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Protein

Undifferentiated embryonic cell transcription factor 1

Gene

UTF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional coactivator of ATF2.1 Publication

GO - Molecular functioni

  • HMG box domain binding Source: Ensembl
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • male gonad development Source: UniProtKB
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiQ5T230

Names & Taxonomyi

Protein namesi
Recommended name:
Undifferentiated embryonic cell transcription factor 1
Gene namesi
Name:UTF1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000171794.3
HGNCiHGNC:12634 UTF1
MIMi604130 gene
neXtProtiNX_Q5T230

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi296L → P: Abolishes coactivation activity; when associated with P-303. 1 Publication1
Mutagenesisi303L → P: Abolishes coactivation activity; when associated with P-296. 1 Publication1

Organism-specific databases

DisGeNETi8433
OpenTargetsiENSG00000171794
PharmGKBiPA37259

Polymorphism and mutation databases

BioMutaiUTF1
DMDMi74756257

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002745511 – 341Undifferentiated embryonic cell transcription factor 1Add BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei21PhosphoserineBy similarity1
Modified residuei54PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ5T230
PaxDbiQ5T230
PeptideAtlasiQ5T230
PRIDEiQ5T230
ProteomicsDBi64306

PTM databases

iPTMnetiQ5T230
PhosphoSitePlusiQ5T230

Expressioni

Gene expression databases

BgeeiENSG00000171794
CleanExiHS_UTF1
GenevisibleiQ5T230 HS

Interactioni

Subunit structurei

Binds to the N-terminal region of ATF2. Associates with the TFIID complex through interaction with TBP.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114013, 2 interactors
IntActiQ5T230, 2 interactors
STRINGi9606.ENSP00000305906

Structurei

3D structure databases

ProteinModelPortaliQ5T230
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni279 – 310Leucine-zipperAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 273Pro-richSequence analysisAdd BLAST269

Domaini

The leucine-zipper domain is required for coactivation activity. When this domain is deleted, the protein is able to stimulate transcription from a number of gene promoters (By similarity).By similarity

Phylogenomic databases

eggNOGiKOG4282 Eukaryota
ENOG410YYXY LUCA
GeneTreeiENSGT00390000014419
HOGENOMiHOG000060176
HOVERGENiHBG094142
InParanoidiQ5T230
OMAiCRRRYKF
OrthoDBiEOG091G0Q6M
PhylomeDBiQ5T230
TreeFamiTF337319

Sequencei

Sequence statusi: Complete.

Q5T230-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLRPRRPPP LAPPAPPSPA SPDPEPRTPG DAPGTPPRRP ASPSALGELG
60 70 80 90 100
LPVSPGSAQR TPWSARETEL LLGTLLQPAV WRALLLDRRQ ALPTYRRVSA
110 120 130 140 150
ALAQQQVRRT PAQCRRRYKF LKDKFREAHG QPPGPFDEQI RKLMGLLGDN
160 170 180 190 200
GRKRPRRRSP GSGRPQRARR PVPNAHAPAP SEPDATPLPT ARDRDADPTW
210 220 230 240 250
TLRFSPSPPK SADASPAPGS PPAPAPTALA TCIPEDRAPV RGPGSPPPPP
260 270 280 290 300
AREDPDSPPG RPEDCAPPPA APPSLNTALL QTLGHLGDIA NILGPLRDQL
310 320 330 340
LTLNQHVEQL RGAFDQTVSL AVGFILGSAA AERGVLRDPC Q
Length:341
Mass (Da):36,439
Last modified:December 21, 2004 - v1
Checksum:i65E58A4B4206FC05
GO

Sequence cautioni

The sequence AAT38949 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05148573G → R. Corresponds to variant dbSNP:rs11599284Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB011076 mRNA Translation: BAA33463.2
AY606112 mRNA Translation: AAT38949.1 Different initiation.
AL445199 Genomic DNA Translation: CAI17342.1
CCDSiCCDS31318.1
RefSeqiNP_003568.2, NM_003577.2
UniGeneiHs.458406

Genome annotation databases

EnsembliENST00000304477; ENSP00000305906; ENSG00000171794
GeneIDi8433
KEGGihsa:8433
UCSCiuc001lmc.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUTF1_HUMAN
AccessioniPrimary (citable) accession number: Q5T230
Secondary accession number(s): O75833, Q6J1H3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: December 21, 2004
Last modified: July 18, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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