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Protein

Zinc finger protein 648

Gene

ZNF648

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri279 – 301C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 358C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 648
Gene namesi
Name:ZNF648
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000179930.5
HGNCiHGNC:18190 ZNF648
neXtProtiNX_Q5T619

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179930
PharmGKBiPA134974398

Polymorphism and mutation databases

BioMutaiZNF648
DMDMi74762240

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002521621 – 568Zinc finger protein 648Add BLAST568

Proteomic databases

PaxDbiQ5T619
PeptideAtlasiQ5T619
PRIDEiQ5T619
ProteomicsDBi64563

PTM databases

iPTMnetiQ5T619
PhosphoSitePlusiQ5T619

Expressioni

Gene expression databases

BgeeiENSG00000179930
CleanExiHS_ZNF648

Organism-specific databases

HPAiHPA053897

Interactioni

Protein-protein interaction databases

IntActiQ5T619, 59 interactors
STRINGi9606.ENSP00000344129

Structurei

3D structure databases

ProteinModelPortaliQ5T619
SMRiQ5T619
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri279 – 301C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 358C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00920000149219
HOGENOMiHOG000234617
InParanoidiQ5T619
OMAiDHRKHIR
OrthoDBiEOG091G02KC
PhylomeDBiQ5T619
TreeFamiTF337055

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

Sequencei

Sequence statusi: Complete.

Q5T619-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQVDSQDRW GEASPLSSLT EEAHDTQMLS MNLESDDEDG GEAEKEGTAD
60 70 80 90 100
PVACPRGSSP VTHENPDLPW PHPLGKEEEK FSDSSSAGGM GQKPVEMSGK
110 120 130 140 150
ASWSRDVTKI NETQGSPGAS RALGSLPSGL AHKLLGQMQP LGDRLPAGDD
160 170 180 190 200
GYSGANQDAV LDVPPSFPSN GKYLCAHKSV DTSAGNSSLL CFPRPGSNWD
210 220 230 240 250
LPTQETHTPA QASATPASLA AAVLAKARNS RKVQNQAGRR EGGEAEARPY
260 270 280 290 300
RCLRGGRAFQ KPSKPLSPAE TRGGAAKRYA CELCGKAYSH RGTLQQHRRL
310 320 330 340 350
HTGERPYQCS FCDKAYTWSS DHRKHIRTHT GEKPYPCPDC GKAFVRSSDL
360 370 380 390 400
RKHQRNMHSN NKPFPCSECG LTFNKPLSLL RHQRTHLGAK PFRCPACDRE
410 420 430 440 450
FAVASRMVEH QRVHSGERPF PCPTCGKCFT KSSNLSEHQT LHTGQRPFKC
460 470 480 490 500
ADCGVAFAQP SRLVRHQRIH TGERPFPCTQ CGQAFARSST LKRHQQIHSG
510 520 530 540 550
EKGFLCAECG RAFRIASELA QHIRMHNGER PYQCEDCGQA FTRSNHLQRH
560
RAKHGTCKKE PIPSSSDE
Length:568
Mass (Da):62,341
Last modified:December 21, 2004 - v1
Checksum:iA751072B8C9810F4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05288742E → K. Corresponds to variant dbSNP:rs12564283Ensembl.1
Natural variantiVAR_033585111N → K. Corresponds to variant dbSNP:rs12568050Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355482 Genomic DNA No translation available.
BC137223 mRNA Translation: AAI37224.1
BC137224 mRNA Translation: AAI37225.1
CCDSiCCDS30952.1
RefSeqiNP_001009992.1, NM_001009992.1
XP_016855790.1, XM_017000301.1
XP_016855791.1, XM_017000302.1
UniGeneiHs.684328

Genome annotation databases

EnsembliENST00000339948; ENSP00000344129; ENSG00000179930
GeneIDi127665
KEGGihsa:127665
UCSCiuc001goz.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN648_HUMAN
AccessioniPrimary (citable) accession number: Q5T619
Secondary accession number(s): B2RP16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 21, 2004
Last modified: July 18, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

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