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UniProtKB - Q5T3U5 (MRP7_HUMAN)

Entry version 142 (10 Feb 2021)
Sequence version 1 (21 Dec 2004)
Previous versions | rss
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Protein

ATP-binding cassette sub-family C member 10

Gene

ABCC10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:12527806, PubMed:15256465). Mediates multidrug resistance (MDR) in cancer cells by preventing the intracellular accumulation of certain antitumor drugs, such as, docetaxel and paclitaxel (PubMed:15256465, PubMed:23087055). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP (PubMed:12527806).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=0.057 mM for leukotriene C41 Publication
  2. KM=3.3 mM for ATP1 Publication
  3. KM=57.8 µM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius)1 Publication
  1. Vmax=20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius)1 Publication

pH dependencei

Optimum pH is 7.5.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi633 – 640ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1280 – 1287ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q5T3U5

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-382556, ABC-family proteins mediated transport

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q5T3U5

Protein family/group databases

Transport Classification Database

More...TCDBi		3.A.1.208.31, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family C member 10 (EC:7.6.2.21 Publication, EC:7.6.2.31 Publication)
Alternative name(s):
Multidrug resistance-associated protein 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ABCC10
Synonyms:MRP7, SIMRP7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:52, ABCC10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612509, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q5T3U5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000124574.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 52HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei70 – 90HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei102 – 122HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei133 – 153HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei172 – 192HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei293 – 313HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei320 – 340HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei391 – 411HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei414 – 434HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei507 – 527HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei538 – 558HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei875 – 895HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei933 – 953HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei974 – 994HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1051 – 1071HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1153 – 1173HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1182 – 1202HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		89845

Open Targets

More...OpenTargetsi		ENSG00000124574

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24392

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q5T3U5, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2073687

Drug and drug target database

More...DrugBanki		DB00091, Cyclosporine
DB00987, Cytarabine
DB00694, Daunorubicin
DB01248, Docetaxel
DB00997, Doxorubicin
DB00783, Estradiol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB00773, Etoposide
DB00441, Gemcitabine
DB00563, Methotrexate
DB01229, Paclitaxel
DB00203, Sildenafil
DB04348, Taurocholic acid
DB00300, Tenofovir disoproxil
DB00661, Verapamil
DB00541, Vincristine

DrugCentral

More...DrugCentrali		Q5T3U5

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ABCC10

Domain mapping of disease mutations (DMDM)

More...DMDMi		74756298

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002535761 – 1492ATP-binding cassette sub-family C member 10Add BLAST1492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei463PhosphothreonineCombined sources1
Modified residuei467PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q5T3U5

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q5T3U5

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q5T3U5

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q5T3U5

PeptideAtlas

More...PeptideAtlasi		Q5T3U5

PRoteomics IDEntifications database

More...PRIDEi		Q5T3U5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		64416 [Q5T3U5-1]
64417 [Q5T3U5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q5T3U5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q5T3U5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in spleen.1 Publication
Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000124574, Expressed in right hemisphere of cerebellum and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q5T3U5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q5T3U5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000124574, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124617, 14 interactors

Protein interaction database and analysis system

More...IntActi		Q5T3U5, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000361608

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q5T3U5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q5T3U5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini285 – 563ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST279
Domaini598 – 824ABC transporter 1PROSITE-ProRule annotationAdd BLAST227
Domaini885 – 1210ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST326
Domaini1246 – 1479ABC transporter 2PROSITE-ProRule annotationAdd BLAST234

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0054, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161082

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000604_27_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q5T3U5

Identification of Orthologs from Complete Genome Data

More...OMAi		PPYAWPS

Database of Orthologous Groups

More...OrthoDBi		138195at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q5T3U5

TreeFam database of animal gene trees

More...TreeFami		TF105203

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T3U5-1) [UniParc]FASTAAdd to basket
Also known as: Mrp7

