UniProtKB - Q5T4F7 (SFRP5_HUMAN)
Protein
Secreted frizzled-related protein 5
Gene
SFRP5
Organism
Homo sapiens (Human)
Status
Functioni
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.
GO - Molecular functioni
- Wnt-protein binding Source: GO_Central
GO - Biological processi
- anatomical structure morphogenesis Source: ProtInc
- apoptotic process Source: ProtInc
- canonical Wnt signaling pathway Source: GO_Central
- cell differentiation Source: UniProtKB-KW
- establishment or maintenance of cell polarity Source: ProtInc
- multicellular organism development Source: UniProtKB-KW
- negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
- negative regulation of cell population proliferation Source: BHF-UCL
- negative regulation of DNA-binding transcription factor activity Source: BHF-UCL
- negative regulation of protein kinase B signaling Source: BHF-UCL
- negative regulation of Wnt signaling pathway Source: ParkinsonsUK-UCL
- negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis Source: BHF-UCL
- regulation of BMP signaling pathway Source: InterPro
- signal transduction Source: ProtInc
- visual perception Source: ProtInc
Keywordsi
Molecular function | Developmental protein |
Biological process | Differentiation, Wnt signaling pathway |
Enzyme and pathway databases
PathwayCommonsi | Q5T4F7 |
Protein family/group databases
MEROPSi | I93.002 |
Names & Taxonomyi
Protein namesi | Recommended name: Secreted frizzled-related protein 5Short name: sFRP-5 Alternative name(s): Frizzled-related protein 1b Short name: FRP-1b Secreted apoptosis-related protein 3 Short name: SARP-3 |
Gene namesi | Name:SFRP5 Synonyms:FRP1B, SARP3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10779, SFRP5 |
MIMi | 604158, gene |
neXtProti | NX_Q5T4F7 |
VEuPathDBi | HostDB:ENSG00000120057.4 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 6425 |
OpenTargetsi | ENSG00000120057 |
PharmGKBi | PA35695 |
Miscellaneous databases
Pharosi | Q5T4F7, Tbio |
Genetic variation databases
BioMutai | SFRP5 |
DMDMi | 150421670 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_0000032555 | 30 – 317 | Secreted frizzled-related protein 5Add BLAST | 288 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 53 ↔ 116 | By similarity | ||
Disulfide bondi | 63 ↔ 109 | By similarity | ||
Disulfide bondi | 100 ↔ 135 | By similarity | ||
Disulfide bondi | 124 ↔ 162 | By similarity | ||
Disulfide bondi | 128 ↔ 152 | By similarity | ||
Disulfide bondi | 181 ↔ 253 | By similarity | ||
Disulfide bondi | 184 ↔ 255 | By similarity | ||
Disulfide bondi | 198 ↔ 303 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | Q5T4F7 |
PaxDbi | Q5T4F7 |
PeptideAtlasi | Q5T4F7 |
PRIDEi | Q5T4F7 |
ProteomicsDBi | 64458 |
PTM databases
iPTMneti | Q5T4F7 |
PhosphoSitePlusi | Q5T4F7 |
Expressioni
Tissue specificityi
Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.3 Publications
Gene expression databases
Bgeei | ENSG00000120057, Expressed in pigmented layer of retina and 181 other tissues |
Genevisiblei | Q5T4F7, HS |
Organism-specific databases
HPAi | ENSG00000120057, Group enriched (gallbladder, heart muscle, intestine, pancreas, retina) |
Interactioni
GO - Molecular functioni
- Wnt-protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 112323, 4 interactors |
STRINGi | 9606.ENSP00000266066 |
Miscellaneous databases
RNActi | Q5T4F7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 165 | FZPROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 181 – 303 | NTRPROSITE-ProRule annotationAdd BLAST | 123 |
Domaini
The FZ domain is involved in binding with Wnt ligands.By similarity
Sequence similaritiesi
Belongs to the secreted frizzled-related protein (sFRP) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3577, Eukaryota |
GeneTreei | ENSGT00940000160608 |
HOGENOMi | CLU_054647_1_0_1 |
InParanoidi | Q5T4F7 |
OMAi | PVSKICT |
OrthoDBi | 1306779at2759 |
PhylomeDBi | Q5T4F7 |
TreeFami | TF350133 |
Family and domain databases
CDDi | cd07444, CRD_SFRP5, 1 hit |
Gene3Di | 1.10.2000.10, 1 hit 2.40.50.120, 1 hit |
InterProi | View protein in InterPro IPR015526, Frizzled/SFRP IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR034860, SFRP-5 IPR041761, SFRP5_CRD IPR008993, TIMP-like_OB-fold |
PANTHERi | PTHR11309, PTHR11309, 1 hit PTHR11309:SF46, PTHR11309:SF46, 1 hit |
Pfami | View protein in Pfam PF01392, Fz, 1 hit PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00063, FRI, 1 hit |
SUPFAMi | SSF50242, SSF50242, 1 hit SSF63501, SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50189, NTR, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5T4F7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAAAAGGGV RTAALALLLG ALHWAPARCE EYDYYGWQAE PLHGRSYSKP
60 70 80 90 100
PQCLDIPADL PLCHTVGYKR MRLPNLLEHE SLAEVKQQAS SWLPLLAKRC
110 120 130 140 150
HSDTQVFLCS LFAPVCLDRP IYPCRSLCEA VRAGCAPLME AYGFPWPEML
160 170 180 190 200
HCHKFPLDND LCIAVQFGHL PATAPPVTKI CAQCEMEHSA DGLMEQMCSS
210 220 230 240 250
DFVVKMRIKE IKIENGDRKL IGAQKKKKLL KPGPLKRKDT KRLVLHMKNG
260 270 280 290 300
AGCPCPQLDS LAGSFLVMGR KVDGQLLLMA VYRWDKKNKE MKFAVKFMFS
310
YPCSLYYPFF YGAAEPH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 33 | D → H (PubMed:9642118).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_021412 | 7 | G → A4 PublicationsCorresponds to variant dbSNP:rs11815012Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF017988 mRNA Translation: AAB70794.1 AF117758 mRNA Translation: AAD25052.1 CR596705 mRNA No translation available. AL358938 Genomic DNA No translation available. BC050435 mRNA Translation: AAH50435.2 |
CCDSi | CCDS7472.1 |
PIRi | JE0175 |
RefSeqi | NP_003006.2, NM_003015.3 |
Genome annotation databases
Ensembli | ENST00000266066; ENSP00000266066; ENSG00000120057 |
GeneIDi | 6425 |
KEGGi | hsa:6425 |
UCSCi | uc001kor.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF017988 mRNA Translation: AAB70794.1 AF117758 mRNA Translation: AAD25052.1 CR596705 mRNA No translation available. AL358938 Genomic DNA No translation available. BC050435 mRNA Translation: AAH50435.2 |
CCDSi | CCDS7472.1 |
PIRi | JE0175 |
RefSeqi | NP_003006.2, NM_003015.3 |
3D structure databases
SMRi | Q5T4F7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112323, 4 interactors |
STRINGi | 9606.ENSP00000266066 |
Protein family/group databases
MEROPSi | I93.002 |
PTM databases
iPTMneti | Q5T4F7 |
PhosphoSitePlusi | Q5T4F7 |
Genetic variation databases
BioMutai | SFRP5 |
DMDMi | 150421670 |
Proteomic databases
MassIVEi | Q5T4F7 |
PaxDbi | Q5T4F7 |
PeptideAtlasi | Q5T4F7 |
PRIDEi | Q5T4F7 |
ProteomicsDBi | 64458 |
Protocols and materials databases
Antibodypediai | 17373, 251 antibodies |
Genome annotation databases
Ensembli | ENST00000266066; ENSP00000266066; ENSG00000120057 |
GeneIDi | 6425 |
KEGGi | hsa:6425 |
UCSCi | uc001kor.5, human |
Organism-specific databases
CTDi | 6425 |
DisGeNETi | 6425 |
GeneCardsi | SFRP5 |
HGNCi | HGNC:10779, SFRP5 |
HPAi | ENSG00000120057, Group enriched (gallbladder, heart muscle, intestine, pancreas, retina) |
MIMi | 604158, gene |
neXtProti | NX_Q5T4F7 |
OpenTargetsi | ENSG00000120057 |
PharmGKBi | PA35695 |
VEuPathDBi | HostDB:ENSG00000120057.4 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3577, Eukaryota |
GeneTreei | ENSGT00940000160608 |
HOGENOMi | CLU_054647_1_0_1 |
InParanoidi | Q5T4F7 |
OMAi | PVSKICT |
OrthoDBi | 1306779at2759 |
PhylomeDBi | Q5T4F7 |
TreeFami | TF350133 |
Enzyme and pathway databases
PathwayCommonsi | Q5T4F7 |
Miscellaneous databases
BioGRID-ORCSi | 6425, 4 hits in 985 CRISPR screens |
GeneWikii | SFRP5 |
GenomeRNAii | 6425 |
Pharosi | Q5T4F7, Tbio |
PROi | PR:Q5T4F7 |
RNActi | Q5T4F7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000120057, Expressed in pigmented layer of retina and 181 other tissues |
Genevisiblei | Q5T4F7, HS |
Family and domain databases
CDDi | cd07444, CRD_SFRP5, 1 hit |
Gene3Di | 1.10.2000.10, 1 hit 2.40.50.120, 1 hit |
InterProi | View protein in InterPro IPR015526, Frizzled/SFRP IPR020067, Frizzled_dom IPR036790, Frizzled_dom_sf IPR001134, Netrin_domain IPR018933, Netrin_module_non-TIMP IPR034860, SFRP-5 IPR041761, SFRP5_CRD IPR008993, TIMP-like_OB-fold |
PANTHERi | PTHR11309, PTHR11309, 1 hit PTHR11309:SF46, PTHR11309:SF46, 1 hit |
Pfami | View protein in Pfam PF01392, Fz, 1 hit PF01759, NTR, 1 hit |
SMARTi | View protein in SMART SM00643, C345C, 1 hit SM00063, FRI, 1 hit |
SUPFAMi | SSF50242, SSF50242, 1 hit SSF63501, SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038, FZ, 1 hit PS50189, NTR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SFRP5_HUMAN | |
Accessioni | Q5T4F7Primary (citable) accession number: Q5T4F7 Secondary accession number(s): O14780, Q86TH7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 15, 2005 |
Last sequence update: | June 26, 2007 | |
Last modified: | April 7, 2021 | |
This is version 145 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families