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UniProtKB - Q5T2E6 (ARMD3_HUMAN)
Protein
Armadillo-like helical domain-containing protein 3
Gene
ARMH3
Organism
Homo sapiens (Human)
Status
Functioni
Involved in GBF1 recruitment, Golgi maintenance and protein secretion.
1 PublicationGO - Biological processi
- regulation of Golgi organization Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | Q5T2E6 |
SignaLinki | Q5T2E6 |
Names & Taxonomyi
Protein namesi | Recommended name: Armadillo-like helical domain-containing protein 3Curated |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25788, ARMH3 |
neXtProti | NX_Q5T2E6 |
VEuPathDBi | HostDB:ENSG00000120029 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Single-pass membrane protein Sequence analysis
Note: The majority of ARMD3 is cytosolic, with a portion colocalizing with GBF1 at juxtanuclear Golgi sites.1 Publication
Cytosol
- cytosol Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 520 – 538 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Cytoplasm, Golgi apparatus, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 79591 |
OpenTargetsi | ENSG00000120029 |
PharmGKBi | PA134903060 |
Miscellaneous databases
Pharosi | Q5T2E6, Tdark |
Genetic variation databases
BioMutai | C10orf76 |
DMDMi | 74744614 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000284515 | 1 – 689 | Armadillo-like helical domain-containing protein 3Add BLAST | 689 |
Proteomic databases
EPDi | Q5T2E6 |
jPOSTi | Q5T2E6 |
MassIVEi | Q5T2E6 |
MaxQBi | Q5T2E6 |
PaxDbi | Q5T2E6 |
PeptideAtlasi | Q5T2E6 |
PRIDEi | Q5T2E6 |
ProteomicsDBi | 64333 [Q5T2E6-1] 64334 [Q5T2E6-2] 64335 [Q5T2E6-3] |
PTM databases
iPTMneti | Q5T2E6 |
PhosphoSitePlusi | Q5T2E6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000120029, Expressed in heart left ventricle and 220 other tissues |
ExpressionAtlasi | Q5T2E6, baseline and differential |
Genevisiblei | Q5T2E6, HS |
Organism-specific databases
HPAi | ENSG00000120029, Low tissue specificity |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 122733, 27 interactors |
IntActi | Q5T2E6, 2 interactors |
STRINGi | 9606.ENSP00000359050 |
Miscellaneous databases
RNActi | Q5T2E6, protein |
Structurei
3D structure databases
AlphaFoldDBi | Q5T2E6 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family & Domainsi
Sequence similaritiesi
Belongs to the ARMH3 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4654, Eukaryota |
GeneTreei | ENSGT00390000002554 |
HOGENOMi | CLU_029861_2_0_1 |
InParanoidi | Q5T2E6 |
OMAi | GFWTEFF |
PhylomeDBi | Q5T2E6 |
TreeFami | TF300220 |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR039868, ARMD3-like IPR013636, ARMH3_C |
PANTHERi | PTHR13608, PTHR13608, 1 hit |
Pfami | View protein in Pfam PF08427, DUF1741, 1 hit |
SMARTi | View protein in SMART SM01158, DUF1741, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5T2E6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAQVEKRGGL LRKSSASKKP LKEKVVLMYD EIFMTEDPSK CSPRFWEELF
60 70 80 90 100
LMKVNLEYLE GKLESLDGEE LMKIKDNINC LFQHCIQALG EEHPIRVVNA
110 120 130 140 150
LQTLCALIRG VHQKNKSTSG FDIINMLMGF DKAELCMKNL MESLDSLLCA
160 170 180 190 200
EGSESLKSLC LKLLLCLVTV TDNISQNTIL EYVMINSIFE AILQILSHPP
210 220 230 240 250
SRREHGYDAV VLLALLVNYR KYESVNPYIV KLSIVDDEAT LNGMGLVIAQ
260 270 280 290 300
ALSEYNRQYK DKEEEHQSGF FSALTNMVGS MFIADAHEKI SVQTNEAILL
310 320 330 340 350
ALYEAVHLNR NFITVLAQSH PEMGLVTTPV SPAPTTPVTP LGTTPPSSDV
360 370 380 390 400
ISSVELPLDA DVQTSNLLIT FLKYSSIVMQ DTKDEHRLHS GKLCLIILTC
410 420 430 440 450
IAEDQYANAF LHDDNMNFRV NLHRMPMRHR KKAADKNLPC RPLVCAVLDL
460 470 480 490 500
MVEFIVTHMM KEFPMDLYIR CIQVVHKLLC YQKKCRVRLH YTWRELWSAL
510 520 530 540 550
INLLKFLMSN ETVLLAKHNI FTLALMIVNL FNMFITYGDT FLPTPSSYDE
560 570 580 590 600
LYYEIIRMHQ SFDNLYSMVL RLSTNAGQWK EAASKVTHAL VNIRAIINHF
610 620 630 640 650
NPKIESYAAV NHISQLSEEQ VLEVVRANYD TLTLKLQDGL DQYERYSEQH
660 670 680
KEAAFFKELV RSISTNVRRN LAFHTLSQEV LLKEFSTIS
Isoform 3 (identifier: Q5T2E6-3) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
1-424: Missing.
569-584: VLRLSTNAGQWKEAAS → EPSSTTLTPKLSPTLL
585-689: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5T2E8 | Q5T2E8_HUMAN | Armadillo-like helical domain-conta... | ARMH3 | 94 | Annotation score: | ||
Q5T2E7 | Q5T2E7_HUMAN | Armadillo-like helical domain-conta... | ARMH3 | 198 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 672 | A → V in BAB14447 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_024552 | 1 – 424 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 424 | |
Alternative sequenceiVSP_024553 | 569 – 584 | VLRLS…KEAAS → EPSSTTLTPKLSPTLL in isoform 3. 1 PublicationAdd BLAST | 16 | |
Alternative sequenceiVSP_024554 | 585 – 689 | Missing in isoform 3. 1 PublicationAdd BLAST | 105 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023176 mRNA Translation: BAB14447.1 AC010789 Genomic DNA No translation available. AL391827 Genomic DNA No translation available. BC110511 mRNA No translation available. |
CCDSi | CCDS41563.1 [Q5T2E6-1] |
RefSeqi | NP_078817.2, NM_024541.2 [Q5T2E6-1] XP_011538453.1, XM_011540151.2 [Q5T2E6-1] |
Genome annotation databases
Ensembli | ENST00000370033.9; ENSP00000359050.4; ENSG00000120029.13 |
GeneIDi | 79591 |
KEGGi | hsa:79591 |
MANE-Selecti | ENST00000370033.9; ENSP00000359050.4; NM_024541.3; NP_078817.2 |
UCSCi | uc009xwy.2, human [Q5T2E6-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK023176 mRNA Translation: BAB14447.1 AC010789 Genomic DNA No translation available. AL391827 Genomic DNA No translation available. BC110511 mRNA No translation available. |
CCDSi | CCDS41563.1 [Q5T2E6-1] |
RefSeqi | NP_078817.2, NM_024541.2 [Q5T2E6-1] XP_011538453.1, XM_011540151.2 [Q5T2E6-1] |
3D structure databases
AlphaFoldDBi | Q5T2E6 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 122733, 27 interactors |
IntActi | Q5T2E6, 2 interactors |
STRINGi | 9606.ENSP00000359050 |
PTM databases
iPTMneti | Q5T2E6 |
PhosphoSitePlusi | Q5T2E6 |
Genetic variation databases
BioMutai | C10orf76 |
DMDMi | 74744614 |
Proteomic databases
EPDi | Q5T2E6 |
jPOSTi | Q5T2E6 |
MassIVEi | Q5T2E6 |
MaxQBi | Q5T2E6 |
PaxDbi | Q5T2E6 |
PeptideAtlasi | Q5T2E6 |
PRIDEi | Q5T2E6 |
ProteomicsDBi | 64333 [Q5T2E6-1] 64334 [Q5T2E6-2] 64335 [Q5T2E6-3] |
Protocols and materials databases
Antibodypediai | 64513, 13 antibodies from 7 providers |
DNASUi | 79591 |
Genome annotation databases
Ensembli | ENST00000370033.9; ENSP00000359050.4; ENSG00000120029.13 |
GeneIDi | 79591 |
KEGGi | hsa:79591 |
MANE-Selecti | ENST00000370033.9; ENSP00000359050.4; NM_024541.3; NP_078817.2 |
UCSCi | uc009xwy.2, human [Q5T2E6-1] |
Organism-specific databases
CTDi | 79591 |
DisGeNETi | 79591 |
GeneCardsi | ARMH3 |
HGNCi | HGNC:25788, ARMH3 |
HPAi | ENSG00000120029, Low tissue specificity |
neXtProti | NX_Q5T2E6 |
OpenTargetsi | ENSG00000120029 |
PharmGKBi | PA134903060 |
VEuPathDBi | HostDB:ENSG00000120029 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4654, Eukaryota |
GeneTreei | ENSGT00390000002554 |
HOGENOMi | CLU_029861_2_0_1 |
InParanoidi | Q5T2E6 |
OMAi | GFWTEFF |
PhylomeDBi | Q5T2E6 |
TreeFami | TF300220 |
Enzyme and pathway databases
PathwayCommonsi | Q5T2E6 |
SignaLinki | Q5T2E6 |
Miscellaneous databases
BioGRID-ORCSi | 79591, 52 hits in 1065 CRISPR screens |
ChiTaRSi | ARMH3, human |
GenomeRNAii | 79591 |
Pharosi | Q5T2E6, Tdark |
PROi | PR:Q5T2E6 |
RNActi | Q5T2E6, protein |
Gene expression databases
Bgeei | ENSG00000120029, Expressed in heart left ventricle and 220 other tissues |
ExpressionAtlasi | Q5T2E6, baseline and differential |
Genevisiblei | Q5T2E6, HS |
Family and domain databases
InterProi | View protein in InterPro IPR016024, ARM-type_fold IPR039868, ARMD3-like IPR013636, ARMH3_C |
PANTHERi | PTHR13608, PTHR13608, 1 hit |
Pfami | View protein in Pfam PF08427, DUF1741, 1 hit |
SMARTi | View protein in SMART SM01158, DUF1741, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARMD3_HUMAN | |
Accessioni | Q5T2E6Primary (citable) accession number: Q5T2E6 Secondary accession number(s): Q2TB87, Q9H8Z9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 17, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | May 25, 2022 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Uncharacterized protein families (UPF)
List of uncharacterized protein family (UPF) entries - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families