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Protein

Zinc finger CCCH domain-containing protein 13

Gene

ZC3H13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755). Acts as a key regulator of m6A methylation by promoting m6A methylation of mRNAs at the 3'-UTR (By similarity). Controls embryonic stem cells (ESCs) pluripotency via its role in m6A methylation (By similarity). In the WMM complex, anchors component of the MACOM subcomplex in the nucleus (By similarity). Also required for bridging WTAP to the RNA-binding component RBM15 (RBM15 or RBM15B) (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri36 – 64C3H1-typePROSITE-ProRule annotationAdd BLAST29

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • mRNA methylation Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • regulation of stem cell population maintenance Source: UniProtKB
  • RNA splicing Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processmRNA processing, mRNA splicing
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 13Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZC3H131 PublicationImported
Synonyms:KIAA08531 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000123200.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20368 ZC3H13

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616453 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T200

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000123200

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134907656

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZC3H13

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68052314

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000507781 – 1668Zinc finger CCCH domain-containing protein 13Add BLAST1668

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei64PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki194Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei198PhosphoserineCombined sources1
Modified residuei207PhosphoserineCombined sources1
Modified residuei209PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei237PhosphothreonineCombined sources1
Modified residuei238PhosphoserineCombined sources1
Modified residuei242PhosphoserineCombined sources1
Modified residuei263PhosphothreonineCombined sources1
Modified residuei265PhosphoserineCombined sources1
Modified residuei316PhosphoserineCombined sources1
Modified residuei318PhosphoserineCombined sources1
Modified residuei325PhosphoserineCombined sources1
Modified residuei328PhosphoserineCombined sources1
Modified residuei354PhosphothreonineCombined sources1
Modified residuei364PhosphothreonineCombined sources1
Modified residuei370PhosphoserineCombined sources1
Modified residuei372PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei643PhosphoserineCombined sources1
Modified residuei831PhosphoserineCombined sources1
Modified residuei833PhosphoserineCombined sources1
Modified residuei837PhosphoserineCombined sources1
Modified residuei845PhosphoserineCombined sources1
Modified residuei848PhosphoserineCombined sources1
Modified residuei853PhosphoserineCombined sources1
Modified residuei873PhosphoserineCombined sources1
Modified residuei875PhosphoserineCombined sources1
Modified residuei877PhosphoserineCombined sources1
Modified residuei882PhosphothreonineCombined sources1
Modified residuei943PhosphoserineCombined sources1
Modified residuei986PhosphoserineCombined sources1
Modified residuei993PhosphoserineCombined sources1
Modified residuei1010PhosphoserineCombined sources1
Modified residuei1014PhosphoserineCombined sources1
Modified residuei1017PhosphoserineCombined sources1
Modified residuei1033PhosphothreonineCombined sources1
Modified residuei1170PhosphothreonineCombined sources1
Modified residuei1191PhosphoserineCombined sources1
Modified residuei1194PhosphoserineCombined sources1
Modified residuei1208PhosphoserineCombined sources1
Modified residuei1210PhosphoserineCombined sources1
Modified residuei1230PhosphoserineCombined sources1
Modified residuei1364PhosphoserineCombined sources1
Modified residuei1366PhosphoserineCombined sources1
Modified residuei1382PhosphoserineCombined sources1
Modified residuei1386PhosphoserineCombined sources1
Modified residuei1406PhosphoserineCombined sources1
Modified residuei1409PhosphoserineCombined sources1
Modified residuei1438PhosphoserineCombined sources1
Modified residuei1465PhosphoserineCombined sources1
Isoform 2 (identifier: Q5T200-2)
Modified residuei1453PhosphoserineCombined sources1
Modified residuei1456PhosphoserineCombined sources1
Modified residuei1466PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q5T200

MaxQB - The MaxQuant DataBase

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MaxQBi
Q5T200

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q5T200

PeptideAtlas

More...
PeptideAtlasi
Q5T200

PRoteomics IDEntifications database

More...
PRIDEi
Q5T200

ProteomicsDB human proteome resource

More...
ProteomicsDBi
64298
64299 [Q5T200-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T200

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T200

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q5T200

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000123200 Expressed in 234 organ(s), highest expression level in frontal cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_ZC3H13

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5T200 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5T200 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA039340
HPA040140
HPA047806