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERLLAQLCG SSAAWPLPLW EGDTTGHCFT QLVLSALPHA LLAVLSACYL 
        60         70         80         90        100
GTPRSPDYIL PCSPGWRLRL AASFLLSVFP LLDLLPVALP PGAGPGPIGL 
       110        120        130        140        150
EVLAGCVAAV AWISHSLALW VLAHSPHGHS RGPLALALVA LLPAPALVLT 
       160        170        180        190        200
VLWHCQRGTL LPPLLPGPMA RLCLLILQLA ALLAYALGWA APGGPREPWA 
       210        220        230        240        250
QEPLLPEDQE PEVAEDGESW LSRFSYAWLA PLLARGACGE LRQPQDICRL 
       260        270        280        290        300
PHRLQPTYLA RVFQAHWQEG ARLWRALYGA FGRCYLALGL LKLVGTMLGF 
       310        320        330        340        350
SGPLLLSLLV GFLEEGQEPL SHGLLYALGL AGGAVLGAVL QNQYGYEVYK 
       360        370        380        390        400
VTLQARGAVL NILYCKALQL GPSRPPTGEA LNLLGTDSER LLNFAGSFHE 
       410        420        430        440        450
AWGLPLQLAI TLYLLYQQVG VAFVGGLILA LLLVPVNKVI ATRIMASNQE 
       460        470        480        490        500
MLQHKDARVK LVTELLSGIR VIKFCGWEQA LGARVEACRA RELGRLRVIK 
       510        520        530        540        550
YLDAACVYLW AALPVVISIV IFITYVLMGH QLTATKVFTA LALVRMLILP 
       560        570        580        590        600
LNNFPWVING LLEAKVSLDR IQLFLDLPNH NPQAYYSPDP PAEPSTVLEL 
       610        620        630        640        650
HGALFSWDPV GTSLETFISH LEVKKGMLVG IVGKVGCGKS SLLAAIAGEL 
       660        670        680        690        700
HRLRGHVAVR GLSKGFGLAT QEPWIQFATI RDNILFGKTF DAQLYKEVLE 
       710        720        730        740        750
ACALNDDLSI LPAGDQTEVG EKGVTLSGGQ RARIALARAV YQEKELYLLD 
       760        770        780        790        800
DPLAAVDADV ANHLLHRCIL GMLSYTTRLL CTHRTEYLER ADAVLLMEAG 
       810        820        830        840        850
RLIRAGPPSE ILPLVQAVPK AWAENGQESD SATAQSVQNP EKTKEGLEEE 
       860        870        880        890        900
QSTSGRLLQE ESKKEGAVAL HVYQAYWKAV GQGLALAILF SLLLMQATRN 
       910        920        930        940        950
AADWWLSHWI SQLKAENSSQ EAQPSTSPAS MGLFSPQLLL FSPGNLYIPV 
       960        970        980        990       1000
FPLPKAAPNG SSDIRFYLTV YATIAGVNSL CTLLRAVLFA AGTLQAAATL 
      1010       1020       1030       1040       1050
HRRLLHRVLM APVTFFNATP TGRILNRFSS DVACADDSLP FILNILLANA 
      1060       1070       1080       1090       1100
AGLLGLLAVL GSGLPWLLLL LPPLSIMYYH VQRHYRASSR ELRRLGSLTL 
      1110       1120       1130       1140       1150
SPLYSHLADT LAGLSVLRAT GATYRFEEEN LRLLELNQRC QFATSATMQW 
      1160       1170       1180       1190       1200
LDIRLQLMGA AVVSAIAGIA LVQHQQGLAN PGLVGLSLSY ALSLTGLLSG 
      1210       1220       1230       1240       1250
LVSSFTQTEA MLVSVERLEE YTCDLPQEPQ GQPLQLGTGW LTQGGVEFQD 
      1260       1270       1280       1290       1300
VVLAYRPGLP NALDGVTFCV QPGEKLGIVG RTGSGKSSLL LVLFRLLEPS 
      1310       1320       1330       1340       1350
SGRVLLDGVD TSQLELAQLR SQLAIIPQEP FLFSGTVREN LDPQGLHKDR 
      1360       1370       1380       1390       1400
ALWQALKQCH LSEVITSMGG LDGELGEGGR SLSLGQRQLL CLARALLTDA 
      1410       1420       1430       1440       1450
KILCIDEATA SVDQKTDQLL QQTICKRFAN KTVLTIAHRL NTILNSDRVL 
      1460       1470       1480       1490 
VLQAGRVVEL DSPATLRNQP HSLFQQLLQS SQQGVPASLG GP
Length:1,492
Mass (Da):161,629
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6FBC260DEFB3DF30
GO
Isoform 2 (identifier: Q5T3U5-2) [UniParc]FASTAAdd to basket
Also known as: Mrp7A

The sequence of this isoform differs from the canonical sequence as follows:
     1-43: Missing.
     44-52: VLSACYLGT → MCLLVFPLV
     588-588: P → PDCGRLGAQIKWLLCS

Show »
Length:1,464
Mass (Da):158,781
Checksum:i31644BE052337EB3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9B3D6R9B3_HUMAN
Multidrug resistance-associated pro...
ABCC10
277Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y904H0Y904_HUMAN
Multidrug resistance-associated pro...
ABCC10
129Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA92227 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15736 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti208D → E in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti220Missing in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti631I → T in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti764L → P in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti809S → P in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti888I → T in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1030S → F in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1134L → F in BAB15736 (PubMed:11214971).Curated1
Sequence conflicti1276L → V in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1455G → E in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1481S → C in AAK39642 (PubMed:12566991).Curated1
Sequence conflicti1490G → R in AAK39642 (PubMed:12566991).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_028391948I → T. Corresponds to variant dbSNP:rs2125739Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0210781 – 43Missing in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_02107944 – 52VLSACYLGT → MCLLVFPLV in isoform 2. 1 Publication9
Alternative sequenceiVSP_021080588P → PDCGRLGAQIKWLLCS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AY032599 mRNA Translation: AAK39642.1
AK000002 mRNA Translation: BAA92227.1 Different initiation.
AK024446 mRNA Translation: BAB15736.1 Sequence problems.
AL359813 Genomic DNA No translation available.
AL133613 mRNA Translation: CAB63742.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4896.1 [Q5T3U5-2]
CCDS56430.1 [Q5T3U5-1]

