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UniProtKB - Q5T3J3 (LRIF1_HUMAN)

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Protein

Ligand-dependent nuclear receptor-interacting factor 1

Gene

LRIF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Represses the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA). This repression may occur through direct recruitment of histone deacetylases.1 Publication

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ligand-dependent nuclear receptor-interacting factor 1
Alternative name(s):
Receptor-interacting factor 1
Gene namesi
Name:LRIF1
Synonyms:C1orf103, RIF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000121931.15
HGNCiHGNC:30299 LRIF1
MIMi615354 gene
neXtProtiNX_Q5T3J3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi628 – 630KKR → AAA: Slightly reduces nuclear localization. 1 Publication3
Mutagenesisi642 – 644KKR → AAA: Abolishes nuclear localization. 1 Publication3

Organism-specific databases

DisGeNETi55791
OpenTargetsiENSG00000121931
PharmGKBiPA142672487

Polymorphism and mutation databases

BioMutaiLRIF1
DMDMi74744778

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002506861 – 769Ligand-dependent nuclear receptor-interacting factor 1Add BLAST769

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki259Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki279Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei402PhosphoserineCombined sources1
Modified residuei430PhosphoserineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Cross-linki446Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei502PhosphoserineCombined sources1
Modified residuei599PhosphoserineCombined sources1
Cross-linki605Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki702Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei732PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ5T3J3
MaxQBiQ5T3J3
PaxDbiQ5T3J3
PeptideAtlasiQ5T3J3
PRIDEiQ5T3J3
ProteomicsDBi64403
64404 [Q5T3J3-2]

PTM databases

iPTMnetiQ5T3J3
PhosphoSitePlusiQ5T3J3

Expressioni

Tissue specificityi

Widely expressed, with the highest expression levels in heart, liver and placenta.1 Publication

Gene expression databases

BgeeiENSG00000121931
CleanExiHS_C1orf103
HS_RIF1
GenevisibleiQ5T3J3 HS

Organism-specific databases

HPAiHPA044515

Interactioni

Subunit structurei

Interacts with RARA.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi120905, 174 interactors
IntActiQ5T3J3, 52 interactors
MINTiQ5T3J3
STRINGi9606.ENSP00000358778

Structurei

3D structure databases

ProteinModelPortaliQ5T3J3
SMRiQ5T3J3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili740 – 769Sequence analysisAdd BLAST30

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi628 – 631Nuclear localization signal1 Publication4
Motifi642 – 645Nuclear localization signal1 Publication4

Sequence similaritiesi

Belongs to the LRIF1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE1C Eukaryota
ENOG41129E9 LUCA
GeneTreeiENSGT00390000017353
HOVERGENiHBG080960
InParanoidiQ5T3J3
OMAiCVSGCMY
OrthoDBiEOG091G029S
PhylomeDBiQ5T3J3
TreeFamiTF336147

Family and domain databases

InterProiView protein in InterPro
IPR026191 LRIF1
PANTHERiPTHR16131 PTHR16131, 1 hit
PfamiView protein in Pfam
PF15741 LRIF1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q5T3J3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNNLRRVFL KPAEENSGNA SRCVSGCMYQ VVQTIGSDGK NLLQLLPIPK 
        60         70         80         90        100
SSGNLIPLVQ SSVMSDALKG NTGKPVQVTF QTQISSSSTS ASVQLPIFQP 
       110        120        130        140        150
ASSSNYFLTR TVDTSEKGRV TSVGTGNFSS SVSKVQSHGV KIDGLTMQTF 
       160        170        180        190        200
AVPPSTQKDS SFIVVNTQSL PVTVKSPVLP SGHHLQIPAH AEVKSVPASS 
       210        220        230        240        250
LPPSVQQKIL ATATTSTSGM VEASQMPTVI YVSPVNTVKN VVTKNFQNIY 
       260        270        280        290        300
PKPVTEIAKP VILNTTQIPK NVATETQLKG GQHSQAAPVK WIFQDNLQPF 
       310        320        330        340        350
TPSLVPVKSS NNVASKILKT FVDRKNLGDN TINMPPLSTI DPSGTRSKNM 
       360        370        380        390        400
PIKDNALVMF NGKVYLLAKK GTDVLPSQID QQNSVSPDTP VRKDTLQTVS 
       410        420        430        440        450
SSPVTEISRE VVNIVLAKSK SSQMETKSLS NTQLASMANL RAEKNKVEKP 
       460        470        480        490        500
SPSTTNPHMN QSSNYLKQSK TLFTNPIFPV GFSTGHNAPR KVTAVIYARK 
       510        520        530        540        550
GSVLQSIEKI SSSVDATTVT SQQCVFRDQE PKIHNEMAST SDKGAQGRND 
       560        570        580        590        600
KKDSQGRSNK ALHLKSDAEF KKIFGLTKDL RVCLTRIPDH LTSGEGFDSF 
       610        620        630        640        650
SSLVKSGTYK ETEFMVKEGE RKQQNFDKKR KAKTNKKMDH IKKRKTENAY 
       660        670        680        690        700
NAIINGEANV TGSQLLSSIL PTSDVSQHNI LTSHSKTRQE KRTEMEYYTH 
       710        720        730        740        750
EKQEKGTLNS NAAYEQSHFF NKNYTEDIFP VTPPELEETI RDEKIRRLKQ 
       760 
VLREKEAALE EMRKKMHQK
Length:769
Mass (Da):84,568
Last modified:December 21, 2004 - v1
Checksum:iD39A2BB494F16AAA
GO
Isoform 2 (identifier: Q5T3J3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-536: Missing.

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):26,917
Checksum:iD1E3BE5BCD299BAB
GO

Sequence cautioni

The sequence AAH08115 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAO43631 differs from that shown. Reason: Frameshift at position 23.Curated
The sequence BAA92097 differs from that shown. Reason: Frameshift at position 667.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66 – 68DAL → NA in AAO43631 (Ref. 1) Curated3
Sequence conflicti72 – 80TGKPVQVTF → PGNQFSY in AAO43631 (Ref. 1) Curated9
Sequence conflicti108 – 111LTRT → PSRP in AAO43631 (Ref. 1) Curated4
Sequence conflicti666Missing in BAA92097 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050703438A → T. Corresponds to variant dbSNP:rs2232041Ensembl.1
Natural variantiVAR_027599599S → P. Corresponds to variant dbSNP:rs2232045Ensembl.1
Natural variantiVAR_027600641I → M. Corresponds to variant dbSNP:rs2232047Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0207211 – 536Missing in isoform 2. 1 PublicationAdd BLAST536

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY190122 mRNA Translation: AAO43631.1 Frameshift.
AK001826 mRNA Translation: BAA91928.1
AK002131 mRNA Translation: BAA92097.1 Frameshift.
AL360270 Genomic DNA No translation available.
BC008115 mRNA Translation: AAH08115.1 Different initiation.
AL834466 mRNA Translation: CAD39125.1
CCDSiCCDS30800.1 [Q5T3J3-1]
CCDS41366.1 [Q5T3J3-2]
RefSeqiNP_001006946.1, NM_001006945.1 [Q5T3J3-2]
NP_060842.3, NM_018372.3 [Q5T3J3-1]
UniGeneiHs.25245

Genome annotation databases

EnsembliENST00000369763; ENSP00000358778; ENSG00000121931 [Q5T3J3-1]
ENST00000485275; ENSP00000432290; ENSG00000121931 [Q5T3J3-2]
ENST00000494675; ENSP00000435259; ENSG00000121931 [Q5T3J3-2]
GeneIDi55791
KEGGihsa:55791
UCSCiuc001dzz.4 human [Q5T3J3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLRIF1_HUMAN
AccessioniPrimary (citable) accession number: Q5T3J3
Secondary accession number(s): Q86XS4
, Q8N3B6, Q96HT4, Q9NUM5, Q9NV32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 21, 2004
Last modified: July 18, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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