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Protein

Coiled-coil domain-containing protein 183

Gene

CCDC183

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 183
Gene namesi
Name:CCDC183
Synonyms:KIAA1984
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000213213.13
HGNCiHGNC:28236 CCDC183
MIMi615955 gene
neXtProtiNX_Q5T5S1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213213
PharmGKBiPA134944889

Polymorphism and mutation databases

BioMutaiKIAA1984
DMDMi296439313

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002934651 – 534Coiled-coil domain-containing protein 183Add BLAST534

Proteomic databases

EPDiQ5T5S1
MaxQBiQ5T5S1
PaxDbiQ5T5S1
PeptideAtlasiQ5T5S1
PRIDEiQ5T5S1
ProteomicsDBi64547
64548 [Q5T5S1-2]
64549 [Q5T5S1-3]
64550 [Q5T5S1-4]

PTM databases

CarbonylDBiQ5T5S1
iPTMnetiQ5T5S1
PhosphoSitePlusiQ5T5S1

Expressioni

Gene expression databases

BgeeiENSG00000213213 Expressed in 89 organ(s), highest expression level in left testis
ExpressionAtlasiQ5T5S1 baseline and differential

Organism-specific databases

HPAiHPA043812

Interactioni

Protein-protein interaction databases

BioGridi124391, 31 interactors
STRINGi9606.ENSP00000338013

Structurei

3D structure databases

ProteinModelPortaliQ5T5S1
SMRiQ5T5S1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili10 – 54Sequence analysisAdd BLAST45
Coiled coili136 – 209Sequence analysisAdd BLAST74
Coiled coili323 – 396Sequence analysisAdd BLAST74

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi530 – 534Poly-Lys5

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II7I Eukaryota
ENOG410YH5U LUCA
GeneTreeiENSGT00900000141046
HOGENOMiHOG000050237
HOVERGENiHBG058359
InParanoidiQ5T5S1
OMAiCSHLWDI
OrthoDBiEOG091G0IUD
PhylomeDBiQ5T5S1
TreeFamiTF324955

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T5S1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRHSETDVE EQTQELKTIT QLQEQCRALQ IQGVKENMDQ NKATLALLRS
60 70 80 90 100
NIRRGAQDWA LAKKYDQWTI SKACGKNLPL RLAHCRSTME VVREKLRKYV
110 120 130 140 150
FDRVNMHNLL IHLVRRRGQK LESMQLELDS LRSQPDASKE ELRLLQIIRQ
160 170 180 190 200
LENNIEKTMI KIITSQNIHL LYLDLLDYLK TVLAGYPIEL DKLQNLVVNY
210 220 230 240 250
CSELSDMKIM SQDAMMITDE VKRNMRQREA SFIEERRARE NRLNQQKKLI
260 270 280 290 300
DKIHTKETSE KYRRGQMDLD FPSNLMSTET LKLRRKETST AEMEYQSGVT
310 320 330 340 350
AVVEKVKSAV RCSHVWDITS RFLAQRNTEE NLELQMEDCE EWRVQLKALV
360 370 380 390 400
KQLELEEAVL KFRQKPSSIS FKSVEKKMTD MLKEEEERLQ LAHSNMTKGQ
410 420 430 440 450
ELLLTIQMGI DNLYVRLMGI NLPATQREVV LSNTLDLNSK LAYCEGKLTY
460 470 480 490 500
LADRVQMVSR TEEGDTKVRD TLESSTLMEK YNTRISFENR EEDMIDTFQF
510 520 530
PDMDHSYVPS RAEIKRQAQR LIEGKLKAAK KKKK
Length:534
Mass (Da):62,689
Last modified:May 18, 2010 - v3
Checksum:iD38115A57A2E228D
GO
Isoform 2 (identifier: Q5T5S1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     427-515: REVVLSNTLD...SYVPSRAEIK → VPGVRLSCHTPGPWAGPEG

Note: No experimental confirmation available.Curated
Show »
Length:464
Mass (Da):54,204
Checksum:i20C5106AE55240DA
GO
Isoform 3 (identifier: Q5T5S1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-88: Missing.
     283-534: Missing.

Show »
Length:194
Mass (Da):23,210
Checksum:i2DCB391A47A9C853
GO
Isoform 4 (identifier: Q5T5S1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-42: Missing.
     43-90: ATLALLRSNI...RLAHCRSTME → MLRSRRGTEQ...HEWAVPFPTQ
     370-424: SFKSVEKKMT...VRLMGINLPA → RCPGLPGLRA...HLHTPELLSP
     425-534: Missing.

