LRIF1

Functionⁱ

Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211).2 Publications

GO - Molecular functionⁱ

retinoic acid receptor binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

dosage compensation by inactivation of X chromosome
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23542155
regulation of transcription, DNA-templated Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ligand-dependent nuclear receptor-interacting factor 1Curated Alternative name(s): HP1-binding protein enriched in inactive X chromosome protein 11 Publication Short name: HBiX11 Publication Receptor-interacting factor 11 Publication
Gene namesⁱ	Name:LRIF1Imported Synonyms:C1orf103Imported, RIF11 Publication
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000121931.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:30299 LRIF1
MIMⁱ	615354 gene
neXtProtⁱ	NX_Q5T3J3

Keywords - Cellular componentⁱ

Chromosome, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	582 – 584	VCL → DCE: Abolishes interaction with HP1 (CBX1/HP1-beta, CBX3/HP1-gamma and CBX5/HP1-alpha). 1 Publication	3
Mutagenesisⁱ	628 – 630	KKR → AAA: Slightly reduces nuclear localization. 1 Publication	3
Mutagenesisⁱ	642 – 644	KKR → AAA: Abolishes nuclear localization. 1 Publication	3

Organism-specific databases

DisGeNET More...DisGeNETⁱ	55791
Open Targets More...OpenTargetsⁱ	ENSG00000121931
PharmGKBⁱ	PA142672487

Polymorphism and mutation databases

BioMutaⁱ	LRIF1
DMDMⁱ	74744778

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000250686	1 – 769	Ligand-dependent nuclear receptor-interacting factor 1Add BLAST		769

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	259	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	279	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	402	PhosphoserineCombined sources	1
Modified residueⁱ	430	PhosphoserineCombined sources	1
Modified residueⁱ	436	PhosphoserineCombined sources	1
Cross-linkⁱ	446	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	502	PhosphoserineCombined sources	1
Modified residueⁱ	599	PhosphoserineCombined sources	1
Cross-linkⁱ	605	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	702	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	732	PhosphothreonineCombined sources	1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q5T3J3
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q5T3J3
PaxDbⁱ	Q5T3J3
PeptideAtlas More...PeptideAtlasⁱ	Q5T3J3
PRIDEⁱ	Q5T3J3
ProteomicsDBⁱ	64403 64404 [Q5T3J3-2]

PTM databases

iPTMnetⁱ	Q5T3J3
PhosphoSitePlusⁱ	Q5T3J3

Expressionⁱ

Tissue specificityⁱ

Widely expressed, with the highest expression levels in heart, liver and placenta.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000121931 Expressed in 210 organ(s), highest expression level in testis
CleanExⁱ	HS_C1orf103 HS_RIF1
Genevisibleⁱ	Q5T3J3 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044515

HPAⁱ

HPA044515

Interactionⁱ

Subunit structureⁱ

Interacts with RARA (PubMed:17455211). Interacts with SMCHD1; leading to recruitment to inactivated chromosome X in females (PubMed:23542155). Interacts (via PxVxL motif) with HP1 (CBX1/HP1-beta, CBX3/HP1-gamma and CBX5/HP1-alpha) (PubMed:23542155).2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CBX3	Q13185	4	EBI-473196,EBI-78176
CBX5	P45973	3	EBI-473196,EBI-78219
GIT1	Q9Y2X7	2	EBI-473196,EBI-466061

GO - Molecular functionⁱ

retinoic acid receptor binding Source: InterPro

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	120905, 174 interactors
IntActⁱ	Q5T3J3, 52 interactors
Molecular INTeraction database More...MINTⁱ	Q5T3J3
STRINGⁱ	9606.ENSP00000358778

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q5T3J3
SMRⁱ	Q5T3J3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	740 – 769	Sequence analysisAdd BLAST		30

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	580 – 584	PxVxL motif1 Publication	5
Motifⁱ	628 – 631	Nuclear localization signal1 Publication	4
Motifⁱ	642 – 645	Nuclear localization signal1 Publication	4

Domainⁱ

The Pro-Xaa-Val-Xaa-Leu (PxVxL) motif mediates interaction with HP1 (CBX1/HP1-beta, CBX3/HP1-gamma and CBX5/HP1-alpha).1 Publication

Sequence similaritiesⁱ

Belongs to the LRIF1 family.Curated

Keywords - Domainⁱ

Coiled coil

Phylogenomic databases

eggNOGⁱ	ENOG410IE1C Eukaryota ENOG41129E9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017353
HOVERGENⁱ	HBG080960
InParanoidⁱ	Q5T3J3
OMAⁱ	QNEMAST
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G029S
PhylomeDBⁱ	Q5T3J3
TreeFamⁱ	TF336147

Family and domain databases

InterProⁱ	View protein in InterPro IPR026191 LRIF1
PANTHERⁱ	PTHR16131 PTHR16131, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15741 LRIF1, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q5T3J3-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNNLRRVFL KPAEENSGNA SRCVSGCMYQ VVQTIGSDGK NLLQLLPIPK 
        60         70         80         90        100
SSGNLIPLVQ SSVMSDALKG NTGKPVQVTF QTQISSSSTS ASVQLPIFQP 
       110        120        130        140        150
ASSSNYFLTR TVDTSEKGRV TSVGTGNFSS SVSKVQSHGV KIDGLTMQTF 
       160        170        180        190        200
AVPPSTQKDS SFIVVNTQSL PVTVKSPVLP SGHHLQIPAH AEVKSVPASS 
       210        220        230        240        250
LPPSVQQKIL ATATTSTSGM VEASQMPTVI YVSPVNTVKN VVTKNFQNIY 
       260        270        280        290        300
PKPVTEIAKP VILNTTQIPK NVATETQLKG GQHSQAAPVK WIFQDNLQPF 
       310        320        330        340        350
TPSLVPVKSS NNVASKILKT FVDRKNLGDN TINMPPLSTI DPSGTRSKNM 
       360        370        380        390        400
PIKDNALVMF NGKVYLLAKK GTDVLPSQID QQNSVSPDTP VRKDTLQTVS 
       410        420        430        440        450
SSPVTEISRE VVNIVLAKSK SSQMETKSLS NTQLASMANL RAEKNKVEKP 
       460        470        480        490        500
SPSTTNPHMN QSSNYLKQSK TLFTNPIFPV GFSTGHNAPR KVTAVIYARK 
       510        520        530        540        550
GSVLQSIEKI SSSVDATTVT SQQCVFRDQE PKIHNEMAST SDKGAQGRND 
       560        570        580        590        600
KKDSQGRSNK ALHLKSDAEF KKIFGLTKDL RVCLTRIPDH LTSGEGFDSF 
       610        620        630        640        650
SSLVKSGTYK ETEFMVKEGE RKQQNFDKKR KAKTNKKMDH IKKRKTENAY 
       660        670        680        690        700
NAIINGEANV TGSQLLSSIL PTSDVSQHNI LTSHSKTRQE KRTEMEYYTH 
       710        720        730        740        750
EKQEKGTLNS NAAYEQSHFF NKNYTEDIFP VTPPELEETI RDEKIRRLKQ 
       760 
VLREKEAALE EMRKKMHQK

Length:769

Mass (Da):84,568

Last modified:December 21, 2004 - v1

Checksum:ⁱD39A2BB494F16AAA

GO

Isoform 2 (identifier: Q5T3J3-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-536: Missing.

