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UniProtKB - Q5T4F7 (SFRP5_HUMAN)

Entry version 137 (13 Nov 2019)
Sequence version 3 (26 Jun 2007)
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Protein

Secreted frizzled-related protein 5

Gene

SFRP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • Wnt-protein binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Wnt signaling pathway

Protein family/group databases

MEROPS protease database

More...MEROPSi		I93.002

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Secreted frizzled-related protein 5
Short name:
sFRP-5
Alternative name(s):
Frizzled-related protein 1b
Short name:
FRP-1b
Secreted apoptosis-related protein 3
Short name:
SARP-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SFRP5
Synonyms:FRP1B, SARP3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:10779 SFRP5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604158 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5T4F7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		6425

Open Targets

More...OpenTargetsi		ENSG00000120057

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35695

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5T4F7

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SFRP5

Domain mapping of disease mutations (DMDM)

More...DMDMi		150421670

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003255530 – 317Secreted frizzled-related protein 5Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi53 ↔ 116By similarity
Disulfide bondi63 ↔ 109By similarity
Disulfide bondi100 ↔ 135By similarity
Disulfide bondi124 ↔ 162By similarity
Disulfide bondi128 ↔ 152By similarity
Disulfide bondi181 ↔ 253By similarity
Disulfide bondi184 ↔ 255By similarity
Disulfide bondi198 ↔ 303By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5T4F7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5T4F7

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5T4F7

PeptideAtlas

More...PeptideAtlasi		Q5T4F7

PRoteomics IDEntifications database

More...PRIDEi		Q5T4F7

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		64458

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5T4F7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5T4F7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000120057 Expressed in 169 organ(s), highest expression level in pigmented layer of retina

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5T4F7 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		112323, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000266066

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5T4F7

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 165FZPROSITE-ProRule annotationAdd BLAST118
Domaini181 – 303NTRPROSITE-ProRule annotationAdd BLAST123

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the secreted frizzled-related protein (sFRP) family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3577 Eukaryota
ENOG410XRC8 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160608

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000231058

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5T4F7

KEGG Orthology (KO)

More...KOi		K02222

Identification of Orthologs from Complete Genome Data

More...OMAi		LHWAPAR

Database of Orthologous Groups

More...OrthoDBi		1306779at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5T4F7

TreeFam database of animal gene trees

More...TreeFami		TF350133

Family and domain databases

Conserved Domains Database

More...CDDi		cd07444 CRD_SFRP5, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.2000.10, 1 hit
2.40.50.120, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015526 Frizzled/SFRP
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR034860 SFRP-5
IPR041761 SFRP5_CRD
IPR008993 TIMP-like_OB-fold

The PANTHER Classification System

More...PANTHERi		PTHR11309 PTHR11309, 1 hit
PTHR11309:SF46 PTHR11309:SF46, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01392 Fz, 1 hit
PF01759 NTR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00643 C345C, 1 hit
SM00063 FRI, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50242 SSF50242, 1 hit
SSF63501 SSF63501, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50038 FZ, 1 hit
PS50189 NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q5T4F7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRAAAAGGGV RTAALALLLG ALHWAPARCE EYDYYGWQAE PLHGRSYSKP 
        60         70         80         90        100
PQCLDIPADL PLCHTVGYKR MRLPNLLEHE SLAEVKQQAS SWLPLLAKRC 
       110        120        130        140        150
HSDTQVFLCS LFAPVCLDRP IYPCRSLCEA VRAGCAPLME AYGFPWPEML 
       160        170        180        190        200
HCHKFPLDND LCIAVQFGHL PATAPPVTKI CAQCEMEHSA DGLMEQMCSS 
       210        220        230        240        250
DFVVKMRIKE IKIENGDRKL IGAQKKKKLL KPGPLKRKDT KRLVLHMKNG 
       260        270        280        290        300
AGCPCPQLDS LAGSFLVMGR KVDGQLLLMA VYRWDKKNKE MKFAVKFMFS 
       310 
YPCSLYYPFF YGAAEPH
Length:317
Mass (Da):35,563
Last modified:June 26, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4BF060F1161751F9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33D → H (PubMed:9642118).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0214127G → A4 PublicationsCorresponds to variant dbSNP:rs11815012Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF017988 mRNA Translation: AAB70794.1
AF117758 mRNA Translation: AAD25052.1
CR596705 mRNA No translation available.
AL358938 Genomic DNA No translation available.
BC050435 mRNA Translation: AAH50435.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7472.1

Protein sequence database of the Protein Information Resource

More...PIRi		JE0175

NCBI Reference Sequences

More...RefSeqi		NP_003006.2, NM_003015.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000266066; ENSP00000266066; ENSG00000120057

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6425

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6425

UCSC genome browser

More...UCSCi		uc001kor.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF017988 mRNA Translation: AAB70794.1
AF117758 mRNA Translation: AAD25052.1
CR596705 mRNA No translation available.
AL358938 Genomic DNA No translation available.
BC050435 mRNA Translation: AAH50435.2
CCDSiCCDS7472.1
PIRiJE0175
RefSeqiNP_003006.2, NM_003015.3

3D structure databases

SMRiQ5T4F7
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112323, 4 interactors
STRINGi9606.ENSP00000266066

Protein family/group databases

MEROPSiI93.002

PTM databases

iPTMnetiQ5T4F7
PhosphoSitePlusiQ5T4F7

Polymorphism and mutation databases

BioMutaiSFRP5
DMDMi150421670

Proteomic databases

jPOSTiQ5T4F7
MassIVEiQ5T4F7
PaxDbiQ5T4F7
PeptideAtlasiQ5T4F7
PRIDEiQ5T4F7
ProteomicsDBi64458

Genome annotation databases

EnsembliENST00000266066; ENSP00000266066; ENSG00000120057
GeneIDi6425
KEGGihsa:6425
UCSCiuc001kor.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6425
DisGeNETi6425

GeneCards: human genes, protein and diseases

More...GeneCardsi		SFRP5
HGNCiHGNC:10779 SFRP5
MIMi604158 gene
neXtProtiNX_Q5T4F7
OpenTargetsiENSG00000120057
PharmGKBiPA35695

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
GeneTreeiENSGT00940000160608
HOGENOMiHOG000231058
InParanoidiQ5T4F7
KOiK02222
OMAiLHWAPAR
OrthoDBi1306779at2759
PhylomeDBiQ5T4F7
TreeFamiTF350133

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SFRP5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6425
PharosiQ5T4F7

Protein Ontology

More...PROi		PR:Q5T4F7

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000120057 Expressed in 169 organ(s), highest expression level in pigmented layer of retina
GenevisibleiQ5T4F7 HS

Family and domain databases

CDDicd07444 CRD_SFRP5, 1 hit
Gene3Di1.10.2000.10, 1 hit
2.40.50.120, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR034860 SFRP-5
IPR041761 SFRP5_CRD
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR11309 PTHR11309, 1 hit
PTHR11309:SF46 PTHR11309:SF46, 1 hit
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM00643 C345C, 1 hit
SM00063 FRI, 1 hit
SUPFAMiSSF50242 SSF50242, 1 hit
SSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50189 NTR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSFRP5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T4F7
Secondary accession number(s): O14780, Q86TH7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 26, 2007
Last modified: November 13, 2019
This is version 137 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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