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Entry version 130 (08 May 2019)
Sequence version 2 (15 May 2007)
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Protein

Sickle tail protein homolog

Gene

KIAA1217

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal development of intervertebral disks.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sickle tail protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIAA1217
Synonyms:SKT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25428 KIAA1217

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
617367 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T5P2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
56243

Open Targets

More...
OpenTargetsi
ENSG00000120549

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134893343

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KIAA1217

Domain mapping of disease mutations (DMDM)

More...
DMDMi
147733121

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002878971 – 1943Sickle tail protein homologAdd BLAST1943

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei169PhosphoserineBy similarity1
Modified residuei244PhosphotyrosineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi357O-linked (GlcNAc) serineBy similarity1
Modified residuei361PhosphoserineCombined sources1
Modified residuei365PhosphoserineBy similarity1
Modified residuei393PhosphotyrosineCombined sources1
Modified residuei470PhosphothreonineCombined sources1
Modified residuei474PhosphoserineBy similarity1
Modified residuei526PhosphoserineCombined sources1
Modified residuei809PhosphoserineBy similarity1
Modified residuei1027PhosphoserineBy similarity1
Modified residuei1030PhosphoserineBy similarity1
Modified residuei1033PhosphoserineBy similarity1
Modified residuei1044PhosphoserineCombined sources1
Modified residuei1461PhosphoserineBy similarity1
Modified residuei1739PhosphoserineCombined sources1
Modified residuei1841PhosphoserineBy similarity1
Modified residuei1896PhosphoserineBy similarity1
Modified residuei1899PhosphoserineBy similarity1
Modified residuei1902PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T5P2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5T5P2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T5P2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T5P2

PeptideAtlas

More...
PeptideAtlasi
Q5T5P2

PRoteomics IDEntifications database

More...
PRIDEi
Q5T5P2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
64537
64538 [Q5T5P2-2]
64539 [Q5T5P2-3]
64540 [Q5T5P2-4]
64541 [Q5T5P2-6]
64542 [Q5T5P2-7]
64543 [Q5T5P2-8]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T5P2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T5P2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000120549 Expressed in 195 organ(s), highest expression level in oviduct epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5T5P2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T5P2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA004941

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CPNE4 (via VWFA domain).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
121111, 29 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T5P2, 32 interactors

Molecular INTeraction database

More...
MINTi
Q5T5P2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000365637

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5T5P2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili557 – 581Sequence analysisAdd BLAST25
Coiled coili644 – 685Sequence analysisAdd BLAST42
Coiled coili957 – 985Sequence analysisAdd BLAST29
Coiled coili1464 – 1490Sequence analysisAdd BLAST27
Coiled coili1656 – 1686Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi295 – 364Pro-richSequence analysisAdd BLAST70
Compositional biasi1794 – 1905Ser-richSequence analysisAdd BLAST112

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG2A Eukaryota
ENOG410ZC52 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156098

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293351

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T5P2

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHEGRMS

Database of Orthologous Groups

More...
OrthoDBi
65773at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T5P2

TreeFam database of animal gene trees

More...
TreeFami
TF332255

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022782 AIP3-like_C
IPR026725 Skt

The PANTHER Classification System

More...
PANTHERi
PTHR22741:SF11 PTHR22741:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03915 AIP3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (9+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 9 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 9 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T5P2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEENESQKCE PCLPYSADRR QMQEQGKGNL HVTSPEDAEC RRTKERLSNG
60 70 80 90 100
NSRGSVSKSS RNIPRRHTLG GPRSSKEILG MQTSEMDRKR EAFLEHLKQK
110 120 130 140 150
YPHHASAIMG HQERLRDQTR SPKLSHSPQP PSLGDPVEHL SETSADSLEA
160 170 180 190 200
MSEGDAPTPF SRGSRTRASL PVVRSTNQTK ERSLGVLYLQ YGDETKQLRM
210 220 230 240 250
PNEITSADTI RALFVSAFPQ QLTMKMLESP SVAIYIKDES RNVYYELNDV
260 270 280 290 300
RNIQDRSLLK VYNKDPAHAF NHTPKTMNGD MRMQRELVYA RGDGPGAPRP
310 320 330 340 350
GSTAHPPHAI PNSPPSTPVP HSMPPSPSRI PYGGTRSMVV PGNATIPRDR
360 370 380 390 400
ISSLPVSRPI SPSPSAILER RDVKPDEDMS GKNIAMYRNE GFYADPYLYH
410 420 430 440 450
EGRMSIASSH GGHPLDVPDH IIAYHRTAIR SASAYCNPSM QAEMHMEQSL
460 470 480 490 500
YRQKSRKYPD SHLPTLGSKT PPASPHRVSD LRMIDMHAHY NAHGPPHTMQ
510 520 530 540 550
PDRASPSRQA FKKEPGTLVY IEKPRSAAGL SSLVDLGPPL MEKQVFAYST
560 570 580 590 600
ATIPKDRETR ERMQAMEKQI ASLTGLVQSA LFKGPITSYS KDASSEKMMK
610 620 630 640 650
TTANRNHTDS AGTPHVSGGK MLSALESTVP PSQPPPVGTS AIHMSLLEMR
660 670 680 690 700
RSVAELRLQL QQMRQLQLQN QELLRAMMKK AELEISGKVM ETMKRLEDPV
710 720 730 740 750
QRQRVLVEQE RQKYLHEEEK IVKKLCELED FVEDLKKDST AASRLVTLKD
760 770 780 790 800
VEDGAFLLRQ VGEAVATLKG EFPTLQNKMR AILRIEVEAV RFLKEEPHKL
810 820 830 840 850
DSLLKRVRSM TDVLTMLRRH VTDGLLKGTD AAQAAQYMAM EKATAAEVLK
860 870 880 890 900
SQEEAAHTSG QPFHSTGAPG DAKSEVVPLS GMMVRHAQSS PVVIQPSQHS
910 920 930 940 950
VALLNPAQNL PHVASSPAVP QEATSTLQMS QAPQSPQIPM NGSAMQSLFI
960 970 980 990 1000
EEIHSVSAKN RAVSIEKAEK KWEEKRQNLD HYNGKEFEKL LEEAQANIMK
1010 1020 1030 1040 1050
SIPNLEMPPA TGPLPRGDAP VDKVELSEDS PNSEQDLEKL GGKSPPPPPP
1060 1070 1080 1090 1100
PPRRSYLPGS GLTTTRSGDV VYTGRKENIT AKASSEDAGP SPQTRATKYP
1110 1120 1130 1140 1150
AEEPASAWTP SPPPVTTSSS KDEEEEEEEG DKIMAELQAF QKCSFMDVNS
1160 1170 1180 1190 1200
NSHAEPSRAD SHVKDTRSGA TVPPKEKKNL EFFHEDVRKS DVEYENGPQM
1210 1220 1230 1240 1250
EFQKVTTGAV RPSDPPKWER GMENSISDAS RTSEYKTEII MKENSISNMS
1260 1270 1280 1290 1300
LLRDSRNYSQ ETVPKASFGF SGISPLEDEI NKGSKISGLQ YSIPDTENQT
1310 1320 1330 1340 1350
LNYGKTKEME KQNTDKCHVS SHTRLTESSV HDFKTEDQEV ITTDFGQVVL
1360 1370 1380 1390 1400
RPKEARHANV NPNEDGESSS SSPTEENAAT DNIAFMITET TVQVLSSGEV
1410 1420 1430 1440 1450
HDIVSQKGED IQTVNIDARK EMTPRQEGTD NEDPVVCLDK KPVIIIFDEP
1460 1470 1480 1490 1500
MDIRSAYKRL STIFEECDEE LERMMMEEKI EEEEEEENGD SVVQNNNTSQ
1510 1520 1530 1540 1550
MSHKKVAPGN LRTGQQVETK SQPHSLATET RNPGGQEMNR TELNKFSHVD
1560 1570 1580 1590 1600
SPNSECKGED ATDDQFESPK KKFKFKFPKK QLAALTQAIR TGTKTGKKTL
1610 1620 1630 1640 1650
QVVVYEEEEE DGTLKQHKEA KRFEIARSQP EDTPENTVRR QEQPSIESTS
1660 1670 1680 1690 1700
PISRTDEIRK NTYRTLDSLE QTIKQLENTI SEMSPKALVD TSCSSNRDSV
1710 1720 1730 1740 1750
ASSSHIAQEA SPRPLLVPDE GPTALEPPTS IPSASRKGSS GAPQTSRMPV
1760 1770 1780 1790 1800
PMSAKNRPGT LDKPGKQSKL QDPRQYRQAN GSAKKSGGDF KPTSPSLPAS
1810 1820 1830 1840 1850
KIPALSPSSG KSSSLPSSSG DSSNLPNPPA TKPSIASNPL SPQTGPPAHS
1860 1870 1880 1890 1900
ASLIPSVSNG SLKFQSLTHT GKGHHLSFSP QSQNGRAPPP LSFSSSPPSP
1910 1920 1930 1940
ASSVSLNQGA KGTRTIHTPS LTSYKAQNGS SSKATPSTAK ETS
Length:1,943
Mass (Da):214,116
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDFE67FADE56E0349
GO
Isoform 21 Publication (identifier: Q5T5P2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1139-1737: Missing.

