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Entry version 122 (10 Feb 2021)
Sequence version 1 (21 Dec 2004)
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Protein

Cilia- and flagella-associated protein 58

Gene

CFAP58

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5T655

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cilia- and flagella-associated protein 58Imported
Alternative name(s):
Coiled-coil domain-containing protein 147Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CFAP58Imported
Synonyms:C10orf80Imported, CCDC147Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26676, CFAP58

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T655

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000120051.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, Cilium

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000120051

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162381518

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5T655, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CFAP58

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74745166

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002743171 – 872Cilia- and flagella-associated protein 58Add BLAST872

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T655

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5T655

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5T655

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T655

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T655

PeptideAtlas

More...
PeptideAtlasi
Q5T655

PRoteomics IDEntifications database

More...
PRIDEi
Q5T655

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64567

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T655

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T655

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120051, Expressed in oocyte and 116 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5T655, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T655, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000120051, Tissue enhanced (fallopian tube, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127743, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T655, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000358718

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5T655, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5T655

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili106 – 595Sequence analysisAdd BLAST490
Coiled coili642 – 839Sequence analysisAdd BLAST198

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CFAP58 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPV7, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063534

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006364_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T655

Identification of Orthologs from Complete Genome Data

More...
OMAi
CQDDMRL

Database of Orthologous Groups

More...
OrthoDBi
1077673at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T655

TreeFam database of animal gene trees

More...
TreeFami
TF328680

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5T655-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEEKGGKQV LEESAFEEME RDFQGVLHEL SGDKSLEKFR IEYERLHAVM
60 70 80 90 100
KKSYDNEKRL MAKCRELNAE IVVNSAKVAT ALKLSQDDQT TIASLKKEIE
110 120 130 140 150
KAWKMVDSAY DKEQKAKETI LALKEEIVNL TKLVEQGSGL SMDQHSNIRD
160 170 180 190 200
LLRFKEEVTK ERDQLLSEVV KLRESLAQTT EQQQETERSK EEAEHAISQF
210 220 230 240 250
QQEIQQRQNE ASREFRKKEK LEKELKQIQA DMDSRQTEIK ALQQYVQKSK
260 270 280 290 300
EELQKLEQQL KEQKILNERA AKELEQFQMR NAKLQQENEQ HSLVCEQLSQ
310 320 330 340 350
ENQQKALELK AKEEEVHQMR LDIGKLNKIR EQIHKKLHHT EDQKAEVEQH
360 370 380 390 400
KETLKNQIVG LEREVEASKK QAELDRKAMD ELLRERDILN KNMLKAVNAT
410 420 430 440 450
QKQTDLVKLH EQAKRNLEGE IQNYKDEAQK QRKIIFHLEK ERDRYINQAS
460 470 480 490 500
DLTQKVLMNM EDIKVRETQI FDYRKKIAES EIKLKQQQNL YEAVRSDRNL
510 520 530 540 550
YSKNLVEAQD EITDMKRKLK IMIHQVDELK EDISAKESAL VKLHLEQQRI
560 570 580 590 600
EKEKETLKAE LQKLRQQALE TKHFIEKQEA EERKLLRIIA EADGERLRQK
610 620 630 640 650
KELDQVISER DILGSQLVRR NDELALLYEK IKIQQSVLNK GESQYNQRLE
660 670 680 690 700
DMRILRLEIK KLRREKGILA RSMANVEELR QEFFHMQREL LKERTRCRAL
710 720 730 740 750
EEELENPLNV HRWRKLEASD PNAYELIQKI HTLQKRLISK TEEVVEKELL
760 770 780 790 800
LQEKEKLYME LKHVLARQPG PEAAEQLKLY RRTLHDKKQQ LKVLSSELNM
810 820 830 840 850
YEVQSKEYKY EVEKLTNELQ NLKKKYLAQK RKEQLQKNKD TAPMDNTFLM
860 870
VKPNGPGFTG GGFPLRSTKM TF
Length:872
Mass (Da):103,417
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4393742E91D81DD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9H4Y4Q9H4Y4_HUMAN
Cilia- and flagella-associated prot...
CFAP58
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_030255496S → T. Corresponds to variant dbSNP:rs11192036Ensembl.1
Natural variantiVAR_030256804Q → H. Corresponds to variant dbSNP:rs7087328Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL162742 Genomic DNA No translation available.
AL355378 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49595.1
BC036225 mRNA Translation: AAH36225.1
BC109126 mRNA Translation: AAI09127.1
AK093227 mRNA Translation: BAC04102.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31282.1

NCBI Reference Sequences

More...
RefSeqi
NP_001008723.1, NM_001008723.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000369704; ENSP00000358718; ENSG00000120051

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
159686

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:159686

UCSC genome browser

More...
UCSCi
uc001kyh.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162742 Genomic DNA No translation available.
AL355378 Genomic DNA No translation available.
CH471066 Genomic DNA Translation: EAW49595.1
BC036225 mRNA Translation: AAH36225.1
BC109126 mRNA Translation: AAI09127.1
AK093227 mRNA Translation: BAC04102.1
CCDSiCCDS31282.1
RefSeqiNP_001008723.1, NM_001008723.1

3D structure databases

SMRiQ5T655
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127743, 13 interactors
IntActiQ5T655, 7 interactors
STRINGi9606.ENSP00000358718

PTM databases

iPTMnetiQ5T655
PhosphoSitePlusiQ5T655

Genetic variation databases

BioMutaiCFAP58
DMDMi74745166

Proteomic databases

EPDiQ5T655
jPOSTiQ5T655
MassIVEiQ5T655
MaxQBiQ5T655
PaxDbiQ5T655
PeptideAtlasiQ5T655
PRIDEiQ5T655
ProteomicsDBi64567

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48984, 102 antibodies

Genome annotation databases

EnsembliENST00000369704; ENSP00000358718; ENSG00000120051
GeneIDi159686
KEGGihsa:159686
UCSCiuc001kyh.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
159686

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CFAP58
HGNCiHGNC:26676, CFAP58
HPAiENSG00000120051, Tissue enhanced (fallopian tube, testis)
neXtProtiNX_Q5T655
OpenTargetsiENSG00000120051
PharmGKBiPA162381518
VEuPathDBiHostDB:ENSG00000120051.14

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QPV7, Eukaryota
GeneTreeiENSGT00530000063534
HOGENOMiCLU_006364_0_0_1
InParanoidiQ5T655
OMAiCQDDMRL
OrthoDBi1077673at2759
PhylomeDBiQ5T655
TreeFamiTF328680

Enzyme and pathway databases

PathwayCommonsiQ5T655

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
159686, 3 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CFAP58, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
159686
PharosiQ5T655, Tdark

Protein Ontology

More...
PROi
PR:Q5T655
RNActiQ5T655, protein

Gene expression databases

BgeeiENSG00000120051, Expressed in oocyte and 116 other tissues
ExpressionAtlasiQ5T655, baseline and differential
GenevisibleiQ5T655, HS

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCFA58_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T655
Secondary accession number(s): D3DRA6, Q8NA27
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 21, 2004
Last modified: February 10, 2021
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human variants curated from literature reports
    Index of human variants curated from literature reports
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with genetic variants
    List of human entries with genetic variants
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