UniProtKB - Q5T215 (TPC3L_HUMAN)
Protein
Trafficking protein particle complex subunit 3-like protein
Gene
TRAPPC3L
Organism
Homo sapiens (Human)
Status
Functioni
May play a role in vesicular transport from endoplasmic reticulum to Golgi.By similarity
GO - Biological processi
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- intra-Golgi vesicle-mediated transport Source: GO_Central
Keywordsi
Biological process | ER-Golgi transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q5T215 |
Names & Taxonomyi
Protein namesi | Recommended name: Trafficking protein particle complex subunit 3-like proteinShort name: TRAPPC3-like protein Alternative name(s): BET3-like protein |
Gene namesi | Name:TRAPPC3L Synonyms:BET3L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21090, TRAPPC3L |
MIMi | 614137, gene |
neXtProti | NX_Q5T215 |
VEuPathDBi | HostDB:ENSG00000173626.9 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum By similarity
Golgi apparatus
- cis-Golgi network By similarity
Cytosol
- cytosol Source: GO_Central
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB-SubCell
Golgi apparatus
- cis-Golgi network membrane Source: GO_Central
Other locations
- TRAPP complex Source: UniProtKB
Keywords - Cellular componenti
Endoplasmic reticulum, Golgi apparatusPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000173626 |
PharmGKBi | PA134866254 |
Miscellaneous databases
Pharosi | Q5T215, Tdark |
Genetic variation databases
BioMutai | TRAPPC3L |
DMDMi | 74744542 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000305083 | 1 – 181 | Trafficking protein particle complex subunit 3-like proteinAdd BLAST | 181 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 68 | S-palmitoyl cysteineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, PalmitateProteomic databases
jPOSTi | Q5T215 |
MassIVEi | Q5T215 |
PaxDbi | Q5T215 |
PeptideAtlasi | Q5T215 |
PRIDEi | Q5T215 |
ProteomicsDBi | 64304 [Q5T215-1] 64305 [Q5T215-2] |
PTM databases
iPTMneti | Q5T215 |
PhosphoSitePlusi | Q5T215 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173626, Expressed in dorsal root ganglion and 116 other tissues |
ExpressionAtlasi | Q5T215, baseline and differential |
Genevisiblei | Q5T215, HS |
Organism-specific databases
HPAi | ENSG00000173626, Tissue enhanced (lymphoid tissue, placenta) |
Interactioni
Subunit structurei
Homodimer.
Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
1 PublicationProtein-protein interaction databases
BioGRIDi | 128706, 12 interactors |
CORUMi | Q5T215 |
IntActi | Q5T215, 1 interactor |
STRINGi | 9606.ENSP00000357591 |
Miscellaneous databases
RNActi | Q5T215, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3330, Eukaryota |
GeneTreei | ENSGT00390000003880 |
HOGENOMi | CLU_087110_2_0_1 |
InParanoidi | Q5T215 |
OMAi | HKINRDL |
OrthoDBi | 1334804at2759 |
PhylomeDBi | Q5T215 |
TreeFami | TF300091 |
Family and domain databases
CDDi | cd14942, TRAPPC3_bet3, 1 hit |
InterProi | View protein in InterPro IPR016721, Bet3 IPR024096, NO_sig/Golgi_transp_ligand-bd IPR007194, TRAPP_component |
PANTHERi | PTHR13048, PTHR13048, 1 hit |
Pfami | View protein in Pfam PF04051, TRAPP, 1 hit |
PIRSFi | PIRSF018293, TRAPP_I_complex_Bet3, 1 hit |
SUPFAMi | SSF111126, SSF111126, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q5T215-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRPAHRRPE YHKINKDLFV LTYGALVAQL CKDYEKDEDV NQYLDKMGYG
60 70 80 90 100
IGTRLVEDFL ARSCVGRCHS YSEIIDIIAQ VAFKMYLGIT PSVTCNNSSK
110 120 130 140 150
NEFSLILEKN PLVEFVEELP AGRSSLCYCN LLCGIIRGAL EMVHLAADVT
160 170 180
FLQDRLKGDS VTEIGITFLK KRDEKKYRGK K