Show »
Length:1,344
Mass (Da):146,879
Checksum:i5648CE8248B1ADA7
GO
Isoform 3 (identifier: Q5T5P2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     1779-1782: ANGS → VVLP
     1783-1943: Missing.

Show »
Length:1,465
Mass (Da):162,360
Checksum:i418F12AC78926686
GO
Isoform 41 Publication (identifier: Q5T5P2-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     1139-1737: Missing.
     1779-1782: ANGS → VVLP
     1783-1943: Missing.

Show »
Length:866
Mass (Da):95,123
Checksum:i24CDAF47EE1EBB7E
GO
Isoform 5 (identifier: Q5T5P2-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     560-594: Missing.
     1179-1737: Missing.

Show »
Length:1,349
Mass (Da):147,424
Checksum:iF2BA6806FFB23CB1
GO
Isoform 61 Publication (identifier: Q5T5P2-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     1205-1737: Missing.
     1779-1782: ANGS → VVLP
     1783-1943: Missing.

Show »
Length:932
Mass (Da):102,692
Checksum:iFA65349E05AFBC5B
GO
Isoform 7 (identifier: Q5T5P2-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-282: Missing.
     560-594: Missing.
     1179-1737: Missing.
     1779-1782: ANGS → VVLP
     1783-1943: Missing.

Show »
Length:906
Mass (Da):99,494
Checksum:i14A5BFA2BE6A6007
GO
Isoform 9 (identifier: Q5T5P2-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-80: Missing.
     1139-1737: Missing.

Show »
Length:1,264
Mass (Da):137,913
Checksum:iBCD625CB6C41767D
GO
Isoform 10 (identifier: Q5T5P2-10) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     560-594: Missing.
     1028-1028: Missing.
     1205-1737: Missing.

Note: No experimental confirmation available.
Show »
Length:1,374
Mass (Da):150,493
Checksum:i16DF21048B2134CE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T5P0Q5T5P0_HUMAN
Sickle tail protein homolog
KIAA1217
783Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5T5P1Q5T5P1_HUMAN
Sickle tail protein homolog
KIAA1217
933Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RRK8A0A0U1RRK8_HUMAN
Sickle tail protein homolog
KIAA1217
453Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GU17A0A1B0GU17_HUMAN
Sickle tail protein homolog
KIAA1217
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQK8A0A0U1RQK8_HUMAN
Sickle tail protein homolog
KIAA1217
180Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH18764 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AL833280 differs from that shown. Reason: Frameshift at position 976.Curated
The sequence BAC86241 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAF63529 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAE45879 differs from that shown. Reason: Erroneous termination at position 1251. Translated as Leu.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti498T → A in AL833280 (PubMed:17974005).Curated1
Sequence conflicti508R → H in BX648451 (PubMed:17974005).Curated1
Sequence conflicti679K → R in AL833280 (PubMed:17974005).Curated1
Sequence conflicti795E → G in CAE45879 (PubMed:17974005).Curated1
Sequence conflicti829T → M in BX648451 (PubMed:17974005).Curated1
Sequence conflicti914A → P in BX648451 (PubMed:17974005).Curated1
Sequence conflicti1267S → N in BAC86241 (PubMed:14702039).Curated1
Sequence conflicti1306T → A in AL833280 (PubMed:17974005).Curated1
Sequence conflicti1743P → L in AL833280 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051358145A → G. Corresponds to variant dbSNP:rs17506606Ensembl.1
Natural variantiVAR_051359887A → T1 PublicationCorresponds to variant dbSNP:rs10828663Ensembl.1
Natural variantiVAR_0513601362P → A. Corresponds to variant dbSNP:rs16924863Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0524271 – 282Missing in isoform 3, isoform 4, isoform 6 and isoform 7. 3 PublicationsAdd BLAST282
Alternative sequenceiVSP_0541071 – 80Missing in isoform 9. 1 PublicationAdd BLAST80
Alternative sequenceiVSP_052428560 – 594Missing in isoform 3, isoform 4, isoform 5, isoform 6, isoform 7 and isoform 10. 4 PublicationsAdd BLAST35
Alternative sequenceiVSP_0548741028Missing in isoform 10. 1 Publication1
Alternative sequenceiVSP_0524291139 – 1737Missing in isoform 2, isoform 4 and isoform 9. 3 PublicationsAdd BLAST599
Alternative sequenceiVSP_0303531179 – 1737Missing in isoform 5 and isoform 7. 2 PublicationsAdd BLAST559
Alternative sequenceiVSP_0524301205 – 1737Missing in isoform 6 and isoform 10. 1 PublicationAdd BLAST533
Alternative sequenceiVSP_0524311779 – 1782ANGS → VVLP in isoform 3, isoform 4, isoform 6 and isoform 7. 3 Publications4
Alternative sequenceiVSP_0524321783 – 1943Missing in isoform 3, isoform 4, isoform 6 and isoform 7. 3 PublicationsAdd BLAST161

