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Entry version 147 (17 Jun 2020)
Sequence version 1 (21 Dec 2004)
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Protein

Transcription factor HIVEP3

Gene

HIVEP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri192 – 214C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri220 – 242C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri640 – 670CCHC HIVEP-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri1754 – 1776C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1782 – 1806C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8939902 Regulation of RUNX2 expression and activity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor HIVEP3
Alternative name(s):
Human immunodeficiency virus type I enhancer-binding protein 3
Kappa-B and V(D)J recombination signal sequences-binding protein
Kappa-binding protein 1
Short name:
KBP-1
Zinc finger protein ZAS3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HIVEP3
Synonyms:KBP1, KIAA1555, KRC, ZAS3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000127124.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13561 HIVEP3

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606649 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5T1R4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
59269

Open Targets

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OpenTargetsi
ENSG00000127124

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA29299

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q5T1R4 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
HIVEP3

Domain mapping of disease mutations (DMDM)

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DMDMi
74756245

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003316271 – 2406Transcription factor HIVEP3Add BLAST2406

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated on threonine and serine residues.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5T1R4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5T1R4

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q5T1R4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5T1R4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5T1R4

PeptideAtlas

More...
PeptideAtlasi
Q5T1R4

PRoteomics IDEntifications database

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PRIDEi
Q5T1R4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
64282 [Q5T1R4-1]
64283 [Q5T1R4-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5T1R4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5T1R4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By 12-O-tetradecanoylphorbol-13 acetate (TPA).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000127124 Expressed in buccal mucosa cell and 176 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q5T1R4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000127124 Tissue enhanced (brain, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TRAF1 AND TRAF2 as well as with JUN.

Forms a multimeric complex with RUNX2 and E3 ubiquitin ligase WWP1 (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121861, 12 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q5T1R4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000361664

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q5T1R4 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q5T1R4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1964 – 196714
Repeati1970 – 197324
Repeati1993 – 199634
Repeati1998 – 200144
Repeati2067 – 207054
Repeati2079 – 208264

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni192 – 242ZAS1Add BLAST51
Regioni211 – 1074No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUNBy similarityAdd BLAST864
Regioni264 – 287Acidic 1Add BLAST24
Regioni862 – 883Acidic 2Add BLAST22
Regioni1754 – 1806ZAS2Add BLAST53
Regioni1817 – 1872Acidic 3Add BLAST56
Regioni2053 – 21486 X 4 AA tandem repeats of S-P-X-[RK]Add BLAST96

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1442 – 1466Sequence analysisAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi903 – 909Nuclear localization signalSequence analysis7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi308 – 334Ser-richAdd BLAST27
Compositional biasi378 – 414Ser-richAdd BLAST37
Compositional biasi797 – 819Ser-richAdd BLAST23
Compositional biasi844 – 880Glu/Pro-richAdd BLAST37
Compositional biasi916 – 948Ser-richAdd BLAST33
Compositional biasi1907 – 1936Ser-richAdd BLAST30

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ZAS2 domain binds DNA as dimers, tetramers, and multiple of tetramers and readily forms highly ordred DNA-protein structures.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri192 – 214C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri220 – 242C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri640 – 670CCHC HIVEP-typePROSITE-ProRule annotationAdd BLAST31
Zinc fingeri1754 – 1776C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1782 – 1806C2H2-type 4PROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157218

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000719_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5T1R4

KEGG Orthology (KO)

More...
KOi
K09239

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHQKQPK

Database of Orthologous Groups

More...
OrthoDBi
212048at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5T1R4

TreeFam database of animal gene trees

More...
TreeFami
TF331837

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034729 ZF_CCHC_HIVEP
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51811 ZF_CCHC_HIVEP, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms can be generated by alternative splicing or polyadenylation. HIVEP3L transcript may lack exon 7 leading to a premature codon stop.1 Publication
Isoform 1 (identifier: Q5T1R4-1) [UniParc]FASTAAdd to basket
Also known as: HIVEP3S

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPEQSVKGT KKAEGSPRKR LTKGEAIQTS VSSSVPYPGS GTAATQESPA
60 70 80 90 100
QELLAPQPFP GPSSVLREGS QEKTGQQQKP PKRPPIEASV HISQLPQHPL
110 120 130 140 150
TPAFMSPGKP EHLLEGSTWQ LVDPMRPGPS GSFVAPGLHP QSQLLPSHAS
160 170 180 190 200
IIPPEDLPGV PKVFVPRPSQ VSLKPTEEAH KKERKPQKPG KYICQYCSRP
210 220 230 240 250
CAKPSVLQKH IRSHTGERPY PCGPCGFSFK TKSNLYKHRK SHAHRIKAGL
260 270 280 290 300
ASGMGGEMYP HGLEMERIPG EEFEEPTEGE STDSEEETSA TSGHPAELSP
310 320 330 340 350
RPKQPLLSSG LYSSGSHSSS HERCSLSQSS TAQSLEDPPP FVEPSSEHPL
360 370 380 390 400
SHKPEDTHTI KQKLALRLSE RKKVIDEQAF LSPGSKGSTE SGYFSRSESA
410 420 430 440 450
EQQVSPPNTN AKSYAEIIFG KCGRIGQRTA MLTATSTQPL LPLSTEDKPS
460 470 480 490 500
LVPLSVPRTQ VIEHITKLIT INEAVVDTSE IDSVKPRRSS LSRRSSMESP
510 520 530 540 550
KSSLYREPLS SHSEKTKPEQ SLLSLQHPPS TAPPVPLLRS HSMPSAACTI
560 570 580 590 600
STPHHPFRGS YSFDDHITDS EALSHSSHVF TSHPRMLKRQ PAIELPLGGE
610 620 630 640 650
YSSEEPGPSS KDTASKPSDE VEPKESELTK KTKKGLKTKG VIYECNICGA
660 670 680 690 700
RYKKRDNYEA HKKYYCSELQ IAKPISAGTH TSPEAEKSQI EHEPWSQMMH
710 720 730 740 750
YKLGTTLELT PLRKRRKEKS LGDEEEPPAF ESTKSQFGSP GPSDAARNLP
760 770 780 790 800
LESTKSPAEP SKSVPSLEGP TGFQPRTPKP GSGSESGKER RTTSKEISVI
810 820 830 840 850
QHTSSFEKSD SLEQPSGLEG EDKPLAQFPS PPPAPHGRSA HSLQPKLVRQ
860 870 880 890 900
PNIQVPEILV TEEPDRPDTE PEPPPKEPEK TEEFQWPQRS QTLAQLPAEK
910 920 930 940 950
LPPKKKRLRL AEMAQSSGES SFESSVPLSR SPSQESNVSL SGSSRSASFE
960 970 980 990 1000
RDDHGKAEAP SPSSDMRPKP LGTHMLTVPS HHPHAREMRR SASEQSPNVS
1010 1020 1030 1040 1050
HSAHMTETRS KSFDYGSLSL TGPSAPAPVA PPARVAPPER RKCFLVRQAS
1060 1070 1080 1090 1100
LSRPPESELE VAPKGRQESE EPQPSSSKPS AKSSLSQISS AATSHGGPPG
1110 1120 1130 1140 1150
GKGPGQDRPP LGPTVPYTEA LQVFHHPVAQ TPLHEKPYLP PPVSLFSFQH
1160 1170 1180 1190 1200
LVQHEPGQSP EFFSTQAMSS LLSSPYSMPP LPPSLFQAPP LPLQPTVLHP
1210 1220 1230 1240 1250
GQLHLPQLMP HPANIPFRQP PSFLPMPYPT SSALSSGFFL PLQSQFALQL
1260 1270 1280 1290 1300
PGDVESHLPQ IKTSLAPLAT GSAGLSPSTE YSSDIRLPPV APPASSSAPT
1310 1320 1330 1340 1350
SAPPLALPAC PDTMVSLVVP VRVQTNMPSY GSAMYTTLSQ ILVTQSQGSS
1360 1370 1380 1390 1400
ATVALPKFEE PPSKGTTVCG ADVHEVGPGP SGLSEEQSRA FPTPYLRVPV
1410 1420 1430 1440 1450
TLPERKGTSL SSESILSLEG SSSTAGGSKR VLSPAGSLEL TMETQQQKRV
1460 1470 1480 1490 1500
KEEEASKADE KLELVKPCSV VLTSTEDGKR PEKSHLGNQG QGRRELEMLS
1510 1520 1530 1540 1550
SLSSDPSDTK EIPPLPHPAL SHGTAPGSEA LKEYPQPSGK PHRRGLTPLS
1560 1570 1580 1590 1600
VKKEDSKEQP DLPSLAPPSS LPLSETSSRP AKSQEGTDSK KVLQFPSLHT
1610 1620 1630 1640 1650
TTNVSWCYLN YIKPNHIQHA DRRSSVYAGW CISLYNPNLP GVSTKAALSL
1660 1670 1680 1690 1700
LRSKQKVSKE TYTMATAPHP EAGRLVPSSS RKPRMTEVHL PSLVSPEGQK
1710 1720 1730 1740 1750
DLARVEKEEE RRGEPEEDAP ASQRGEPARI KIFEGGYKSN EEYVYVRGRG
1760 1770 1780 1790 1800
RGKYVCEECG IRCKKPSMLK KHIRTHTDVR PYVCKHCHFA FKTKGNLTKH
1810 1820 1830 1840 1850
MKSKAHSKKC QETGVLEELE AEEGTSDDLF QDSEGREGSE AVEEHQFSDL
1860 1870 1880 1890 1900
EDSDSDSDLD EDEDEDEEES QDELSRPSSE APPPGPPHAL RADSSPILGP
1910 1920 1930 1940 1950
QPPDAPASGT EATRGSSVSE AERLTASSCS MSSQSMPGLP WLGPAPLGSV
1960 1970 1980 1990 2000
EKDTGSALSY KPVSPRRPWS PSKEAGSRPP LARKHSLTKN DSSPQRCSPA
2010 2020 2030 2040 2050
REPQASAPSP PGLHVDPGRG MGALPCGSPR LQLSPLTLCP LGRELAPRAH
2060 2070 2080 2090 2100
VLSKLEGTTD PGLPRYSPTR RWSPGQAESP PRSAPPGKWA LAGPGSPSAG
2110 2120 2130 2140 2150
EHGPGLGLDP RVLFPPAPLP HKLLSRSPET CASPWQKAES RSPSCSPGPA
2160 2170 2180 2190 2200
HPLSSRPFSA LHDFHGHILA RTEENIFSHL PLHSQHLTRA PCPLIPIGGI
2210 2220 2230 2240 2250
QMVQARPGAH PTLLPGPTAA WVSGFSGGGS DLTGAREAQE RGRWSPTESS
2260 2270 2280 2290 2300
SASVSPVAKV SKFTLSSELE GGDYPKERER TGGGPGRPPD WTPHGTGAPA
2310 2320 2330 2340 2350
EPTPTHSPCT PPDTLPRPPQ GRRAAQSWSP RLESPRAPTN PEPSATPPLD
2360 2370 2380 2390 2400
RSSSVGCLAE ASARFPARTR NLSGEPRTRQ DSPKPSGSGE PRAHPHQPED

