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Entry version 145 (29 Sep 2021)
Sequence version 2 (28 Nov 2006)
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Protein

39S ribosomal protein L2, mitochondrial

Gene

MRPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5T653

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5368286, Mitochondrial translation initiation
R-HSA-5389840, Mitochondrial translation elongation
R-HSA-5419276, Mitochondrial translation termination

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q5T653

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
39S ribosomal protein L2, mitochondrial
Short name:
L2mt
Short name:
MRP-L2
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL2m1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRPL2
ORF Names:CGI-22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:14056, MRPL2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611822, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T653

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000112651

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000112651

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30949

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5T653, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MRPL2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
118573672

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 60MitochondrionSequence analysisAdd BLAST60
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000026164061 – 30539S ribosomal protein L2, mitochondrialAdd BLAST245

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T653

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5T653

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5T653

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T653

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T653

PeptideAtlas

More...
PeptideAtlasi
Q5T653

PRoteomics IDEntifications database

More...
PRIDEi
Q5T653

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64566

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q5T653

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q5T653, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T653

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q5T653

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T653

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5T653

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112651, Expressed in muscle of leg and 229 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5T653, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T653, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000112651, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
119260, 106 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-5226, 39S mitochondrial large ribosomal subunit

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q5T653

Protein interaction database and analysis system

More...
IntActi
Q5T653, 38 interactors

Molecular INTeraction database

More...
MINTi
Q5T653

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373404

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5T653, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1305
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5T653

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni264 – 283DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi269 – 283Basic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0438, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153244

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_036235_1_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T653

Identification of Orthologs from Complete Genome Data

More...
OMAi
CHLIHAA

Database of Orthologous Groups

More...
OrthoDBi
1156335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T653

TreeFam database of animal gene trees

More...
TreeFami
TF314647

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.30.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012340, NA-bd_OB-fold
IPR022666, Rbsml_prot_L2_RNA-bd_dom
IPR014722, Rib_L2_dom2
IPR002171, Ribosomal_L2
IPR022669, Ribosomal_L2_C
IPR008991, Translation_prot_SH3-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13691, PTHR13691, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00181, Ribosomal_L2, 1 hit
PF03947, Ribosomal_L2_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01383, Ribosomal_L2, 1 hit
SM01382, Ribosomal_L2_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50104, SSF50104, 1 hit
SSF50249, SSF50249, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q5T653-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALCALTRAL RSLNLAPPTV AAPAPSLFPA AQMMNNGLLQ QPSALMLLPC
60 70 80 90 100
RPVLTSVALN ANFVSWKSRT KYTITPVKMR KSGGRDHTGR IRVHGIGGGH
110 120 130 140 150
KQRYRMIDFL RFRPEETKSG PFEEKVIQVR YDPCRSADIA LVAGGSRKRW
160 170 180 190 200
IIATENMQAG DTILNSNHIG RMAVAAREGD AHPLGALPVG TLINNVESEP
210 220 230 240 250
GRGAQYIRAA GTCGVLLRKV NGTAIIQLPS KRQMQVLETC VATVGRVSNV
260 270 280 290 300
DHNKRVIGKA GRNRWLGKRP NSGRWHRKGG WAGRKIRPLP PMKSYVKLPS

ASAQS
Length:305
Mass (Da):33,301
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE1D777E2CF9DBCB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IY40C9IY40_HUMAN
39S ribosomal protein L2, mitochond...
MRPL2
225Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZG7C9JZG7_HUMAN
39S ribosomal protein L2, mitochond...
MRPL2
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JZW2C9JZW2_HUMAN
39S ribosomal protein L2, mitochond...
MRPL2
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J5E0C9J5E0_HUMAN
39S ribosomal protein L2, mitochond...
MRPL2
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD27731 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti11 – 12RS → LV in AAD27731 (PubMed:10810093).Curated2
Sequence conflicti223 – 224TA → HS in AAD27731 (PubMed:10810093).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_029470300S → F. Corresponds to variant dbSNP:rs10456521Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF132956 mRNA Translation: AAD27731.1 Frameshift.
AK314948 mRNA Translation: BAG37453.1
AL355385 Genomic DNA No translation available.
BC013685 mRNA Translation: AAH13685.1
BC020212 mRNA Translation: AAH20212.1
AB051617 Genomic DNA Translation: BAB54945.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34454.1

NCBI Reference Sequences

More...
RefSeqi
NP_001287777.1, NM_001300848.1
NP_057034.2, NM_015950.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000388752; ENSP00000373404; ENSG00000112651

