Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Syntaxin-binding protein 5

Gene

STXBP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity).By similarity

GO - Molecular functioni

  • GTPase activator activity Source: GO_Central
  • Rab GTPase binding Source: GO_Central
  • syntaxin-1 binding Source: BHF-UCL
  • syntaxin binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processExocytosis, Protein transport, Transport

Enzyme and pathway databases

SignaLinkiQ5T5C0

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-binding protein 5
Alternative name(s):
Lethal(2) giant larvae protein homolog 3
Tomosyn-1
Gene namesi
Name:STXBP5
Synonyms:LLGL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000164506.14
HGNCiHGNC:19665 STXBP5
MIMi604586 gene
neXtProtiNX_Q5T5C0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi134957
OpenTargetsiENSG00000164506
PharmGKBiPA134954258

Polymorphism and mutation databases

BioMutaiSTXBP5
DMDMi74762236

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000512441 – 1151Syntaxin-binding protein 5Add BLAST1151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei692PhosphoserineCombined sources1
Modified residuei723Phosphoserine; by PKABy similarity1
Modified residuei759PhosphoserineCombined sources1
Modified residuei762PhosphothreonineCombined sources1
Modified residuei782PhosphoserineBy similarity1
Modified residuei784PhosphothreonineBy similarity1
Modified residuei785PhosphoserineCombined sources1
Modified residuei900PhosphoserineBy similarity1
Modified residuei902PhosphoserineBy similarity1
Modified residuei1039PhosphothreonineCombined sources1
Modified residuei1058PhosphoserineBy similarity1
Modified residuei1131PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T5C0
MaxQBiQ5T5C0
PaxDbiQ5T5C0
PeptideAtlasiQ5T5C0
PRIDEiQ5T5C0
ProteomicsDBi64509
64510 [Q5T5C0-2]
64511 [Q5T5C0-3]

PTM databases

iPTMnetiQ5T5C0
PhosphoSitePlusiQ5T5C0

Expressioni

Gene expression databases

BgeeiENSG00000164506 Expressed in 188 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_STXBP5
ExpressionAtlasiQ5T5C0 baseline and differential
GenevisibleiQ5T5C0 HS

Organism-specific databases

HPAiCAB079016
HPA039991
HPA049727

Interactioni

Subunit structurei

Interacts with STX1A and STX1B via its v-SNARE homology domain. Part of a complex that contains STX1, STXBP5, SNAP25 and SYT1. Part of a complex that contains STXBP5, STX4A and SNAP23 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126417, 13 interactors
IntActiQ5T5C0, 1 interactor
STRINGi9606.ENSP00000321826

Structurei

3D structure databases

ProteinModelPortaliQ5T5C0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati61 – 94WD 1Add BLAST34
Repeati101 – 140WD 2Add BLAST40
Repeati145 – 181WD 3Add BLAST37
Repeati200 – 234WD 4Add BLAST35
Repeati240 – 272WD 5Add BLAST33
Repeati294 – 336WD 6Add BLAST43
Repeati344 – 378WD 7Add BLAST35
Repeati400 – 477WD 8Add BLAST78
Repeati505 – 619WD 9Add BLAST115
Repeati633 – 695WD 10Add BLAST63
Repeati794 – 851WD 11Add BLAST58
Repeati860 – 934WD 12Add BLAST75
Repeati939 – 983WD 13Add BLAST45
Repeati997 – 1020WD 14Add BLAST24
Domaini1086 – 1146v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST61

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi22 – 27Poly-Gln6
Compositional biasi584 – 590Poly-Ser7

Sequence similaritiesi

Belongs to the WD repeat L(2)GL family.Curated

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410INFH Eukaryota
ENOG410XTER LUCA
GeneTreeiENSGT00390000000018
HOGENOMiHOG000110929
HOVERGENiHBG083064
InParanoidiQ5T5C0
KOiK08518
OMAiLGQAMYL
OrthoDBiEOG091G0LY3
PhylomeDBiQ5T5C0
TreeFamiTF314585

