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Entry version 130 (13 Feb 2019)
Sequence version 1 (21 Dec 2004)
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Protein

Armadillo repeat-containing protein 4

Gene

ARMC4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ciliary protein that may be involved in a late step of axonemal outer dynein arm assembly.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cilium movement Source: SYSCILIA_CCNET
  • determination of left/right symmetry Source: SYSCILIA_CCNET
  • outer dynein arm assembly Source: SYSCILIA_CCNET
  • regulation of cilium beat frequency Source: SYSCILIA_CCNET

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCilium biogenesis/degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Armadillo repeat-containing protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARMC4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169126.15

Human Gene Nomenclature Database

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HGNCi
HGNC:25583 ARMC4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615408 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T2S8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ciliary dyskinesia, primary, 23 (CILD23)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. Contrary to the wild-type protein, disease-causing variant Trp-927 is unable to rescue the phenotype (randomization of heart looping) of the morpholino knockdown of the orthologous protein in zebrafish (PubMed:23849778).1 Publication
Disease descriptionA disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. Patients may exhibit randomization of left-right body asymmetry and situs inversus, due to dysfunction of monocilia at the embryonic node. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.
See also OMIM:615451
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070228927L → W in CILD23; no effect on subcellular location, markedly reduced ciliary beat frequency and amplitude or complete immotility in most, but not all, respiratory cilia. 1 PublicationCorresponds to variant dbSNP:rs587777047EnsemblClinVar.1

Keywords - Diseasei

Ciliopathy, Kartagener syndrome, Primary ciliary dyskinesia

Organism-specific databases

DisGeNET

More...
DisGeNETi
55130

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
ARMC4

MalaCards human disease database

More...
MalaCardsi
ARMC4
MIMi615451 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000169126

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
244 Primary ciliary dyskinesia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134877125

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ARMC4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74744660

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002439311 – 1044Armadillo repeat-containing protein 4Add BLAST1044

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei552N6-methyllysineCombined sources1

Keywords - PTMi

Methylation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T2S8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q5T2S8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q5T2S8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T2S8

PeptideAtlas

More...
PeptideAtlasi
Q5T2S8

PRoteomics IDEntifications database

More...
PRIDEi
Q5T2S8

ProteomicsDB human proteome resource

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ProteomicsDBi
64357

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T2S8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T2S8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in respiratory epithelial cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169126 Expressed in 96 organ(s), highest expression level in bronchial epithelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5T2S8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T2S8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037829

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120436, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q5T2S8, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000306410

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5T2S8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati484 – 523ARM 1Add BLAST40
Repeati525 – 564ARM 2Add BLAST40
Repeati622 – 661ARM 3Add BLAST40
Repeati663 – 702ARM 4Add BLAST40
Repeati746 – 785ARM 5Add BLAST40
Repeati828 – 867ARM 6Add BLAST40
Repeati871 – 910ARM 7Add BLAST40
Repeati912 – 951ARM 8Add BLAST40
Repeati953 – 992ARM 9Add BLAST40
Repeati994 – 1033ARM 10Add BLAST40

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0167 Eukaryota
ENOG410XRTN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156625

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013178

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG080865

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q5T2S8

Identification of Orthologs from Complete Genome Data

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OMAi
PWRQVHG

Database of Orthologous Groups

More...
OrthoDBi
310809at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T2S8

TreeFam database of animal gene trees

More...
TreeFami
TF324155

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00514 Arm, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185 ARM, 13 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50176 ARM_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T2S8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVALRKLTQ WTAAGHGTGI LEITPLNEAI LKEIIVFVES FIYKHPQEAK
60 70 80 90 100
FVFVEPLEWN TSLAPSAFES GYVVSETTVK SEEVDKNGQP LLFLSVPQIK
110 120 130 140 150
IRSFGQLSRL LLIAKTGKLK EAQACVEANR DPIVKILGSD YNTMKENSIA
160 170 180 190 200
LNILGKITRD DDPESEIKMK IAMLLKQLDL HLLNHSLKHI SLEISLSPMT
210 220 230 240 250
VKKDIELLKR FSGKGNQTVL ESIEYTSDYE FSNGCRAPPW RQIRGEICYV
260 270 280 290 300
LVKPHDGETL CITCSAGGVF LNGGKTDDEG DVNYERKGSI YKNLVTFLRE
310 320 330 340 350
KSPKFSENMS KLGISFSEDQ QKEKDQLGKA PKKEEAAALR KDISGSDKRS
360 370 380 390 400
LEKNQINFWR NQMTKRWEPS LNWKTTVNYK GKGSAKEIQE DKHTGKLEKP
410 420 430 440 450
RPSVSHGRAQ LLRKSAEKIE ETVSDSSSES EEDEEPPDHR QEASADLPSE
460 470 480 490 500
YWQIQKLVKY LKGGNQTATV IALCSMRDFS LAQETCQLAI RDVGGLEVLI
510 520 530 540 550
NLLETDEVKC KIGSLKILKE ISHNPQIRQN IVDLGGLPIM VNILDSPHKS
560 570 580 590 600
LKCLAAETIA NVAKFKRARR VVRQHGGITK LVALLDCAHD STKPAQSSLY
610 620 630 640 650
EARDVEVARC GALALWSCSK SHTNKEAIRK AGGIPLLARL LKTSHENMLI
660 670 680 690 700
PVVGTLQECA SEENYRAAIK AERIIENLVK NLNSENEQLQ EHCAMAIYQC
710 720 730 740 750
AEDKETRDLV RLHGGLKPLA SLLNNTDNKE RLAAVTGAIW KCSISKENVT
760 770 780 790 800
KFREYKAIET LVGLLTDQPE EVLVNVVGAL GECCQERENR VIVRKCGGIQ
810 820 830 840 850
PLVNLLVGIN QALLVNVTKA VGACAVEPES MMIIDRLDGV RLLWSLLKNP
860 870 880 890 900
HPDVKASAAW ALCPCIKNAK DAGEMVRSFV GGLELIVNLL KSDNKEVLAS
910 920 930 940 950
VCAAITNIAK DQENLAVITD HGVVPLLSKL ANTNNNKLRH HLAEAISRCC
960 970 980 990 1000
MWGRNRVAFG EHKAVAPLVR YLKSNDTNVH RATAQALYQL SEDADNCITM
1010 1020 1030 1040
HENGAVKLLL DMVGSPDQDL QEAAAGCISN IRRLALATEK ARYT
Length:1,044
Mass (Da):115,679
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0D869AFC3B03E9D
GO
Isoform 2 (identifier: Q5T2S8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-475: Missing.
     1008-1044: LLLDMVGSPD...ALATEKARYT → TESRHVARLE...LQRRQDTLEI

Note: No experimental confirmation available.
Show »
Length:612
Mass (Da):67,624
Checksum:i8F59AD9C864D9CBC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T2S9Q5T2S9_HUMAN
Armadillo repeat-containing protein...
ARMC4
389Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
R4GN11R4GN11_HUMAN
Armadillo repeat-containing protein...
ARMC4
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050672343I → T. Corresponds to variant dbSNP:rs4405206EnsemblClinVar.1
Natural variantiVAR_070228927L → W in CILD23; no effect on subcellular location, markedly reduced ciliary beat frequency and amplitude or complete immotility in most, but not all, respiratory cilia. 1 PublicationCorresponds to variant dbSNP:rs587777047EnsemblClinVar.1
Natural variantiVAR_033514935N → K. Corresponds to variant dbSNP:rs35181927EnsemblClinVar.1
Natural variantiVAR_0506731041A → S. Corresponds to variant dbSNP:rs3737184EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0566951 – 475Missing in isoform 2. 1 PublicationAdd BLAST475
Alternative sequenceiVSP_0566961008 – 1044LLLDM…KARYT → TESRHVARLECSDNDLGSLQ PPPPGFKRFSCLSLLSSWDY SFYWIWLGPLTRISRKLQLV VYPISAGWLLLQRRQDTLEI in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK292521 mRNA Translation: BAF85210.1
AK302048 mRNA Translation: BAH13617.1
AC024606 Genomic DNA No translation available.
AL390866 Genomic DNA No translation available.
AL355372 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86050.1
BC140846 mRNA Translation: AAI40847.1
AL136859 mRNA Translation: CAB66793.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7157.1 [Q5T2S8-1]

NCBI Reference Sequences

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RefSeqi
NP_001276949.1, NM_001290020.1 [Q5T2S8-1]
NP_001276950.1, NM_001290021.1 [Q5T2S8-2]
NP_001299618.1, NM_001312689.1
NP_060546.2, NM_018076.4 [Q5T2S8-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.127530

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305242; ENSP00000306410; ENSG00000169126 [Q5T2S8-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
55130

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:55130

UCSC genome browser

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UCSCi
uc001itz.3 human [Q5T2S8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292521 mRNA Translation: BAF85210.1
AK302048 mRNA Translation: BAH13617.1
AC024606 Genomic DNA No translation available.
AL390866 Genomic DNA No translation available.
AL355372 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86050.1
BC140846 mRNA Translation: AAI40847.1
AL136859 mRNA Translation: CAB66793.2
CCDSiCCDS7157.1 [Q5T2S8-1]
RefSeqiNP_001276949.1, NM_001290020.1 [Q5T2S8-1]
NP_001276950.1, NM_001290021.1 [Q5T2S8-2]
NP_001299618.1, NM_001312689.1
NP_060546.2, NM_018076.4 [Q5T2S8-1]
UniGeneiHs.127530

3D structure databases

ProteinModelPortaliQ5T2S8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120436, 3 interactors
IntActiQ5T2S8, 2 interactors
STRINGi9606.ENSP00000306410

PTM databases

iPTMnetiQ5T2S8
PhosphoSitePlusiQ5T2S8

Polymorphism and mutation databases

BioMutaiARMC4
DMDMi74744660

Proteomic databases

EPDiQ5T2S8
jPOSTiQ5T2S8
MaxQBiQ5T2S8
PaxDbiQ5T2S8
PeptideAtlasiQ5T2S8
PRIDEiQ5T2S8
ProteomicsDBi64357

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305242; ENSP00000306410; ENSG00000169126 [Q5T2S8-1]
GeneIDi55130
KEGGihsa:55130
UCSCiuc001itz.3 human [Q5T2S8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55130
DisGeNETi55130
EuPathDBiHostDB:ENSG00000169126.15

GeneCards: human genes, protein and diseases

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GeneCardsi
ARMC4
GeneReviewsiARMC4
HGNCiHGNC:25583 ARMC4
HPAiHPA037829
MalaCardsiARMC4
MIMi615408 gene
615451 phenotype
neXtProtiNX_Q5T2S8
OpenTargetsiENSG00000169126
Orphaneti244 Primary ciliary dyskinesia
PharmGKBiPA134877125

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0167 Eukaryota
ENOG410XRTN LUCA
GeneTreeiENSGT00940000156625
HOGENOMiHOG000013178
HOVERGENiHBG080865
InParanoidiQ5T2S8
OMAiPWRQVHG
OrthoDBi310809at2759
PhylomeDBiQ5T2S8
TreeFamiTF324155

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ARMC4 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55130

Protein Ontology

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PROi
PR:Q5T2S8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000169126 Expressed in 96 organ(s), highest expression level in bronchial epithelial cell
ExpressionAtlasiQ5T2S8 baseline and differential
GenevisibleiQ5T2S8 HS

Family and domain databases

Gene3Di1.25.10.10, 4 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
PfamiView protein in Pfam
PF00514 Arm, 2 hits
SMARTiView protein in SMART
SM00185 ARM, 13 hits
SUPFAMiSSF48371 SSF48371, 2 hits
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARMC4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T2S8
Secondary accession number(s): A8K906, B7Z7I1, Q9H0C0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: December 21, 2004
Last modified: February 13, 2019
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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