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Protein

39S ribosomal protein L2, mitochondrial

Gene

MRPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L2, mitochondrial
Short name:
L2mt
Short name:
MRP-L2
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL2m1 Publication
Gene namesi
Name:MRPL2
ORF Names:CGI-22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112651.11
HGNCiHGNC:14056 MRPL2
MIMi611822 gene
neXtProtiNX_Q5T653

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000112651
PharmGKBiPA30949

Polymorphism and mutation databases

BioMutaiMRPL2
DMDMi118573672

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 60MitochondrionSequence analysisAdd BLAST60
ChainiPRO_000026164061 – 30539S ribosomal protein L2, mitochondrialAdd BLAST245

Proteomic databases

EPDiQ5T653
MaxQBiQ5T653
PaxDbiQ5T653
PeptideAtlasiQ5T653
PRIDEiQ5T653
ProteomicsDBi64566
TopDownProteomicsiQ5T653

PTM databases

iPTMnetiQ5T653
PhosphoSitePlusiQ5T653
SwissPalmiQ5T653

Expressioni

Gene expression databases

BgeeiENSG00000112651 Expressed in 217 organ(s), highest expression level in muscle of leg
CleanExiHS_MRPL2
ExpressionAtlasiQ5T653 baseline and differential
GenevisibleiQ5T653 HS

Organism-specific databases

HPAiHPA007455
HPA064814

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.3 Publications

Protein-protein interaction databases

BioGridi119260, 56 interactors
CORUMiQ5T653
IntActiQ5T653, 20 interactors
MINTiQ5T653
STRINGi9606.ENSP00000373404

Structurei

Secondary structure

1305
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ5T653
SMRiQ5T653
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0438 Eukaryota
COG0090 LUCA
GeneTreeiENSGT00390000000189
HOGENOMiHOG000046229
HOVERGENiHBG057412
InParanoidiQ5T653
KOiK02886
OMAiCHLIHAA
OrthoDBiEOG091G0K6T
PhylomeDBiQ5T653
TreeFamiTF314647

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR022666 Rbsml_prot_L2_RNA-bd_dom
IPR014722 Rib_L2_dom2
IPR002171 Ribosomal_L2
IPR022669 Ribosomal_L2_C
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR13691 PTHR13691, 1 hit
PfamiView protein in Pfam
PF00181 Ribosomal_L2, 1 hit
PF03947 Ribosomal_L2_C, 1 hit
PIRSFiPIRSF002158 Ribosomal_L2, 1 hit
SMARTiView protein in SMART
SM01383 Ribosomal_L2, 1 hit
SM01382 Ribosomal_L2_C, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q5T653-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALCALTRAL RSLNLAPPTV AAPAPSLFPA AQMMNNGLLQ QPSALMLLPC
60 70 80 90 100
RPVLTSVALN ANFVSWKSRT KYTITPVKMR KSGGRDHTGR IRVHGIGGGH
110 120 130 140 150
KQRYRMIDFL RFRPEETKSG PFEEKVIQVR YDPCRSADIA LVAGGSRKRW
160 170 180 190 200
IIATENMQAG DTILNSNHIG RMAVAAREGD AHPLGALPVG TLINNVESEP
210 220 230 240 250
GRGAQYIRAA GTCGVLLRKV NGTAIIQLPS KRQMQVLETC VATVGRVSNV
260 270 280 290 300
DHNKRVIGKA GRNRWLGKRP NSGRWHRKGG WAGRKIRPLP PMKSYVKLPS

ASAQS
Length:305
Mass (Da):33,301
Last modified:November 28, 2006 - v2
Checksum:iAE1D777E2CF9DBCB
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IY40C9IY40_HUMAN
39S ribosomal protein L2, mitochond...
MRPL2
225Annotation score:
C9JZG7C9JZG7_HUMAN
39S ribosomal protein L2, mitochond...
MRPL2
103Annotation score:
C9JZW2C9JZW2_HUMAN
39S ribosomal protein L2, mitochond...
MRPL2
96Annotation score:
C9J5E0C9J5E0_HUMAN
39S ribosomal protein L2, mitochond...
MRPL2
94Annotation score:

