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UniProtKB - Q5T481 (RBM20_HUMAN)

Entry version 117 (26 Feb 2020)
Sequence version 3 (11 Jan 2011)
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Protein

RNA-binding protein 20

Gene

RBM20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that acts as a regulator of mRNA splicing of a subset of genes involved in cardiac development. Regulates splicing of TTN (Titin).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding protein 20
Alternative name(s):
RNA-binding motif protein 20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBM20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:27424 RBM20

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		613171 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5T481

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Cardiomyopathy, dilated 1DD (CMD1DD)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_068802535V → I in CMD1DD. 1 PublicationCorresponds to variant dbSNP:rs183007628EnsemblClinVar.1
Natural variantiVAR_063092634R → Q in CMD1DD. 2 PublicationsCorresponds to variant dbSNP:rs267607001EnsemblClinVar.1
Natural variantiVAR_068803634R → W in CMD1DD. 1 PublicationCorresponds to variant dbSNP:rs796734066EnsemblClinVar.1
Natural variantiVAR_068804635S → A in CMD1DD; causes the formation of anomalous isoforms in TTN (Titin). 1 Publication1
Natural variantiVAR_068805636R → C in CMD1DD. 1 PublicationCorresponds to variant dbSNP:rs267607002EnsemblClinVar.1
Natural variantiVAR_063093636R → H in CMD1DD. 2 PublicationsCorresponds to variant dbSNP:rs267607004EnsemblClinVar.1
Natural variantiVAR_063094636R → S in CMD1DD. 1 PublicationCorresponds to variant dbSNP:rs267607002EnsemblClinVar.1
Natural variantiVAR_063095637S → G in CMD1DD. 2 PublicationsCorresponds to variant dbSNP:rs267607005EnsemblClinVar.1
Natural variantiVAR_063096638P → L in CMD1DD. 1 PublicationCorresponds to variant dbSNP:rs267607003EnsemblClinVar.1
Natural variantiVAR_068806716R → Q in CMD1DD. 1 PublicationCorresponds to variant dbSNP:rs375798246EnsemblClinVar.1

Keywords - Diseasei

Cardiomyopathy, Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		282996

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		RBM20

MalaCards human disease database

More...MalaCardsi		RBM20
MIMi613172 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		154 Familial isolated dilated cardiomyopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134934622

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5T481 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RBM20

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373512

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003288241 – 1227RNA-binding protein 20Add BLAST1227

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei498PhosphoserineCombined sources1
Modified residuei679PhosphoserineCombined sources1
Modified residuei801PhosphoserineCombined sources1
Modified residuei876PhosphoserineCombined sources1
Modified residuei977PhosphoserineBy similarity1
Modified residuei980PhosphoserineCombined sources1
Modified residuei1048PhosphoserineBy similarity1
Modified residuei1060PhosphoserineCombined sources1
Modified residuei1080PhosphoserineBy similarity1
Modified residuei1115PhosphoserineBy similarity1
Modified residuei1120PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q5T481

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5T481

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5T481

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5T481

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5T481

PeptideAtlas

More...PeptideAtlasi		Q5T481

PRoteomics IDEntifications database

More...PRIDEi		Q5T481

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		64438

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5T481

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5T481

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the heart.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000203867 Expressed in left ventricle myocardium and 133 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5T481 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA035806
HPA070358

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		129433, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q5T481, 4 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358532

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5T481 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5T481

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini518 – 593RRMPROSITE-ProRule annotationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi13 – 86Pro-richAdd BLAST74
Compositional biasi843 – 931Glu-richAdd BLAST89

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IGBX Eukaryota
ENOG410ZE4G LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_007364_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5T481

Database of Orthologous Groups

More...OrthoDBi		614199at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5T481

TreeFam database of animal gene trees

More...TreeFami		TF333921

Family and domain databases

Conserved Domains Database

More...CDDi		cd12685 RRM_RBM20, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034791 RBM20
IPR034790 RBM20_RRM
IPR000504 RRM_dom

The PANTHER Classification System

More...PANTHERi		PTHR15592:SF11 PTHR15592:SF11, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360 RRM, 1 hit
SM00451 ZnF_U1, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102 RRM, 1 hit
PS50171 ZF_MATRIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5T481-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLAAAMSQD ADPSGPEQPD RVACSVPGAR ASPAPSGPRG MQQPPPPPQP 
        60         70         80         90        100
PPPPQAGLPQ IIQNAAKLLD KNPFSVSNPN PLLPSPASLQ LAQLQAQLTL 
       110        120        130        140        150
HRLKLAQTAV TNNTAAATVL NQVLSKVAMS QPLFNQLRHP SVITGPHGHA 
       160        170        180        190        200
GVPQHAAAIP STRFPSNAIA FSPPSQTRGP GPSMNLPNQP PSAMVMHPFT 
       210        220        230        240        250
GVMPQTPGQP AVILGIGKTG PAPATAGFYE YGKASSGQTY GPETDGQPGF 
       260        270        280        290        300
LPSSASTSGS VTYEGHYSHT GQDGQAAFSK DFYGPNSQGS HVASGFPAEQ 
       310        320        330        340        350
AGGLKSEVGP LLQGTNSQWE SPHGFSGQSK PDLTAGPMWP PPHNQPYELY 
       360        370        380        390        400
DPEEPTSDRT PPSFGGRLNN SKQGFIGAGR RAKEDQALLS VRPLQAHELN 
       410        420        430        440        450
DFHGVAPLHL PHICSICDKK VFDLKDWELH VKGKLHAQKC LVFSENAGIR 
       460        470        480        490        500
CILGSAEGTL CASPNSTAVY NPAGNEDYAS NLGTSYVPIP ARSFTQSSPT 
       510        520        530        540        550
FPLASVGTTF AQRKGAGRVV HICNLPEGSC TENDVINLGL PFGKVTNYIL 
       560        570        580        590        600
MKSTNQAFLE MAYTEAAQAM VQYYQEKSAV INGEKLLIRM SKRYKELQLK 
       610        620        630        640        650
KPGKAVAAII QDIHSQRERD MFREADRYGP ERPRSRSPVS RSLSPRSHTP 
       660        670        680        690        700
SFTSCSSSHS PPGPSRADWG NGRDSWEHSP YARREEERDP APWRDNGDDK 
       710        720        730        740        750
RDRMDPWAHD RKHHPRQLDK AELDERPEGG RPHREKYPRS GSPNLPHSVS 
       760        770        780        790        800
SYKSREDGYY RKEPKAKWDK YLKQQQDAPG RSRRKDEARL RESRHPHPDD 
       810        820        830        840        850
SGKEDGLGPK VTRAPEGAKA KQNEKNKTKR TDRDQEGADD RKENTMAENE 
       860        870        880        890        900
AGKEEQEGME ESPQSVGRQE KEAEFSDPEN TRTKKEQDWE SESEAEGESW 
       910        920        930        940        950
YPTNMEELVT VDEVGEEEDF IVEPDIPELE EIVPIDQKDK ICPETCLCVT 
       960        970        980        990       1000
TTLDLDLAQD FPKEGVKAVG NGAAEISLKS PRELPSASTS CPSDMDVEMP 
      1010       1020       1030       1040       1050
GLNLDAERKP AESETGLSLE DSDCYEKEAK GVESSDVHPA PTVQQMSSPK 
      1060       1070       1080       1090       1100
PAEERARQPS PFVDDCKTRG TPEDGACEGS PLEEKASPPI ETDLQNQACQ 
      1110       1120       1130       1140       1150
EVLTPENSRY VEMKSLEVRS PEYTEVELKQ PLSLPSWEPE DVFSELSIPL 
      1160       1170       1180       1190       1200
GVEFVVPRTG FYCKLCGLFY TSEETAKMSH CRSAVHYRNL QKYLSQLAEE 
      1210       1220 
GLKETEGADS PRPEDSGIVP RFERKKL
Length:1,227
Mass (Da):134,357
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i19C64D887C6288D7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_042532173P → T. Corresponds to variant dbSNP:rs7908490EnsemblClinVar.1
Natural variantiVAR_068802535V → I in CMD1DD. 1 PublicationCorresponds to variant dbSNP:rs183007628EnsemblClinVar.1
Natural variantiVAR_063092634R → Q in CMD1DD. 2 PublicationsCorresponds to variant dbSNP:rs267607001EnsemblClinVar.1
Natural variantiVAR_068803634R → W in CMD1DD. 1 PublicationCorresponds to variant dbSNP:rs796734066EnsemblClinVar.1
Natural variantiVAR_068804635S → A in CMD1DD; causes the formation of anomalous isoforms in TTN (Titin). 1 Publication1
Natural variantiVAR_068805636R → C in CMD1DD. 1 PublicationCorresponds to variant dbSNP:rs267607002EnsemblClinVar.1
Natural variantiVAR_063093636R → H in CMD1DD. 2 PublicationsCorresponds to variant dbSNP:rs267607004EnsemblClinVar.1
Natural variantiVAR_063094636R → S in CMD1DD. 1 PublicationCorresponds to variant dbSNP:rs267607002EnsemblClinVar.1
Natural variantiVAR_063095637S → G in CMD1DD. 2 PublicationsCorresponds to variant dbSNP:rs267607005EnsemblClinVar.1
Natural variantiVAR_063096638P → L in CMD1DD. 1 PublicationCorresponds to variant dbSNP:rs267607003EnsemblClinVar.1
Natural variantiVAR_068806716R → Q in CMD1DD. 1 PublicationCorresponds to variant dbSNP:rs375798246EnsemblClinVar.1
Natural variantiVAR_042533768W → S. Corresponds to variant dbSNP:rs1417635Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
EU822950 mRNA Translation: ACF49364.1
AL136368 Genomic DNA No translation available.
AL359260 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44477.1

NCBI Reference Sequences

More...RefSeqi		NP_001127835.2, NM_001134363.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369519; ENSP00000358532; ENSG00000203867

Database of genes from NCBI RefSeq genomes

More...GeneIDi		282996

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:282996

UCSC genome browser

More...UCSCi		uc001kzf.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU822950 mRNA Translation: ACF49364.1
AL136368 Genomic DNA No translation available.
AL359260 Genomic DNA No translation available.
CCDSiCCDS44477.1
RefSeqiNP_001127835.2, NM_001134363.2

3D structure databases

SMRiQ5T481
ModBaseiSearch...

Protein-protein interaction databases

BioGridi129433, 4 interactors
IntActiQ5T481, 4 interactors
STRINGi9606.ENSP00000358532

PTM databases

iPTMnetiQ5T481
PhosphoSitePlusiQ5T481

Polymorphism and mutation databases

BioMutaiRBM20
DMDMi317373512

Proteomic databases

EPDiQ5T481
jPOSTiQ5T481
MassIVEiQ5T481
MaxQBiQ5T481
PaxDbiQ5T481
PeptideAtlasiQ5T481
PRIDEiQ5T481
ProteomicsDBi64438

Genome annotation databases

EnsembliENST00000369519; ENSP00000358532; ENSG00000203867
GeneIDi282996
KEGGihsa:282996
UCSCiuc001kzf.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		282996
DisGeNETi282996

GeneCards: human genes, protein and diseases

More...GeneCardsi		RBM20
GeneReviewsiRBM20
HGNCiHGNC:27424 RBM20
HPAiHPA035806
HPA070358
MalaCardsiRBM20
MIMi613171 gene
613172 phenotype
neXtProtiNX_Q5T481
Orphaneti154 Familial isolated dilated cardiomyopathy
PharmGKBiPA134934622

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IGBX Eukaryota
ENOG410ZE4G LUCA
HOGENOMiCLU_007364_0_0_1
InParanoidiQ5T481
OrthoDBi614199at2759
PhylomeDBiQ5T481
TreeFamiTF333921

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RBM20 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		282996
PharosiQ5T481 Tbio

Protein Ontology

More...PROi		PR:Q5T481
RNActiQ5T481 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000203867 Expressed in left ventricle myocardium and 133 other tissues
GenevisibleiQ5T481 HS

Family and domain databases

CDDicd12685 RRM_RBM20, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR034791 RBM20
IPR034790 RBM20_RRM
IPR000504 RRM_dom
PANTHERiPTHR15592:SF11 PTHR15592:SF11, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00451 ZnF_U1, 2 hits
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS50171 ZF_MATRIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBM20_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T481
Secondary accession number(s): A6NIP5, B5A868, Q5JVI1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: January 11, 2011
Last modified: February 26, 2020
This is version 117 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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