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB033043 mRNA Translation: BAA86531.2
AL157473 mRNA Translation: CAB75668.1
AL833280 mRNA No translation available.
BX640796 mRNA Translation: CAE45879.1 Sequence problems.
BX648451 mRNA No translation available.
AC063961 Genomic DNA No translation available.
AL353583 Genomic DNA No translation available.
AL356113 Genomic DNA No translation available.
AL392104 Genomic DNA No translation available.
AL157781 Genomic DNA No translation available.
AL353650 Genomic DNA No translation available.
AL355977 Genomic DNA No translation available.
AL356477 Genomic DNA No translation available.
AL391499 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86124.1
BC018764 mRNA Translation: AAH18764.1 Different initiation.
BC098577 mRNA Translation: AAH98577.1
BC136521 mRNA Translation: AAI36522.1
AB291616 mRNA Translation: BAF63529.1 Different initiation.
AK125675 mRNA Translation: BAC86241.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31165.1 [Q5T5P2-1]
CCDS41496.1 [Q5T5P2-9]
CCDS60501.1 [Q5T5P2-7]
CCDS60502.1 [Q5T5P2-10]
CCDS60504.1 [Q5T5P2-6]
CCDS60505.1 [Q5T5P2-4]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46910

NCBI Reference Sequences

More...
RefSeqi
NP_001091970.1, NM_001098500.2 [Q5T5P2-9]
NP_001269696.1, NM_001282767.1 [Q5T5P2-10]
NP_001269697.1, NM_001282768.1 [Q5T5P2-7]
NP_001269698.1, NM_001282769.1 [Q5T5P2-6]
NP_001269699.1, NM_001282770.1 [Q5T5P2-4]
NP_062536.2, NM_019590.4 [Q5T5P2-1]
XP_005252573.1, XM_005252516.3 [Q5T5P2-3]
XP_016871918.1, XM_017016429.1 [Q5T5P2-9]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307544; ENSP00000302343; ENSG00000120549 [Q5T5P2-6]
ENST00000376451; ENSP00000365634; ENSG00000120549 [Q5T5P2-3]
ENST00000376452; ENSP00000365635; ENSG00000120549 [Q5T5P2-10]
ENST00000376454; ENSP00000365637; ENSG00000120549 [Q5T5P2-1]
ENST00000376462; ENSP00000365645; ENSG00000120549 [Q5T5P2-9]
ENST00000396445; ENSP00000379722; ENSG00000120549 [Q5T5P2-8]
ENST00000396446; ENSP00000379723; ENSG00000120549 [Q5T5P2-4]
ENST00000430453; ENSP00000389680; ENSG00000120549 [Q5T5P2-9]
ENST00000458595; ENSP00000392625; ENSG00000120549 [Q5T5P2-7]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
56243