Note: No experimental confirmation available.
Show »
Length:383
Mass (Da):44,321
Checksum:iBB2411FDF2E327BC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9W6G5E9W6_HUMAN
Coiled-coil domain-containing prote...
CCDC183 hCG_2039834
318Annotation score:

Sequence cautioni

Isoform 2 : The sequence AAH64582 differs from that shown. Reason: Frameshift at position 222.Curated
Isoform 2 : The sequence AAH64582 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB85570 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03304638M → T. Corresponds to variant dbSNP:rs945386Ensembl.1
Natural variantiVAR_033047113L → R. Corresponds to variant dbSNP:rs4546744Ensembl.1
Natural variantiVAR_033048129D → A. Corresponds to variant dbSNP:rs7859194Ensembl.1
Natural variantiVAR_033049342W → R3 PublicationsCorresponds to variant dbSNP:rs2811795Ensembl.1
Natural variantiVAR_063112421N → T2 PublicationsCorresponds to variant dbSNP:rs2254143Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0264771 – 88Missing in isoform 3. 1 PublicationAdd BLAST88
Alternative sequenceiVSP_0264781 – 42Missing in isoform 4. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_02647943 – 90ATLAL…RSTME → MLRSRRGTEQVPSPRFPVGL PRASTRPPAGGLHGGPLRNH EWAVPFPTQ in isoform 4. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_026481283 – 534Missing in isoform 3. 1 PublicationAdd BLAST252
Alternative sequenceiVSP_026483370 – 424SFKSV…INLPA → RCPGLPGLRATHPSLTKAPG CSQAGSWEYTHCQQACVSHR GARGLHLHTPELLSP in isoform 4. 1 PublicationAdd BLAST55
Alternative sequenceiVSP_026484425 – 534Missing in isoform 4. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_026482427 – 515REVVL…RAEIK → VPGVRLSCHTPGPWAGPEG in isoform 2. 1 PublicationAdd BLAST89

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075864 mRNA Translation: BAB85570.1 Different initiation.
AK092639 mRNA Translation: BAC03931.1
AL355987 Genomic DNA No translation available.
BC064582 mRNA Translation: AAH64582.1 Sequence problems.
BC137317 mRNA Translation: AAI37318.1
BC137318 mRNA Translation: AAI37319.1
CCDSiCCDS43906.1 [Q5T5S1-1]
RefSeqiNP_001034463.4, NM_001039374.4 [Q5T5S1-1]
UniGeneiHs.728796

Genome annotation databases

EnsembliENST00000338005; ENSP00000338013; ENSG00000213213 [Q5T5S1-1]
GeneIDi84960
KEGGihsa:84960
UCSCiuc004cjf.4 human [Q5T5S1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075864 mRNA Translation: BAB85570.1 Different initiation.
AK092639 mRNA Translation: BAC03931.1
AL355987 Genomic DNA No translation available.
BC064582 mRNA Translation: AAH64582.1 Sequence problems.
BC137317 mRNA Translation: AAI37318.1
BC137318 mRNA Translation: AAI37319.1
CCDSiCCDS43906.1 [Q5T5S1-1]
RefSeqiNP_001034463.4, NM_001039374.4 [Q5T5S1-1]
UniGeneiHs.728796

3D structure databases

ProteinModelPortaliQ5T5S1
SMRiQ5T5S1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124391, 31 interactors
STRINGi9606.ENSP00000338013

PTM databases

CarbonylDBiQ5T5S1
iPTMnetiQ5T5S1
PhosphoSitePlusiQ5T5S1

Polymorphism and mutation databases

BioMutaiKIAA1984
DMDMi296439313

Proteomic databases

EPDiQ5T5S1
MaxQBiQ5T5S1
PaxDbiQ5T5S1
PeptideAtlasiQ5T5S1
PRIDEiQ5T5S1
ProteomicsDBi64547
64548 [Q5T5S1-2]
64549 [Q5T5S1-3]
64550 [Q5T5S1-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338005; ENSP00000338013; ENSG00000213213 [Q5T5S1-1]
GeneIDi84960
KEGGihsa:84960
UCSCiuc004cjf.4 human [Q5T5S1-1]

Organism-specific databases

CTDi84960
EuPathDBiHostDB:ENSG00000213213.13
GeneCardsiCCDC183
HGNCiHGNC:28236 CCDC183
HPAiHPA043812
MIMi615955 gene
neXtProtiNX_Q5T5S1
OpenTargetsiENSG00000213213
PharmGKBiPA134944889
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II7I Eukaryota
ENOG410YH5U LUCA
GeneTreeiENSGT00900000141046
HOGENOMiHOG000050237
HOVERGENiHBG058359
InParanoidiQ5T5S1
OMAiCSHLWDI
OrthoDBiEOG091G0IUD
PhylomeDBiQ5T5S1
TreeFamiTF324955

Miscellaneous databases

ChiTaRSiCCDC183 human
GenomeRNAii84960
PROiPR:Q5T5S1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213213 Expressed in 89 organ(s), highest expression level in left testis
ExpressionAtlasiQ5T5S1 baseline and differential

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCC183_HUMAN
AccessioniPrimary (citable) accession number: Q5T5S1
Secondary accession number(s): B2RP89
, C9JD38, Q6P2D9, Q8NAI4, Q8TF18
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 91 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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