RVPPNA
Length:2,406
Mass (Da):259,465
Last modified:December 21, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAFCCFDAF87014A7D
GO
Isoform 2 (identifier: Q5T1R4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2136-2136: Missing.

Show »
Length:2,405
Mass (Da):259,336
Checksum:i2FC59B5BAB2DE97D
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB13381 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti44A → P in AAK01082 (PubMed:11161801).Curated1
Sequence conflicti94 – 95QL → HV in AAK01082 (PubMed:11161801).Curated2
Sequence conflicti123D → S in AAK01082 (PubMed:11161801).Curated1
Sequence conflicti127P → L in AAK01082 (PubMed:11161801).Curated1
Sequence conflicti133 – 134FV → LL in AAK01082 (PubMed:11161801).Curated2
Sequence conflicti589R → P in AAK01082 (PubMed:11161801).Curated1
Sequence conflicti901L → A in AAK01082 (PubMed:11161801).Curated1
Sequence conflicti961S → D in AAK01082 (PubMed:11161801).Curated1
Sequence conflicti1034 – 1035RV → GE in AAK01082 (PubMed:11161801).Curated2
Sequence conflicti1048 – 1049QA → SP in AAK01082 (PubMed:11161801).Curated2
Sequence conflicti1110P → A in AAK01082 (PubMed:11161801).Curated1
Sequence conflicti1180P → L in BAB13381 (PubMed:10997877).Curated1
Sequence conflicti1180P → L in AAI52564 (PubMed:15489334).Curated1
Sequence conflicti1279T → Q in AAK01082 (PubMed:11161801).Curated1
Sequence conflicti1524T → Q in AAK01082 (PubMed:11161801).Curated1
Sequence conflicti2376P → S in AAK01082 (PubMed:11161801).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04291035V → I. Corresponds to variant dbSNP:rs2146315Ensembl.1
Natural variantiVAR_042911484V → M in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs780211835Ensembl.1
Natural variantiVAR_042912575H → R3 PublicationsCorresponds to variant dbSNP:rs2810566Ensembl.1
Natural variantiVAR_0429131087Q → H. Corresponds to variant dbSNP:rs17363472Ensembl.1
Natural variantiVAR_0429142023A → P3 PublicationsCorresponds to variant dbSNP:rs2483689Ensembl.1
Natural variantiVAR_0429152109D → A3 PublicationsCorresponds to variant dbSNP:rs2991344Ensembl.1
Natural variantiVAR_0429162272G → R1 PublicationCorresponds to variant dbSNP:rs11809423EnsemblClinVar.1
Natural variantiVAR_0429172339T → A3 PublicationsCorresponds to variant dbSNP:rs9439043EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0332792136Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF278765 mRNA Translation: AAK01082.1
AB046775 mRNA Translation: BAB13381.2 Different initiation.
AL445933 Genomic DNA No translation available.
BC152563 mRNA Translation: AAI52564.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS44124.1 [Q5T1R4-2]
CCDS463.1 [Q5T1R4-1]

