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Protein

Arginine vasopressin-induced protein 1

Gene

AVPI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling.By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine vasopressin-induced protein 1
Short name:
AVP-induced protein 1
Gene namesi
Name:AVPI1
ORF Names:NPD013, PP5395
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000119986.6
HGNCiHGNC:30898 AVPI1
neXtProtiNX_Q5T686

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000119986
PharmGKBiPA134905326

Polymorphism and mutation databases

BioMutaiAVPI1
DMDMi317373474

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002824021 – 147Arginine vasopressin-induced protein 1Add BLAST147

Proteomic databases

EPDiQ5T686
MaxQBiQ5T686
PaxDbiQ5T686
PeptideAtlasiQ5T686
PRIDEiQ5T686
ProteomicsDBi64571

PTM databases

iPTMnetiQ5T686
PhosphoSitePlusiQ5T686

Expressioni

Gene expression databases

BgeeiENSG00000119986 Expressed in 219 organ(s), highest expression level in adrenal tissue
CleanExiHS_AVPI1
GenevisibleiQ5T686 HS

Organism-specific databases

HPAiHPA037649

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi121901, 20 interactors
IntActiQ5T686, 31 interactors
MINTiQ5T686
STRINGi9606.ENSP00000359660

Structurei

3D structure databases

ProteinModelPortaliQ5T686
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410J3FQ Eukaryota
ENOG410Y6AI LUCA
GeneTreeiENSGT00510000049872
HOGENOMiHOG000034240
HOVERGENiHBG057214
InParanoidiQ5T686
OMAiTSYLHQI
OrthoDBiEOG091G1212
PhylomeDBiQ5T686
TreeFamiTF338287

Family and domain databases

InterProiView protein in InterPro
IPR039579 AVPI1
IPR020282 Avpi1/C8orf4_dom
PANTHERiPTHR14350 PTHR14350, 1 hit
PfamiView protein in Pfam
PF15063 TC1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD287216 Arg_vasopressin-induced_prot_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5T686-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTPASVVSE PPPWQAPIEA RGRKQASANI FQDAELLQIQ ALFQRSGDQL
60 70 80 90 100
AEERAQIIWE CAGDHRVAEA LKRLRRKRPP RQKPLGHSLH HCSRLRILEP
110 120 130 140
HSALANPQSA TETASSEQYL HSRKKSARIR RNWRKSGPTS YLHQIRH
Length:147
Mass (Da):16,773
Last modified:January 11, 2011 - v3
Checksum:iE01AEFEEF3F9006B
GO

Sequence cautioni

The sequence AAG44474 differs from that shown. Reason: Frameshift at position 28.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65H → R in AAG44474 (Ref. 2) Curated1
Sequence conflicti81R → K in BAD96819 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03140541A → G3 PublicationsCorresponds to variant dbSNP:rs2275047Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218019 mRNA Translation: AAG17261.1
AF241786 mRNA Translation: AAG44474.1 Frameshift.
AK223099 mRNA Translation: BAD96819.1
AK222493 mRNA Translation: BAD96213.1
AL355315 Genomic DNA No translation available.
BC000877 mRNA Translation: AAH00877.1
CCDSiCCDS7470.1
RefSeqiNP_068378.2, NM_021732.2
XP_016871983.1, XM_017016494.1
UniGeneiHs.23918

Genome annotation databases

EnsembliENST00000370626; ENSP00000359660; ENSG00000119986
GeneIDi60370
KEGGihsa:60370
UCSCiuc057vge.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218019 mRNA Translation: AAG17261.1
AF241786 mRNA Translation: AAG44474.1 Frameshift.
AK223099 mRNA Translation: BAD96819.1
AK222493 mRNA Translation: BAD96213.1
AL355315 Genomic DNA No translation available.
BC000877 mRNA Translation: AAH00877.1
CCDSiCCDS7470.1
RefSeqiNP_068378.2, NM_021732.2
XP_016871983.1, XM_017016494.1
UniGeneiHs.23918

3D structure databases

ProteinModelPortaliQ5T686
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121901, 20 interactors
IntActiQ5T686, 31 interactors
MINTiQ5T686
STRINGi9606.ENSP00000359660

PTM databases

iPTMnetiQ5T686
PhosphoSitePlusiQ5T686

Polymorphism and mutation databases

BioMutaiAVPI1
DMDMi317373474

Proteomic databases

EPDiQ5T686
MaxQBiQ5T686
PaxDbiQ5T686
PeptideAtlasiQ5T686
PRIDEiQ5T686
ProteomicsDBi64571

Protocols and materials databases

DNASUi60370
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370626; ENSP00000359660; ENSG00000119986
GeneIDi60370
KEGGihsa:60370
UCSCiuc057vge.1 human

Organism-specific databases

CTDi60370
EuPathDBiHostDB:ENSG00000119986.6
GeneCardsiAVPI1
H-InvDBiHIX0009099
HGNCiHGNC:30898 AVPI1
HPAiHPA037649
neXtProtiNX_Q5T686
OpenTargetsiENSG00000119986
PharmGKBiPA134905326
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3FQ Eukaryota
ENOG410Y6AI LUCA
GeneTreeiENSGT00510000049872
HOGENOMiHOG000034240
HOVERGENiHBG057214
InParanoidiQ5T686
OMAiTSYLHQI
OrthoDBiEOG091G1212
PhylomeDBiQ5T686
TreeFamiTF338287

Miscellaneous databases

ChiTaRSiAVPI1 human
GeneWikiiAVPI1
GenomeRNAii60370
PROiPR:Q5T686

Gene expression databases

BgeeiENSG00000119986 Expressed in 219 organ(s), highest expression level in adrenal tissue
CleanExiHS_AVPI1
GenevisibleiQ5T686 HS

Family and domain databases

InterProiView protein in InterPro
IPR039579 AVPI1
IPR020282 Avpi1/C8orf4_dom
PANTHERiPTHR14350 PTHR14350, 1 hit
PfamiView protein in Pfam
PF15063 TC1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD287216 Arg_vasopressin-induced_prot_1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAVPI1_HUMAN
AccessioniPrimary (citable) accession number: Q5T686
Secondary accession number(s): Q53G32, Q9H2R9, Q9HBN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 105 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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