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Protein

ATPase family AAA domain-containing protein 3C

Gene

ATAD3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi177 – 184ATPSequence analysis8

GO - Molecular functioni

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 3C
Gene namesi
Name:ATAD3C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000215915.9
HGNCiHGNC:32151 ATAD3C
neXtProtiNX_Q5T2N8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi219293
PharmGKBiPA134903201

Polymorphism and mutation databases

BioMutaiATAD3C
DMDMi162416279

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003119791 – 411ATPase family AAA domain-containing protein 3CAdd BLAST411

Proteomic databases

EPDiQ5T2N8
MaxQBiQ5T2N8
PaxDbiQ5T2N8
PeptideAtlasiQ5T2N8
PRIDEiQ5T2N8
ProteomicsDBi64348

PTM databases

iPTMnetiQ5T2N8
PhosphoSitePlusiQ5T2N8
SwissPalmiQ5T2N8

Expressioni

Gene expression databases

BgeeiENSG00000215915
ExpressionAtlasiQ5T2N8 baseline and differential
GenevisibleiQ5T2N8 HS

Organism-specific databases

HPAiHPA065305

Interactioni

Protein-protein interaction databases

BioGridi128521, 9 interactors
IntActiQ5T2N8, 3 interactors
STRINGi9606.ENSP00000368062

Structurei

3D structure databases

ProteinModelPortaliQ5T2N8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0742 Eukaryota
COG1223 LUCA
GeneTreeiENSGT00730000111059
HOGENOMiHOG000231291
HOVERGENiHBG058506
InParanoidiQ5T2N8
OMAiDWAINAC
OrthoDBiEOG091G04JN
PhylomeDBiQ5T2N8
TreeFamiTF313922

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR021911 DUF3523
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF12037 DUF3523, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q5T2N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKDALNLAQ MQEQTLQLEQ QSKLKQLVNE DLRKQEESVQ KHHQTFLESI
60 70 80 90 100
RAAGTLFGEG FRAFVTDRDK VTATVAGLTL LAVGVYSAKN ATAVTGRYIE
110 120 130 140 150
ARLGKPSLVR ETSRITVLEA LRHPIQQVSR RLLSRPQDVL EGVVLSPSLE
160 170 180 190 200
ARVRDIAIMT RNIKKNRGLY RHILLYGPPG TGKTLFAKKL ALHSGMDYAI
210 220 230 240 250
MTGGDVAPMG REGVTAMHKL FDWANTSRRG LLLFVDEADA FLRKRATEKI
260 270 280 290 300
SEDLRATLNA FLYRTGQHSN KFMLILASCH PEQFDWAINA CIDVMVHFDL
310 320 330 340 350
PGQEERARLV RMYLNEYVLK PATEGKRRLK LAQFDYGRKC LEIARLTEGM
360 370 380 390 400
SCRKIAQLAV SWQATAYASK DGVLTEAMMD ACVQDFVQQH QQMMRWLKGE
410
RPGPEDEQPS S
Length:411
Mass (Da):46,380
Last modified:December 4, 2007 - v2
Checksum:iD97236C78380C4C2
GO

Sequence cautioni

The sequence AAI01212 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence AAI01213 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence BAC04369 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated
The sequence CAI22067 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI22656 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091918 mRNA No translation available.
AK094502 mRNA Translation: BAC04369.1 Sequence problems.
AL157945, AL391244 Genomic DNA Translation: CAI22067.1 Sequence problems.
AL391244, AL157945 Genomic DNA Translation: CAI22656.1 Sequence problems.
BC101211 mRNA Translation: AAI01212.1 Sequence problems.
BC101212 mRNA Translation: AAI01213.1 Sequence problems.
CCDSiCCDS44039.1
RefSeqiNP_001034300.2, NM_001039211.2
UniGeneiHs.724767

Genome annotation databases

EnsembliENST00000378785; ENSP00000368062; ENSG00000215915
GeneIDi219293
KEGGihsa:219293
UCSCiuc001aft.2 human

Similar proteinsi

Entry informationi

Entry nameiATD3C_HUMAN
AccessioniPrimary (citable) accession number: Q5T2N8
Secondary accession number(s): Q8N1Z5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: June 20, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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