NCBI Reference Sequences

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RefSeqi
NP_001121186.1, NM_001127714.2 [Q5T1R4-2]
NP_078779.2, NM_024503.4 [Q5T1R4-1]
XP_011540186.1, XM_011541884.2 [Q5T1R4-1]
XP_016857481.1, XM_017001992.1 [Q5T1R4-1]
XP_016857482.1, XM_017001993.1 [Q5T1R4-1]
XP_016857483.1, XM_017001994.1 [Q5T1R4-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000372583; ENSP00000361664; ENSG00000127124 [Q5T1R4-1]
ENST00000372584; ENSP00000361665; ENSG00000127124 [Q5T1R4-2]
ENST00000643665; ENSP00000494598; ENSG00000127124 [Q5T1R4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
59269

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:59269

UCSC genome browser

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UCSCi
uc001cgz.5 human [Q5T1R4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF278765 mRNA Translation: AAK01082.1
AB046775 mRNA Translation: BAB13381.2 Different initiation.
AL445933 Genomic DNA No translation available.
BC152563 mRNA Translation: AAI52564.1
CCDSiCCDS44124.1 [Q5T1R4-2]
CCDS463.1 [Q5T1R4-1]
RefSeqiNP_001121186.1, NM_001127714.2 [Q5T1R4-2]
NP_078779.2, NM_024503.4 [Q5T1R4-1]
XP_011540186.1, XM_011541884.2 [Q5T1R4-1]
XP_016857481.1, XM_017001992.1 [Q5T1R4-1]
XP_016857482.1, XM_017001993.1 [Q5T1R4-1]
XP_016857483.1, XM_017001994.1 [Q5T1R4-2]

3D structure databases

SMRiQ5T1R4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121861, 12 interactors
CORUMiQ5T1R4
STRINGi9606.ENSP00000361664

PTM databases

iPTMnetiQ5T1R4
PhosphoSitePlusiQ5T1R4

Polymorphism and mutation databases

BioMutaiHIVEP3
DMDMi74756245

Proteomic databases

EPDiQ5T1R4
jPOSTiQ5T1R4
MassIVEiQ5T1R4
MaxQBiQ5T1R4
PaxDbiQ5T1R4
PeptideAtlasiQ5T1R4
PRIDEiQ5T1R4
ProteomicsDBi64282 [Q5T1R4-1]
64283 [Q5T1R4-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
32189 28 antibodies

Genome annotation databases

EnsembliENST00000372583; ENSP00000361664; ENSG00000127124 [Q5T1R4-1]
ENST00000372584; ENSP00000361665; ENSG00000127124 [Q5T1R4-2]
ENST00000643665; ENSP00000494598; ENSG00000127124 [Q5T1R4-2]
GeneIDi59269
KEGGihsa:59269
UCSCiuc001cgz.5 human [Q5T1R4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
59269
DisGeNETi59269
EuPathDBiHostDB:ENSG00000127124.13

GeneCards: human genes, protein and diseases

More...
GeneCardsi
HIVEP3
HGNCiHGNC:13561 HIVEP3
HPAiENSG00000127124 Tissue enhanced (brain, lymphoid tissue)
MIMi606649 gene
neXtProtiNX_Q5T1R4
OpenTargetsiENSG00000127124
PharmGKBiPA29299

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000157218
HOGENOMiCLU_000719_1_0_1
InParanoidiQ5T1R4
KOiK09239
OMAiGHQKQPK
OrthoDBi212048at2759
PhylomeDBiQ5T1R4
TreeFamiTF331837

Enzyme and pathway databases

ReactomeiR-HSA-8939902 Regulation of RUNX2 expression and activity

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
59269 14 hits in 809 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HIVEP3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
HIVEP3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
59269
PharosiQ5T1R4 Tbio

Protein Ontology

More...
PROi
PR:Q5T1R4
RNActiQ5T1R4 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000127124 Expressed in buccal mucosa cell and 176 other tissues
GenevisibleiQ5T1R4 HS

Family and domain databases

InterProiView protein in InterPro
IPR034729 ZF_CCHC_HIVEP
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 5 hits
SUPFAMiSSF57667 SSF57667, 3 hits
PROSITEiView protein in PROSITE
PS51811 ZF_CCHC_HIVEP, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZEP3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5T1R4
Secondary accession number(s): A7YY91
, Q5T1R5, Q9BZS0, Q9HCL7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: December 21, 2004
Last modified: June 17, 2020
This is version 147 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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