Protein sequence database of the Protein Information Resource

More...PIRi		T43469

NCBI Reference Sequences

More...RefSeqi		NP_001185863.1, NM_001198934.1 [Q5T3U5-1]
NP_258261.2, NM_033450.2 [Q5T3U5-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000244533; ENSP00000244533; ENSG00000124574 [Q5T3U5-2]
ENST00000372530; ENSP00000361608; ENSG00000124574 [Q5T3U5-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		89845

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:89845

UCSC genome browser

More...UCSCi		uc003ouy.2, human [Q5T3U5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

ABCMdb

Database for mutations in ABC proteins

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032599 mRNA Translation: AAK39642.1
AK000002 mRNA Translation: BAA92227.1 Different initiation.
AK024446 mRNA Translation: BAB15736.1 Sequence problems.
AL359813 Genomic DNA No translation available.
AL133613 mRNA Translation: CAB63742.1
CCDSiCCDS4896.1 [Q5T3U5-2]
CCDS56430.1 [Q5T3U5-1]
PIRiT43469
RefSeqiNP_001185863.1, NM_001198934.1 [Q5T3U5-1]
NP_258261.2, NM_033450.2 [Q5T3U5-2]

3D structure databases

SMRiQ5T3U5
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi124617, 14 interactors
IntActiQ5T3U5, 9 interactors
STRINGi9606.ENSP00000361608

Chemistry databases

ChEMBLiCHEMBL2073687
DrugBankiDB00091, Cyclosporine
DB00987, Cytarabine
DB00694, Daunorubicin
DB01248, Docetaxel
DB00997, Doxorubicin
DB00783, Estradiol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB00773, Etoposide
DB00441, Gemcitabine
DB00563, Methotrexate
DB01229, Paclitaxel
DB00203, Sildenafil
DB04348, Taurocholic acid
DB00300, Tenofovir disoproxil
DB00661, Verapamil
DB00541, Vincristine
DrugCentraliQ5T3U5

Protein family/group databases

TCDBi3.A.1.208.31, the atp-binding cassette (abc) superfamily

PTM databases

iPTMnetiQ5T3U5
PhosphoSitePlusiQ5T3U5

Genetic variation databases

BioMutaiABCC10
DMDMi74756298

Proteomic databases

jPOSTiQ5T3U5
MassIVEiQ5T3U5
MaxQBiQ5T3U5
PaxDbiQ5T3U5
PeptideAtlasiQ5T3U5
PRIDEiQ5T3U5
ProteomicsDBi64416 [Q5T3U5-1]
64417 [Q5T3U5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		30398, 266 antibodies

The DNASU plasmid repository

More...DNASUi		89845

Genome annotation databases

EnsembliENST00000244533; ENSP00000244533; ENSG00000124574 [Q5T3U5-2]
ENST00000372530; ENSP00000361608; ENSG00000124574 [Q5T3U5-1]
GeneIDi89845
KEGGihsa:89845
UCSCiuc003ouy.2, human [Q5T3U5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		89845
DisGeNETi89845

GeneCards: human genes, protein and diseases

More...GeneCardsi		ABCC10
HGNCiHGNC:52, ABCC10
HPAiENSG00000124574, Low tissue specificity
MIMi612509, gene
neXtProtiNX_Q5T3U5
OpenTargetsiENSG00000124574
PharmGKBiPA24392
VEuPathDBiHostDB:ENSG00000124574.14

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0054, Eukaryota
GeneTreeiENSGT00940000161082
HOGENOMiCLU_000604_27_1_1
InParanoidiQ5T3U5
OMAiPPYAWPS
OrthoDBi138195at2759
PhylomeDBiQ5T3U5
TreeFamiTF105203

Enzyme and pathway databases

PathwayCommonsiQ5T3U5
ReactomeiR-HSA-382556, ABC-family proteins mediated transport
SABIO-RKiQ5T3U5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		89845, 0 hits in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ABCC10, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ABCC10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		89845
PharosiQ5T3U5, Tbio

Protein Ontology

More...PROi		PR:Q5T3U5
RNActiQ5T3U5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000124574, Expressed in right hemisphere of cerebellum and 230 other tissues
ExpressionAtlasiQ5T3U5, baseline and differential
GenevisibleiQ5T3U5, HS

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011527, ABC1_TM_dom
IPR036640, ABC1_TM_sf
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00664, ABC_membrane, 2 hits
PF00005, ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90123, SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929, ABC_TM1F, 2 hits
PS00211, ABC_TRANSPORTER_1, 2 hits
PS50893, ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRP7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T3U5
Secondary accession number(s): Q8NHX7
, Q9H7N2, Q9NXY3, Q9UF48
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: December 21, 2004
Last modified: February 10, 2021
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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