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the WMM complex, a N6-methyltransferase complex composed of a catalytic subcomplex, named MAC, and of an associated subcomplex, named MACOM (PubMed:29507755). The MAC subcomplex is composed of METTL3 and METTL14. The MACOM subcomplex is composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, and, in some cases of RBM15 (RBM15 or RBM15B) (PubMed:29507755). Also component of a MACOM-like complex, named WTAP complex, composed of WTAP, ZC3H13, CBLL1/HAKAI, VIRMA, RBM15, BCLAF1 and THRAP3 (PubMed:24100041).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SCHIP1P0DPB32EBI-2679720,EBI-1397509

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116719, 58 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1605 WMM N6-adenosine-methyltransferase complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q5T200

Protein interaction database and analysis system

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IntActi
Q5T200, 17 interactors

Molecular INTeraction database

More...
MINTi
Q5T200

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000282007

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q5T200

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5T200

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili645 – 789Sequence analysisAdd BLAST145
Coiled coili1300 – 1366Sequence analysisAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi204 – 242Ser-richAdd BLAST39
Compositional biasi316 – 349Ser-richAdd BLAST34
Compositional biasi350 – 652Arg/Ser-richAdd BLAST303
Compositional biasi653 – 842Arg/Glu-richAdd BLAST190
Compositional biasi957 – 1028Lys-richAdd BLAST72
Compositional biasi1189 – 1295Ser-richAdd BLAST107

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZC3H13 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri36 – 64C3H1-typePROSITE-ProRule annotationAdd BLAST29

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1874 Eukaryota
ENOG410XQ2A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111163

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG107115

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T200

KEGG Orthology (KO)

