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Entry version 110 (03 Jul 2019)
Sequence version 3 (11 Jan 2011)
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Protein

Arginine vasopressin-induced protein 1

Gene

AVPI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Arginine vasopressin-induced protein 1
Short name:
AVP-induced protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AVPI1
ORF Names:NPD013, PP5395
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:30898 AVPI1

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q5T686

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
60370

Open Targets

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OpenTargetsi
ENSG00000119986

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134905326

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AVPI1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
317373474

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002824021 – 147Arginine vasopressin-induced protein 1Add BLAST147

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5T686

MaxQB - The MaxQuant DataBase

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MaxQBi
Q5T686

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5T686

PeptideAtlas

More...
PeptideAtlasi
Q5T686

PRoteomics IDEntifications database

More...
PRIDEi
Q5T686

ProteomicsDB human proteome resource

More...
ProteomicsDBi
64571

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q5T686

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q5T686

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000119986 Expressed in 219 organ(s), highest expression level in adrenal tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5T686 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037649

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
121901, 20 interactors

Protein interaction database and analysis system

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IntActi
Q5T686, 31 interactors

Molecular INTeraction database

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MINTi
Q5T686

STRING: functional protein association networks

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STRINGi
9606.ENSP00000359660

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J3FQ Eukaryota
ENOG410Y6AI LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00510000049872

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000034240

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T686

Identification of Orthologs from Complete Genome Data

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OMAi
RIRRNWR

Database of Orthologous Groups

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OrthoDBi
1572792at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q5T686

TreeFam database of animal gene trees

More...
TreeFami
TF338287

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039579 AVPI1
IPR020282 Avpi1/C8orf4_dom

The PANTHER Classification System

More...
PANTHERi
PTHR14350 PTHR14350, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15063 TC1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5T686-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTPASVVSE PPPWQAPIEA RGRKQASANI FQDAELLQIQ ALFQRSGDQL
60 70 80 90 100
AEERAQIIWE CAGDHRVAEA LKRLRRKRPP RQKPLGHSLH HCSRLRILEP
110 120 130 140
HSALANPQSA TETASSEQYL HSRKKSARIR RNWRKSGPTS YLHQIRH
Length:147
Mass (Da):16,773
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE01AEFEEF3F9006B
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG44474 differs from that shown. Reason: Frameshift at position 28.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti65H → R in AAG44474 (Ref. 2) Curated1
Sequence conflicti81R → K in BAD96819 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03140541A → G3 PublicationsCorresponds to variant dbSNP:rs2275047Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF218019 mRNA Translation: AAG17261.1
AF241786 mRNA Translation: AAG44474.1 Frameshift.
AK223099 mRNA Translation: BAD96819.1
AK222493 mRNA Translation: BAD96213.1
AL355315 Genomic DNA No translation available.
BC000877 mRNA Translation: AAH00877.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS7470.1

NCBI Reference Sequences

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RefSeqi
NP_068378.2, NM_021732.2
XP_016871983.1, XM_017016494.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000370626; ENSP00000359660; ENSG00000119986

Database of genes from NCBI RefSeq genomes

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GeneIDi
60370

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:60370

UCSC genome browser

More...
UCSCi
uc057vge.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218019 mRNA Translation: AAG17261.1
AF241786 mRNA Translation: AAG44474.1 Frameshift.
AK223099 mRNA Translation: BAD96819.1
AK222493 mRNA Translation: BAD96213.1
AL355315 Genomic DNA No translation available.
BC000877 mRNA Translation: AAH00877.1
CCDSiCCDS7470.1
RefSeqiNP_068378.2, NM_021732.2
XP_016871983.1, XM_017016494.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi121901, 20 interactors
IntActiQ5T686, 31 interactors
MINTiQ5T686
STRINGi9606.ENSP00000359660

PTM databases

iPTMnetiQ5T686
PhosphoSitePlusiQ5T686

Polymorphism and mutation databases

BioMutaiAVPI1
DMDMi317373474

Proteomic databases

EPDiQ5T686
MaxQBiQ5T686
PaxDbiQ5T686
PeptideAtlasiQ5T686
PRIDEiQ5T686
ProteomicsDBi64571

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
60370
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370626; ENSP00000359660; ENSG00000119986
GeneIDi60370
KEGGihsa:60370
UCSCiuc057vge.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
60370
DisGeNETi60370

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AVPI1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0009099
HGNCiHGNC:30898 AVPI1
HPAiHPA037649
neXtProtiNX_Q5T686
OpenTargetsiENSG00000119986
PharmGKBiPA134905326

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J3FQ Eukaryota
ENOG410Y6AI LUCA
GeneTreeiENSGT00510000049872
HOGENOMiHOG000034240
InParanoidiQ5T686
OMAiRIRRNWR
OrthoDBi1572792at2759
PhylomeDBiQ5T686
TreeFamiTF338287

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
AVPI1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AVPI1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
60370

Protein Ontology

More...
PROi
PR:Q5T686

Gene expression databases

BgeeiENSG00000119986 Expressed in 219 organ(s), highest expression level in adrenal tissue
GenevisibleiQ5T686 HS

Family and domain databases

InterProiView protein in InterPro
IPR039579 AVPI1
IPR020282 Avpi1/C8orf4_dom
PANTHERiPTHR14350 PTHR14350, 1 hit
PfamiView protein in Pfam
PF15063 TC1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAVPI1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T686
Secondary accession number(s): Q53G32, Q9H2R9, Q9HBN9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: January 11, 2011
Last modified: July 3, 2019
This is version 110 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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