« Hide

        10         20         30         40         50
MASTSDKGAQ GRNDKKDSQG RSNKALHLKS DAEFKKIFGL TKDLRVCLTR 
        60         70         80         90        100
IPDHLTSGEG FDSFSSLVKS GTYKETEFMV KEGERKQQNF DKKRKAKTNK 
       110        120        130        140        150
KMDHIKKRKT ENAYNAIING EANVTGSQLL SSILPTSDVS QHNILTSHSK 
       160        170        180        190        200
TRQEKRTEME YYTHEKQEKG TLNSNAAYEQ SHFFNKNYTE DIFPVTPPEL 
       210        220        230 
EETIRDEKIR RLKQVLREKE AALEEMRKKM HQK

Note: No experimental confirmation available.

Show »

Length:233

Mass (Da):26,917

Checksum:ⁱD1E3BE5BCD299BAB

GO

Sequence cautionⁱ

The sequence AAH08115 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAO43631 differs from that shown. Reason: Frameshift at position 23.Curated

The sequence BAA92097 differs from that shown. Reason: Frameshift at position 667.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	66 – 68	DAL → NA in AAO43631 (Ref. 1) Curated	3
Sequence conflictⁱ	72 – 80	TGKPVQVTF → PGNQFSY in AAO43631 (Ref. 1) Curated	9
Sequence conflictⁱ	108 – 111	LTRT → PSRP in AAO43631 (Ref. 1) Curated	4
Sequence conflictⁱ	666	Missing in BAA92097 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_050703	438	A → T. Corresponds to variant dbSNP:rs2232041Ensembl.	1
Natural variantⁱVAR_027599	599	S → P. Corresponds to variant dbSNP:rs2232045Ensembl.	1
Natural variantⁱVAR_027600	641	I → M. Corresponds to variant dbSNP:rs2232047Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_020721	1 – 536	Missing in isoform 2. 1 PublicationAdd BLAST		536

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY190122 mRNA Translation: AAO43631.1 Frameshift. AK001826 mRNA Translation: BAA91928.1 AK002131 mRNA Translation: BAA92097.1 Frameshift. AL360270 Genomic DNA No translation available. BC008115 mRNA Translation: AAH08115.1 Different initiation. AL834466 mRNA Translation: CAD39125.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30800.1 [Q5T3J3-1] CCDS41366.1 [Q5T3J3-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001006946.1, NM_001006945.1 [Q5T3J3-2] NP_060842.3, NM_018372.3 [Q5T3J3-1]
UniGeneⁱ	Hs.25245

Genome annotation databases

Ensemblⁱ	ENST00000369763; ENSP00000358778; ENSG00000121931 [Q5T3J3-1] ENST00000485275; ENSP00000432290; ENSG00000121931 [Q5T3J3-2] ENST00000494675; ENSP00000435259; ENSG00000121931 [Q5T3J3-2]
GeneIDⁱ	55791
KEGGⁱ	hsa:55791
UCSC genome browser More...UCSCⁱ	uc001dzz.4 human [Q5T3J3-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q5T3J3	Isoform 2 of Ligand-dependent nuclear receptor-interacting factor 1		HUMAN		233	UniRef100_Q5T3J3
UPI000021D190		HUMAN		742

Protein	Similar proteins		Species	Score	Length	Source
Q5T3J3	Isoform 2 of Ligand-dependent nuclear receptor-interacting factor 1		HUMAN		233	UniRef90_Q5T3J3
Ligand dependent nuclear receptor interacting factor 1		PANTR		769
LRIF1 isoform 1		PONAB		769
Uncharacterized protein		PANPA		769
Uncharacterized protein		MACFA		769
+62

Protein	Similar proteins		Species	Score	Length	Source
Q5T3J3	Ligand-dependent nuclear receptor-interacting factor 1		MOUSE		755	UniRef50_Q5T3J3
Ligand-dependent nuclear receptor-interacting factor 1		RAT		748
Isoform 2 of Ligand-dependent nuclear receptor-interacting factor 1		HUMAN		233
LRIF1 isoform 1		PONAB		769
Ligand dependent nuclear receptor interacting factor 1		PANTR		769
+305

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY190122 mRNA Translation: AAO43631.1 Frameshift. AK001826 mRNA Translation: BAA91928.1 AK002131 mRNA Translation: BAA92097.1 Frameshift. AL360270 Genomic DNA No translation available. BC008115 mRNA Translation: AAH08115.1 Different initiation. AL834466 mRNA Translation: CAD39125.1
CCDSⁱ	CCDS30800.1 [Q5T3J3-1] CCDS41366.1 [Q5T3J3-2]
RefSeqⁱ	NP_001006946.1, NM_001006945.1 [Q5T3J3-2] NP_060842.3, NM_018372.3 [Q5T3J3-1]
UniGeneⁱ	Hs.25245

3D structure databases

ProteinModelPortalⁱ	Q5T3J3
SMRⁱ	Q5T3J3
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	120905, 174 interactors
IntActⁱ	Q5T3J3, 52 interactors
MINTⁱ	Q5T3J3
STRINGⁱ	9606.ENSP00000358778

PTM databases

iPTMnetⁱ	Q5T3J3
PhosphoSitePlusⁱ	Q5T3J3

Polymorphism and mutation databases

BioMutaⁱ	LRIF1
DMDMⁱ	74744778

Proteomic databases

EPDⁱ	Q5T3J3
MaxQBⁱ	Q5T3J3
PaxDbⁱ	Q5T3J3
PeptideAtlasⁱ	Q5T3J3
PRIDEⁱ	Q5T3J3
ProteomicsDBⁱ	64403 64404 [Q5T3J3-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	55791
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000369763; ENSP00000358778; ENSG00000121931 [Q5T3J3-1] ENST00000485275; ENSP00000432290; ENSG00000121931 [Q5T3J3-2] ENST00000494675; ENSP00000435259; ENSG00000121931 [Q5T3J3-2]
GeneIDⁱ	55791
KEGGⁱ	hsa:55791
UCSCⁱ	uc001dzz.4 human [Q5T3J3-1]

Organism-specific databases

CTDⁱ	55791
DisGeNETⁱ	55791
EuPathDBⁱ	HostDB:ENSG00000121931.15
GeneCardsⁱ	LRIF1
HGNCⁱ	HGNC:30299 LRIF1
HPAⁱ	HPA044515
MIMⁱ	615354 gene
neXtProtⁱ	NX_Q5T3J3
OpenTargetsⁱ	ENSG00000121931
PharmGKBⁱ	PA142672487
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IE1C Eukaryota ENOG41129E9 LUCA
GeneTreeⁱ	ENSGT00390000017353
HOVERGENⁱ	HBG080960
InParanoidⁱ	Q5T3J3
OMAⁱ	QNEMAST
OrthoDBⁱ	EOG091G029S
PhylomeDBⁱ	Q5T3J3
TreeFamⁱ	TF336147

Miscellaneous databases

ChiTaRSⁱ	LRIF1 human
GeneWikiⁱ	C1orf103
GenomeRNAiⁱ	55791
Protein Ontology More...PROⁱ	PR:Q5T3J3
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000121931 Expressed in 210 organ(s), highest expression level in testis
CleanExⁱ	HS_C1orf103 HS_RIF1
Genevisibleⁱ	Q5T3J3 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR026191 LRIF1
PANTHERⁱ	PTHR16131 PTHR16131, 1 hit
Pfamⁱ	View protein in Pfam PF15741 LRIF1, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LRIF1_HUMAN
Accessionⁱ	Q5T3J3Primary (citable) accession number: Q5T3J3 Secondary accession number(s): Q86XS4 , Q8N3B6, Q96HT4, Q9NUM5, Q9NV32
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
	Last sequence update:	December 21, 2004
	Last modified:	November 7, 2018
	This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q5T3J3 (LRIF1_HUMAN)

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Ligand-dependent nuclear receptor-interacting factor 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytoskeleton

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