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Protein

Late cornified envelope protein 3C

Gene

LCE3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens (PubMed:28634035).1 Publication1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAntimicrobial
Biological processKeratinization

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Late cornified envelope protein 3C1 Publication
Alternative name(s):
Late envelope protein 151 Publication
Small proline-rich-like epidermal differentiation complex protein 3A1 Publication
Gene namesi
Name:LCE3C1 PublicationImported
Synonyms:LEP151 Publication, SPRL3A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000244057.3
HGNCiHGNC:16612 LCE3C
MIMi612615 gene
neXtProtiNX_Q5T5A8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi353144
OpenTargetsiENSG00000244057
PharmGKBiPA38407

Polymorphism and mutation databases

BioMutaiLCE3C
DMDMi74745051

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002353351 – 94Late cornified envelope protein 3CAdd BLAST94

Proteomic databases

PaxDbiQ5T5A8
PRIDEiQ5T5A8
ProteomicsDBi64507

Expressioni

Tissue specificityi

Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.1 Publication

Gene expression databases

BgeeiENSG00000244057 Expressed in 18 organ(s), highest expression level in ectocervix
CleanExiHS_LCE3C

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi131650, 16 interactors
IntActiQ5T5A8, 48 interactors
STRINGi9606.ENSP00000334644

Structurei

3D structure databases

ProteinModelPortaliQ5T5A8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi12 – 33Pro-richAdd BLAST22

Sequence similaritiesi

Belongs to the LCE family.Curated

Phylogenomic databases

GeneTreeiENSGT00920000149213
HOVERGENiHBG079887
InParanoidiQ5T5A8
OMAiGSCCGHG
PhylomeDBiQ5T5A8
TreeFamiTF338709

Family and domain databases

InterProiView protein in InterPro
IPR028205 LCE
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 1 hit
PfamiView protein in Pfam
PF14672 LCE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5T5A8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSCQQNQQQC QPPPSCPSPK CPPKSPAQCL PPPSSDCALS SGGCGPSSES
60 70 80 90
GCCLSHHRHF RSHQCRRQRS NSCDRGSGQQ GGGSCRGHGS GGCC
Length:94
Mass (Da):9,729
Last modified:December 21, 2004 - v1
Checksum:iACA3379E00D9562C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356426 Genomic DNA No translation available.
CH878618 Genomic DNA Translation: EAW50650.1
BC130365 mRNA Translation: AAI30366.1
BC130367 mRNA Translation: AAI30368.1
CCDSiCCDS1015.1
RefSeqiNP_848521.1, NM_178434.2
UniGeneiHs.490211

Genome annotation databases

EnsembliENST00000333881; ENSP00000334644; ENSG00000244057
GeneIDi353144
KEGGihsa:353144
UCSCiuc001fac.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356426 Genomic DNA No translation available.
CH878618 Genomic DNA Translation: EAW50650.1
BC130365 mRNA Translation: AAI30366.1
BC130367 mRNA Translation: AAI30368.1
CCDSiCCDS1015.1
RefSeqiNP_848521.1, NM_178434.2
UniGeneiHs.490211

3D structure databases

ProteinModelPortaliQ5T5A8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131650, 16 interactors
IntActiQ5T5A8, 48 interactors
STRINGi9606.ENSP00000334644

Polymorphism and mutation databases

BioMutaiLCE3C
DMDMi74745051

Proteomic databases

PaxDbiQ5T5A8
PRIDEiQ5T5A8
ProteomicsDBi64507

Protocols and materials databases

DNASUi353144
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333881; ENSP00000334644; ENSG00000244057
GeneIDi353144
KEGGihsa:353144
UCSCiuc001fac.2 human

Organism-specific databases

CTDi353144
DisGeNETi353144
EuPathDBiHostDB:ENSG00000244057.3
GeneCardsiLCE3C
HGNCiHGNC:16612 LCE3C
MIMi612615 gene
neXtProtiNX_Q5T5A8
OpenTargetsiENSG00000244057
PharmGKBiPA38407
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00920000149213
HOVERGENiHBG079887
InParanoidiQ5T5A8
OMAiGSCCGHG
PhylomeDBiQ5T5A8
TreeFamiTF338709

Enzyme and pathway databases

ReactomeiR-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRSiLCE3C human
GenomeRNAii353144
PROiPR:Q5T5A8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000244057 Expressed in 18 organ(s), highest expression level in ectocervix
CleanExiHS_LCE3C

Family and domain databases

InterProiView protein in InterPro
IPR028205 LCE
IPR026075 SPRR/LCE
PANTHERiPTHR23263 PTHR23263, 1 hit
PfamiView protein in Pfam
PF14672 LCE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLCE3C_HUMAN
AccessioniPrimary (citable) accession number: Q5T5A8
Secondary accession number(s): A1L420
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 21, 2004
Last modified: September 12, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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