Sequence cautioni

The sequence AAD27731 differs from that shown. Reason: Frameshift at positions 274 and 283.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11 – 12RS → LV in AAD27731 (PubMed:10810093).Curated2
Sequence conflicti223 – 224TA → HS in AAD27731 (PubMed:10810093).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029470300S → F. Corresponds to variant dbSNP:rs10456521Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132956 mRNA Translation: AAD27731.1 Frameshift.
AK314948 mRNA Translation: BAG37453.1
AL355385 Genomic DNA No translation available.
BC013685 mRNA Translation: AAH13685.1
BC020212 mRNA Translation: AAH20212.1
AB051617 Genomic DNA Translation: BAB54945.1
CCDSiCCDS34454.1
RefSeqiNP_001287777.1, NM_001300848.1
NP_057034.2, NM_015950.4
UniGeneiHs.55041

Genome annotation databases

EnsembliENST00000388752; ENSP00000373404; ENSG00000112651
GeneIDi51069
KEGGihsa:51069
UCSCiuc003ots.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132956 mRNA Translation: AAD27731.1 Frameshift.
AK314948 mRNA Translation: BAG37453.1
AL355385 Genomic DNA No translation available.
BC013685 mRNA Translation: AAH13685.1
BC020212 mRNA Translation: AAH20212.1
AB051617 Genomic DNA Translation: BAB54945.1
CCDSiCCDS34454.1
RefSeqiNP_001287777.1, NM_001300848.1
NP_057034.2, NM_015950.4
UniGeneiHs.55041

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40D1-305[»]
3J9Melectron microscopy3.50D1-305[»]
5OOLelectron microscopy3.06D1-305[»]
5OOMelectron microscopy3.03D1-305[»]
ProteinModelPortaliQ5T653
SMRiQ5T653
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119260, 56 interactors
CORUMiQ5T653
IntActiQ5T653, 20 interactors
MINTiQ5T653
STRINGi9606.ENSP00000373404

PTM databases

iPTMnetiQ5T653
PhosphoSitePlusiQ5T653
SwissPalmiQ5T653

Polymorphism and mutation databases

BioMutaiMRPL2
DMDMi118573672

Proteomic databases

EPDiQ5T653
MaxQBiQ5T653
PaxDbiQ5T653
PeptideAtlasiQ5T653
PRIDEiQ5T653
ProteomicsDBi64566
TopDownProteomicsiQ5T653

Protocols and materials databases

DNASUi51069
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000388752; ENSP00000373404; ENSG00000112651
GeneIDi51069
KEGGihsa:51069
UCSCiuc003ots.2 human

Organism-specific databases

CTDi51069
EuPathDBiHostDB:ENSG00000112651.11
GeneCardsiMRPL2
HGNCiHGNC:14056 MRPL2
HPAiHPA007455
HPA064814
MIMi611822 gene
neXtProtiNX_Q5T653
OpenTargetsiENSG00000112651
PharmGKBiPA30949
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0438 Eukaryota
COG0090 LUCA
GeneTreeiENSGT00390000000189
HOGENOMiHOG000046229
HOVERGENiHBG057412
InParanoidiQ5T653
KOiK02886
OMAiCHLIHAA
OrthoDBiEOG091G0K6T
PhylomeDBiQ5T653
TreeFamiTF314647

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL2 human
GenomeRNAii51069
PROiPR:Q5T653
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112651 Expressed in 217 organ(s), highest expression level in muscle of leg
CleanExiHS_MRPL2
ExpressionAtlasiQ5T653 baseline and differential
GenevisibleiQ5T653 HS

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR022666 Rbsml_prot_L2_RNA-bd_dom
IPR014722 Rib_L2_dom2
IPR002171 Ribosomal_L2
IPR022669 Ribosomal_L2_C
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR13691 PTHR13691, 1 hit
PfamiView protein in Pfam
PF00181 Ribosomal_L2, 1 hit
PF03947 Ribosomal_L2_C, 1 hit
PIRSFiPIRSF002158 Ribosomal_L2, 1 hit
SMARTiView protein in SMART
SM01383 Ribosomal_L2, 1 hit
SM01382 Ribosomal_L2_C, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM02_HUMAN
AccessioniPrimary (citable) accession number: Q5T653
Secondary accession number(s): B2RC56
, Q8WUL1, Q96Q56, Q9Y311
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: November 7, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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