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Protein

Cyclin-J

Gene

CCNJ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Keywordsi

Molecular functionCyclin

Enzyme and pathway databases

SignaLinkiQ5T5M9

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-J
Gene namesi
Name:CCNJ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000107443.15
HGNCiHGNC:23434 CCNJ
neXtProtiNX_Q5T5M9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi54619
OpenTargetsiENSG00000107443
PharmGKBiPA134911603

Polymorphism and mutation databases

BioMutaiCCNJ
DMDMi160380581

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003093161 – 372Cyclin-JAdd BLAST372

Proteomic databases

PaxDbiQ5T5M9
PeptideAtlasiQ5T5M9
PRIDEiQ5T5M9
ProteomicsDBi64530
64531 [Q5T5M9-2]
64532 [Q5T5M9-3]

PTM databases

iPTMnetiQ5T5M9
PhosphoSitePlusiQ5T5M9

Expressioni

Gene expression databases

BgeeiENSG00000107443
CleanExiHS_CCNJ
GenevisibleiQ5T5M9 HS

Organism-specific databases

HPAiHPA036531
HPA058151

Interactioni

Protein-protein interaction databases

BioGridi120077, 5 interactors
IntActiQ5T5M9, 1 interactor
STRINGi9606.ENSP00000388902

Structurei

3D structure databases

ProteinModelPortaliQ5T5M9
SMRiQ5T5M9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 143Cyclin N-terminalAdd BLAST129

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiENOG410IEPY Eukaryota
ENOG410Y1BM LUCA
GeneTreeiENSGT00390000001183
HOGENOMiHOG000006591
HOVERGENiHBG106031
InParanoidiQ5T5M9
OMAiRHPVSEQ
OrthoDBiEOG091G09DD
PhylomeDBiQ5T5M9
TreeFamiTF101009

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR028859 Cyclin-J
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PANTHERiPTHR10177:SF62 PTHR10177:SF62, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T5M9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELEGQWWRG QLAADIHQAL RYKELKLPSY KGQSPQLSLR RYFADLIAIV
60 70 80 90 100
SNRFTLCPSA RHLAVYLLDL FMDRYDISIQ QLHLVALSCL LLASKFEEKE
110 120 130 140 150
DSVPKLEQLN SLGCMTNMNL VLTKQNLLHM ELLLLETFQW NLCLPTAAHF
160 170 180 190 200
IEYYLSEAVH ETDLHDGWPM ICLEKTKLYM AKYADYFLEV SLQVAAACVA
210 220 230 240 250
SSRIILRLSP TWPTRLHRLT AYSWDFLVQC IERLLIAHDN DVKEANKQRG
260 270 280 290 300
QAGPQSAQLS VFQTASQPSR PVHFQQPQYL HQTHQTSLQY RHPTSEQPSC
310 320 330 340 350
QQIVSTTHTS SYTLQTCPAG FQTSVQGLGH MQTGVGMSLA IPVEVKPCLS
360 370
VSYNRSYQIN EHYPCITPCF ER
Length:372
Mass (Da):42,581
Last modified:February 20, 2007 - v2
Checksum:i5CCADA91E11CF5D7
GO
Isoform 2 (identifier: Q5T5M9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-194: Missing.

Show »
Length:371
Mass (Da):42,482
Checksum:i9A4B47A6230CD78B
GO
Isoform 3 (identifier: Q5T5M9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     193-193: Q → QDYAFLNYAPSL

Show »
Length:383
Mass (Da):43,836
Checksum:iC6FAE3DDD5AFBEB8
GO

Sequence cautioni

The sequence BAA91887 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041163193Q → QDYAFLNYAPSL in isoform 3. 1 Publication1
Alternative sequenceiVSP_029128194Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK001757 mRNA Translation: BAA91887.1 Different initiation.
AK297264 mRNA Translation: BAH12533.1
AL356155 Genomic DNA No translation available.
BC043175 mRNA Translation: AAH43175.1
CCDSiCCDS44462.1 [Q5T5M9-3]
CCDS44463.1 [Q5T5M9-2]
CCDS7445.1 [Q5T5M9-1]
RefSeqiNP_001127847.1, NM_001134375.1 [Q5T5M9-3]
NP_001127848.1, NM_001134376.1 [Q5T5M9-2]
NP_061957.2, NM_019084.4 [Q5T5M9-1]
XP_011538187.1, XM_011539885.2 [Q5T5M9-3]
UniGeneiHs.596479

Genome annotation databases

EnsembliENST00000265992; ENSP00000265992; ENSG00000107443 [Q5T5M9-1]
ENST00000403870; ENSP00000384498; ENSG00000107443 [Q5T5M9-2]
ENST00000465148; ENSP00000435373; ENSG00000107443 [Q5T5M9-3]
GeneIDi54619
KEGGihsa:54619
UCSCiuc001klm.4 human [Q5T5M9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCNJ_HUMAN
AccessioniPrimary (citable) accession number: Q5T5M9
Secondary accession number(s): B7Z4E7, Q86XL1, Q9NV69
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: February 20, 2007
Last modified: June 20, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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