GJC2

Functionⁱ

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems.1 Publication

Caution

It is uncertain whether Met-1 or Met-4 is the initiator.Curated

GO - Molecular functionⁱ

gap junction channel activity involved in cell communication by electrical coupling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17344063

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development Source: Ensembl
cell-cell signaling Source: Ensembl
cell communication by electrical coupling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17344063
negative regulation of G1/S transition of mitotic cell cycle Source: Ensembl
positive regulation of calcium ion transmembrane transport Source: Ensembl
positive regulation of gene expression Source: Ensembl
positive regulation of oligodendrocyte progenitor proliferation Source: Ensembl
regulation of protein phosphorylation Source: Ensembl
response to toxic substance Source: Ensembl

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-190861 Gap junction assembly

Reactomeⁱ

R-HSA-190861 Gap junction assembly

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Gap junction gamma-2 protein Alternative name(s): Connexin-46.6 Short name: Cx46.6 Connexin-47 Short name: Cx47 Gap junction alpha-12 protein
Gene namesⁱ	Name:GJC2 Synonyms:GJA12
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000198835.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:17494 GJC2
MIMⁱ	608803 gene
neXtProtⁱ	NX_Q5T442

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 25	CytoplasmicSequence analysisAdd BLAST	25
Transmembraneⁱ	26 – 46	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	47 – 78	ExtracellularSequence analysisAdd BLAST	32
Transmembraneⁱ	79 – 99	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	100 – 216	CytoplasmicSequence analysisAdd BLAST	117
Transmembraneⁱ	217 – 237	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	238 – 265	ExtracellularSequence analysisAdd BLAST	28
Transmembraneⁱ	266 – 286	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	287 – 439	CytoplasmicSequence analysisAdd BLAST	153

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Leukodystrophy, hypomyelinating, 2 (HLD2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive hypomyelinating leukodystrophy with symptoms of Pelizaeus-Merzbacher disease. Clinically characterized by nystagmus, impaired motor development, ataxia, choreoathetotic movements, dysarthria, and progressive spasticity.

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_023754	90	P → S in HLD2. 1 PublicationCorresponds to variant dbSNP:rs74315312EnsemblClinVar.	1
Natural variantⁱVAR_023755	272	Y → D in HLD2. 1 PublicationCorresponds to variant dbSNP:rs74315314EnsemblClinVar.	1
Natural variantⁱVAR_023756	286	M → T in HLD2. 1 PublicationCorresponds to variant dbSNP:rs74315311EnsemblClinVar.	1

Spastic paraplegia 44, autosomal recessive (SPG44)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_063172	36	I → M in SPG44; does not form functional homotypic channels. 1 PublicationCorresponds to variant dbSNP:rs75469429EnsemblClinVar.		1

Lymphedema, hereditary, 1C (LMPH1C)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_063877	48	S → L in LMPH1C. 1 PublicationCorresponds to variant dbSNP:rs267606847EnsemblClinVar.		1
Natural variantⁱVAR_063880	260	R → C in LMPH1C. 1 PublicationCorresponds to variant dbSNP:rs267606846EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation, Hereditary spastic paraplegia, Leukodystrophy, Neurodegeneration

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57165
MalaCards human disease database More...MalaCardsⁱ	GJC2
MIMⁱ	608804 phenotype 613206 phenotype 613480 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000198835
Orphanetⁱ	320401 Autosomal recessive spastic paraplegia type 44 79452 Milroy disease 280282 Pelizaeus-Merzbacher-like disease due to GJC2 mutation
PharmGKBⁱ	PA162389696

Polymorphism and mutation databases

BioMutaⁱ	GJC2
DMDMⁱ	74744875

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000057842	1 – 439	Gap junction gamma-2 proteinAdd BLAST		439

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	371	PhosphoserineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q5T442
PeptideAtlas More...PeptideAtlasⁱ	Q5T442
PRIDEⁱ	Q5T442
ProteomicsDBⁱ	64429

PTM databases

iPTMnetⁱ	Q5T442
PhosphoSitePlusⁱ	Q5T442

Expressionⁱ

Tissue specificityⁱ

Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000198835 Expressed in 141 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_GJC2
Genevisibleⁱ	Q5T442 HS

Interactionⁱ

Subunit structureⁱ

A connexon is composed of a hexamer of connexins. Interacts with TJP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridⁱ	121419, 1 interactor
IntActⁱ	Q5T442, 1 interactor
STRINGⁱ	9606.ENSP00000355675

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5T442
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	143 – 176	Glu-richAdd BLAST		34

Sequence similaritiesⁱ

Belongs to the connexin family. Gamma-type subfamily.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFK3 Eukaryota ENOG410Z7PN LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000143998
HOGENOMⁱ	HOG000231126
HOVERGENⁱ	HBG009576
InParanoidⁱ	Q5T442
KEGG Orthology (KO) More...KOⁱ	K07619
OMAⁱ	ARAHDQN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08B8
PhylomeDBⁱ	Q5T442
TreeFamⁱ	TF329606

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 2 hits
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q5T442-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTNMSWSFLT RLLEEIHNHS TFVGKVWLTV LVVFRIVLTA VGGEAIYSDE 
        60         70         80         90        100
QAKFTCNTRQ PGCDNVCYDA FAPLSHVRFW VFQIVVISTP SVMYLGYAVH 
       110        120        130        140        150
RLARASEQER RRALRRRPGP RRAPRAHLPP PHAGWPEPAD LGEEEPMLGL 
       160        170        180        190        200
GEEEEEEETG AAEGAGEEAE EAGAEEACTK AVGADGKAAG TPGPTGQHDG 
       210        220        230        240        250
RRRIQREGLM RVYVAQLVAR AAFEVAFLVG QYLLYGFEVR PFFPCSRQPC 
       260        270        280        290        300
PHVVDCFVSR PTEKTVFLLV MYVVSCLCLL LNLCEMAHLG LGSAQDAVRG 
       310        320        330        340        350
RRGPPASAPA PAPRPPPCAF PAAAAGLACP PDYSLVVRAA ERARAHDQNL 
       360        370        380        390        400
ANLALQALRD GAAAGDRDRD SSPCVGLPAA SRGPPRAGAP ASRTGSATSA 
       410        420        430 
GTVGEQGRPG THERPGAKPR AGSEKGSASS RDGKTTVWI

Length:439

Mass (Da):47,002

Last modified:December 21, 2004 - v1

Checksum:ⁱ09725B5DC476672A

GO

Sequence cautionⁱ

The sequence AAB94511 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAH35840 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	83	Q → H in AAB94511 (Ref. 1) Curated		1
Sequence conflictⁱ	252	H → Q in AAB94511 (Ref. 1) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_063876	19	H → P Associated with lymphedema in a small family. 1 Publication	1
Natural variantⁱVAR_063172	36	I → M in SPG44; does not form functional homotypic channels. 1 PublicationCorresponds to variant dbSNP:rs75469429EnsemblClinVar.	1
Natural variantⁱVAR_063877	48	S → L in LMPH1C. 1 PublicationCorresponds to variant dbSNP:rs267606847EnsemblClinVar.	1
Natural variantⁱVAR_023754	90	P → S in HLD2. 1 PublicationCorresponds to variant dbSNP:rs74315312EnsemblClinVar.	1
Natural variantⁱVAR_063878	125	R → Q Associated with lymphedema in a small family. 1 Publication	1
Natural variantⁱVAR_063879	149	G → S Associated with lymphedema in a small family. 1 PublicationCorresponds to variant dbSNP:rs577325764Ensembl.	1
Natural variantⁱVAR_063880	260	R → C in LMPH1C. 1 PublicationCorresponds to variant dbSNP:rs267606846EnsemblClinVar.	1
Natural variantⁱVAR_023755	272	Y → D in HLD2. 1 PublicationCorresponds to variant dbSNP:rs74315314EnsemblClinVar.	1
Natural variantⁱVAR_023756	286	M → T in HLD2. 1 PublicationCorresponds to variant dbSNP:rs74315311EnsemblClinVar.	1
Natural variantⁱVAR_063881	316	P → L Associated with lymphedema in a small family. 1 PublicationCorresponds to variant dbSNP:rs760502262EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF014643 Genomic DNA Translation: AAB94511.1 Different initiation. AL359510 Genomic DNA No translation available. BC035840 mRNA Translation: AAH35840.1 Different initiation. BC089439 mRNA Translation: AAH89439.1 AY285161 mRNA Translation: AAP37488.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1569.1
NCBI Reference Sequences More...RefSeqⁱ	NP_065168.2, NM_020435.3
UniGeneⁱ	Hs.100072 Hs.743715

Genome annotation databases

Ensemblⁱ	ENST00000366714; ENSP00000355675; ENSG00000198835
GeneIDⁱ	57165
KEGGⁱ	hsa:57165
UCSC genome browser More...UCSCⁱ	uc001hsk.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5T442	Gap junction protein		MACMU		441	UniRef90_Q5T442
Gap junction protein		PONAB		441
Gap junction protein		CERAT		441
Gap junction protein		PAPAN		441
Gap junction protein		CHLSB		441
+14

Protein	Similar proteins		Species	Score	Length	Source
Q5T442	Gap junction gamma-2 protein		BOVIN		429	UniRef50_Q5T442
Gap junction protein		CHLSB		441
Gap junction protein		CERAT		441
Gap junction protein		MACMU		441
Gap junction protein		PAPAN		441
+43

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF014643 Genomic DNA Translation: AAB94511.1 Different initiation. AL359510 Genomic DNA No translation available. BC035840 mRNA Translation: AAH35840.1 Different initiation. BC089439 mRNA Translation: AAH89439.1 AY285161 mRNA Translation: AAP37488.1
CCDSⁱ	CCDS1569.1
RefSeqⁱ	NP_065168.2, NM_020435.3
UniGeneⁱ	Hs.100072 Hs.743715

3D structure databases

ProteinModelPortalⁱ	Q5T442
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121419, 1 interactor
IntActⁱ	Q5T442, 1 interactor
STRINGⁱ	9606.ENSP00000355675

PTM databases

iPTMnetⁱ	Q5T442
PhosphoSitePlusⁱ	Q5T442

Polymorphism and mutation databases

BioMutaⁱ	GJC2
DMDMⁱ	74744875

Proteomic databases

PaxDbⁱ	Q5T442
PeptideAtlasⁱ	Q5T442
PRIDEⁱ	Q5T442
ProteomicsDBⁱ	64429

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000366714; ENSP00000355675; ENSG00000198835
GeneIDⁱ	57165
KEGGⁱ	hsa:57165
UCSCⁱ	uc001hsk.4 human

Organism-specific databases

CTDⁱ	57165
DisGeNETⁱ	57165
EuPathDBⁱ	HostDB:ENSG00000198835.3
GeneCardsⁱ	GJC2
HGNCⁱ	HGNC:17494 GJC2
MalaCardsⁱ	GJC2
MIMⁱ	608803 gene 608804 phenotype 613206 phenotype 613480 phenotype
neXtProtⁱ	NX_Q5T442
OpenTargetsⁱ	ENSG00000198835
Orphanetⁱ	320401 Autosomal recessive spastic paraplegia type 44 79452 Milroy disease 280282 Pelizaeus-Merzbacher-like disease due to GJC2 mutation
PharmGKBⁱ	PA162389696
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFK3 Eukaryota ENOG410Z7PN LUCA
GeneTreeⁱ	ENSGT00910000143998
HOGENOMⁱ	HOG000231126
HOVERGENⁱ	HBG009576
InParanoidⁱ	Q5T442
KOⁱ	K07619
OMAⁱ	ARAHDQN
OrthoDBⁱ	EOG091G08B8
PhylomeDBⁱ	Q5T442
TreeFamⁱ	TF329606

Enzyme and pathway databases

Reactomeⁱ	R-HSA-190861 Gap junction assembly

Reactomeⁱ

R-HSA-190861 Gap junction assembly

Miscellaneous databases

GeneWikiⁱ	GJC2
GenomeRNAiⁱ	57165
Protein Ontology More...PROⁱ	PR:Q5T442
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000198835 Expressed in 141 organ(s), highest expression level in C1 segment of cervical spinal cord
CleanExⁱ	HS_GJC2
Genevisibleⁱ	Q5T442 HS

Family and domain databases

Gene3Dⁱ	1.20.1440.80, 2 hits
InterProⁱ	View protein in InterPro IPR000500 Connexin IPR019570 Connexin_CCC IPR017990 Connexin_CS IPR013092 Connexin_N IPR038359 Connexin_N_sf
PANTHERⁱ	PTHR11984 PTHR11984, 1 hit
Pfamⁱ	View protein in Pfam PF00029 Connexin, 1 hit
PRINTSⁱ	PR00206 CONNEXIN
SMARTⁱ	View protein in SMART SM00037 CNX, 1 hit SM01089 Connexin_CCC, 1 hit
PROSITEⁱ	View protein in PROSITE PS00407 CONNEXINS_1, 1 hit PS00408 CONNEXINS_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CXG2_HUMAN
Accessionⁱ	Q5T442Primary (citable) accession number: Q5T442 Secondary accession number(s): O43440, Q7Z7J2, Q8IWJ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
	Last sequence update:	December 21, 2004
	Last modified:	November 7, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - Q5T442 (CXG2_HUMAN)

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Gap junction gamma-2 protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