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSL6 | A0A0A0MSL6_HUMAN | Trafficking protein particle comple... | TRAPPC3L | 167 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_028222 | 1 – 84 | Missing in isoform 2. 1 PublicationAdd BLAST | 84 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL445224 Genomic DNA No translation available. AL121953 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48227.1 BC127757 mRNA Translation: AAI27758.1 BC127758 mRNA Translation: AAI27759.1 |
CCDSi | CCDS47468.1 [Q5T215-1] |
RefSeqi | NP_001132916.1, NM_001139444.2 [Q5T215-1] |
Genome annotation databases
Ensembli | ENST00000356128; ENSP00000348445; ENSG00000173626 [Q5T215-2] ENST00000368602; ENSP00000357591; ENSG00000173626 [Q5T215-1] |
GeneIDi | 100128327 |
KEGGi | hsa:100128327 |
UCSCi | uc003pwx.4, human [Q5T215-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL445224 Genomic DNA No translation available. AL121953 Genomic DNA No translation available. CH471051 Genomic DNA Translation: EAW48227.1 BC127757 mRNA Translation: AAI27758.1 BC127758 mRNA Translation: AAI27759.1 |
CCDSi | CCDS47468.1 [Q5T215-1] |
RefSeqi | NP_001132916.1, NM_001139444.2 [Q5T215-1] |
3D structure databases
SMRi | Q5T215 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 128706, 12 interactors |
CORUMi | Q5T215 |
IntActi | Q5T215, 1 interactor |
STRINGi | 9606.ENSP00000357591 |
PTM databases
iPTMneti | Q5T215 |
PhosphoSitePlusi | Q5T215 |
Genetic variation databases
BioMutai | TRAPPC3L |
DMDMi | 74744542 |
Proteomic databases
jPOSTi | Q5T215 |
MassIVEi | Q5T215 |
PaxDbi | Q5T215 |
PeptideAtlasi | Q5T215 |
PRIDEi | Q5T215 |
ProteomicsDBi | 64304 [Q5T215-1] 64305 [Q5T215-2] |
Genome annotation databases
Ensembli | ENST00000356128; ENSP00000348445; ENSG00000173626 [Q5T215-2] ENST00000368602; ENSP00000357591; ENSG00000173626 [Q5T215-1] |
GeneIDi | 100128327 |
KEGGi | hsa:100128327 |
UCSCi | uc003pwx.4, human [Q5T215-1] |
Organism-specific databases
CTDi | 100128327 |
GeneCardsi | TRAPPC3L |
HGNCi | HGNC:21090, TRAPPC3L |
HPAi | ENSG00000173626, Tissue enhanced (lymphoid tissue, placenta) |
MIMi | 614137, gene |
neXtProti | NX_Q5T215 |
OpenTargetsi | ENSG00000173626 |
PharmGKBi | PA134866254 |
VEuPathDBi | HostDB:ENSG00000173626.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3330, Eukaryota |
GeneTreei | ENSGT00390000003880 |
HOGENOMi | CLU_087110_2_0_1 |
InParanoidi | Q5T215 |
OMAi | HKINRDL |
OrthoDBi | 1334804at2759 |
PhylomeDBi | Q5T215 |
TreeFami | TF300091 |
Enzyme and pathway databases
PathwayCommonsi | Q5T215 |
Miscellaneous databases
BioGRID-ORCSi | 100128327, 5 hits in 947 CRISPR screens |
ChiTaRSi | TRAPPC3L, human |
GenomeRNAii | 100128327 |
Pharosi | Q5T215, Tdark |
PROi | PR:Q5T215 |
RNActi | Q5T215, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173626, Expressed in dorsal root ganglion and 116 other tissues |
ExpressionAtlasi | Q5T215, baseline and differential |
Genevisiblei | Q5T215, HS |
Family and domain databases
CDDi | cd14942, TRAPPC3_bet3, 1 hit |
InterProi | View protein in InterPro IPR016721, Bet3 IPR024096, NO_sig/Golgi_transp_ligand-bd IPR007194, TRAPP_component |
PANTHERi | PTHR13048, PTHR13048, 1 hit |
Pfami | View protein in Pfam PF04051, TRAPP, 1 hit |
PIRSFi | PIRSF018293, TRAPP_I_complex_Bet3, 1 hit |
SUPFAMi | SSF111126, SSF111126, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TPC3L_HUMAN | |
Accessioni | Q5T215Primary (citable) accession number: Q5T215 Secondary accession number(s): Q5T213, Q5T214 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 2, 2007 |
Last sequence update: | December 21, 2004 | |
Last modified: | April 7, 2021 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families