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KOi
K22909

Identification of Orthologs from Complete Genome Data

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OMAi
GQVFSPK

Database of Orthologous Groups

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OrthoDBi
EOG091G01GI

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T200

TreeFam database of animal gene trees

More...
TreeFami
TF332670

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00642 zf-CCCH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00356 ZnF_C3H1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF90229 SSF90229, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50103 ZF_C3H1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5T200-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKIRRKVTV ENTKTISDST SRRPSVFERL GPSTGSTAET QCRNWLKTGN
60 70 80 90 100
CLYGNTCRFV HGPSPRGKGY SSNYRRSPER PTGDLRERMK NKRQDVDTEP
110 120 130 140 150
QKRNTEESSS PVRKESSRGR HREKEDIKIT KERTPESEEE NVEWETNRDD
160 170 180 190 200
SDNGDINYDY VHELSLEMKR QKIQRELMKL EQENMEKREE IIIKKEVSPE
210 220 230 240 250
VVRSKLSPSP SLRKSSKSPK RKSSPKSSSA SKKDRKTSAV SSPLLDQQRN
260 270 280 290 300
SKTNQSKKKG PRTPSPPPPI PEDIALGKKY KEKYKVKDRI EEKTRDGKDR
310 320 330 340 350
GRDFERQREK RDKPRSTSPA GQHHSPISSR HHSSSSQSGS SIQRHSPSPR
360 370 380 390 400
RKRTPSPSYQ RTLTPPLRRS ASPYPSHSLS SPQRKQSPPR HRSPMREKGR
410 420 430 440 450
HDHERTSQSH DRRHERREDT RGKRDREKDS REEREYEQDQ SSSRDHRDDR
460 470 480 490 500
EPRDGRDRRD ARDTRDRREL RDSRDMRDSR EMRDYSRDTK ESRDPRDSRS
510 520 530 540 550
TRDAHDYRDR EGRDTHRKED TYPEESRSYG RNHLREESSR TEIRNESRNE
560 570 580 590 600
SRSEIRNDRM GRSRGRVPEL PEKGSRGSRG SQIDSHSSNS NYHDSWETRS
610 620 630 640 650
SYPERDRYPE RDNRDQARDS SFERRHGERD RRDNRERDQR PSSPIRHQGR
660 670 680 690 700
NDELERDERR EERRVDRVDD RRDERARERD RERERDRERE RERERERDRE
710 720 730 740 750
REKERELERE RARERERERE KERDRERDRD RDHDRERERE RERDREKERE
760 770 780 790 800
REREERERER ERERERERER ERERERARER DKERERQRDW EDKDKGRDDR
810 820 830 840 850
REKREEIRED RNPRDGHDER KSKKRYRNEG SPSPRQSPKR RREHSPDSDA
860 870 880 890 900
YNSGDDKNEK HRLLSQVVRP QESRSLSPSH LTEDRQGRWK EEDRKPERKE
910 920 930 940 950
SSRRYEEQEL KEKVSSVDKQ REQTEILESS RMRAQDIIGH HQSEDRETSD
960 970 980 990 1000
RAHDENKKKA KIQKKPIKKK KEDDVGIERG NIETTSEDGQ VFSPKKGQKK
1010 1020 1030 1040 1050
KSIEKKRKKS KGDSDISDEE AAQQSKKKRG PRTPPITTKE ELVEMCNGKN
1060 1070 1080 1090 1100
GILEDSQKKE DTAFSDWSDE DVPDRTEVTE AEHTATATTP GSTPSPLSSL
1110 1120 1130 1140 1150
LPPPPPVATA TATTVPATLA ATTAAAATSF STSAITISTS ATPTNTTNNT
1160 1170 1180 1190 1200
FANEDSHRKC HRTRVEKVET PHVTIEDAQH RKPMDQKRSS SLGSNRSNRS
1210 1220 1230 1240 1250
HTSGRLRSPS NDSAHRSGDD QSGRKRVLHS GSRDREKTKS LEITGERKSR
1260 1270 1280 1290 1300
IDQLKRGEPS RSTSSDRQDS RSHSSRRSSP ESDRQVHSRS GSFDSRDRLQ
1310 1320 1330 1340 1350
ERDRYEHDRE RERERRDTRQ REWDRDADKD WPRNRDRDRL RERERERERD
1360 1370 1380 1390 1400
KRRDLDRERE RLISDSVERD RDRDRDRTFE SSQIESVKRC EAKLEGEHER
1410 1420 1430 1440 1450
DLESTSRDSL ALDKERMDKD LGSVQGFEET NKSERTESLE GDDESKLDDA
1460 1470 1480 1490 1500
HSLGSGAGEG YEPISDDELD EILAGDAEKR EDQQDEEKMP DPLDVIDVDW
1510 1520 1530 1540 1550
SGLMPKHPKE PREPGAALLK FTPGAVMLRV GISKKLAGSE LFAKVKETCQ
1560 1570 1580 1590 1600
RLLEKPKDAD NLFEHELGAL NMAALLRKEE RASLLSNLGP CCKALCFRRD
1610 1620 1630 1640 1650
SAIRKQLVKN EKGTIKQAYT SAPMVDNELL RLSLRLFKRK TTCHAPGHEK
1660
TEDNKLSQSS IQQELCVS
Note: Gene prediction confirmed by EST data.
Length:1,668
Mass (Da):196,635
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB7E8118D3B5954D6
GO
Isoform 2 (identifier: Q5T200-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1440-1440: E → EA
     1558-1563: DADNLF → GSFILL
     1564-1668: Missing.

Show »
Length:1,564
Mass (Da):184,869
Checksum:iEDF7A3EA9DB7448B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T9K0Q5T9K0_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H13
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WX14A0A087WX14_HUMAN
Zinc finger CCCH domain-containing ...
ZC3H13
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti702 – 704EKE → KAR in BAA74876 (PubMed:10048485).Curated3
Sequence conflicti967I → K in CAD38544 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0227271429E → D4 PublicationsCorresponds to variant dbSNP:rs9534264Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0272021440E → EA in isoform 2. 2 Publications1
Alternative sequenceiVSP_0142521558 – 1563DADNLF → GSFILL in isoform 2. 2 Publications6
Alternative sequenceiVSP_0142531564 – 1668Missing in isoform 2. 2 PublicationsAdd BLAST105

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY283618 mRNA Translation: AAP37483.1
AL157758 Genomic DNA No translation available.
AL445232 Genomic DNA No translation available.
AL831833 mRNA Translation: CAD38544.1
AL136745 mRNA Translation: CAB66679.2
AB020660 mRNA Translation: BAA74876.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS81766.1 [Q5T200-1]
CCDS9400.1 [Q5T200-2]

