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Entry version 105 (12 Aug 2020)
Sequence version 1 (21 Dec 2004)
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Protein

Uncharacterized protein C6orf118

Gene

C6orf118

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q5T5N4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized protein C6orf118
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000112539.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21233, C6orf118

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T5N4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000112539

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134954942

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5T5N4, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C6orf118

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71152375

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000895231 – 469Uncharacterized protein C6orf118Add BLAST469

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5T5N4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5T5N4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T5N4

PeptideAtlas

More...
PeptideAtlasi
Q5T5N4

PRoteomics IDEntifications database

More...
PRIDEi
Q5T5N4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64534

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T5N4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T5N4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000112539, Expressed in right uterine tube and 97 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T5N4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000112539, Tissue enhanced (brain, fallopian tube, pituitary gland, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127954, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T5N4, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000230301

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5T5N4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5T5N4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili346 – 375Sequence analysisAdd BLAST30
Coiled coili423 – 453Sequence analysisAdd BLAST31

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RB3J, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009877

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_040125_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T5N4

Identification of Orthologs from Complete Genome Data

More...
OMAi
KDHREDV

Database of Orthologous Groups

More...
OrthoDBi
1005609at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T5N4

TreeFam database of animal gene trees

More...
TreeFami
TF329261

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032755, TSNAXIP1_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15739, TSNAXIP1_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5T5N4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEEREPELY LKWKHCETPG VKTLCNLKHC ETPGVKTLCN LKKLLNRLQK
60 70 80 90 100
DHREDVYLYI SGHLNPNKLY QPPETILQHW PNAHRPKGER ASEVGEPPAG
110 120 130 140 150
KVARMKEALA HFTIHTALVP SEAQDTPLFR YLNPQASLSH TSEEDFLPVE
160 170 180 190 200
AVREGKEEKK GGPPGRGPPG WRRREELRLP DLKVLCYQEA GSRGTRDRHH
210 220 230 240 250
YVSSYLAGAT SADRYRMFLR FQKEVLAKQD LLKNDFTGSK AAAGHERKLQ
260 270 280 290 300
QELQKICTCS PQQFNRLHVF GKVFEDICNS SLIFGDLLKK VKDEYELYMA
310 320 330 340 350
TLLESQPAAQ YEALLAQLKA LGQRPVKTAD MDLAREELRM LVTATKAALE
360 370 380 390 400
QNDRLRSELE MEVALLQSAK ERSESSEKHI IDENRLTLTE KVEKKRCEIL
410 420 430 440 450
SKWDEIQALE KEIKTTLVHT GISDITENRI KSIEHEAIQL ETENMILKKK
460
IKGPLEIYQG ICKIRGNRR
Length:469
Mass (Da):53,772
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE38A4E9C3290040
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050807166R → L. Corresponds to variant dbSNP:rs36007498Ensembl.1
Natural variantiVAR_022887256I → M. Corresponds to variant dbSNP:rs510579Ensembl.1
Natural variantiVAR_050808271G → E1 PublicationCorresponds to variant dbSNP:rs17852379Ensembl.1
Natural variantiVAR_050809301T → M. Corresponds to variant dbSNP:rs540751Ensembl.1
Natural variantiVAR_022888363V → L. Corresponds to variant dbSNP:rs9459350Ensembl.1
Natural variantiVAR_050810385R → Q1 PublicationCorresponds to variant dbSNP:rs17856754Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL356125 Genomic DNA No translation available.
AL117345 Genomic DNA No translation available.
BC026278 mRNA Translation: AAH26278.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5288.1

NCBI Reference Sequences

More...
RefSeqi
NP_659417.2, NM_144980.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000230301; ENSP00000230301; ENSG00000112539

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
168090

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:168090

UCSC genome browser

More...
UCSCi
uc003qum.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356125 Genomic DNA No translation available.
AL117345 Genomic DNA No translation available.
BC026278 mRNA Translation: AAH26278.1
CCDSiCCDS5288.1
RefSeqiNP_659417.2, NM_144980.3

3D structure databases

SMRiQ5T5N4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi127954, 5 interactors
IntActiQ5T5N4, 4 interactors
STRINGi9606.ENSP00000230301

PTM databases

iPTMnetiQ5T5N4
PhosphoSitePlusiQ5T5N4

Polymorphism and mutation databases

BioMutaiC6orf118
DMDMi71152375

Proteomic databases

EPDiQ5T5N4
MassIVEiQ5T5N4
PaxDbiQ5T5N4
PeptideAtlasiQ5T5N4
PRIDEiQ5T5N4
ProteomicsDBi64534

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
33511, 18 antibodies

Genome annotation databases

EnsembliENST00000230301; ENSP00000230301; ENSG00000112539
GeneIDi168090
KEGGihsa:168090
UCSCiuc003qum.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
168090
EuPathDBiHostDB:ENSG00000112539.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C6orf118
HGNCiHGNC:21233, C6orf118
HPAiENSG00000112539, Tissue enhanced (brain, fallopian tube, pituitary gland, testis)
neXtProtiNX_Q5T5N4
OpenTargetsiENSG00000112539
PharmGKBiPA134954942

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RB3J, Eukaryota
GeneTreeiENSGT00390000009877
HOGENOMiCLU_040125_0_0_1
InParanoidiQ5T5N4
OMAiKDHREDV
OrthoDBi1005609at2759
PhylomeDBiQ5T5N4
TreeFamiTF329261

Enzyme and pathway databases

PathwayCommonsiQ5T5N4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
168090, 6 hits in 858 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C6orf118, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
168090
PharosiQ5T5N4, Tdark

Protein Ontology

More...
PROi
PR:Q5T5N4
RNActiQ5T5N4, protein

Gene expression databases

BgeeiENSG00000112539, Expressed in right uterine tube and 97 other tissues
GenevisibleiQ5T5N4, HS

Family and domain databases

InterProiView protein in InterPro
IPR032755, TSNAXIP1_N
PfamiView protein in Pfam
PF15739, TSNAXIP1_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCF118_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T5N4
Secondary accession number(s): Q8TC11
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: December 21, 2004
Last modified: August 12, 2020
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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