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Protein

Solute carrier family 35 member F1

Gene

SLC35F1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative solute transporter.Curated

GO - Molecular functioni

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.7.24.9 the drug/metabolite transporter (dmt) superfamily

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member F1
Gene namesi
Name:SLC35F1
Synonyms:C6orf169
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000196376.10
HGNCiHGNC:21483 SLC35F1
neXtProtiNX_Q5T1Q4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Transmembranei129 – 147HelicalSequence analysisAdd BLAST19
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
Transmembranei284 – 304HelicalSequence analysisAdd BLAST21
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Transmembranei335 – 355HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi222553
OpenTargetsiENSG00000196376
PharmGKBiPA134985447

Polymorphism and mutation databases

BioMutaiSLC35F1
DMDMi160177559

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073071 – 408Solute carrier family 35 member F1Add BLAST408

Proteomic databases

PaxDbiQ5T1Q4
PeptideAtlasiQ5T1Q4
PRIDEiQ5T1Q4
ProteomicsDBi64281

PTM databases

iPTMnetiQ5T1Q4
PhosphoSitePlusiQ5T1Q4

Expressioni

Gene expression databases

BgeeiENSG00000196376 Expressed in 151 organ(s), highest expression level in substantia nigra
CleanExiHS_SLC35F1
GenevisibleiQ5T1Q4 HS

Organism-specific databases

HPAiHPA019576

Interactioni

Protein-protein interaction databases

BioGridi128804, 4 interactors
IntActiQ5T1Q4, 7 interactors
STRINGi9606.ENSP00000353557

Structurei

3D structure databases

ProteinModelPortaliQ5T1Q4
SMRiQ5T1Q4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC35F solute transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2766 Eukaryota
COG0697 LUCA
GeneTreeiENSGT00390000015655
HOGENOMiHOG000241333
HOVERGENiHBG058983
InParanoidiQ5T1Q4
KOiK15287
OMAiQQGAGEN
OrthoDBiEOG091G0O0G
PhylomeDBiQ5T1Q4
TreeFamiTF313645

Family and domain databases

InterProiView protein in InterPro
IPR009262 SLC35_F1/F2/F6
PfamiView protein in Pfam
PF06027 SLC35F, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q5T1Q4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPPEQPQQQ LQPPSPAPPN HVVTTIENLP AEGSGGGGSL SASSRAGVRQ
60 70 80 90 100
RIRKVLNREM LISVALGQVL SLLICGIGLT SKYLSEDFHA NTPVFQSFLN
110 120 130 140 150
YILLFLVYTT TLAVRQGEEN LLAILRRRWW KYMILGLIDL EANYLVVKAY
160 170 180 190 200
QYTTLTSIQL LDCFVIPVVI LLSWFFLLIR YKAVHFIGIV VCILGMGCMV
210 220 230 240 250
GADVLVGRHQ GAGENKLVGD LLVLGGATLY GISNVWEEYI IRTLSRVEFL
260 270 280 290 300
GMIGLFGAFF SGIQLAIMEH KELLKVPWDW QIGLLYVGFS ACMFGLYSFM
310 320 330 340 350
PVVIKKTSAT SVNLSLLTAD LYSLFCGLFL FHYKFSGLYL LSFFTILIGL
360 370 380 390 400
VLYSSTSTYI AQDPRVYKQF RNPSGPVVDL PTTAQVEPSV TYTSLGQETE

EEPHVRVA
Length:408
Mass (Da):45,346
Last modified:February 20, 2007 - v2
Checksum:i2E459610FC84ECD8
GO
Isoform 2 (identifier: Q5T1Q4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-59: Missing.

Note: No experimental confirmation available.
Show »
Length:349
Mass (Da):39,127
Checksum:i08336293619D0C28
GO

Sequence cautioni

The sequence AAH36493 differs from that shown. Reason: Frameshift at positions 53 and 242.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11 – 13LQP → AER in AAH36493 (PubMed:15489334).Curated3
Sequence conflicti53R → G in AAH36493 (PubMed:15489334).Curated1
Sequence conflicti154T → N in AAH28615 (PubMed:15489334).Curated1
Sequence conflicti301P → Q in AAH28615 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0572631 – 59Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295860 mRNA Translation: BAG58664.1
AL449196
, AL133379, AL136478, Z95326 Genomic DNA Translation: CAI16177.2
AL450405 Genomic DNA No translation available.
AL590621 Genomic DNA No translation available.
KF458261 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48199.1
CH471051 Genomic DNA Translation: EAW48200.1
BC028615 mRNA Translation: AAH28615.1
BC036493 mRNA Translation: AAH36493.1 Frameshift.
BC114925 mRNA Translation: AAI14926.1
BX640761 mRNA Translation: CAE45867.1
CCDSiCCDS34524.1 [Q5T1Q4-1]
RefSeqiNP_001025029.2, NM_001029858.3 [Q5T1Q4-1]
XP_005266922.1, XM_005266865.4 [Q5T1Q4-1]
UniGeneiHs.654841

Genome annotation databases

EnsembliENST00000360388; ENSP00000353557; ENSG00000196376 [Q5T1Q4-1]
ENST00000621341; ENSP00000484738; ENSG00000196376 [Q5T1Q4-2]
GeneIDi222553
KEGGihsa:222553
UCSCiuc003pxx.4 human [Q5T1Q4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS35F1_HUMAN
AccessioniPrimary (citable) accession number: Q5T1Q4
Secondary accession number(s): B4DJ02
, E1P564, Q1RMG1, Q4G0U9, Q4G167, Q6N007
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: September 12, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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