Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 648

Gene

ZNF648

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri279 – 301C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 358C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 648
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF648
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000179930.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:18190 ZNF648

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T619

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000179930

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134974398

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF648

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762240

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002521621 – 568Zinc finger protein 648Add BLAST568

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T619

PeptideAtlas

More...
PeptideAtlasi
Q5T619

PRoteomics IDEntifications database

More...
PRIDEi
Q5T619

ProteomicsDB human proteome resource

More...
ProteomicsDBi
64563

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T619

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T619

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179930 Expressed in 9 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZNF648

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA053897

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q5T619, 59 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000344129

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5T619

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5T619

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri279 – 301C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri307 – 329C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri335 – 358C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri364 – 386C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri532 – 554C2H2-type 10PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163676

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T619

Identification of Orthologs from Complete Genome Data

More...
OMAi
DHRKHIR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02KC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T619

TreeFam database of animal gene trees

More...
TreeFami
TF337055

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 10 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5T619-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQVDSQDRW GEASPLSSLT EEAHDTQMLS MNLESDDEDG GEAEKEGTAD
60 70 80 90 100
PVACPRGSSP VTHENPDLPW PHPLGKEEEK FSDSSSAGGM GQKPVEMSGK
110 120 130 140 150
ASWSRDVTKI NETQGSPGAS RALGSLPSGL AHKLLGQMQP LGDRLPAGDD
160 170 180 190 200
GYSGANQDAV LDVPPSFPSN GKYLCAHKSV DTSAGNSSLL CFPRPGSNWD
210 220 230 240 250
LPTQETHTPA QASATPASLA AAVLAKARNS RKVQNQAGRR EGGEAEARPY
260 270 280 290 300
RCLRGGRAFQ KPSKPLSPAE TRGGAAKRYA CELCGKAYSH RGTLQQHRRL
310 320 330 340 350
HTGERPYQCS FCDKAYTWSS DHRKHIRTHT GEKPYPCPDC GKAFVRSSDL
360 370 380 390 400
RKHQRNMHSN NKPFPCSECG LTFNKPLSLL RHQRTHLGAK PFRCPACDRE
410 420 430 440 450
FAVASRMVEH QRVHSGERPF PCPTCGKCFT KSSNLSEHQT LHTGQRPFKC
460 470 480 490 500
ADCGVAFAQP SRLVRHQRIH TGERPFPCTQ CGQAFARSST LKRHQQIHSG
510 520 530 540 550
EKGFLCAECG RAFRIASELA QHIRMHNGER PYQCEDCGQA FTRSNHLQRH
560
RAKHGTCKKE PIPSSSDE
Length:568
Mass (Da):62,341
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA751072B8C9810F4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05288742E → K. Corresponds to variant dbSNP:rs12564283Ensembl.1
Natural variantiVAR_033585111N → K. Corresponds to variant dbSNP:rs12568050Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL355482 Genomic DNA No translation available.
BC137223 mRNA Translation: AAI37224.1
BC137224 mRNA Translation: AAI37225.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30952.1

NCBI Reference Sequences

More...
RefSeqi
NP_001009992.1, NM_001009992.1
XP_016855790.1, XM_017000301.1
XP_016855791.1, XM_017000302.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.684328

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000339948; ENSP00000344129; ENSG00000179930

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
127665

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:127665

UCSC genome browser

More...
UCSCi
uc001goz.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL355482 Genomic DNA No translation available.
BC137223 mRNA Translation: AAI37224.1
BC137224 mRNA Translation: AAI37225.1
CCDSiCCDS30952.1
RefSeqiNP_001009992.1, NM_001009992.1
XP_016855790.1, XM_017000301.1
XP_016855791.1, XM_017000302.1
UniGeneiHs.684328

3D structure databases

ProteinModelPortaliQ5T619
SMRiQ5T619
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ5T619, 59 interactors
STRINGi9606.ENSP00000344129

PTM databases

iPTMnetiQ5T619
PhosphoSitePlusiQ5T619

Polymorphism and mutation databases

BioMutaiZNF648
DMDMi74762240

Proteomic databases

PaxDbiQ5T619
PeptideAtlasiQ5T619
PRIDEiQ5T619
ProteomicsDBi64563

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339948; ENSP00000344129; ENSG00000179930
GeneIDi127665
KEGGihsa:127665
UCSCiuc001goz.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
127665
EuPathDBiHostDB:ENSG00000179930.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZNF648
HGNCiHGNC:18190 ZNF648
HPAiHPA053897
neXtProtiNX_Q5T619
OpenTargetsiENSG00000179930
PharmGKBiPA134974398

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000163676
HOGENOMiHOG000234617
InParanoidiQ5T619
OMAiDHRKHIR
OrthoDBiEOG091G02KC
PhylomeDBiQ5T619
TreeFamiTF337055

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZNF648 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
127665

Protein Ontology

More...
PROi
PR:Q5T619

Gene expression databases

BgeeiENSG00000179930 Expressed in 9 organ(s), highest expression level in liver
CleanExiHS_ZNF648

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 8 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 10 hits
SUPFAMiSSF57667 SSF57667, 6 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 10 hits
PS50157 ZINC_FINGER_C2H2_2, 10 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN648_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T619
Secondary accession number(s): B2RP16
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 21, 2004
Last modified: December 5, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again