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:56243

UCSC genome browser

More...
UCSCi
uc001irs.5 human [Q5T5P2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033043 mRNA Translation: BAA86531.2
AL157473 mRNA Translation: CAB75668.1
AL833280 mRNA No translation available.
BX640796 mRNA Translation: CAE45879.1 Sequence problems.
BX648451 mRNA No translation available.
AC063961 Genomic DNA No translation available.
AL353583 Genomic DNA No translation available.
AL356113 Genomic DNA No translation available.
AL392104 Genomic DNA No translation available.
AL157781 Genomic DNA No translation available.
AL353650 Genomic DNA No translation available.
AL355977 Genomic DNA No translation available.
AL356477 Genomic DNA No translation available.
AL391499 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86124.1
BC018764 mRNA Translation: AAH18764.1 Different initiation.
BC098577 mRNA Translation: AAH98577.1
BC136521 mRNA Translation: AAI36522.1
AB291616 mRNA Translation: BAF63529.1 Different initiation.
AK125675 mRNA Translation: BAC86241.1 Different initiation.
CCDSiCCDS31165.1 [Q5T5P2-1]
CCDS41496.1 [Q5T5P2-9]
CCDS60501.1 [Q5T5P2-7]
CCDS60502.1 [Q5T5P2-10]
CCDS60504.1 [Q5T5P2-6]
CCDS60505.1 [Q5T5P2-4]
PIRiT46910
RefSeqiNP_001091970.1, NM_001098500.2 [Q5T5P2-9]
NP_001269696.1, NM_001282767.1 [Q5T5P2-10]
NP_001269697.1, NM_001282768.1 [Q5T5P2-7]
NP_001269698.1, NM_001282769.1 [Q5T5P2-6]
NP_001269699.1, NM_001282770.1 [Q5T5P2-4]
NP_062536.2, NM_019590.4 [Q5T5P2-1]
XP_005252573.1, XM_005252516.3 [Q5T5P2-3]
XP_016871918.1, XM_017016429.1 [Q5T5P2-9]

3D structure databases

SMRiQ5T5P2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121111, 29 interactors
IntActiQ5T5P2, 32 interactors
MINTiQ5T5P2
STRINGi9606.ENSP00000365637

PTM databases

iPTMnetiQ5T5P2
PhosphoSitePlusiQ5T5P2

Polymorphism and mutation databases

BioMutaiKIAA1217
DMDMi147733121

Proteomic databases

EPDiQ5T5P2
jPOSTiQ5T5P2
MaxQBiQ5T5P2
PaxDbiQ5T5P2
PeptideAtlasiQ5T5P2
PRIDEiQ5T5P2
ProteomicsDBi64537
64538 [Q5T5P2-2]
64539 [Q5T5P2-3]
64540 [Q5T5P2-4]
64541 [Q5T5P2-6]
64542 [Q5T5P2-7]
64543 [Q5T5P2-8]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307544; ENSP00000302343; ENSG00000120549 [Q5T5P2-6]
ENST00000376451; ENSP00000365634; ENSG00000120549 [Q5T5P2-3]
ENST00000376452; ENSP00000365635; ENSG00000120549 [Q5T5P2-10]
ENST00000376454; ENSP00000365637; ENSG00000120549 [Q5T5P2-1]
ENST00000376462; ENSP00000365645; ENSG00000120549 [Q5T5P2-9]
ENST00000396445; ENSP00000379722; ENSG00000120549 [Q5T5P2-8]
ENST00000396446; ENSP00000379723; ENSG00000120549 [Q5T5P2-4]
ENST00000430453; ENSP00000389680; ENSG00000120549 [Q5T5P2-9]
ENST00000458595; ENSP00000392625; ENSG00000120549 [Q5T5P2-7]
GeneIDi56243
KEGGihsa:56243
UCSCiuc001irs.5 human [Q5T5P2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
56243
DisGeNETi56243

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KIAA1217

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0008709
HGNCiHGNC:25428 KIAA1217
HPAiHPA004941
MIMi617367 gene
neXtProtiNX_Q5T5P2
OpenTargetsiENSG00000120549
PharmGKBiPA134893343

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IG2A Eukaryota
ENOG410ZC52 LUCA
GeneTreeiENSGT00940000156098
HOGENOMiHOG000293351
InParanoidiQ5T5P2
OMAiFHEGRMS
OrthoDBi65773at2759
PhylomeDBiQ5T5P2
TreeFamiTF332255

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KIAA1217 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
56243

Protein Ontology

More...
PROi
PR:Q5T5P2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000120549 Expressed in 195 organ(s), highest expression level in oviduct epithelium
ExpressionAtlasiQ5T5P2 baseline and differential
GenevisibleiQ5T5P2 HS

Family and domain databases

InterProiView protein in InterPro
IPR022782 AIP3-like_C
IPR026725 Skt
PANTHERiPTHR22741:SF11 PTHR22741:SF11, 1 hit
PfamiView protein in Pfam
PF03915 AIP3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSKT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T5P2
Secondary accession number(s): A5LHW9
, A6NLF3, A6PVQ5, A6PVQ6, A6PVQ7, B9EGK4, Q4KMG4, Q5T5P3, Q5T7H3, Q6MZZ6, Q6ZUI4, Q8WV45, Q9NSR2, Q9ULK3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 8, 2019
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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