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
51069

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:51069

UCSC genome browser

More...
UCSCi
uc003ots.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132956 mRNA Translation: AAD27731.1 Frameshift.
AK314948 mRNA Translation: BAG37453.1
AL355385 Genomic DNA No translation available.
BC013685 mRNA Translation: AAH13685.1
BC020212 mRNA Translation: AAH20212.1
AB051617 Genomic DNA Translation: BAB54945.1
CCDSiCCDS34454.1
RefSeqiNP_001287777.1, NM_001300848.1
NP_057034.2, NM_015950.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40D1-305[»]
3J9Melectron microscopy3.50D1-305[»]
5OOLelectron microscopy3.06D1-305[»]
5OOMelectron microscopy3.03D1-305[»]
6I9Relectron microscopy3.90D1-305[»]
6NU2electron microscopy3.90D61-296[»]
6NU3electron microscopy4.40D1-305[»]
6VLZelectron microscopy2.97D1-305[»]
6VMIelectron microscopy2.96D1-305[»]
6ZM5electron microscopy2.89D1-305[»]
6ZM6electron microscopy2.59D1-305[»]
6ZS9electron microscopy4.00XD1-305[»]
6ZSAelectron microscopy4.00XD1-305[»]
6ZSBelectron microscopy4.50XD1-305[»]
6ZSCelectron microscopy3.50XD1-305[»]
6ZSDelectron microscopy3.70XD1-305[»]
6ZSEelectron microscopy5.00XD1-305[»]
6ZSGelectron microscopy4.00XD1-305[»]
7A5Felectron microscopy4.40D31-305[»]
7A5Gelectron microscopy4.33D31-305[»]
7A5Helectron microscopy3.30D1-305[»]
7A5Ielectron microscopy3.70D31-305[»]
7A5Jelectron microscopy3.10D1-305[»]
7A5Kelectron microscopy3.70D31-305[»]
7L08electron microscopy3.49D1-305[»]
7L20electron microscopy3.15D1-305[»]
7O9Kelectron microscopy3.10D1-305[»]
7O9Melectron microscopy2.50D1-305[»]
7ODRelectron microscopy2.90D1-305[»]
7ODSelectron microscopy3.10D1-305[»]
7ODTelectron microscopy3.10D1-305[»]
7OF0electron microscopy2.20D1-305[»]
7OF2electron microscopy2.70D1-305[»]
7OF3electron microscopy2.70D1-305[»]
7OF4electron microscopy2.70D1-305[»]
7OF5electron microscopy2.90D1-305[»]
7OF6electron microscopy2.60D1-305[»]
7OF7electron microscopy2.50D1-305[»]
7OG4electron microscopy3.80XD1-305[»]
SMRiQ5T653
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119260, 106 interactors
ComplexPortaliCPX-5226, 39S mitochondrial large ribosomal subunit
CORUMiQ5T653
IntActiQ5T653, 38 interactors
MINTiQ5T653
STRINGi9606.ENSP00000373404

PTM databases

GlyGeniQ5T653, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ5T653
MetOSiteiQ5T653
PhosphoSitePlusiQ5T653
SwissPalmiQ5T653

Genetic variation databases

BioMutaiMRPL2
DMDMi118573672

Proteomic databases

EPDiQ5T653
jPOSTiQ5T653
MassIVEiQ5T653
MaxQBiQ5T653
PaxDbiQ5T653
PeptideAtlasiQ5T653
PRIDEiQ5T653
ProteomicsDBi64566
TopDownProteomicsiQ5T653

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2348, 150 antibodies

The DNASU plasmid repository

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DNASUi
51069

Genome annotation databases

EnsembliENST00000388752; ENSP00000373404; ENSG00000112651
GeneIDi51069
KEGGihsa:51069
UCSCiuc003ots.2, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
51069

GeneCards: human genes, protein and diseases

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GeneCardsi
MRPL2
HGNCiHGNC:14056, MRPL2
HPAiENSG00000112651, Low tissue specificity
MIMi611822, gene
neXtProtiNX_Q5T653
OpenTargetsiENSG00000112651
PharmGKBiPA30949
VEuPathDBiHostDB:ENSG00000112651

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0438, Eukaryota
GeneTreeiENSGT00940000153244
HOGENOMiCLU_036235_1_2_1
InParanoidiQ5T653
OMAiCHLIHAA
OrthoDBi1156335at2759
PhylomeDBiQ5T653
TreeFamiTF314647

Enzyme and pathway databases

PathwayCommonsiQ5T653
ReactomeiR-HSA-5368286, Mitochondrial translation initiation
R-HSA-5389840, Mitochondrial translation elongation
R-HSA-5419276, Mitochondrial translation termination
SIGNORiQ5T653

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
51069, 256 hits in 1020 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MRPL2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
51069
PharosiQ5T653, Tdark

Protein Ontology

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PROi
PR:Q5T653
RNActiQ5T653, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000112651, Expressed in muscle of leg and 229 other tissues
ExpressionAtlasiQ5T653, baseline and differential
GenevisibleiQ5T653, HS

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR012340, NA-bd_OB-fold
IPR022666, Rbsml_prot_L2_RNA-bd_dom
IPR014722, Rib_L2_dom2
IPR002171, Ribosomal_L2
IPR022669, Ribosomal_L2_C
IPR008991, Translation_prot_SH3-like_sf
PANTHERiPTHR13691, PTHR13691, 1 hit
PfamiView protein in Pfam
PF00181, Ribosomal_L2, 1 hit
PF03947, Ribosomal_L2_C, 1 hit
SMARTiView protein in SMART
SM01383, Ribosomal_L2, 1 hit
SM01382, Ribosomal_L2_C, 1 hit
SUPFAMiSSF50104, SSF50104, 1 hit
SSF50249, SSF50249, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRM02_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T653
Secondary accession number(s): B2RC56
, Q8WUL1, Q96Q56, Q9Y311
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: September 29, 2021
This is version 145 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Ribosomal proteins
    Ribosomal proteins families and list of entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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