266.1 Different initiation. AK125935 mRNA Translation: BAG54267.1 AL139113 Genomic DNA No translation available. AL354989 Genomic DNA No translation available. BC007890 mRNA Translation: AAH07890.1 BC111762 mRNA Translation: AAI11763.1 Different initiation. AB040924 mRNA Translation: BAA96015.1 |
CCDSi | CCDS6547.1 [Q5T6F2-1] CCDS75828.1 [Q5T6F2-2] |
RefSeqi | NP_001269458.1, NM_001282529.1 NP_001269459.1, NM_001282530.1 [Q5T6F2-2] NP_060919.3, NM_018449.3 |
3D structure databases
AlphaFoldDBi | Q5T6F2 |
SMRi | Q5T6F2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 120938, 130 interactors |
IntActi | Q5T6F2, 54 interactors |
MINTi | Q5T6F2 |
STRINGi | 9606.ENSP00000368540 |
PTM databases
GlyGeni | Q5T6F2, 36 sites, 2 O-linked glycans (36 sites) |
iPTMneti | Q5T6F2 |
MetOSitei | Q5T6F2 |
PhosphoSitePlusi | Q5T6F2 |
Genetic variation databases
BioMutai | UBAP2 |
DMDMi | 74745207 |
Proteomic databases
EPDi | Q5T6F2 |
jPOSTi | Q5T6F2 |
MassIVEi | Q5T6F2 |
MaxQBi | Q5T6F2 |
PaxDbi | Q5T6F2 |
PeptideAtlasi | Q5T6F2 |
PRIDEi | Q5T6F2 |
ProteomicsDBi | 63305 64579 [Q5T6F2-1] |
Protocols and materials databases
Antibodypediai | 11067, 73 antibodies from 20 providers |
DNASUi | 55833 |
Genome annotation databases
Ensembli | ENST00000379238.7; ENSP00000368540.2; ENSG00000137073.24 ENST00000682239.1; ENSP00000507293.1; ENSG00000137073.24 ENST00000684158.1; ENSP00000508372.1; ENSG00000137073.24 |
GeneIDi | 55833 |
KEGGi | hsa:55833 |
MANE-Selecti | ENST00000379238.7; ENSP00000368540.2; NM_001370062.2; NP_001356991.2 |
UCSCi | uc003zto.2, human [Q5T6F2-1] |
Organism-specific databases
CTDi | 55833 |
DisGeNETi | 55833 |
GeneCardsi | UBAP2 |
HGNCi | HGNC:14185, UBAP2 |
HPAi | ENSG00000137073, Low tissue specificity |
neXtProti | NX_Q5T6F2 |
OpenTargetsi | ENSG00000137073 |
PharmGKBi | PA38379 |
VEuPathDBi | HostDB:ENSG00000137073 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QPRH, Eukaryota |
GeneTreei | ENSGT00390000003453 |
HOGENOMi | CLU_009850_0_0_1 |
InParanoidi | Q5T6F2 |
OMAi | PSQAKHR |
OrthoDBi | 234795at2759 |
PhylomeDBi | Q5T6F2 |
TreeFami | TF328468 |
Enzyme and pathway databases
PathwayCommonsi | Q5T6F2 |
SignaLinki | Q5T6F2 |
SIGNORi | Q5T6F2 |
Miscellaneous databases
BioGRID-ORCSi | 55833, 15 hits in 1085 CRISPR screens |
ChiTaRSi | UBAP2, human |
GeneWikii | UBAP2 |
GenomeRNAii | 55833 |
Pharosi | Q5T6F2, Tbio |
PROi | PR:Q5T6F2 |
RNActi | Q5T6F2, protein |
Gene expression databases
Bgeei | ENSG00000137073, Expressed in sperm and 245 other tissues |
ExpressionAtlasi | Q5T6F2, baseline and differential |
Genevisiblei | Q5T6F2, HS |
Family and domain databases
InterProi | View protein in InterPro IPR015940, UBA IPR009060, UBA-like_sf IPR022166, UBAP2/Lig |
Pfami | View protein in Pfam PF12478, DUF3697, 1 hit |
SMARTi | View protein in SMART SM00165, UBA, 1 hit |
SUPFAMi | SSF46934, SSF46934, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | UBAP2_HUMAN | |
Accessioni | Q5T6F2Primary (citable) accession number: Q5T6F2 Secondary accession number(s): Q2M2R4 Q9P237 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 9, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | May 25, 2022 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports