UniProtKB - Q5T1M7 (Q5T1M7_HUMAN)
Protein
Submitted name:
60 kDa U4/U6 snRNP-specific spliceosomal protein
Gene
PRPF4
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: 60 kDa U4/U6 snRNP-specific spliceosomal proteinImportedSubmitted name: PRP4 pre-mRNA processing factor 4 homolog (Yeast), isoform CRA_bImported |
Gene namesi | Name:PRPF4Imported ORF Names:hCG_29193Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000136875.12 |
Subcellular locationi
Nucleus
- Nucleus speckle ARBA annotation
Nucleus
- nuclear speck Source: HPA
- spliceosomal complex Source: UniProtKB-KW
Keywords - Cellular componenti
SpliceosomeARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000136875, Expressed in corpus epididymis and 234 other tissues |
ExpressionAtlasi | Q5T1M7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 226 – 521 | WD_REPEATS_REGIONInterPro annotationAdd BLAST | 296 | |
Repeati | 268 – 317 | WDPROSITE-ProRule annotationAdd BLAST | 50 | |
Repeati | 318 – 359 | WDPROSITE-ProRule annotationAdd BLAST | 42 | |
Repeati | 360 – 401 | WDPROSITE-ProRule annotationAdd BLAST | 42 | |
Repeati | 402 – 443 | WDPROSITE-ProRule annotationAdd BLAST | 42 | |
Repeati | 444 – 476 | WDPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 487 – 521 | WDPROSITE-ProRule annotationAdd BLAST | 35 |
Keywords - Domaini
RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotationPhylogenomic databases
HOGENOMi | CLU_000288_57_20_1 |
OMAi | DSSWRLW |
Family and domain databases
Gene3Di | 1.10.720.150, 1 hit 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR014906, PRP4-like IPR036285, PRP4-like_sf IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF08799, PRP4, 1 hit PF00400, WD40, 6 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00500, SFM, 1 hit SM00320, WD40, 7 hits |
SUPFAMi | SSF158230, SSF158230, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5T1M7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASSRASSTA TKTKAPDDLV APVVKKPHIY YGSLEEKERE RLAKGESGIL
60 70 80 90 100
GKDGLKAGIE AGNINITSGE VFEIEEHISE RQAEVLAEFE RRKRARQINV
110 120 130 140 150
STDDSEVKAC LRALGEPITL FGEGPAERRE RLRNILSVVG TDALKKTKKD
160 170 180 190 200
DEKSKKSKEE YQQTWYHEGP NSLKVARLWI ANYSLPRAMK RLEEARLHKE
210 220 230 240 250
IPETTRTSQM QELHKSLRSL NNFCSQIGDD RPISYCHFSP NSKMLATACW
260 270 280 290 300
SGLCKLWSVP DCNLLHTLRG HNTNVGAIVF HPKSTVSLDP KDVNLASCAA
310 320 330 340 350
DGSVKLWSLD SDEPVADIEG HTVRVARVMW HPSGRFLGTT CYDRSWRLWD
360 370 380 390 400
LEAQEEILHQ EGHSMGVYDI AFHQDGSLAG TGGLDAFGRV WDLRTGRCIM
410 420 430 440 450
FLEGHLKEIY GINFSPNGYH IATGSGDNTC KVWDLRQRRC VYTIPAHQNL
460 470 480 490 500
VTGVKFEPIH GNFLLTGAYD NTAKIWTHPG WSPLKTLAGH EGKVMGLDIS
510 520
SDGQLIATCS YDRTFKLWMA E
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY572489 mRNA Translation: AAS78572.1 CH471090 Genomic DNA Translation: EAW87363.1 |
RefSeqi | NP_001231855.1, NM_001244926.1 |
Genome annotation databases
GeneIDi | 9128 |
UCSCi | uc004bgy.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY572489 mRNA Translation: AAS78572.1 CH471090 Genomic DNA Translation: EAW87363.1 |
RefSeqi | NP_001231855.1, NM_001244926.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | Q5T1M7 |
PRIDEi | Q5T1M7 |
Protocols and materials databases
Antibodypediai | 15276, 132 antibodies |
DNASUi | 9128 |
Genome annotation databases
GeneIDi | 9128 |
UCSCi | uc004bgy.4, human |
Organism-specific databases
CTDi | 9128 |
VEuPathDBi | HostDB:ENSG00000136875.12 |
Phylogenomic databases
HOGENOMi | CLU_000288_57_20_1 |
OMAi | DSSWRLW |
Miscellaneous databases
BioGRID-ORCSi | 9128, 746 hits in 1000 CRISPR screens |
GenomeRNAii | 9128 |
Gene expression databases
Bgeei | ENSG00000136875, Expressed in corpus epididymis and 234 other tissues |
ExpressionAtlasi | Q5T1M7, baseline and differential |
Family and domain databases
Gene3Di | 1.10.720.150, 1 hit 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR014906, PRP4-like IPR036285, PRP4-like_sf IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF08799, PRP4, 1 hit PF00400, WD40, 6 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00500, SFM, 1 hit SM00320, WD40, 7 hits |
SUPFAMi | SSF158230, SSF158230, 1 hit SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 2 hits PS50082, WD_REPEATS_2, 6 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q5T1M7_HUMAN | |
Accessioni | Q5T1M7Primary (citable) accession number: Q5T1M7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 10, 2005 |
Last sequence update: | May 10, 2005 | |
Last modified: | April 7, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |