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UniProtKB - Q5T3U5 (MRP7_HUMAN)

Protein

Multidrug resistance-associated protein 7

Gene

ABCC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.2 Publications

Kineticsi

  1. KM=57.8 µM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius)1 Publication
  1. Vmax=20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius)1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi633 – 640ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1280 – 1287ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-382556 ABC-family proteins mediated transport

Protein family/group databases

TCDBi3.A.1.208.31 the atp-binding cassette (abc) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Multidrug resistance-associated protein 7
Alternative name(s):
ATP-binding cassette sub-family C member 10
Gene namesi
Name:ABCC10
Synonyms:MRP7, SIMRP7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124574.14
HGNCiHGNC:52 ABCC10
MIMi612509 gene
neXtProtiNX_Q5T3U5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei32 – 52HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei70 – 90HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei102 – 122HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei133 – 153HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei172 – 192HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei293 – 313HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei320 – 340HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei391 – 411HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei414 – 434HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei507 – 527HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei538 – 558HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei875 – 895HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei933 – 953HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei974 – 994HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1051 – 1071HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1153 – 1173HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1182 – 1202HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi89845
OpenTargetsiENSG00000124574
PharmGKBiPA24392

Chemistry databases

ChEMBLiCHEMBL2073687
DrugBankiDB00091 Cyclosporine
DB00987 Cytarabine
DB00694 Daunorubicin
DB01248 Docetaxel
DB00997 Doxorubicin
DB00783 Estradiol
DB00773 Etoposide
DB00441 Gemcitabine
DB00563 Methotrexate
DB01229 Paclitaxel
DB00203 Sildenafil
DB04348 Taurocholic Acid
DB00300 Tenofovir
DB00661 Verapamil
DB00541 Vincristine

Polymorphism and mutation databases

BioMutaiABCC10
DMDMi74756298

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002535761 – 1492Multidrug resistance-associated protein 7Add BLAST1492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei463PhosphothreonineCombined sources1
Modified residuei467PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T3U5
MaxQBiQ5T3U5
PaxDbiQ5T3U5
PeptideAtlasiQ5T3U5
PRIDEiQ5T3U5
ProteomicsDBi64416
64417 [Q5T3U5-2]

PTM databases

iPTMnetiQ5T3U5
PhosphoSitePlusiQ5T3U5

Expressioni

Tissue specificityi

Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed.1 Publication

Gene expression databases

BgeeiENSG00000124574 Expressed in 219 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_ABCC10
ExpressionAtlasiQ5T3U5 baseline and differential
GenevisibleiQ5T3U5 HS

Organism-specific databases

HPAiHPA041607
HPA045464

Interactioni

Protein-protein interaction databases

BioGridi124617, 12 interactors
STRINGi9606.ENSP00000361608

Structurei

3D structure databases

ProteinModelPortaliQ5T3U5
SMRiQ5T3U5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 563ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST279
Domaini598 – 824ABC transporter 1PROSITE-ProRule annotationAdd BLAST227
Domaini885 – 1210ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST326
Domaini1246 – 1479ABC transporter 2PROSITE-ProRule annotationAdd BLAST234

Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00930000150947
HOVERGENiHBG107141
InParanoidiQ5T3U5
KOiK05674
OMAiNYSAGEK
OrthoDBiEOG091G00IN
PhylomeDBiQ5T3U5
TreeFamiTF105203

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T3U5-1) [UniParc]FASTAAdd to basket
Also known as: Mrp7

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERLLAQLCG SSAAWPLPLW EGDTTGHCFT QLVLSALPHA LLAVLSACYL 
        60         70         80         90        100
GTPRSPDYIL PCSPGWRLRL AASFLLSVFP LLDLLPVALP PGAGPGPIGL 
       110        120        130        140        150
EVLAGCVAAV AWISHSLALW VLAHSPHGHS RGPLALALVA LLPAPALVLT 
       160        170        180        190        200
VLWHCQRGTL LPPLLPGPMA RLCLLILQLA ALLAYALGWA APGGPREPWA 
       210        220        230        240        250
QEPLLPEDQE PEVAEDGESW LSRFSYAWLA PLLARGACGE LRQPQDICRL 
       260        270        280        290        300
PHRLQPTYLA RVFQAHWQEG ARLWRALYGA FGRCYLALGL LKLVGTMLGF 
       310        320        330        340        350
SGPLLLSLLV GFLEEGQEPL SHGLLYALGL AGGAVLGAVL QNQYGYEVYK 
       360        370        380        390        400
VTLQARGAVL NILYCKALQL GPSRPPTGEA LNLLGTDSER LLNFAGSFHE 
       410        420        430        440        450
AWGLPLQLAI TLYLLYQQVG VAFVGGLILA LLLVPVNKVI ATRIMASNQE 
       460        470        480        490        500
MLQHKDARVK LVTELLSGIR VIKFCGWEQA LGARVEACRA RELGRLRVIK 
       510        520        530        540        550
YLDAACVYLW AALPVVISIV IFITYVLMGH QLTATKVFTA LALVRMLILP 
       560        570        580        590        600
LNNFPWVING LLEAKVSLDR IQLFLDLPNH NPQAYYSPDP PAEPSTVLEL 
       610        620        630        640        650
HGALFSWDPV GTSLETFISH LEVKKGMLVG IVGKVGCGKS SLLAAIAGEL 
       660        670        680        690        700
HRLRGHVAVR GLSKGFGLAT QEPWIQFATI RDNILFGKTF DAQLYKEVLE 
       710        720        730        740        750
ACALNDDLSI LPAGDQTEVG EKGVTLSGGQ RARIALARAV YQEKELYLLD 
       760        770        780        790        800
DPLAAVDADV ANHLLHRCIL GMLSYTTRLL CTHRTEYLER ADAVLLMEAG 
       810        820        830        840        850
RLIRAGPPSE ILPLVQAVPK AWAENGQESD SATAQSVQNP EKTKEGLEEE 
       860        870        880        890        900
QSTSGRLLQE ESKKEGAVAL HVYQAYWKAV GQGLALAILF SLLLMQATRN 
       910        920        930        940        950
AADWWLSHWI SQLKAENSSQ EAQPSTSPAS MGLFSPQLLL FSPGNLYIPV 
       960        970        980        990       1000
FPLPKAAPNG SSDIRFYLTV YATIAGVNSL CTLLRAVLFA AGTLQAAATL 
      1010       1020       1030       1040       1050
HRRLLHRVLM APVTFFNATP TGRILNRFSS DVACADDSLP FILNILLANA 
      1060       1070       1080       1090       1100
AGLLGLLAVL GSGLPWLLLL LPPLSIMYYH VQRHYRASSR ELRRLGSLTL 
      1110       1120       1130       1140       1150
SPLYSHLADT LAGLSVLRAT GATYRFEEEN LRLLELNQRC QFATSATMQW 
      1160       1170       1180       1190       1200
LDIRLQLMGA AVVSAIAGIA LVQHQQGLAN PGLVGLSLSY ALSLTGLLSG 
      1210       1220       1230       1240       1250
LVSSFTQTEA MLVSVERLEE YTCDLPQEPQ GQPLQLGTGW LTQGGVEFQD 
      1260       1270       1280       1290       1300
VVLAYRPGLP NALDGVTFCV QPGEKLGIVG RTGSGKSSLL LVLFRLLEPS 
      1310       1320       1330       1340       1350
SGRVLLDGVD TSQLELAQLR SQLAIIPQEP FLFSGTVREN LDPQGLHKDR 
      1360       1370       1380       1390       1400
ALWQALKQCH LSEVITSMGG LDGELGEGGR SLSLGQRQLL CLARALLTDA 
      1410       1420       1430       1440       1450
KILCIDEATA SVDQKTDQLL QQTICKRFAN KTVLTIAHRL NTILNSDRVL 
      1460       1470       1480       1490 
VLQAGRVVEL DSPATLRNQP HSLFQQLLQS SQQGVPASLG GP
Length:1,492
Mass (Da):161,629
Last modified:December 21, 2004 - v1
Checksum:i6FBC260DEFB3DF30
GO
Isoform 2 (identifier: Q5T3U5-2) [UniParc]FASTAAdd to basket
Also known as: Mrp7A

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.
     44-52: VLSACYLGT → MCLLVFPLV
     588-588: P → PDCGRLGAQIKWLLCS

Show »
Length:1,464
Mass (Da):158,781
Checksum:i31644BE052337EB3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9B3D6R9B3_HUMAN
Multidrug resistance-associated pro...
ABCC10
277Annotation score:
H0Y904H0Y904_HUMAN
Multidrug resistance-associated pro...
ABCC10
129Annotation score:

Sequence cautioni

The sequence BAA92227 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15736 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti208D → E in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti220Missing in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti631I → T in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti764L → P in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti809S → P in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti888I → T in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1030S → F in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1134L → F in BAB15736 (PubMed:11214971).Curated1
Sequence conflicti1276L → V in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1455G → E in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1481S → C in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1490G → R in AAK39642 (PubMed:12566991).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_028391948I → T. Corresponds to variant dbSNP:rs2125739Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0210781 – 43Missing in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_02107944 – 52VLSACYLGT → MCLLVFPLV in isoform 2. 1 Publication9
Alternative sequenceiVSP_021080588P → PDCGRLGAQIKWLLCS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032599 mRNA Translation: AAK39642.1
AK000002 mRNA Translation: BAA92227.1 Different initiation.
AK024446 mRNA Translation: BAB15736.1 Sequence problems.
AL359813 Genomic DNA No translation available.
AL133613 mRNA Translation: CAB63742.1
CCDSiCCDS4896.1 [Q5T3U5-2]
CCDS56430.1 [Q5T3U5-1]
PIRiT43469
RefSeqiNP_001185863.1, NM_001198934.1 [Q5T3U5-1]
NP_258261.2, NM_033450.2 [Q5T3U5-2]
UniGeneiHs.55879

Genome annotation databases

EnsembliENST00000244533; ENSP00000244533; ENSG00000124574 [Q5T3U5-2]
ENST00000372530; ENSP00000361608; ENSG00000124574 [Q5T3U5-1]
GeneIDi89845
KEGGihsa:89845
UCSCiuc003ouy.2 human [Q5T3U5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032599 mRNA Translation: AAK39642.1
AK000002 mRNA Translation: BAA92227.1 Different initiation.
AK024446 mRNA Translation: BAB15736.1 Sequence problems.
AL359813 Genomic DNA No translation available.
AL133613 mRNA Translation: CAB63742.1
CCDSiCCDS4896.1 [Q5T3U5-2]
CCDS56430.1 [Q5T3U5-1]
PIRiT43469
RefSeqiNP_001185863.1, NM_001198934.1 [Q5T3U5-1]
NP_258261.2, NM_033450.2 [Q5T3U5-2]
UniGeneiHs.55879

3D structure databases

ProteinModelPortaliQ5T3U5
SMRiQ5T3U5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124617, 12 interactors
STRINGi9606.ENSP00000361608

Chemistry databases

ChEMBLiCHEMBL2073687
DrugBankiDB00091 Cyclosporine
DB00987 Cytarabine
DB00694 Daunorubicin
DB01248 Docetaxel
DB00997 Doxorubicin
DB00783 Estradiol
DB00773 Etoposide
DB00441 Gemcitabine
DB00563 Methotrexate
DB01229 Paclitaxel
DB00203 Sildenafil
DB04348 Taurocholic Acid
DB00300 Tenofovir
DB00661 Verapamil
DB00541 Vincristine

Protein family/group databases

TCDBi3.A.1.208.31 the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiQ5T3U5
PhosphoSitePlusiQ5T3U5

Polymorphism and mutation databases

BioMutaiABCC10
DMDMi74756298

Proteomic databases

EPDiQ5T3U5
MaxQBiQ5T3U5
PaxDbiQ5T3U5
PeptideAtlasiQ5T3U5
PRIDEiQ5T3U5
ProteomicsDBi64416
64417 [Q5T3U5-2]

Protocols and materials databases

DNASUi89845
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244533; ENSP00000244533; ENSG00000124574 [Q5T3U5-2]
ENST00000372530; ENSP00000361608; ENSG00000124574 [Q5T3U5-1]
GeneIDi89845
KEGGihsa:89845
UCSCiuc003ouy.2 human [Q5T3U5-1]

Organism-specific databases

CTDi89845
DisGeNETi89845
EuPathDBiHostDB:ENSG00000124574.14
GeneCardsiABCC10
HGNCiHGNC:52 ABCC10
HPAiHPA041607
HPA045464
MIMi612509 gene
neXtProtiNX_Q5T3U5
OpenTargetsiENSG00000124574
PharmGKBiPA24392
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0054 Eukaryota
COG1132 LUCA
GeneTreeiENSGT00930000150947
HOVERGENiHBG107141
InParanoidiQ5T3U5
KOiK05674
OMAiNYSAGEK
OrthoDBiEOG091G00IN
PhylomeDBiQ5T3U5
TreeFamiTF105203

Enzyme and pathway databases

ReactomeiR-HSA-382556 ABC-family proteins mediated transport

Miscellaneous databases

ChiTaRSiABCC10 human
GeneWikiiABCC10
GenomeRNAii89845
PROiPR:Q5T3U5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124574 Expressed in 219 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_ABCC10
ExpressionAtlasiQ5T3U5 baseline and differential
GenevisibleiQ5T3U5 HS

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMRP7_HUMAN
AccessioniPrimary (citable) accession number: Q5T3U5
Secondary accession number(s): Q8NHX7
, Q9H7N2, Q9NXY3, Q9UF48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 21, 2004
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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