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UniProtKB - Q5T3N0 (Q5T3N0_HUMAN)
Protein
Annexin
Gene
ANXA1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- calcium-dependent phospholipid binding Source: UniProtKB-KW
- calcium ion binding Source: InterPro
- phospholipase A2 inhibitor activity Source: UniProtKB-KW
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
Keywordsi
Molecular function | Phospholipase A2 inhibitorARBA annotation |
Biological process | Adaptive immunityARBA annotation, Immunity |
Ligand | Calcium, Calcium/phospholipid-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: AnnexinUniRule annotation |
Gene namesi | Name:ANXA1 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:533, ANXA1 |
VEuPathDBi | HostDB:ENSG00000135046 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Extracellular region or secreted
- extracellular exosome ARBA annotation
- extracellular space ARBA annotation
Endosome
- Early endosome ARBA annotation
- Endosome membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Plasma membrane
- Apical cell membrane ARBA annotation
- Basolateral cell membrane ARBA annotation
- Cell membrane ARBA annotation; Peripheral membrane protein ARBA annotation; Extracellular side ARBA annotation
- Lateral cell membrane ARBA annotation
Other locations
- cilium ARBA annotation
- phagocytic cup ARBA annotation
- Cytoplasmic vesicle membrane ARBA annotation; Peripheral membrane protein ARBA annotation
- secretory vesicle lumen ARBA annotation
- Membrane ARBA annotation; Peripheral membrane protein ARBA annotation
Cytosol
- cytosol Source: HPA
Endosome
- early endosome Source: UniProtKB-SubCell
- endosome membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular space Source: UniProtKB-SubCell
Nucleus
- nucleoplasm Source: HPA
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- basolateral plasma membrane Source: UniProtKB-SubCell
- lateral plasma membrane Source: UniProtKB-SubCell
- phagocytic cup Source: UniProtKB-SubCell
- plasma membrane Source: HPA
Other locations
- cilium Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membraneARBA annotation, Cell projection, CiliumARBA annotation, CytoplasmARBA annotation, Membrane, NucleusARBA annotationPTM / Processingi
Proteomic databases
MaxQBi | Q5T3N0 |
PeptideAtlasi | Q5T3N0 |
PRIDEi | Q5T3N0 |
ProteomicsDBi | 64409 |
PTM databases
SwissPalmi | Q5T3N0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000135046, Expressed in esophagus and 240 other tissues |
ExpressionAtlasi | Q5T3N0, baseline and differential |
Family & Domainsi
Domaini
The full-length protein can bind eight Ca2+ ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca2+, these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.UniRule annotation
Sequence similaritiesi
Keywords - Domaini
AnnexinUniRule annotationARBA annotation, RepeatUniRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155221 |
HOGENOMi | CLU_025300_2_3_1 |
OMAi | AKADRCE |
Family and domain databases
Gene3Di | 1.10.220.10, 1 hit |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR002388, ANX1 |
PANTHERi | PTHR10502:SF17, PTHR10502:SF17, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 1 hit |
PRINTSi | PR00196, ANNEXIN PR00197, ANNEXINI |
SMARTi | View protein in SMART SM00335, ANX, 1 hit |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 1 hit PS51897, ANNEXIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q5T3N0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAMVSEFLKQ AWFIENEEQE YVQTVKSSKG GPGSAVSPYP TFNPSSDVAA
60 70 80 90 100
LHKAIMVKGV DEATIIDILT KRNNAQRQQI KAAYLQETGK PLDETLKKAL
110
TGHLEEVVLA LLKTP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP04083 | ANXA1_HUMAN | Annexin A1 | ANXA1 ANX1, LPC1 | 346 | Annotation score: | ||
Q5T3N1 | Q5T3N1_HUMAN | Annexin | ANXA1 | 204 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 115 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL359997 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000415424.5; ENSP00000414013.1; ENSG00000135046.14 |
UCSCi | uc064tth.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL359997 Genomic DNA No translation available. |
3D structure databases
SMRi | Q5T3N0 |
ModBasei | Search... |
PTM databases
SwissPalmi | Q5T3N0 |
Proteomic databases
MaxQBi | Q5T3N0 |
PeptideAtlasi | Q5T3N0 |
PRIDEi | Q5T3N0 |
ProteomicsDBi | 64409 |
Protocols and materials databases
Antibodypediai | 2190, 1195 antibodies from 51 providers |
Genome annotation databases
Ensembli | ENST00000415424.5; ENSP00000414013.1; ENSG00000135046.14 |
UCSCi | uc064tth.1, human |
Organism-specific databases
HGNCi | HGNC:533, ANXA1 |
OpenTargetsi | ENSG00000135046 |
VEuPathDBi | HostDB:ENSG00000135046 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155221 |
HOGENOMi | CLU_025300_2_3_1 |
OMAi | AKADRCE |
Miscellaneous databases
ChiTaRSi | ANXA1, human |
Gene expression databases
Bgeei | ENSG00000135046, Expressed in esophagus and 240 other tissues |
ExpressionAtlasi | Q5T3N0, baseline and differential |
Family and domain databases
Gene3Di | 1.10.220.10, 1 hit |
InterProi | View protein in InterPro IPR001464, Annexin IPR018502, Annexin_repeat IPR018252, Annexin_repeat_CS IPR037104, Annexin_sf IPR002388, ANX1 |
PANTHERi | PTHR10502:SF17, PTHR10502:SF17, 1 hit |
Pfami | View protein in Pfam PF00191, Annexin, 1 hit |
PRINTSi | PR00196, ANNEXIN PR00197, ANNEXINI |
SMARTi | View protein in SMART SM00335, ANX, 1 hit |
SUPFAMi | SSF47874, SSF47874, 1 hit |
PROSITEi | View protein in PROSITE PS00223, ANNEXIN_1, 1 hit PS51897, ANNEXIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5T3N0_HUMAN | |
Accessioni | Q5T3N0Primary (citable) accession number: Q5T3N0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 21, 2004 |
Last sequence update: | December 21, 2004 | |
Last modified: | May 25, 2022 | |
This is version 131 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |