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Entry version 119 (16 Oct 2019)
Sequence version 1 (21 Dec 2004)
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Protein

CSC1-like protein 2

Gene

TMEM63B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an osmosensitive calcium-permeable cation channel.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport
LigandCalcium

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.17.5.3 the calcium-dependent chloride channel (ca-clc) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CSC1-like protein 2
Alternative name(s):
Transmembrane protein 63B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM63B
Synonyms:C6orf110
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:17735 TMEM63B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T3F8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei41 – 61HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21
Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Transmembranei560 – 580HelicalSequence analysisAdd BLAST21
Transmembranei630 – 650HelicalSequence analysisAdd BLAST21
Transmembranei678 – 698HelicalSequence analysisAdd BLAST21
Transmembranei711 – 731HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000137216

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134911221

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5T3F8

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM63B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74744754

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002807281 – 832CSC1-like protein 2Add BLAST832

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei111PhosphoserineCombined sources1
Modified residuei113PhosphoserineBy similarity1
Modified residuei114PhosphoserineCombined sources1
Modified residuei115PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T3F8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5T3F8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q5T3F8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T3F8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T3F8

PeptideAtlas

More...
PeptideAtlasi
Q5T3F8

PRoteomics IDEntifications database

More...
PRIDEi
Q5T3F8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64388 [Q5T3F8-1]
64389 [Q5T3F8-2]
64390 [Q5T3F8-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T3F8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T3F8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5T3F8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000137216 Expressed in 201 organ(s), highest expression level in nasal cavity epithelium

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5T3F8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T3F8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA029249
HPA029250
HPA029251

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120640, 98 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T3F8, 92 interactors

Molecular INTeraction database

More...
MINTi
Q5T3F8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000259746

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1134 Eukaryota
COG5594 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157084

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T3F8

KEGG Orthology (KO)

More...
KOi
K21989

Identification of Orthologs from Complete Genome Data

More...
OMAi
WLWVHTI

Database of Orthologous Groups

More...
OrthoDBi
395194at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T3F8

TreeFam database of animal gene trees

More...
TreeFami
TF324300

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032880 Csc1_N
IPR027815 PHM7_cyt
IPR003864 RSN1_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14703 PHM7_cyt, 1 hit
PF02714 RSN1_7TM, 1 hit
PF13967 RSN1_TM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T3F8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLPFLLATLG TTALNNSNPK DYCYSARIRS TVLQGLPFGG VPTVLALDFM
60 70 80 90 100
CFLALLFLFS ILRKVAWDYG RLALVTDADR LRRQERDRVE QEYVASAMHG
110 120 130 140 150
DSHDRYERLT SVSSSVDFDQ RDNGFCSWLT AIFRIKDDEI RDKCGGDAVH
160 170 180 190 200
YLSFQRHIIG LLVVVGVLSV GIVLPVNFSG DLLENNAYSF GRTTIANLKS
210 220 230 240 250
GNNLLWLHTS FAFLYLLLTV YSMRRHTSKM RYKEDDLVKR TLFINGISKY
260 270 280 290 300
AESEKIKKHF EEAYPNCTVL EARPCYNVAR LMFLDAERKK AERGKLYFTN
310 320 330 340 350
LQSKENVPTM INPKPCGHLC CCVVRGCEQV EAIEYYTKLE QKLKEDYKRE
360 370 380 390 400
KEKVNEKPLG MAFVTFHNET ITAIILKDFN VCKCQGCTCR GEPRPSSCSE
410 420 430 440 450
SLHISNWTVS YAPDPQNIYW EHLSIRGFIW WLRCLVINVV LFILLFFLTT
460 470 480 490 500
PAIIITTMDK FNVTKPVEYL NNPIITQFFP TLLLWCFSAL LPTIVYYSAF
510 520 530 540 550
FEAHWTRSGE NRTTMHKCYT FLIFMVLLLP SLGLSSLDLF FRWLFDKKFL
560 570 580 590 600
AEAAIRFECV FLPDNGAFFV NYVIASAFIG NAMDLLRIPG LLMYMIRLCL
610 620 630 640 650
ARSAAERRNV KRHQAYEFQF GAAYAWMMCV FTVVMTYSIT CPIIVPFGLM
660 670 680 690 700
YMLLKHLVDR YNLYYAYLPA KLDKKIHSGA VNQVVAAPIL CLFWLLFFST
710 720 730 740 750
MRTGFLAPTS MFTFVVLVIT IVICLCHVCF GHFKYLSAHN YKIEHTETDT
760 770 780 790 800
VDPRSNGRPP TAAAVPKSAK YIAQVLQDSE VDGDGDGAPG SSGDEPPSSS
810 820 830
SQDEELLMPP DALTDTDFQS CEDSLIENEI HQ
Length:832
Mass (Da):94,958
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F28F9DBBA1A6A62
GO
Isoform 2 (identifier: Q5T3F8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     472-491: NPIITQFFPTLLLWCFSALL → VRPHAPVTFHAGSQHTDTRP
     492-832: Missing.

Note: No experimental confirmation available.
Show »
Length:491
Mass (Da):56,308
Checksum:i9A823D414C870C22
GO
Isoform 3 (identifier: Q5T3F8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     704-704: G → D
     705-832: Missing.

Note: No experimental confirmation available.
Show »
Length:704
Mass (Da):81,177
Checksum:i6F5E869C92901E74
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BLW6H3BLW6_HUMAN
CSC1-like protein 2
TMEM63B
761Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCP6H0YCP6_HUMAN
CSC1-like protein 2
TMEM63B
520Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNG1E9PNG1_HUMAN
CSC1-like protein 2
TMEM63B
226Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDJ6H0YDJ6_HUMAN
CSC1-like protein 2
TMEM63B
27Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAH10540 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti298F → L in BAC04207 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031192307V → M1 PublicationCorresponds to variant dbSNP:rs4714759Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_023889472 – 491NPIIT…FSALL → VRPHAPVTFHAGSQHTDTRP in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_023890492 – 832Missing in isoform 2. 1 PublicationAdd BLAST341
Alternative sequenceiVSP_023891704G → D in isoform 3. 1 Publication1
Alternative sequenceiVSP_023892705 – 832Missing in isoform 3. 1 PublicationAdd BLAST128

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK093629 mRNA Translation: BAC04207.1
AL353957 mRNA Translation: CAB89257.1
AL834238 mRNA Translation: CAD38916.1
CR627460 mRNA Translation: CAH10540.1 Frameshift.
AL365192 Genomic DNA No translation available.
BC062989 mRNA Translation: AAH62989.1
BC136769 mRNA Translation: AAI36770.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34461.1 [Q5T3F8-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T48692

NCBI Reference Sequences

More...
RefSeqi
NP_001305721.1, NM_001318792.1 [Q5T3F8-1]
NP_060896.1, NM_018426.2 [Q5T3F8-1]
XP_005249270.1, XM_005249213.4 [Q5T3F8-1]
XP_005249274.1, XM_005249217.1 [Q5T3F8-1]
XP_006715198.1, XM_006715135.1 [Q5T3F8-1]
XP_016866489.1, XM_017011000.1 [Q5T3F8-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000259746; ENSP00000259746; ENSG00000137216 [Q5T3F8-1]
ENST00000323267; ENSP00000327154; ENSG00000137216 [Q5T3F8-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55362

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55362

UCSC genome browser

More...
UCSCi
uc003owr.4 human [Q5T3F8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093629 mRNA Translation: BAC04207.1
AL353957 mRNA Translation: CAB89257.1
AL834238 mRNA Translation: CAD38916.1
CR627460 mRNA Translation: CAH10540.1 Frameshift.
AL365192 Genomic DNA No translation available.
BC062989 mRNA Translation: AAH62989.1
BC136769 mRNA Translation: AAI36770.1
CCDSiCCDS34461.1 [Q5T3F8-1]
PIRiT48692
RefSeqiNP_001305721.1, NM_001318792.1 [Q5T3F8-1]
NP_060896.1, NM_018426.2 [Q5T3F8-1]
XP_005249270.1, XM_005249213.4 [Q5T3F8-1]
XP_005249274.1, XM_005249217.1 [Q5T3F8-1]
XP_006715198.1, XM_006715135.1 [Q5T3F8-1]
XP_016866489.1, XM_017011000.1 [Q5T3F8-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi120640, 98 interactors
IntActiQ5T3F8, 92 interactors
MINTiQ5T3F8
STRINGi9606.ENSP00000259746

Protein family/group databases

TCDBi1.A.17.5.3 the calcium-dependent chloride channel (ca-clc) family

PTM databases

iPTMnetiQ5T3F8
PhosphoSitePlusiQ5T3F8
SwissPalmiQ5T3F8

Polymorphism and mutation databases

BioMutaiTMEM63B
DMDMi74744754

Proteomic databases

EPDiQ5T3F8
jPOSTiQ5T3F8
MassIVEiQ5T3F8
MaxQBiQ5T3F8
PaxDbiQ5T3F8
PeptideAtlasiQ5T3F8
PRIDEiQ5T3F8
ProteomicsDBi64388 [Q5T3F8-1]
64389 [Q5T3F8-2]
64390 [Q5T3F8-3]

Genome annotation databases

EnsembliENST00000259746; ENSP00000259746; ENSG00000137216 [Q5T3F8-1]
ENST00000323267; ENSP00000327154; ENSG00000137216 [Q5T3F8-1]
GeneIDi55362
KEGGihsa:55362
UCSCiuc003owr.4 human [Q5T3F8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55362

GeneCards: human genes, protein and diseases

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GeneCardsi
TMEM63B
HGNCiHGNC:17735 TMEM63B
HPAiHPA029249
HPA029250
HPA029251
neXtProtiNX_Q5T3F8
OpenTargetsiENSG00000137216
PharmGKBiPA134911221

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1134 Eukaryota
COG5594 LUCA
GeneTreeiENSGT00940000157084
InParanoidiQ5T3F8
KOiK21989
OMAiWLWVHTI
OrthoDBi395194at2759
PhylomeDBiQ5T3F8
TreeFamiTF324300

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55362
PharosiQ5T3F8

Protein Ontology

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PROi
PR:Q5T3F8

Gene expression databases

BgeeiENSG00000137216 Expressed in 201 organ(s), highest expression level in nasal cavity epithelium
ExpressionAtlasiQ5T3F8 baseline and differential
GenevisibleiQ5T3F8 HS

Family and domain databases

InterProiView protein in InterPro
IPR032880 Csc1_N
IPR027815 PHM7_cyt
IPR003864 RSN1_7TM
PfamiView protein in Pfam
PF14703 PHM7_cyt, 1 hit
PF02714 RSN1_7TM, 1 hit
PF13967 RSN1_TM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCSCL2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T3F8
Secondary accession number(s): B9EGU3
, Q5T3F9, Q6AHX4, Q6P5A0, Q8N219, Q8NDE1, Q9NSG5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: December 21, 2004
Last modified: October 16, 2019
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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