TMTC4

Functionⁱ

Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3.

1 Publication

Catalytic activityⁱ

dolichyl β-D-mannosyl phosphate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
+
L-seryl-[protein]
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Search chemical reactions in Rhea for this molecule.
=
3-O-(α-D-mannosyl)-L-seryl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
+
dolichyl phosphate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins."
  Larsen I.S.B., Narimatsu Y., Joshi H.J., Siukstaite L., Harrison O.J., Brasch J., Goodman K.M., Hansen L., Shapiro L., Honig B., Vakhrushev S.Y., Clausen H., Halim A.
  Proc. Natl. Acad. Sci. U.S.A. 114:11163-11168(2017) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY.
EC:
2.4.1.109
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins."
  Larsen I.S.B., Narimatsu Y., Joshi H.J., Siukstaite L., Harrison O.J., Brasch J., Goodman K.M., Hansen L., Shapiro L., Honig B., Vakhrushev S.Y., Clausen H., Halim A.
  Proc. Natl. Acad. Sci. U.S.A. 114:11163-11168(2017) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY.
This reaction proceeds in the
forward
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins."
  Larsen I.S.B., Narimatsu Y., Joshi H.J., Siukstaite L., Harrison O.J., Brasch J., Goodman K.M., Hansen L., Shapiro L., Honig B., Vakhrushev S.Y., Clausen H., Halim A.
  Proc. Natl. Acad. Sci. U.S.A. 114:11163-11168(2017) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY.
direction.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
dolichyl β-D-mannosyl phosphate
zoom
+
L-seryl-[protein]
L-serine residue
zoom
=
3-O-(α-D-mannosyl)-L-seryl-[protein]
O-(α-D-mannosyl)-L-serine residue
zoom
+
dolichyl phosphate
zoom
+
H⁺
dolichyl β-D-mannosyl phosphate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
+
L-threonyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
=
3-O-(α-D-mannosyl)-L-threonyl-[protein]
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
+
dolichyl phosphate
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
+
H⁺
Search proteins in UniProtKB for this molecule.
Search chemical reactions in Rhea for this molecule.
See the description of this molecule in ChEBI.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins."
  Larsen I.S.B., Narimatsu Y., Joshi H.J., Siukstaite L., Harrison O.J., Brasch J., Goodman K.M., Hansen L., Shapiro L., Honig B., Vakhrushev S.Y., Clausen H., Halim A.
  Proc. Natl. Acad. Sci. U.S.A. 114:11163-11168(2017) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY.
EC:
2.4.1.109
- Search proteins in UniProtKB for this EC number.
- See the description of this EC number in ENZYME.
- Search reactions for this EC number in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins."
  Larsen I.S.B., Narimatsu Y., Joshi H.J., Siukstaite L., Harrison O.J., Brasch J., Goodman K.M., Hansen L., Shapiro L., Honig B., Vakhrushev S.Y., Clausen H., Halim A.
  Proc. Natl. Acad. Sci. U.S.A. 114:11163-11168(2017) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY.
This reaction proceeds in the
forward
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
1 Publication
Manual assertion based on experiment inⁱ
- Ref.5
  "Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins."
  Larsen I.S.B., Narimatsu Y., Joshi H.J., Siukstaite L., Harrison O.J., Brasch J., Goodman K.M., Hansen L., Shapiro L., Honig B., Vakhrushev S.Y., Clausen H., Halim A.
  Proc. Natl. Acad. Sci. U.S.A. 114:11163-11168(2017) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, CATALYTIC ACTIVITY, PATHWAY.
direction.
Source:
Rhea
Search for this reaction in UniProtKB.
See the description of this reaction in Rhea.
. Show »« Hide
dolichyl β-D-mannosyl phosphate
zoom
+
L-threonyl-[protein]
L-threonine residue
zoom
=
3-O-(α-D-mannosyl)-L-threonyl-[protein]
O-(α-D-mannosyl)-L-threonine residue
zoom
+
dolichyl phosphate
zoom
+
H⁺

Pathwayⁱ: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase

Molecular function

Transferase

Enzyme and pathway databases

PathwayCommonsⁱ	Q5T4D3
SignaLinkⁱ	Q5T4D3
UniPathwayⁱ	UPA00378

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein O-mannosyl-transferase TMTC4Curated (EC:2.4.1.1091 Publication) Alternative name(s): Transmembrane and TPR repeat-containing protein 4Imported
Gene namesⁱ	Name:TMTC4Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:25904, TMTC4
MIMⁱ	618203, gene
neXtProtⁱ	NX_Q5T4D3
VEuPathDBⁱ	HostDB:ENSG00000125247

Topology

Feature key	Position(s)	DescriptionActions	Length
Transmembraneⁱ	15 – 35	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	112 – 132	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	142 – 162	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	166 – 186	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	199 – 219	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	225 – 245	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	269 – 288	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	318 – 337	HelicalSequence analysisAdd BLAST	20
Transmembraneⁱ	355 – 375	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	383 – 403	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	413 – 433	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	441 – 461	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84899
Open Targets More...OpenTargetsⁱ	ENSG00000125247
PharmGKBⁱ	PA142670721

Miscellaneous databases

Pharosⁱ	Q5T4D3, Tdark

Pharosⁱ

Q5T4D3, Tdark

Genetic variation databases

BioMutaⁱ	TMTC4
DMDMⁱ	134035049

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000280295	1 – 741	Protein O-mannosyl-transferase TMTC4Add BLAST		741

Proteomic databases

EPDⁱ	Q5T4D3
jPOSTⁱ	Q5T4D3
MassIVEⁱ	Q5T4D3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5T4D3
PaxDbⁱ	Q5T4D3
PeptideAtlas More...PeptideAtlasⁱ	Q5T4D3
PRIDEⁱ	Q5T4D3
ProteomicsDBⁱ	64449 [Q5T4D3-1] 64450 [Q5T4D3-2] 64451 [Q5T4D3-3] 6752

PTM databases

GlyGenⁱ	Q5T4D3, 1 site
iPTMnetⁱ	Q5T4D3
PhosphoSitePlusⁱ	Q5T4D3

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000125247, Expressed in forebrain and 211 other tissues
ExpressionAtlasⁱ	Q5T4D3, baseline and differential
Genevisibleⁱ	Q5T4D3, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000125247, Tissue enhanced (brain)

HPAⁱ

ENSG00000125247, Tissue enhanced (brain)

Interactionⁱ

GO - Molecular functionⁱ

ATPase binding
Source: MGI
Inferred from physical interactionⁱ
- "Deletion of Tmtc4 activates the unfolded protein response and causes postnatal hearing loss."
  Li J., Akil O., Rouse S.L., McLaughlin C.W., Matthews I.R., Lustig L.R., Chan D.K., Sherr E.H.
  J Clin Invest 128:5150-5162(2018) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	124339, 50 interactors
IntActⁱ	Q5T4D3, 20 interactors
STRINGⁱ	9606.ENSP00000343871

Miscellaneous databases

RNActⁱ	Q5T4D3, protein

RNActⁱ

Q5T4D3, protein

Structureⁱ

3D structure databases

SMRⁱ	Q5T4D3
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	448 – 481	TPR 1Add BLAST	34
Repeatⁱ	482 – 515	TPR 2Add BLAST	34
Repeatⁱ	517 – 549	TPR 3Add BLAST	33
Repeatⁱ	550 – 583	TPR 4Add BLAST	34
Repeatⁱ	584 – 617	TPR 5Add BLAST	34
Repeatⁱ	619 – 651	TPR 6Add BLAST	33
Repeatⁱ	652 – 685	TPR 7Add BLAST	34
Repeatⁱ	686 – 719	TPR 8Add BLAST	34

Sequence similaritiesⁱ

Belongs to the TMTC family.Curated

Keywords - Domainⁱ

Repeat, TPR repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1124, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158521
HOGENOMⁱ	CLU_011615_2_0_1
InParanoidⁱ	Q5T4D3
OMAⁱ	KAWANIL
Database of Orthologous Groups More...OrthoDBⁱ	1320023at2759
PhylomeDBⁱ	Q5T4D3
TreeFamⁱ	TF328339

Family and domain databases

Gene3Dⁱ	1.25.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR013618, TMTC_DUF1736 IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08409, DUF1736, 1 hit PF13181, TPR_8, 1 hit
SMARTⁱ	View protein in SMART SM00028, TPR, 7 hits
SUPFAMⁱ	SSF48452, SSF48452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50005, TPR, 7 hits PS50293, TPR_REGION, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q5T4D3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVLDTDLDH ILPSSVLPPF WAKLVVGSVA IVCFARSYDG DFVFDDSEAI 
        60         70         80         90        100
VNNKDLQAET PLGDLWHHDF WGSRLSSNTS HKSYRPLTVL TFRINYYLSG 
       110        120        130        140        150
GFHPVGFHVV NILLHSGISV LMVDVFSVLF GGLQYTSKGR RLHLAPRASL 
       160        170        180        190        200
LAALLFAVHP VHTECVAGVV GRADLLCALF FLLSFLGYCK AFRESNKEGA 
       210        220        230        240        250
HSSTFWVLLS IFLGAVAMLC KEQGITVLGL NAVFDILVIG KFNVLEIVQK 
       260        270        280        290        300
VLHKDKSLEN LGMLRNGGLL FRMTLLTSGG AGMLYVRWRI MGTGPPAFTE 
       310        320        330        340        350
VDNPASFADS MLVRAVNYNY YYSLNAWLLL CPWWLCFDWS MGCIPLIKSI 
       360        370        380        390        400
SDWRVIALAA LWFCLIGLIC QALCSEDGHK RRILTLGLGF LVIPFLPASN 
       410        420        430        440        450
LFFRVGFVVA ERVLYLPSVG YCVLLTFGFG ALSKHTKKKK LIAAVVLGIL 
       460        470        480        490        500
FINTLRCVLR SGEWRSEEQL FRSALSVCPL NAKVHYNIGK NLADKGNQTA 
       510        520        530        540        550
AIRYYREAVR LNPKYVHAMN NLGNILKERN ELQEAEELLS LAVQIQPDFA 
       560        570        580        590        600
AAWMNLGIVQ NSLKRFEAAE QSYRTAIKHR RKYPDCYYNL GRLYADLNRH 
       610        620        630        640        650
VDALNAWRNA TVLKPEHSLA WNNMIILLDN TGNLAQAEAV GREALELIPN 
       660        670        680        690        700
DHSLMFSLAN VLGKSQKYKE SEALFLKAIK ANPNAASYHG NLAVLYHRWG 
       710        720        730        740 
HLDLAKKHYE ISLQLDPTAS GTKENYGLLR RKLELMQKKA V

Length:741

Mass (Da):82,991

Last modified:March 20, 2007 - v2

Checksum:ⁱ42BB8FE4A7D86C98

GO

Isoform 2 (identifier: Q5T4D3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
594-612: YADLNRHVDALNAWRNATV → VSAGCPVPVEGKMGYFSYL
613-741: Missing.

« Hide

        10         20         30         40         50
MAVLDTDLDH ILPSSVLPPF WAKLVVGSVA IVCFARSYDG DFVFDDSEAI 
        60         70         80         90        100
VNNKDLQAET PLGDLWHHDF WGSRLSSNTS HKSYRPLTVL TFRINYYLSG 
       110        120        130        140        150
GFHPVGFHVV NILLHSGISV LMVDVFSVLF GGLQYTSKGR RLHLAPRASL 
       160        170        180        190        200
LAALLFAVHP VHTECVAGVV GRADLLCALF FLLSFLGYCK AFRESNKEGA 
       210        220        230        240        250
HSSTFWVLLS IFLGAVAMLC KEQGITVLGL NAVFDILVIG KFNVLEIVQK 
       260        270        280        290        300
VLHKDKSLEN LGMLRNGGLL FRMTLLTSGG AGMLYVRWRI MGTGPPAFTE 
       310        320        330        340        350
VDNPASFADS MLVRAVNYNY YYSLNAWLLL CPWWLCFDWS MGCIPLIKSI 
       360        370        380        390        400
SDWRVIALAA LWFCLIGLIC QALCSEDGHK RRILTLGLGF LVIPFLPASN 
       410        420        430        440        450
LFFRVGFVVA ERVLYLPSVG YCVLLTFGFG ALSKHTKKKK LIAAVVLGIL 
       460        470        480        490        500
FINTLRCVLR SGEWRSEEQL FRSALSVCPL NAKVHYNIGK NLADKGNQTA 
       510        520        530        540        550
AIRYYREAVR LNPKYVHAMN NLGNILKERN ELQEAEELLS LAVQIQPDFA 
       560        570        580        590        600
AAWMNLGIVQ NSLKRFEAAE QSYRTAIKHR RKYPDCYYNL GRLVSAGCPV 
       610 
PVEGKMGYFS YL

Show »

Length:612

Mass (Da):68,352

Checksum:ⁱ06E78C12152ACCD6

GO

Isoform 3 (identifier: Q5T4D3-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MIPNQHNAGAGSHQPAVFRM

« Hide

        10         20         30         40         50
MIPNQHNAGA GSHQPAVFRM AVLDTDLDHI LPSSVLPPFW AKLVVGSVAI 
        60         70         80         90        100
VCFARSYDGD FVFDDSEAIV NNKDLQAETP LGDLWHHDFW GSRLSSNTSH 
       110        120        130        140        150
KSYRPLTVLT FRINYYLSGG FHPVGFHVVN ILLHSGISVL MVDVFSVLFG 
       160        170        180        190        200
GLQYTSKGRR LHLAPRASLL AALLFAVHPV HTECVAGVVG RADLLCALFF 
       210        220        230        240        250
LLSFLGYCKA FRESNKEGAH SSTFWVLLSI FLGAVAMLCK EQGITVLGLN 
       260        270        280        290        300
AVFDILVIGK FNVLEIVQKV LHKDKSLENL GMLRNGGLLF RMTLLTSGGA 
       310        320        330        340        350
GMLYVRWRIM GTGPPAFTEV DNPASFADSM LVRAVNYNYY YSLNAWLLLC 
       360        370        380        390        400
PWWLCFDWSM GCIPLIKSIS DWRVIALAAL WFCLIGLICQ ALCSEDGHKR 
       410        420        430        440        450
RILTLGLGFL VIPFLPASNL FFRVGFVVAE RVLYLPSVGY CVLLTFGFGA 
       460        470        480        490        500
LSKHTKKKKL IAAVVLGILF INTLRCVLRS GEWRSEEQLF RSALSVCPLN 
       510        520        530        540        550
AKVHYNIGKN LADKGNQTAA IRYYREAVRL NPKYVHAMNN LGNILKERNE 
       560        570        580        590        600
LQEAEELLSL AVQIQPDFAA AWMNLGIVQN SLKRFEAAEQ SYRTAIKHRR 
       610        620        630        640        650
KYPDCYYNLG RLYADLNRHV DALNAWRNAT VLKPEHSLAW NNMIILLDNT 
       660        670        680        690        700
GNLAQAEAVG REALELIPND HSLMFSLANV LGKSQKYKES EALFLKAIKA 
       710        720        730        740        750
NPNAASYHGN LAVLYHRWGH LDLAKKHYEI SLQLDPTASG TKENYGLLRR 
       760
KLELMQKKAV

Show »

Length:760

Mass (Da):85,005

Checksum:ⁱE99ED6CCBB24EF3D

GO

Isoform 4 (identifier: Q5T4D3-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
55-165: Missing.

« Hide

        10         20         30         40         50
MAVLDTDLDH ILPSSVLPPF WAKLVVGSVA IVCFARSYDG DFVFDDSEAI 
        60         70         80         90        100
VNNKVAGVVG RADLLCALFF LLSFLGYCKA FRESNKEGAH SSTFWVLLSI 
       110        120        130        140        150
FLGAVAMLCK EQGITVLGLN AVFDILVIGK FNVLEIVQKV LHKDKSLENL 
       160        170        180        190        200
GMLRNGGLLF RMTLLTSGGA GMLYVRWRIM GTGPPAFTEV DNPASFADSM 
       210        220        230        240        250
LVRAVNYNYY YSLNAWLLLC PWWLCFDWSM GCIPLIKSIS DWRVIALAAL 
       260        270        280        290        300
WFCLIGLICQ ALCSEDGHKR RILTLGLGFL VIPFLPASNL FFRVGFVVAE 
       310        320        330        340        350
RVLYLPSVGY CVLLTFGFGA LSKHTKKKKL IAAVVLGILF INTLRCVLRS 
       360        370        380        390        400
GEWRSEEQLF RSALSVCPLN AKVHYNIGKN LADKGNQTAA IRYYREAVRL 
       410        420        430        440        450
NPKYVHAMNN LGNILKERNE LQEAEELLSL AVQIQPDFAA AWMNLGIVQN 
       460        470        480        490        500
SLKRFEAAEQ SYRTAIKHRR KYPDCYYNLG RLYADLNRHV DALNAWRNAT 
       510        520        530        540        550
VLKPEHSLAW NNMIILLDNT GNLAQAEAVG REALELIPND HSLMFSLANV 
       560        570        580        590        600
LGKSQKYKES EALFLKAIKA NPNAASYHGN LAVLYHRWGH LDLAKKHYEI 
       610        620        630
SLQLDPTASG TKENYGLLRR KLELMQKKAV

Show »

Length:630

Mass (Da):70,599

Checksum:ⁱD7C6509D6DEA6903

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

X6RF05	X6RF05_HUMAN	Protein O-mannosyl-transferase TMTC... Protein O-mannosyl-transferase TMTC4	TMTC4	54	Annotation score:
C9K0R2	C9K0R2_HUMAN	Protein O-mannosyl-transferase TMTC... Protein O-mannosyl-transferase TMTC4	TMTC4	73	Annotation score:
H7C095	H7C095_HUMAN	Protein O-mannosyl-transferase TMTC... Protein O-mannosyl-transferase TMTC4	TMTC4	114	Annotation score:

Sequence cautionⁱ

The sequence AAH18707 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

The sequence AK056409 differs from that shown. Reason: Frameshift.Curated

The sequence BAB55179 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	441	L → P in BAB55179 (PubMed:14702039).Curated	1
Sequence conflictⁱ	504	Y → N in BAB55179 (PubMed:14702039).Curated	1
Sequence conflictⁱ	667	K → E in BAB55179 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_031117	286	V → M. Corresponds to variant dbSNP:rs3809371Ensembl.	1
Natural variantⁱVAR_031118	419	V → I. Corresponds to variant dbSNP:rs946837Ensembl.	1
Natural variantⁱVAR_036455	655	M → V in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs144940475Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_038261	1	M → MIPNQHNAGAGSHQPAVFRM in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_054873	55 – 165	Missing in isoform 4. 1 PublicationAdd BLAST	111
Alternative sequenceⁱVSP_023622	594 – 612	YADLN…RNATV → VSAGCPVPVEGKMGYFSYL in isoform 2. 1 PublicationAdd BLAST	19
Alternative sequenceⁱVSP_023623	613 – 741	Missing in isoform 2. 1 PublicationAdd BLAST	129

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056409 mRNA No translation available. AK027530 mRNA Translation: BAB55179.1 Different initiation. AK299859 mRNA Translation: BAH13152.1 BX647956 mRNA No translation available. AL359085 Genomic DNA No translation available. BC018707 mRNA Translation: AAH18707.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS41904.1 [Q5T4D3-1] CCDS66575.1 [Q5T4D3-4] CCDS9497.2 [Q5T4D3-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001073137.1, NM_001079669.2 [Q5T4D3-1] NP_001273382.1, NM_001286453.1 [Q5T4D3-4] NP_116202.2, NM_032813.3 [Q5T4D3-3] XP_016876285.1, XM_017020796.1

Genome annotation databases

Ensemblⁱ	ENST00000328767; ENSP00000365409; ENSG00000125247 [Q5T4D3-4] ENST00000342624; ENSP00000343871; ENSG00000125247 [Q5T4D3-3] ENST00000376234; ENSP00000365408; ENSG00000125247
GeneIDⁱ	84899
KEGGⁱ	hsa:84899
MANE-Selectⁱ	ENST00000342624.10; ENSP00000343871.5; NM_032813.5; NP_116202.2 [Q5T4D3-3]
UCSC genome browser More...UCSCⁱ	uc001vot.5, human [Q5T4D3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5T4D3	Isoform 3 of Protein O-mannosyl-transferase TMTC4		HUMAN		760	UniRef90_Q5T4D3
Dolichyl-phosphate-mannose--protein mannosyltransferase		SAPAP		782
Dolichyl-phosphate-mannose--protein mannosyltransferase		MACFA		770
Transmembrane O-mannosyltransferase targeting cadherins 4		MICMU		770
Dolichyl-phosphate-mannose--protein mannosyltransferase		CHLSB		770
+227
Q5T4D3-2	Dolichyl-phosphate-mannose--protein mannosyltransferase		NOMLE		760	UniRef90_Q5T4D3-2
+4

Protein	Similar proteins		Species	Score	Length	Source
Q5T4D3	Isoform 3 of Protein O-mannosyl-transferase TMTC4		HUMAN		760	UniRef50_Q5T4D3
Dolichyl-phosphate-mannose--protein mannosyltransferase		SAPAP		782
Transmembrane O-mannosyltransferase targeting cadherins 4		MICMU		770
Dolichyl-phosphate-mannose--protein mannosyltransferase		MACFA		770
Dolichyl-phosphate-mannose--protein mannosyltransferase		CHLSB		770
+639
Q5T4D3-4	Dolichyl-phosphate-mannose--protein mannosyltransferase		ANATE		621	UniRef50_Q5T4D3-4
Transmembrane O-mannosyltransferase targeting cadherins 4		SANLU		512
Transmembrane O-mannosyltransferase targeting cadherins 4		CAPHI		630
Dolichyl-phosphate-mannose--protein mannosyltransferase		MELGA		543
Transmembrane O-mannosyltransferase targeting cadherins 4		COTJA		654
+102

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK056409 mRNA No translation available. AK027530 mRNA Translation: BAB55179.1 Different initiation. AK299859 mRNA Translation: BAH13152.1 BX647956 mRNA No translation available. AL359085 Genomic DNA No translation available. BC018707 mRNA Translation: AAH18707.1 Different initiation.
CCDSⁱ	CCDS41904.1 [Q5T4D3-1] CCDS66575.1 [Q5T4D3-4] CCDS9497.2 [Q5T4D3-3]
RefSeqⁱ	NP_001073137.1, NM_001079669.2 [Q5T4D3-1] NP_001273382.1, NM_001286453.1 [Q5T4D3-4] NP_116202.2, NM_032813.3 [Q5T4D3-3] XP_016876285.1, XM_017020796.1

3D structure databases

SMRⁱ	Q5T4D3
ModBaseⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	124339, 50 interactors
IntActⁱ	Q5T4D3, 20 interactors
STRINGⁱ	9606.ENSP00000343871

PTM databases

GlyGenⁱ	Q5T4D3, 1 site
iPTMnetⁱ	Q5T4D3
PhosphoSitePlusⁱ	Q5T4D3

Genetic variation databases

BioMutaⁱ	TMTC4
DMDMⁱ	134035049

Proteomic databases

EPDⁱ	Q5T4D3
jPOSTⁱ	Q5T4D3
MassIVEⁱ	Q5T4D3
MaxQBⁱ	Q5T4D3
PaxDbⁱ	Q5T4D3
PeptideAtlasⁱ	Q5T4D3
PRIDEⁱ	Q5T4D3
ProteomicsDBⁱ	64449 [Q5T4D3-1] 64450 [Q5T4D3-2] 64451 [Q5T4D3-3] 6752

Protocols and materials databases

Antibodypediaⁱ	11042, 124 antibodies from 17 providers
The DNASU plasmid repository More...DNASUⁱ	84899

Genome annotation databases

Ensemblⁱ	ENST00000328767; ENSP00000365409; ENSG00000125247 [Q5T4D3-4] ENST00000342624; ENSP00000343871; ENSG00000125247 [Q5T4D3-3] ENST00000376234; ENSP00000365408; ENSG00000125247
GeneIDⁱ	84899
KEGGⁱ	hsa:84899
MANE-Selectⁱ	ENST00000342624.10; ENSP00000343871.5; NM_032813.5; NP_116202.2 [Q5T4D3-3]
UCSCⁱ	uc001vot.5, human [Q5T4D3-1]

Organism-specific databases

CTDⁱ	84899
DisGeNETⁱ	84899
GeneCardsⁱ	TMTC4
HGNCⁱ	HGNC:25904, TMTC4
HPAⁱ	ENSG00000125247, Tissue enhanced (brain)
MIMⁱ	618203, gene
neXtProtⁱ	NX_Q5T4D3
OpenTargetsⁱ	ENSG00000125247
PharmGKBⁱ	PA142670721
VEuPathDBⁱ	HostDB:ENSG00000125247
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1124, Eukaryota
GeneTreeⁱ	ENSGT00940000158521
HOGENOMⁱ	CLU_011615_2_0_1
InParanoidⁱ	Q5T4D3
OMAⁱ	KAWANIL
OrthoDBⁱ	1320023at2759
PhylomeDBⁱ	Q5T4D3
TreeFamⁱ	TF328339

Enzyme and pathway databases

UniPathwayⁱ	UPA00378
PathwayCommonsⁱ	Q5T4D3
SignaLinkⁱ	Q5T4D3

Miscellaneous databases

BioGRID-ORCSⁱ	84899, 10 hits in 1046 CRISPR screens
ChiTaRSⁱ	TMTC4, human
GeneWikiⁱ	TMTC4
GenomeRNAiⁱ	84899
Pharosⁱ	Q5T4D3, Tdark
Protein Ontology More...PROⁱ	PR:Q5T4D3
RNActⁱ	Q5T4D3, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000125247, Expressed in forebrain and 211 other tissues
ExpressionAtlasⁱ	Q5T4D3, baseline and differential
Genevisibleⁱ	Q5T4D3, HS

Family and domain databases

Gene3Dⁱ	1.25.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR013618, TMTC_DUF1736 IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat
Pfamⁱ	View protein in Pfam PF08409, DUF1736, 1 hit PF13181, TPR_8, 1 hit
SMARTⁱ	View protein in SMART SM00028, TPR, 7 hits
SUPFAMⁱ	SSF48452, SSF48452, 1 hit
PROSITEⁱ	View protein in PROSITE PS50005, TPR, 7 hits PS50293, TPR_REGION, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TMTC4_HUMAN
Accessionⁱ	Q5T4D3Primary (citable) accession number: Q5T4D3 Secondary accession number(s): A6NLI7 Q96SU8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
	Last sequence update:	March 20, 2007
	Last modified:	February 23, 2022
	This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteome

Documents

Human chromosome 13
Human chromosome 13: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q5T4D3 (TMTC4_HUMAN)

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Protein O-mannosyl-transferase TMTC4

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Keywords - Coding sequence diversityi

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Functionⁱ

Catalytic activityⁱ

Pathwayⁱ: protein glycosylation

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