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR000664 Lethal2_giant
IPR013905 Lgl_C_dom
IPR013577 LLGL2
IPR001388 Synaptobrevin
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08596 Lgl_C, 1 hit
PF08366 LLGL, 1 hit
PF00400 WD40, 1 hit
PRINTSiPR00962 LETHAL2GIANT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50892 V_SNARE, 1 hit
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T5C0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRKFNIRKVL DGLTAGSSSA SQQQQQQHPP GNREPEIQET LQSEHFQLCK
60 70 80 90 100
TVRHGFPYQP SALAFDPVQK ILAVGTQTGA LRLFGRPGVE CYCQHDSGAA
110 120 130 140 150
VIQLQFLINE GALVSALADD TLHLWNLRQK RPAILHSLKF CRERVTFCHL
160 170 180 190 200
PFQSKWLYVG TERGNIHIVN VESFTLSGYV IMWNKAIELS SKSHPGPVVH
210 220 230 240 250
ISDNPMDEGK LLIGFESGTV VLWDLKSKKA DYRYTYDEAI HSVAWHHEGK
260 270 280 290 300
QFICSHSDGT LTIWNVRSPA KPVQTITPHG KQLKDGKKPE PCKPILKVEF
310 320 330 340 350
KTTRSGEPFI ILSGGLSYDT VGRRPCLTVM HGKSTAVLEM DYSIVDFLTL
360 370 380 390 400
CETPYPNDFQ EPYAVVVLLE KDLVLIDLAQ NGYPIFENPY PLSIHESPVT
410 420 430 440 450
CCEYFADCPV DLIPALYSVG ARQKRQGYSK KEWPINGGNW GLGAQSYPEI
460 470 480 490 500
IITGHADGSV KFWDASAITL QVLYKLKTSK VFEKSRNKDD RPNTDIVDED
510 520 530 540 550
PYAIQIISWC PESRMLCIAG VSAHVIIYRF SKQEVITEVI PMLEVRLLYE
560 570 580 590 600
INDVETPEGE QPPPLPTPVG GSNPQPIPPQ SHPSTSSSSS DGLRDNVPCL
610 620 630 640 650
KVKNSPLKQS PGYQTELVIQ LVWVGGEPPQ QITSLAVNSS YGLVVFGNCN
660 670 680 690 700
GIAMVDYLQK AVLLNLGTIE LYGSNDPYRR EPRSPRKSRQ PSGAGLCDIS
710 720 730 740 750
EGTVVPEDRC KSPTSGSSSP HNSDDEQKMN NFIEKVKTKS RKFSKMVAND
760 770 780 790 800
IAKMSRKLSL PTDLKPDLDV KDNSFSRSRS SSVTSIDKES REAISALHFC
810 820 830 840 850
ETFTRKTDSS PSPCLWVGTT LGTVLVIALN LPPGGEQRLL QPVIVSPSGT
860 870 880 890 900
ILRLKGAILR MAFLDTTGCL IPPAYEPWRE HNVPEEKDEK EKLKKRRPVS
910 920 930 940 950
VSPSSSQEIS ENQYAVICSE KQAKVISLPT QNCAYKQNIT ETSFVLRGDI
960 970 980 990 1000
VALSNSICLA CFCANGHIMT FSLPSLRPLL DVYYLPLTNM RIARTFCFTN
1010 1020 1030 1040 1050
NGQALYLVSP TEIQRLTYSQ ETCENLQEML GELFTPVETP EAPNRGFFKG
1060 1070 1080 1090 1100
LFGGGAQSLD REELFGESSS GKASRSLAQH IPGPGGIEGV KGAASGVVGE
1110 1120 1130 1140 1150
LARARLALDE RGQKLGDLEE RTAAMLSSAE SFSKHAHEIM LKYKDKKWYQ

F
Length:1,151
Mass (Da):127,573
Last modified:December 21, 2004 - v1
Checksum:i247083A17DEA4811
GO
Isoform 2 (identifier: Q5T5C0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-751: Missing.

Show »
Length:1,115
Mass (Da):123,492
Checksum:i2F1874662D9B30F6
GO
Isoform 3 (identifier: Q5T5C0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-768: Missing.

Show »
Length:1,098
Mass (Da):121,597
Checksum:iB8EAE43977084610
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JRH0Q5JRH0_HUMAN
Syntaxin-binding protein 5
STXBP5
263Annotation score:
Q3B794Q3B794_HUMAN
STXBP5 protein
STXBP5
308Annotation score:
H0Y332H0Y332_HUMAN
Syntaxin-binding protein 5
STXBP5
174Annotation score:

Sequence cautioni

The sequence BAC03475 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035235436N → S. Corresponds to variant dbSNP:rs1039084Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016204716 – 768Missing in isoform 3. CuratedAdd BLAST53
Alternative sequenceiVSP_016205716 – 751Missing in isoform 2. 2 PublicationsAdd BLAST36

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356415 Genomic DNA No translation available.
AL355365 Genomic DNA No translation available.
AL590709 Genomic DNA No translation available.
BC113382 mRNA Translation: AAI13383.1
AK055484 mRNA Translation: BAB70930.1
AK090549 mRNA Translation: BAC03475.1 Different initiation.
CCDSiCCDS47499.1 [Q5T5C0-1]
CCDS5211.1 [Q5T5C0-2]
RefSeqiNP_001121187.1, NM_001127715.2 [Q5T5C0-1]
NP_640337.3, NM_139244.4 [Q5T5C0-2]
UniGeneiHs.736439
Hs.86320

Genome annotation databases

EnsembliENST00000321680; ENSP00000321826; ENSG00000164506 [Q5T5C0-1]
ENST00000367480; ENSP00000356450; ENSG00000164506 [Q5T5C0-3]
ENST00000367481; ENSP00000356451; ENSG00000164506 [Q5T5C0-2]
GeneIDi134957
KEGGihsa:134957
UCSCiuc003qlz.4 human [Q5T5C0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356415 Genomic DNA No translation available.
AL355365 Genomic DNA No translation available.
AL590709 Genomic DNA No translation available.
BC113382 mRNA Translation: AAI13383.1
AK055484 mRNA Translation: BAB70930.1
AK090549 mRNA Translation: BAC03475.1 Different initiation.
CCDSiCCDS47499.1 [Q5T5C0-1]
CCDS5211.1 [Q5T5C0-2]
RefSeqiNP_001121187.1, NM_001127715.2 [Q5T5C0-1]
NP_640337.3, NM_139244.4 [Q5T5C0-2]
UniGeneiHs.736439
Hs.86320

3D structure databases

ProteinModelPortaliQ5T5C0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126417, 13 interactors
IntActiQ5T5C0, 1 interactor
STRINGi9606.ENSP00000321826

PTM databases

iPTMnetiQ5T5C0
PhosphoSitePlusiQ5T5C0

Polymorphism and mutation databases

BioMutaiSTXBP5
DMDMi74762236

Proteomic databases

EPDiQ5T5C0
MaxQBiQ5T5C0
PaxDbiQ5T5C0
PeptideAtlasiQ5T5C0
PRIDEiQ5T5C0
ProteomicsDBi64509
64510 [Q5T5C0-2]
64511 [Q5T5C0-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000321680; ENSP00000321826; ENSG00000164506 [Q5T5C0-1]
ENST00000367480; ENSP00000356450; ENSG00000164506 [Q5T5C0-3]
ENST00000367481; ENSP00000356451; ENSG00000164506 [Q5T5C0-2]
GeneIDi134957
KEGGihsa:134957
UCSCiuc003qlz.4 human [Q5T5C0-1]

Organism-specific databases

CTDi134957
DisGeNETi134957
EuPathDBiHostDB:ENSG00000164506.14
GeneCardsiSTXBP5
H-InvDBiHIX0019766
HGNCiHGNC:19665 STXBP5
HPAiCAB079016
HPA039991
HPA049727
MIMi604586 gene
neXtProtiNX_Q5T5C0
OpenTargetsiENSG00000164506
PharmGKBiPA134954258
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410INFH Eukaryota
ENOG410XTER LUCA
GeneTreeiENSGT00390000000018
HOGENOMiHOG000110929
HOVERGENiHBG083064
InParanoidiQ5T5C0
KOiK08518
OMAiLGQAMYL
OrthoDBiEOG091G0LY3
PhylomeDBiQ5T5C0
TreeFamiTF314585

Enzyme and pathway databases

SignaLinkiQ5T5C0

Miscellaneous databases

ChiTaRSiSTXBP5 human
GeneWikiiSTXBP5
GenomeRNAii134957
PROiPR:Q5T5C0
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164506 Expressed in 188 organ(s), highest expression level in anterior cingulate cortex
CleanExiHS_STXBP5
ExpressionAtlasiQ5T5C0 baseline and differential
GenevisibleiQ5T5C0 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR000664 Lethal2_giant
IPR013905 Lgl_C_dom
IPR013577 LLGL2
IPR001388 Synaptobrevin
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08596 Lgl_C, 1 hit
PF08366 LLGL, 1 hit
PF00400 WD40, 1 hit
PRINTSiPR00962 LETHAL2GIANT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS50892 V_SNARE, 1 hit
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTXB5_HUMAN
AccessioniPrimary (citable) accession number: Q5T5C0
Secondary accession number(s): Q14DF3
, Q5T5C1, Q5T5C2, Q8NBG8, Q96NG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again