NCBI Reference Sequences

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RefSeqi
NP_001070256.1, NM_001076788.1
NP_001317493.1, NM_001330564.1
NP_001317494.1, NM_001330565.1 [Q5T200-1]
NP_001317495.1, NM_001330566.1 [Q5T200-1]
NP_001317496.1, NM_001330567.1 [Q5T200-1]
NP_055885.3, NM_015070.5 [Q5T200-2]
XP_005266369.1, XM_005266312.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.136102

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000242848; ENSP00000242848; ENSG00000123200 [Q5T200-1]
ENST00000282007; ENSP00000282007; ENSG00000123200 [Q5T200-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23091

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:23091

UCSC genome browser

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UCSCi
uc001vas.3 human [Q5T200-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY283618 mRNA Translation: AAP37483.1
AL157758 Genomic DNA No translation available.
AL445232 Genomic DNA No translation available.
AL831833 mRNA Translation: CAD38544.1
AL136745 mRNA Translation: CAB66679.2
AB020660 mRNA Translation: BAA74876.1
CCDSiCCDS81766.1 [Q5T200-1]
CCDS9400.1 [Q5T200-2]
RefSeqiNP_001070256.1, NM_001076788.1
NP_001317493.1, NM_001330564.1
NP_001317494.1, NM_001330565.1 [Q5T200-1]
NP_001317495.1, NM_001330566.1 [Q5T200-1]
NP_001317496.1, NM_001330567.1 [Q5T200-1]
NP_055885.3, NM_015070.5 [Q5T200-2]
XP_005266369.1, XM_005266312.1
UniGeneiHs.136102

3D structure databases

ProteinModelPortaliQ5T200
SMRiQ5T200
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116719, 58 interactors
ComplexPortaliCPX-1605 WMM N6-adenosine-methyltransferase complex
CORUMiQ5T200
IntActiQ5T200, 17 interactors
MINTiQ5T200
STRINGi9606.ENSP00000282007

PTM databases

iPTMnetiQ5T200
PhosphoSitePlusiQ5T200

Polymorphism and mutation databases

BioMutaiZC3H13
DMDMi68052314

Proteomic databases

EPDiQ5T200
MaxQBiQ5T200
PaxDbiQ5T200
PeptideAtlasiQ5T200
PRIDEiQ5T200
ProteomicsDBi64298
64299 [Q5T200-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242848; ENSP00000242848; ENSG00000123200 [Q5T200-1]
ENST00000282007; ENSP00000282007; ENSG00000123200 [Q5T200-2]
GeneIDi23091
KEGGihsa:23091
UCSCiuc001vas.3 human [Q5T200-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23091
EuPathDBiHostDB:ENSG00000123200.16

GeneCards: human genes, protein and diseases

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GeneCardsi
ZC3H13

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0000705
HIX0011294
HIX0039579
HGNCiHGNC:20368 ZC3H13
HPAiHPA039340
HPA040140
HPA047806
MIMi616453 gene
neXtProtiNX_Q5T200
OpenTargetsiENSG00000123200
PharmGKBiPA134907656

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1874 Eukaryota
ENOG410XQ2A LUCA
GeneTreeiENSGT00730000111163
HOVERGENiHBG107115
InParanoidiQ5T200
KOiK22909
OMAiGQVFSPK
OrthoDBiEOG091G01GI
PhylomeDBiQ5T200
TreeFamiTF332670

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZC3H13 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZC3H13

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23091
PMAP-CutDBiQ5T200

Protein Ontology

More...
PROi
PR:Q5T200

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000123200 Expressed in 234 organ(s), highest expression level in frontal cortex
CleanExiHS_ZC3H13
ExpressionAtlasiQ5T200 baseline and differential
GenevisibleiQ5T200 HS

Family and domain databases

InterProiView protein in InterPro
IPR000571 Znf_CCCH
IPR036855 Znf_CCCH_sf
PfamiView protein in Pfam
PF00642 zf-CCCH, 1 hit
SMARTiView protein in SMART
SM00356 ZnF_C3H1, 1 hit
SUPFAMiSSF90229 SSF90229, 1 hit
PROSITEiView protein in PROSITE
PS50103 ZF_C3H1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZC3HD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T200
Secondary accession number(s): A2A323
, O94936, Q5T1Z9, Q7Z7J3, Q8NDT6, Q9H0L6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: December 21, 2004
Last modified: December 5, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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